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Fusion gene ID: 12522 |
FusionGeneSummary for FAM126A_TRA2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAM126A_TRA2A | Fusion gene ID: 12522 | Hgene | Tgene | Gene symbol | FAM126A | TRA2A | Gene ID | 84668 | 29896 |
| Gene name | family with sequence similarity 126 member A | transformer 2 alpha homolog | |
| Synonyms | DRCTNNB1A|HCC|HLD5|HYCC1 | AWMS1|HSU53209 | |
| Cytomap | 7p15.3 | 7p15.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | hyccindown regulated by Ctnnb1, adown-regulated by CTNNB1 protein A | transformer-2 protein homolog alphaTRA-2 alphaTRA2-alphaTra2alphahtra-2 alphaputative MAPK activating protein PM24transformer-2 alphatransformer-2 protein homolog A | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BYI3 | Q13595 | |
| Ensembl transtripts involved in fusion gene | ENST00000432176, ENST00000409923, ENST00000498833, ENST00000409763, | ENST00000297071, ENST00000392502, ENST00000538367, ENST00000474586, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 6 X 5=150 |
| # samples | 4 | 7 | |
| ** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAM126A [Title/Abstract] AND TRA2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FAM126A | GO:0046854 | phosphatidylinositol phosphorylation | 26571211 |
| Hgene | FAM126A | GO:0072659 | protein localization to plasma membrane | 26571211 |
| Tgene | TRA2A | GO:0000398 | mRNA splicing, via spliceosome | 9546399 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D9-A4Z6-01A | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| TCGA | RV | SKCM | TCGA-D9-A4Z6-06A | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000432176 | ENST00000297071 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| In-frame | ENST00000432176 | ENST00000392502 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| In-frame | ENST00000432176 | ENST00000538367 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| 5CDS-5UTR | ENST00000432176 | ENST00000474586 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| In-frame | ENST00000409923 | ENST00000297071 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| In-frame | ENST00000409923 | ENST00000392502 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| In-frame | ENST00000409923 | ENST00000538367 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| 5CDS-5UTR | ENST00000409923 | ENST00000474586 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| intron-3CDS | ENST00000498833 | ENST00000297071 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| intron-3CDS | ENST00000498833 | ENST00000392502 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| intron-3CDS | ENST00000498833 | ENST00000538367 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| intron-5UTR | ENST00000498833 | ENST00000474586 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| In-frame | ENST00000409763 | ENST00000297071 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| In-frame | ENST00000409763 | ENST00000392502 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| In-frame | ENST00000409763 | ENST00000538367 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
| 5CDS-5UTR | ENST00000409763 | ENST00000474586 | FAM126A | chr7 | 23023563 | - | TRA2A | chr7 | 23547154 | - |
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FusionProtFeatures for FAM126A_TRA2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAM126A | TRA2A |
| Sequence-specific RNA-binding protein which participatesin the control of pre-mRNA splicing. {ECO:0000269|PubMed:9546399}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >TRA2A | chr7:23023563 | chr7:23547154 | ENST00000297071 | - | 3 | 8 | 226_282 | 175 | 283 | Compositional bias | Note=Arg/Ser-rich (RS2 domain) |
| Tgene | >TRA2A | chr7:23023563 | chr7:23547154 | ENST00000297071 | - | 3 | 8 | 198_225 | 175 | 283 | Region | Note=Linker |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TRA2A | chr7:23023563 | chr7:23547154 | ENST00000297071 | - | 3 | 8 | 30_112 | 175 | 283 | Compositional bias | Note=Arg/Ser-rich (RS1 domain) |
