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Fusion gene ID: 12523 |
FusionGeneSummary for FAM126A_TRO |
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Fusion gene information | Fusion gene name: FAM126A_TRO | Fusion gene ID: 12523 | Hgene | Tgene | Gene symbol | FAM126A | TRO | Gene ID | 84668 | 7216 |
Gene name | family with sequence similarity 126 member A | trophinin | |
Synonyms | DRCTNNB1A|HCC|HLD5|HYCC1 | MAGE-d3|MAGED3 | |
Cytomap | 7p15.3 | Xp11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | hyccindown regulated by Ctnnb1, adown-regulated by CTNNB1 protein A | trophininMAGE superfamily proteinMAGE-D3 antigenmagphininmelanoma antigen, family D, 3 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9BYI3 | Q12816 | |
Ensembl transtripts involved in fusion gene | ENST00000432176, ENST00000409923, ENST00000498833, ENST00000409763, | ENST00000319167, ENST00000173898, ENST00000399736, ENST00000375022, ENST00000484031, ENST00000420798, ENST00000375041, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 1=4 |
# samples | 4 | 2 | |
** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: FAM126A [Title/Abstract] AND TRO [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FAM126A | GO:0046854 | phosphatidylinositol phosphorylation | 26571211 |
Hgene | FAM126A | GO:0072659 | protein localization to plasma membrane | 26571211 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA805483 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000432176 | ENST00000319167 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000432176 | ENST00000173898 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000432176 | ENST00000399736 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000432176 | ENST00000375022 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-intron | ENST00000432176 | ENST00000484031 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000432176 | ENST00000420798 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000432176 | ENST00000375041 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3CDS | ENST00000409923 | ENST00000319167 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409923 | ENST00000173898 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409923 | ENST00000399736 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409923 | ENST00000375022 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-intron | ENST00000409923 | ENST00000484031 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409923 | ENST00000420798 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409923 | ENST00000375041 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3CDS | ENST00000498833 | ENST00000319167 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000498833 | ENST00000173898 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000498833 | ENST00000399736 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000498833 | ENST00000375022 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-intron | ENST00000498833 | ENST00000484031 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000498833 | ENST00000420798 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000498833 | ENST00000375041 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3CDS | ENST00000409763 | ENST00000319167 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409763 | ENST00000173898 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409763 | ENST00000399736 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409763 | ENST00000375022 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-intron | ENST00000409763 | ENST00000484031 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409763 | ENST00000420798 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
intron-3UTR | ENST00000409763 | ENST00000375041 | FAM126A | chr7 | 22983678 | - | TRO | chrX | 54957747 | + |
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FusionProtFeatures for FAM126A_TRO |
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Hgene | Tgene |
FAM126A | TRO |
Could be involved with bystin and tastin in a celladhesion molecule complex that mediates an initial attachment ofthe blastocyst to uterine epithelial cells at the time of theembryo implantation. Directly responsible for homophilic celladhesion. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM126A_TRO |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM126A_TRO |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM126A_TRO |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM126A_TRO |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FAM126A | C1864663 | HYPOMYELINATION AND CONGENITAL CATARACT | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | FAM126A | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | FAM126A | C3714756 | Intellectual Disability | 1 | CTD_human |