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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12574

FusionGeneSummary for FAM13A_GAB1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM13A_GAB1
Fusion gene ID: 12574
HgeneTgene
Gene symbol

FAM13A

GAB1

Gene ID

10144

128869

Gene namefamily with sequence similarity 13 member Aphosphatidylinositol glycan anchor biosynthesis class U
SynonymsARHGAP48|FAM13A1CDC91L1|GAB1
Cytomap

4q22.1

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM13AFAM13A1_v2 proteinfamily with sequence similarity 13, member A1phosphatidylinositol glycan anchor biosynthesis class U proteinCDC91 (cell division cycle 91, S. cerevisiae, homolog)-like 1GPI transamidase component PIG-UGPI transamidase subunitcell division cycle 91-like 1 proteincell division cycle protein 91-li
Modification date2018051920180523
UniProtAcc

O94988

Q13480

Ensembl transtripts involved in fusion geneENST00000395002, ENST00000264344, 
ENST00000503556, ENST00000511976, 
ENST00000508369, ENST00000513837, 
ENST00000502459, ENST00000509094, 
ENST00000515600, 		ENST00000262995, 
ENST00000262994, ENST00000505913, 
ENST00000515388, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 4 X 4=96
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM13A [Title/Abstract] AND GAB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGAB1

GO:0006506

GPI anchor biosynthetic process

15034568

TgeneGAB1

GO:0046425

regulation of JAK-STAT cascade

15034568


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-CZ-5469-01AFAM13Achr4

89726162

-GAB1chr4

144336630

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000395002ENST00000262995FAM13Achr4

89726162

-GAB1chr4

144336630

+
Frame-shiftENST00000395002ENST00000262994FAM13Achr4

89726162

-GAB1chr4

144336630

+
5CDS-5UTRENST00000395002ENST00000505913FAM13Achr4

89726162

-GAB1chr4

144336630

+
5CDS-intronENST00000395002ENST00000515388FAM13Achr4

89726162

-GAB1chr4

144336630

+
Frame-shiftENST00000264344ENST00000262995FAM13Achr4

89726162

-GAB1chr4

144336630

+
Frame-shiftENST00000264344ENST00000262994FAM13Achr4

89726162

-GAB1chr4

144336630

+
5CDS-5UTRENST00000264344ENST00000505913FAM13Achr4

89726162

-GAB1chr4

144336630

+
5CDS-intronENST00000264344ENST00000515388FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000503556ENST00000262995FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000503556ENST00000262994FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-5UTRENST00000503556ENST00000505913FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-intronENST00000503556ENST00000515388FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000511976ENST00000262995FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000511976ENST00000262994FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-5UTRENST00000511976ENST00000505913FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-intronENST00000511976ENST00000515388FAM13Achr4

89726162

-GAB1chr4

144336630

+
Frame-shiftENST00000508369ENST00000262995FAM13Achr4

89726162

-GAB1chr4

144336630

+
Frame-shiftENST00000508369ENST00000262994FAM13Achr4

89726162

-GAB1chr4

144336630

+
5CDS-5UTRENST00000508369ENST00000505913FAM13Achr4

89726162

-GAB1chr4

144336630

+
5CDS-intronENST00000508369ENST00000515388FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000513837ENST00000262995FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000513837ENST00000262994FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-5UTRENST00000513837ENST00000505913FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-intronENST00000513837ENST00000515388FAM13Achr4

89726162

-GAB1chr4

144336630

+
5UTR-3CDSENST00000502459ENST00000262995FAM13Achr4

89726162

-GAB1chr4

144336630

+
5UTR-3CDSENST00000502459ENST00000262994FAM13Achr4

89726162

-GAB1chr4

144336630

+
5UTR-5UTRENST00000502459ENST00000505913FAM13Achr4

89726162

-GAB1chr4

144336630

+
5UTR-intronENST00000502459ENST00000515388FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000509094ENST00000262995FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000509094ENST00000262994FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-5UTRENST00000509094ENST00000505913FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-intronENST00000509094ENST00000515388FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000515600ENST00000262995FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-3CDSENST00000515600ENST00000262994FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-5UTRENST00000515600ENST00000505913FAM13Achr4

89726162

-GAB1chr4

144336630

+
intron-intronENST00000515600ENST00000515388FAM13Achr4

89726162

-GAB1chr4

144336630

+

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FusionProtFeatures for FAM13A_GAB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM13A

O94988

GAB1

Q13480

Adapter protein that plays a role in intracellularsignaling cascades triggered by activated receptor-type kinases.Plays a role in FGFR1 signaling. Probably involved in signaling bythe epidermal growth factor receptor (EGFR) and the insulinreceptor (INSR).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM13A_GAB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM13A_GAB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM13AMPP1, PCNA, PPP2R1A, ERP44, RTEL1, UNC119, TBCCD1GAB1GRAP2, ARHGAP32, ROCK1, PIK3R1, GRB2, PLCG1, C1QBP, MAP3K3, PTPN11, EGFR, CRKL, MET, SHC1, CRK, MARK2, PRKCI, PARD3, MST1R, GAB2, BAG3, GTF2A1L, CASP1, NTRK1, DYNLT1, TRIM15, FRS2, CDH1, PTPRA, LGALS7, TUFM, ARL4C, SYP, ERBB2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM13A_GAB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM13A_GAB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAM13AC0024117Chronic Obstructive Airway Disease1CTD_human
HgeneFAM13AC1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET
TgeneGAB1C0032460Polycystic Ovary Syndrome1CTD_human