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Fusion gene ID: 12519 |
FusionGeneSummary for FAM122C_TFDP1 |
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Fusion gene information | Fusion gene name: FAM122C_TFDP1 | Fusion gene ID: 12519 | Hgene | Tgene | Gene symbol | FAM122C | TFDP1 | Gene ID | 159091 | 7027 |
Gene name | family with sequence similarity 122C | transcription factor Dp-1 | |
Synonyms | - | DILC|DP1|DRTF1|Dp-1 | |
Cytomap | Xq26.3 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | protein FAM122C | transcription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q6P4D5 | Q14186 | |
Ensembl transtripts involved in fusion gene | ENST00000414371, ENST00000370784, ENST00000370785, ENST00000445123, ENST00000475361, | ENST00000375370, ENST00000538138, ENST00000465174, ENST00000544902, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 4 X 6=144 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FAM122C [Title/Abstract] AND TFDP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TFDP1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 7739537 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF853321 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000414371 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000414371 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000414371 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000414371 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000370784 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000370784 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000370784 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000370784 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000370785 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000370785 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000370785 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000370785 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000445123 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000445123 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000445123 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000445123 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000475361 | ENST00000375370 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000475361 | ENST00000538138 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000475361 | ENST00000465174 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
intron-intron | ENST00000475361 | ENST00000544902 | FAM122C | chrX | 133974568 | - | TFDP1 | chr13 | 114279118 | - |
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FusionProtFeatures for FAM122C_TFDP1 |
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Hgene | Tgene |
FAM122C | TFDP1 |
Can stimulate E2F-dependent transcription. Binds DNAcooperatively with E2F family members through the E2 recognitionsite, 5'-TTTC[CG]CGC-3', found in the promoter region of a numberof genes whose products are involved in cell cycle regulation orin DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DPcomplex appears to mediate both cell proliferation and apoptosis.Blocks adipocyte differentiation by repressing CEBPA binding toits target gene promoters (PubMed:20176812).{ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537,ECO:0000269|PubMed:8405995}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM122C_TFDP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM122C_TFDP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM122C_TFDP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM122C_TFDP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TFDP1 | C3495559 | Juvenile arthritis | 1 | CTD_human |