FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12523

FusionGeneSummary for FAM126A_TRO

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM126A_TRO
Fusion gene ID: 12523
HgeneTgene
Gene symbol

FAM126A

TRO

Gene ID

84668

7216

Gene namefamily with sequence similarity 126 member Atrophinin
SynonymsDRCTNNB1A|HCC|HLD5|HYCC1MAGE-d3|MAGED3
Cytomap

7p15.3

Xp11.21

Type of geneprotein-codingprotein-coding
Descriptionhyccindown regulated by Ctnnb1, adown-regulated by CTNNB1 protein AtrophininMAGE superfamily proteinMAGE-D3 antigenmagphininmelanoma antigen, family D, 3
Modification date2018051920180519
UniProtAcc

Q9BYI3

Q12816

Ensembl transtripts involved in fusion geneENST00000432176, ENST00000409923, 
ENST00000498833, ENST00000409763, 
ENST00000319167, ENST00000173898, 
ENST00000399736, ENST00000375022, 
ENST00000484031, ENST00000420798, 
ENST00000375041, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 1=4
# samples 42
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: FAM126A [Title/Abstract] AND TRO [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFAM126A

GO:0046854

phosphatidylinositol phosphorylation

26571211

HgeneFAM126A

GO:0072659

protein localization to plasma membrane

26571211


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA805483FAM126Achr7

22983678

-TROchrX

54957747

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000432176ENST00000319167FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000432176ENST00000173898FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000432176ENST00000399736FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000432176ENST00000375022FAM126Achr7

22983678

-TROchrX

54957747

+
intron-intronENST00000432176ENST00000484031FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000432176ENST00000420798FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000432176ENST00000375041FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3CDSENST00000409923ENST00000319167FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409923ENST00000173898FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409923ENST00000399736FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409923ENST00000375022FAM126Achr7

22983678

-TROchrX

54957747

+
intron-intronENST00000409923ENST00000484031FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409923ENST00000420798FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409923ENST00000375041FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3CDSENST00000498833ENST00000319167FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000498833ENST00000173898FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000498833ENST00000399736FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000498833ENST00000375022FAM126Achr7

22983678

-TROchrX

54957747

+
intron-intronENST00000498833ENST00000484031FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000498833ENST00000420798FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000498833ENST00000375041FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3CDSENST00000409763ENST00000319167FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409763ENST00000173898FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409763ENST00000399736FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409763ENST00000375022FAM126Achr7

22983678

-TROchrX

54957747

+
intron-intronENST00000409763ENST00000484031FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409763ENST00000420798FAM126Achr7

22983678

-TROchrX

54957747

+
intron-3UTRENST00000409763ENST00000375041FAM126Achr7

22983678

-TROchrX

54957747

+

Top

FusionProtFeatures for FAM126A_TRO


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM126A

Q9BYI3

TRO

Q12816

Could be involved with bystin and tastin in a celladhesion molecule complex that mediates an initial attachment ofthe blastocyst to uterine epithelial cells at the time of theembryo implantation. Directly responsible for homophilic celladhesion.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAM126A_TRO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAM126A_TRO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM126A_TRO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM126A_TRO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAM126AC1864663HYPOMYELINATION AND CONGENITAL CATARACT2CTD_human;ORPHANET;UNIPROT
HgeneFAM126AC0236969Substance-Related Disorders1CTD_human
HgeneFAM126AC3714756Intellectual Disability1CTD_human