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Fusion gene ID: 12573 |
FusionGeneSummary for FAM13A_ABCG2 |
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Fusion gene information | Fusion gene name: FAM13A_ABCG2 | Fusion gene ID: 12573 | Hgene | Tgene | Gene symbol | FAM13A | ABCG2 | Gene ID | 10144 | 9429 |
Gene name | family with sequence similarity 13 member A | ATP binding cassette subfamily G member 2 (Junior blood group) | |
Synonyms | ARHGAP48|FAM13A1 | ABC15|ABCP|BCRP|BCRP1|BMDP|CD338|CDw338|EST157481|GOUT1|MRX|MXR|MXR-1|MXR1|UAQTL1 | |
Cytomap | 4q22.1 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM13AFAM13A1_v2 proteinfamily with sequence similarity 13, member A1 | ATP-binding cassette sub-family G member 2ABC transporterATP-binding cassette transporter G2ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)breast cancer resistance proteinmitoxantrone resistance-associated proteinmulti drug | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | O94988 | Q9UNQ0 | |
Ensembl transtripts involved in fusion gene | ENST00000395002, ENST00000264344, ENST00000503556, ENST00000511976, ENST00000508369, ENST00000513837, ENST00000502459, ENST00000509094, ENST00000515600, | ENST00000515655, ENST00000237612, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
# samples | 3 | 2 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: FAM13A [Title/Abstract] AND ABCG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SKCM | TCGA-D3-A8GO-06A | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000395002 | ENST00000515655 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
Frame-shift | ENST00000395002 | ENST00000237612 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000264344 | ENST00000515655 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000264344 | ENST00000237612 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
Frame-shift | ENST00000503556 | ENST00000515655 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
Frame-shift | ENST00000503556 | ENST00000237612 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000511976 | ENST00000515655 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000511976 | ENST00000237612 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
Frame-shift | ENST00000508369 | ENST00000515655 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
Frame-shift | ENST00000508369 | ENST00000237612 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
Frame-shift | ENST00000513837 | ENST00000515655 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
Frame-shift | ENST00000513837 | ENST00000237612 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000502459 | ENST00000515655 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000502459 | ENST00000237612 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000509094 | ENST00000515655 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000509094 | ENST00000237612 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000515600 | ENST00000515655 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
intron-3CDS | ENST00000515600 | ENST00000237612 | FAM13A | chr4 | 89744127 | - | ABCG2 | chr4 | 89053787 | - |
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FusionProtFeatures for FAM13A_ABCG2 |
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Hgene | Tgene |
FAM13A | ABCG2 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM13A_ABCG2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM13A_ABCG2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM13A | MPP1, PCNA, PPP2R1A, ERP44, RTEL1, UNC119, TBCCD1 | ABCG2 | DBN1, PCDH7, RAB7A, SYNPO, GOLT1B, MYO5C, PHF12 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM13A_ABCG2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM13A_ABCG2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FAM13A | C0024117 | Chronic Obstructive Airway Disease | 1 | CTD_human |
Hgene | FAM13A | C1800706 | Idiopathic Pulmonary Fibrosis | 1 | CTD_human;ORPHANET |
Tgene | ABCG2 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Tgene | ABCG2 | C0001430 | Adenoma | 1 | CTD_human |
Tgene | ABCG2 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | ABCG2 | C0023892 | Biliary cirrhosis | 1 | CTD_human |
Tgene | ABCG2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | ABCG2 | C0027765 | nervous system disorder | 1 | CTD_human |
Tgene | ABCG2 | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Tgene | ABCG2 | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
Tgene | ABCG2 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
Tgene | ABCG2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | ABCG2 | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |