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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12561

FusionGeneSummary for FAM134C_IDUA

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM134C_IDUA
Fusion gene ID: 12561
HgeneTgene
Gene symbol

FAM134C

IDUA

Gene ID

3425

Gene nameiduronidase, alpha-L-
SynonymsIDA|MPS1
Cytomap

4p16.3

Type of geneprotein-coding
Descriptionalpha-L-iduronidase
Modification date20180524
UniProtAcc

P35475

Ensembl transtripts involved in fusion geneENST00000309428, ENST00000585894, 
ENST00000543197, 
ENST00000247933, 
ENST00000453894, ENST00000509744, 
ENST00000514224, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 3 X 2=18
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAM134C [Title/Abstract] AND IDUA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIDUA

GO:0030209

dermatan sulfate catabolic process

24036510


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE939137FAM134Cchr17

40732512

-IDUAchr4

992408

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000309428ENST00000247933FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000309428ENST00000453894FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000309428ENST00000509744FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000309428ENST00000514224FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000585894ENST00000247933FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000585894ENST00000453894FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000585894ENST00000509744FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000585894ENST00000514224FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000543197ENST00000247933FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000543197ENST00000453894FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000543197ENST00000509744FAM134Cchr17

40732512

-IDUAchr4

992408

-
intron-intronENST00000543197ENST00000514224FAM134Cchr17

40732512

-IDUAchr4

992408

-

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FusionProtFeatures for FAM134C_IDUA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM134C

IDUA

P35475

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAM134C_IDUA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAM134C_IDUA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAM134C_IDUA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAM134C_IDUA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIDUAC0086431Hurler-Scheie Syndrome11ORPHANET;UNIPROT
TgeneIDUAC0086795Pfaundler-Hurler Syndrome9HPO;ORPHANET;UNIPROT
TgeneIDUAC0026708Mucopolysaccharidosis V8ORPHANET;UNIPROT
TgeneIDUAC0023786Mucopolysaccharidosis I5CTD_human