| Tgene | TRA2A | chr7:23023563 | chr7:23547154 | ENST00000297071 | - | 3 | 8 | 119_197 | 175 | 283 | Domain | RRM |
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FusionGeneSequence for FAM126A_TRA2A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FAM126A_ENST00000432176_chr7_23023563_-_TRA2A_ENST00000297071_chr7_23547154_-_159aa MFTSEKGVVEEWLSEFKTLPETSLPNTATNLKDKSSLVSSLTKVIQEPQSEAMERANGMELDGRRIRVDTSITKRAHTPTPGIYMGRPTH >In-frame_FAM126A_ENST00000432176_chr7_23023563_-_TRA2A_ENST00000392502_chr7_23547154_-_158aa MFTSEKGVVEEWLSEFKTLPETSLPNTATNLKDKSSLVSSLTKVIQEPQSEAMERANGMELDGRRIRVDTSITKRAHTPTPGIYMGRPTH >In-frame_FAM126A_ENST00000432176_chr7_23023563_-_TRA2A_ENST00000538367_chr7_23547154_-_159aa MFTSEKGVVEEWLSEFKTLPETSLPNTATNLKDKSSLVSSLTKVIQEPQSEAMERANGMELDGRRIRVDTSITKRAHTPTPGIYMGRPTH >In-frame_FAM126A_ENST00000409923_chr7_23023563_-_TRA2A_ENST00000297071_chr7_23547154_-_159aa MFTSEKGVVEEWLSEFKTLPETSLPNTATNLKDKSSLVSSLTKVIQEPQSEAMERANGMELDGRRIRVDTSITKRAHTPTPGIYMGRPTH >In-frame_FAM126A_ENST00000409923_chr7_23023563_-_TRA2A_ENST00000392502_chr7_23547154_-_158aa MFTSEKGVVEEWLSEFKTLPETSLPNTATNLKDKSSLVSSLTKVIQEPQSEAMERANGMELDGRRIRVDTSITKRAHTPTPGIYMGRPTH >In-frame_FAM126A_ENST00000409923_chr7_23023563_-_TRA2A_ENST00000538367_chr7_23547154_-_159aa MFTSEKGVVEEWLSEFKTLPETSLPNTATNLKDKSSLVSSLTKVIQEPQSEAMERANGMELDGRRIRVDTSITKRAHTPTPGIYMGRPTH >In-frame_FAM126A_ENST00000409763_chr7_23023563_-_TRA2A_ENST00000297071_chr7_23547154_-_108aa AMERANGMELDGRRIRVDTSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYTDRGTDRGTDRTEDTDYRYRRRSPSPTT >In-frame_FAM126A_ENST00000409763_chr7_23023563_-_TRA2A_ENST00000392502_chr7_23547154_-_107aa AMERANGMELDGRRIRVDTSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYTDRGTDRGTDRTEDTDYRYRRSPSPTTS >In-frame_FAM126A_ENST00000409763_chr7_23023563_-_TRA2A_ENST00000538367_chr7_23547154_-_108aa AMERANGMELDGRRIRVDTSITKRAHTPTPGIYMGRPTHSGGGGGGGGGGGGGGGGRRRDSYTDRGTDRGTDRTEDTDYRYRRRSPSPTT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FAM126A_ENST00000432176_chr7_23023563_-_TRA2A_ENST00000297071_chr7_23547154_-_477nt ATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAAT TTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAG CTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCAT AGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGT GGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCT >In-frame_FAM126A_ENST00000432176_chr7_23023563_-_TRA2A_ENST00000392502_chr7_23547154_-_474nt ATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAAT TTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAG CTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCAT AGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGT GGGTATGACAGATATGAAGACTATGATTACCGATACAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGT >In-frame_FAM126A_ENST00000432176_chr7_23023563_-_TRA2A_ENST00000538367_chr7_23547154_-_477nt ATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAAT TTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAG CTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCAT AGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGT GGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCT >In-frame_FAM126A_ENST00000409923_chr7_23023563_-_TRA2A_ENST00000297071_chr7_23547154_-_477nt ATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAAT TTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAG CTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCAT AGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGT GGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCT >In-frame_FAM126A_ENST00000409923_chr7_23023563_-_TRA2A_ENST00000392502_chr7_23547154_-_474nt ATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAAT TTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAG CTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCAT AGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGT GGGTATGACAGATATGAAGACTATGATTACCGATACAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGT >In-frame_FAM126A_ENST00000409923_chr7_23023563_-_TRA2A_ENST00000538367_chr7_23547154_-_477nt ATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAAT TTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAG CTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCAT AGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGT GGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCT >In-frame_FAM126A_ENST00000409763_chr7_23023563_-_TRA2A_ENST00000297071_chr7_23547154_-_324nt GCTATGGAAAGGGCAAATGGAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCA GGCATCTACATGGGCAGACCAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGAT TCTTACTATGATAGAGGATATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTAT >In-frame_FAM126A_ENST00000409763_chr7_23023563_-_TRA2A_ENST00000392502_chr7_23547154_-_321nt GCTATGGAAAGGGCAAATGGAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCA GGCATCTACATGGGCAGACCAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGAT TCTTACTATGATAGAGGATATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACAGACGATCACCTTCTCCTTATTATAGT >In-frame_FAM126A_ENST00000409763_chr7_23023563_-_TRA2A_ENST00000538367_chr7_23547154_-_324nt GCTATGGAAAGGGCAAATGGAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCA GGCATCTACATGGGCAGACCAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGAT TCTTACTATGATAGAGGATATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FAM126A_ENST00000432176_chr7_23023563_-_TRA2A_ENST00000297071_chr7_23547154_-_1489nt GAGAGGCTGGCGGCAGTGGTGGCTCTCCCGGCTGGGTTGTCAGTCAGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAG GAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGC AGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGT TGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATA AAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAA CCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAG GTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACA GAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATG GTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTT AAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTGTTGCTGTTTTCCACCCATTTTATTATACTCTTAAAAGATGTA ATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCCCAATGTTATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTA CCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTTAAAGCTTCTTTTGTGTTAGATACTGTATTAGAGATCTGCATT TATCATGAGTTCCTTTTTTTTTTTAACTTTATTTTTGGGAAAGTAACACATGAAGTAGTTCAGTCATGTCAGGTTTGTCTGGGGTGGAAT GGAACAGTCAGGTAGTTGAAAGTTTTTTTTTAGAGATGAAAAGCTTGTGAACTCCTGTAAAACATGCTGTATTTGAAATACATCTGTTAA AACTTAAAAACTAAAGTGTGATTTTTTTTGTTGTTGTTAAGTTTATTGAAGTTTATTCCCTTAATCAGTGAAGGACAACCCTTATTTATT ACCTAGAGCAGTTGTATAATTCGCTGTTAGAAATTTTGGTATTGGGACAGTGGATAAGCAGGTTATCACATAGCATAGAATTCTTAAAAG >In-frame_FAM126A_ENST00000432176_chr7_23023563_-_TRA2A_ENST00000392502_chr7_23547154_-_1116nt GAGAGGCTGGCGGCAGTGGTGGCTCTCCCGGCTGGGTTGTCAGTCAGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAG GAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGC AGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGT TGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATA AAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAA CCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAG GTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACA GACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTT GCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAG AAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTGTTGCTGTTTTCCACCCATTTTATTATACTCTTAAAAGATGTAATT GTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCCCAATGTTATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCT AGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTTAAAGCTTCTTTTGTGTTAGATACTGTATTAGAGATCTGCATTTAT >In-frame_FAM126A_ENST00000432176_chr7_23023563_-_TRA2A_ENST00000538367_chr7_23547154_-_810nt