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Fusion gene ID: 12521 |
FusionGeneSummary for FAM126A_STEAP1B |
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Fusion gene information | Fusion gene name: FAM126A_STEAP1B | Fusion gene ID: 12521 | Hgene | Tgene | Gene symbol | FAM126A | STEAP1B | Gene ID | 84668 | 256227 |
Gene name | family with sequence similarity 126 member A | STEAP family member 1B | |
Synonyms | DRCTNNB1A|HCC|HLD5|HYCC1 | - | |
Cytomap | 7p15.3 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | hyccindown regulated by Ctnnb1, adown-regulated by CTNNB1 protein A | STEAP family member 1BSTEAP family protein MGC87042 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9BYI3 | Q6NZ63 | |
Ensembl transtripts involved in fusion gene | ENST00000432176, ENST00000409923, ENST00000498833, ENST00000409763, | ENST00000406890, ENST00000404369, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: FAM126A [Title/Abstract] AND STEAP1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FAM126A | GO:0046854 | phosphatidylinositol phosphorylation | 26571211 |
Hgene | FAM126A | GO:0072659 | protein localization to plasma membrane | 26571211 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-3B-A9I3-01A | FAM126A | chr7 | 23015829 | - | STEAP1B | chr7 | 22459455 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000432176 | ENST00000406890 | FAM126A | chr7 | 23015829 | - | STEAP1B | chr7 | 22459455 | - |
5CDS-intron | ENST00000432176 | ENST00000404369 | FAM126A | chr7 | 23015829 | - | STEAP1B | chr7 | 22459455 | - |
In-frame | ENST00000409923 | ENST00000406890 | FAM126A | chr7 | 23015829 | - | STEAP1B | chr7 | 22459455 | - |
5CDS-intron | ENST00000409923 | ENST00000404369 | FAM126A | chr7 | 23015829 | - | STEAP1B | chr7 | 22459455 | - |
intron-3CDS | ENST00000498833 | ENST00000406890 | FAM126A | chr7 | 23015829 | - | STEAP1B | chr7 | 22459455 | - |
intron-intron | ENST00000498833 | ENST00000404369 | FAM126A | chr7 | 23015829 | - | STEAP1B | chr7 | 22459455 | - |
intron-3CDS | ENST00000409763 | ENST00000406890 | FAM126A | chr7 | 23015829 | - | STEAP1B | chr7 | 22459455 | - |
intron-intron | ENST00000409763 | ENST00000404369 | FAM126A | chr7 | 23015829 | - | STEAP1B | chr7 | 22459455 | - |
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FusionProtFeatures for FAM126A_STEAP1B |
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Hgene | Tgene |
FAM126A | STEAP1B |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | STEAP1B | chr7:23015829 | chr7:22459455 | ENST00000406890 | - | 3 | 5 | 100_120 | 235 | 246 | Transmembrane | Helical |
Tgene | STEAP1B | chr7:23015829 | chr7:22459455 | ENST00000406890 | - | 3 | 5 | 145_165 | 235 | 246 | Transmembrane | Helical |
