![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 12525 |
FusionGeneSummary for FAM126B_COQ10B |
![]() |
Fusion gene information | Fusion gene name: FAM126B_COQ10B | Fusion gene ID: 12525 | Hgene | Tgene | Gene symbol | FAM126B | COQ10B | Gene ID | 285172 | 80219 |
Gene name | family with sequence similarity 126 member B | coenzyme Q10B | |
Synonyms | HYCC2 | - | |
Cytomap | 2q33.1 | 2q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM126B | coenzyme Q-binding protein COQ10 homolog B, mitochondrialcoenzyme Q10 homolog B | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8IXS8 | Q9H8M1 | |
Ensembl transtripts involved in fusion gene | ENST00000418596, ENST00000485144, | ENST00000263960, ENST00000409398, ENST00000488445, ENST00000545340, ENST00000409010, | |
Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 4 X 3 X 4=48 |
# samples | 4 | 4 | |
** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FAM126B [Title/Abstract] AND COQ10B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A3UF-01A | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000418596 | ENST00000263960 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
5UTR-intron | ENST00000418596 | ENST00000409398 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
5UTR-3UTR | ENST00000418596 | ENST00000488445 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
5UTR-5UTR | ENST00000418596 | ENST00000545340 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
5UTR-5UTR | ENST00000418596 | ENST00000409010 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
intron-3CDS | ENST00000485144 | ENST00000263960 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
intron-intron | ENST00000485144 | ENST00000409398 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
intron-3UTR | ENST00000485144 | ENST00000488445 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
intron-5UTR | ENST00000485144 | ENST00000545340 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
intron-5UTR | ENST00000485144 | ENST00000409010 | FAM126B | chr2 | 201910219 | - | COQ10B | chr2 | 198324656 | + |
Top |
FusionProtFeatures for FAM126B_COQ10B |
![]() |
Hgene | Tgene |
FAM126B | COQ10B |
Component of a complex required to localizephosphatidylinositol 4-kinase (PI4K) to the plasma membrane.{ECO:0000305|PubMed:26571211}. | Required for the function of coenzyme Q in therespiratory chain. May serve as a chaperone or may be involved inthe transport of Q6 from its site of synthesis to the catalyticsites of the respiratory complexes (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FAM126B_COQ10B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for FAM126B_COQ10B |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM126B | APP, GOLGA2, TRIM27, CDH1, EGFR | COQ10B | ELAVL1, CLPB, CYCS, TIMM8B, BCKDHA, ECH1, PITRM1, POLDIP2, STOML2, CHCHD2, C1QBP |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FAM126B_COQ10B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FAM126B_COQ10B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FAM126B | C0043094 | Weight Gain | 1 | CTD_human |