GAGAGGCTGGCGGCAGTGGTGGCTCTCCCGGCTGGGTTGTCAGTCAGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAG GAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGC AGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGT TGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATA AAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAA CCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAG GTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACA GAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATG GTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTT >In-frame_FAM126A_ENST00000409923_chr7_23023563_-_TRA2A_ENST00000297071_chr7_23547154_-_1444nt AGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGC AGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGAT GTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATG CCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATG GAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGAC CAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGAT ATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGAT CAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTT TTTAATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTT GTGTTGCTGTTTTCCACCCATTTTATTATACTCTTAAAAGATGTAATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAA CCCCAATGTTATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTT TTTAAAGCTTCTTTTGTGTTAGATACTGTATTAGAGATCTGCATTTATCATGAGTTCCTTTTTTTTTTTAACTTTATTTTTGGGAAAGTA ACACATGAAGTAGTTCAGTCATGTCAGGTTTGTCTGGGGTGGAATGGAACAGTCAGGTAGTTGAAAGTTTTTTTTTAGAGATGAAAAGCT TGTGAACTCCTGTAAAACATGCTGTATTTGAAATACATCTGTTAAAACTTAAAAACTAAAGTGTGATTTTTTTTGTTGTTGTTAAGTTTA TTGAAGTTTATTCCCTTAATCAGTGAAGGACAACCCTTATTTATTACCTAGAGCAGTTGTATAATTCGCTGTTAGAAATTTTGGTATTGG GACAGTGGATAAGCAGGTTATCACATAGCATAGAATTCTTAAAAGATACATGTGGGGAAAAGTAGTCTCAAATAAAAGCTAATTTCTTTG >In-frame_FAM126A_ENST00000409923_chr7_23023563_-_TRA2A_ENST00000392502_chr7_23547154_-_1071nt AGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGC AGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGAT GTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATG CCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATG GAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGAC CAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGAT ATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAA GATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTT AATTCTGAGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTG TTGCTGTTTTCCACCCATTTTATTATACTCTTAAAAGATGTAATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCC CAATGTTATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTT >In-frame_FAM126A_ENST00000409923_chr7_23023563_-_TRA2A_ENST00000538367_chr7_23547154_-_765nt AGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGC AGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGAT GTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATG CCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATG GAATGGAGCTGGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGAC CAACTCATAGTGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGAT ATGATCGTGGGTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGAT CAAGATCTCGTTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTT >In-frame_FAM126A_ENST00000409763_chr7_23023563_-_TRA2A_ENST00000297071_chr7_23547154_-_1434nt GGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTC GCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAAT GTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTT GAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCT GGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAG TGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGG GTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCG TTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTG AGATTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTGTTGCTGT TTTCCACCCATTTTATTATACTCTTAAAAGATGTAATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCCCAATGTT ATGTTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTTAAAGCTT CTTTTGTGTTAGATACTGTATTAGAGATCTGCATTTATCATGAGTTCCTTTTTTTTTTTAACTTTATTTTTGGGAAAGTAACACATGAAG TAGTTCAGTCATGTCAGGTTTGTCTGGGGTGGAATGGAACAGTCAGGTAGTTGAAAGTTTTTTTTTAGAGATGAAAAGCTTGTGAACTCC TGTAAAACATGCTGTATTTGAAATACATCTGTTAAAACTTAAAAACTAAAGTGTGATTTTTTTTGTTGTTGTTAAGTTTATTGAAGTTTA TTCCCTTAATCAGTGAAGGACAACCCTTATTTATTACCTAGAGCAGTTGTATAATTCGCTGTTAGAAATTTTGGTATTGGGACAGTGGAT >In-frame_FAM126A_ENST00000409763_chr7_23023563_-_TRA2A_ENST00000392502_chr7_23547154_-_1061nt GGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTC GCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAAT GTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTT GAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCT GGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAG TGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGG GTATGACAGATATGAAGACTATGATTACCGATACAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCGTTC CTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTGAGA TTTCCCCAAGCTGTGGATTCTTCCTACTCCTTAAGAAAAAAACTTTGGTTTATTTAGCATCTACACTTTTGTCAGTTGTGTTGCTGTTTT CCACCCATTTTATTATACTCTTAAAAGATGTAATTGTTGTCATTTTGAACAGTTAAACATCTTGAGTATAAAAAGAACCCCAATGTTATG TTATGCTTTGTAAATTTTTTTTTTTGCTTTTACCTAGATAAACTTCTAGCTAATCAAATAAGGAAAGAAACTGTCTTTTTAAAGCTTCTT >In-frame_FAM126A_ENST00000409763_chr7_23023563_-_TRA2A_ENST00000538367_chr7_23547154_-_755nt GGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTC GCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAAT GTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTT GAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGGCTATGGAAAGGGCAAATGGAATGGAGCT GGATGGTAGAAGAATTCGGGTGGATTATTCTATAACCAAGAGAGCGCACACACCAACACCAGGCATCTACATGGGCAGACCAACTCATAG TGGTGGGGGTGGTGGAGGAGGCGGCGGCGGTGGAGGTGGAGGTGGTGGCAGACGTCGAGATTCTTACTATGATAGAGGATATGATCGTGG GTATGACAGATATGAAGACTATGATTACCGATACAGAAGACGATCACCTTCTCCTTATTATAGTCGATATAGATCACGATCAAGATCTCG TTCCTACAGCCCAAGACGCTATTGATAACGGAATGGTTGCAATTAAGGACATTTTTTTTCCTCTTTTTTTTTTTTTTTTTTTTAATTCTG |
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FusionGenePPI for FAM126A_TRA2A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FAM126A | LPAR6, P2RY8, GAN, CDH1, RGS20, GC, RPGR, P2RX5, SHPK, NR2F2 | TRA2A | TADA2A, YWHAG, NUDT21, SELENBP1, CRABP1, TNNT1, CDK2AP2, C11orf58, ELAVL1, CUL3, CUL5, COPS5, SRSF10, RBM25, SRSF5, CDC5L, SEPT2, NFIA, NHP2L1, NCSTN, SF3A1, BUD31, SF3B3, PHGDH, S100A9, HNRNPC, HNRNPU, PRPF40A, SF3B6, HNRNPM, SAP18, PRPF6, IK, HP1BP3, SEPT7, SMARCB1, PLEC, BARD1, PAXIP1, MAGOH, EIF4A3, PPP1CC, DHX15, U2SURP, CDK6, LBP, NXF1, YTHDC1, CLK3, SRPK2, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, ZNF22, LARP7, SRRM1, MRPS9, MRPS26, THRAP3, LUC7L2, LUC7L, ZNF768, PTCD1, PTCD3, SRRM2, C17orf85, ZFR, PABPC4L, PABPC4, RBBP6, ELAVL2, RPL6, MRPS23, MRPS27, TRUB2, MRPS6, RPL26L1, MTERF3, PAIP1, MRPS18B, MRPL32, C10orf2, MRPS10, DAP3, MEPCE, UPF1, PPIG, LARP1, LARP1B, PHAX, MRPS31, MKRN1, MRPS18C, MRPS5, MRPS7, MRPS22, MRPS15, MRPS35, MRPS25, RRP9, NGRN, MRPS2, MOV10, MRPS33, SRRT, PRPF3, MRPS11, PNN, SRP14, GAR1, MRPS24, CASC3, WDR33, CSNK1E, CSNK1D, MRPS14, GAPDHS, ZCCHC3, MKRN2, ZC3H11A, NOA1, TRA2B, ISY1, SRSF8, CLK1, SRSF7, APOBEC3F, HIST1H2AG, SRSF12, CLK2, MRPL34, MRPS21, SNIP1, NTRK1, SRSF3, SRSF6, EWSR1, CNTRL, CDK2, FEN1, U2AF2, SNRNP70, ZC3H18, C11orf57, SNRPN, NCOA5, PABPC1, SYF2, APOBEC3D, NR3C1, FOXA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM126A_TRA2A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM126A_TRA2A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FAM126A | C1864663 | HYPOMYELINATION AND CONGENITAL CATARACT | 2 | CTD_human;ORPHANET;UNIPROT |
| Hgene | FAM126A | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Hgene | FAM126A | C3714756 | Intellectual Disability | 1 | CTD_human |
| Tgene | TRA2A | C0037274 | Dermatologic disorders | 1 | CTD_human |
| Tgene | TRA2A | C0311375 | Arsenic Poisoning | 1 | CTD_human |
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