Tgene | STEAP1B | chr7:23015829 | chr7:22459455 | ENST00000406890 | - | 3 | 5 | 199_219 | 235 | 246 | Transmembrane | Helical |
Tgene | STEAP1B | chr7:23015829 | chr7:22459455 | ENST00000406890 | - | 3 | 5 | 52_72 | 235 | 246 | Transmembrane | Helical |
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FusionGeneSequence for FAM126A_STEAP1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_FAM126A_ENST00000432176_chr7_23015829_-_STEAP1B_ENST00000406890_chr7_22459455_-_219aa MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVS ASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEV >In-frame_FAM126A_ENST00000409923_chr7_23015829_-_STEAP1B_ENST00000406890_chr7_22459455_-_219aa MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVS ASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEV |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_FAM126A_ENST00000432176_chr7_23015829_-_STEAP1B_ENST00000406890_chr7_22459455_-_659nt ATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAAT TTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGTTGCTAGAACCTGTCTGTCACCAGCTC TTTGAATTCTATCGCAGTGGAGAGGAGCAGTTGCTTCAATTTACGCTGCAATTTCTCCCAGAACTAATTTGGTGCTACCTTGCAGTCTCA GCCAGCAGAAATGTGCATAGCAGTGGATGCATTGAAGCTCTTCTTCTAGGGGTTTACAATTTGGAAATAGTTGACAAACAGGGACATACC AAAGTATTGAGTTTTACGATTCCATCTTTATCCAAACCATCTGTATACCATGAACCTTCCAGCATTGGGTCCATGGCTCTGACTGAGAGT GCACTATCCCAGCATGGTTTGTCAAAAGTGGTATACAGTGGACCTCATCCTCAAAGGGAGATGCTGACAGCACAGAATCGGTTTGAAGTG TTGACATTCCTTTTGTTGTGTTACAATGCTGCCTTAACTTACATGCCCAGTGTTTCTCTTCAGTCACTGTGTCAAATTTGTTCAAGGTAC >In-frame_FAM126A_ENST00000409923_chr7_23015829_-_STEAP1B_ENST00000406890_chr7_22459455_-_659nt ATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAAT TTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGTTGCTAGAACCTGTCTGTCACCAGCTC TTTGAATTCTATCGCAGTGGAGAGGAGCAGTTGCTTCAATTTACGCTGCAATTTCTCCCAGAACTAATTTGGTGCTACCTTGCAGTCTCA GCCAGCAGAAATGTGCATAGCAGTGGATGCATTGAAGCTCTTCTTCTAGGGGTTTACAATTTGGAAATAGTTGACAAACAGGGACATACC AAAGTATTGAGTTTTACGATTCCATCTTTATCCAAACCATCTGTATACCATGAACCTTCCAGCATTGGGTCCATGGCTCTGACTGAGAGT GCACTATCCCAGCATGGTTTGTCAAAAGTGGTATACAGTGGACCTCATCCTCAAAGGGAGATGCTGACAGCACAGAATCGGTTTGAAGTG TTGACATTCCTTTTGTTGTGTTACAATGCTGCCTTAACTTACATGCCCAGTGTTTCTCTTCAGTCACTGTGTCAAATTTGTTCAAGGTAC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_FAM126A_ENST00000432176_chr7_23015829_-_STEAP1B_ENST00000406890_chr7_22459455_-_1252nt GAGAGGCTGGCGGCAGTGGTGGCTCTCCCGGCTGGGTTGTCAGTCAGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAG GAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGCAGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGC AGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGATGTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGT TGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATGCCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATA