FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12519

FusionGeneSummary for FAM122C_TFDP1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM122C_TFDP1
Fusion gene ID: 12519
HgeneTgene
Gene symbol

FAM122C

TFDP1

Gene ID

159091

7027

Gene namefamily with sequence similarity 122Ctranscription factor Dp-1
Synonyms-DILC|DP1|DRTF1|Dp-1
Cytomap

Xq26.3

13q34

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM122Ctranscription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells
Modification date2018051920180523
UniProtAcc

Q6P4D5

Q14186

Ensembl transtripts involved in fusion geneENST00000414371, ENST00000370784, 
ENST00000370785, ENST00000445123, 
ENST00000475361, 
ENST00000375370, 
ENST00000538138, ENST00000465174, 
ENST00000544902, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 4 X 6=144
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM122C [Title/Abstract] AND TFDP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTFDP1

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF853321FAM122CchrX

133974568

-TFDP1chr13

114279118

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000414371ENST00000375370FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000414371ENST00000538138FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000414371ENST00000465174FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000414371ENST00000544902FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000370784ENST00000375370FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000370784ENST00000538138FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000370784ENST00000465174FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000370784ENST00000544902FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000370785ENST00000375370FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000370785ENST00000538138FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000370785ENST00000465174FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000370785ENST00000544902FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000445123ENST00000375370FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000445123ENST00000538138FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000445123ENST00000465174FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000445123ENST00000544902FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000475361ENST00000375370FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000475361ENST00000538138FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000475361ENST00000465174FAM122CchrX

133974568

-TFDP1chr13

114279118

-
intron-intronENST00000475361ENST00000544902FAM122CchrX

133974568

-TFDP1chr13

114279118

-

Top

FusionProtFeatures for FAM122C_TFDP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM122C

Q6P4D5

TFDP1

Q14186

Can stimulate E2F-dependent transcription. Binds DNAcooperatively with E2F family members through the E2 recognitionsite, 5'-TTTC[CG]CGC-3', found in the promoter region of a numberof genes whose products are involved in cell cycle regulation orin DNA replication (PubMed:8405995, PubMed:7739537). The E2F1:DPcomplex appears to mediate both cell proliferation and apoptosis.Blocks adipocyte differentiation by repressing CEBPA binding toits target gene promoters (PubMed:20176812).{ECO:0000269|PubMed:20176812, ECO:0000269|PubMed:7739537,ECO:0000269|PubMed:8405995}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAM122C_TFDP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAM122C_TFDP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM122C_TFDP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM122C_TFDP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTFDP1C3495559Juvenile arthritis1CTD_human