AAGTTATCCAGGAGCCACAAAGTGAGTTGCTAGAACCTGTCTGTCACCAGCTCTTTGAATTCTATCGCAGTGGAGAGGAGCAGTTGCTTC AATTTACGCTGCAATTTCTCCCAGAACTAATTTGGTGCTACCTTGCAGTCTCAGCCAGCAGAAATGTGCATAGCAGTGGATGCATTGAAG CTCTTCTTCTAGGGGTTTACAATTTGGAAATAGTTGACAAACAGGGACATACCAAAGTATTGAGTTTTACGATTCCATCTTTATCCAAAC CATCTGTATACCATGAACCTTCCAGCATTGGGTCCATGGCTCTGACTGAGAGTGCACTATCCCAGCATGGTTTGTCAAAAGTGGTATACA GTGGACCTCATCCTCAAAGGGAGATGCTGACAGCACAGAATCGGTTTGAAGTGTTGACATTCCTTTTGTTGTGTTACAATGCTGCCTTAA CTTACATGCCCAGTGTTTCTCTTCAGTCACTGTGTCAAATTTGTTCAAGGTACATGGTAGGATCAACTTCCTGACCTTGTGACAGATCCT GCCAGTAACATGAGAGGAAATGAGAACGAGGCTTTGGAGCACAGCATTGGATTGCTCATGCAGAACACCACCCAGTGCCCTTTCCCTCTG CCACAATGAACAGCCATGCTGCAGGTGACGGCTGCTCTGTCAACATGGATCCGGCAGGGCAGATGAGTGGATCCCCCAGCGGACTCATGA GAGAGCAAACAAAAAGTCCATATGTGTTGTGCTAATCCACTGAGATTGTGTTGGTTGTTACGGAGCCTAACCTAGCCTATCCCGACACGA >In-frame_FAM126A_ENST00000409923_chr7_23015829_-_STEAP1B_ENST00000406890_chr7_22459455_-_1207nt AGTGAGAGGAGGGGGAAGATGGCTCACCGGGACCCGTTCTGCTAGGAAGAAGGGGAGCAGGTGGTGCTGCTACTCGGGAGGAAGCAGAGC AGCCTCCGTCGCTGTCGCTGAGAGCCTCACGAGTCGAGGTCCTGCAGGTGGAGCTCCGGCAGCCGCCCTGGTTGAAGGTTTAGAACAGAT GTGGAAAAATGTTTACTTCAGAGAAAGGGGTTGTGGAGGAATGGTTGTCAGAGTTTAAGACATTACCAGAAACATCTTTACCAAATTATG CCACAAATTTGAAAGACAAGAGTTCTTTAGTTTCATCTCTCTATAAAGTTATCCAGGAGCCACAAAGTGAGTTGCTAGAACCTGTCTGTC ACCAGCTCTTTGAATTCTATCGCAGTGGAGAGGAGCAGTTGCTTCAATTTACGCTGCAATTTCTCCCAGAACTAATTTGGTGCTACCTTG CAGTCTCAGCCAGCAGAAATGTGCATAGCAGTGGATGCATTGAAGCTCTTCTTCTAGGGGTTTACAATTTGGAAATAGTTGACAAACAGG GACATACCAAAGTATTGAGTTTTACGATTCCATCTTTATCCAAACCATCTGTATACCATGAACCTTCCAGCATTGGGTCCATGGCTCTGA CTGAGAGTGCACTATCCCAGCATGGTTTGTCAAAAGTGGTATACAGTGGACCTCATCCTCAAAGGGAGATGCTGACAGCACAGAATCGGT TTGAAGTGTTGACATTCCTTTTGTTGTGTTACAATGCTGCCTTAACTTACATGCCCAGTGTTTCTCTTCAGTCACTGTGTCAAATTTGTT CAAGGTACATGGTAGGATCAACTTCCTGACCTTGTGACAGATCCTGCCAGTAACATGAGAGGAAATGAGAACGAGGCTTTGGAGCACAGC ATTGGATTGCTCATGCAGAACACCACCCAGTGCCCTTTCCCTCTGCCACAATGAACAGCCATGCTGCAGGTGACGGCTGCTCTGTCAACA TGGATCCGGCAGGGCAGATGAGTGGATCCCCCAGCGGACTCATGAGAGAGCAAACAAAAAGTCCATATGTGTTGTGCTAATCCACTGAGA TTGTGTTGGTTGTTACGGAGCCTAACCTAGCCTATCCCGACACGAGGATCAGACATGATAATCAAATGTGTTTATAAAGTGTTGGATGGA |
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FusionGenePPI for FAM126A_STEAP1B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
FAM126A | LPAR6, P2RY8, GAN, CDH1, RGS20, GC, RPGR, P2RX5, SHPK, NR2F2 | STEAP1B | STEAP1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM126A_STEAP1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM126A_STEAP1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FAM126A | C1864663 | HYPOMYELINATION AND CONGENITAL CATARACT | 2 | CTD_human;ORPHANET;UNIPROT |
Hgene | FAM126A | C0236969 | Substance-Related Disorders | 1 | CTD_human |
Hgene | FAM126A | C3714756 | Intellectual Disability | 1 | CTD_human |