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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1251

FusionGeneSummary for AHSG_CD74

check button Fusion gene summary
Fusion gene informationFusion gene name: AHSG_CD74
Fusion gene ID: 1251
HgeneTgene
Gene symbol

AHSG

CD74

Gene ID

197

972

Gene namealpha 2-HS glycoproteinCD74 molecule
SynonymsA2HS|AHS|APMR1|FETUA|HSGADHLAG|HLADG|II|Ia-GAMMA
Cytomap

3q27.3

5q33.1

Type of geneprotein-codingprotein-coding
Descriptionalpha-2-HS-glycoproteinalpha-2-Z-globulinba-alpha-2-glycoproteinfetuin-AHLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated
Modification date2018052320180522
UniProtAcc

P02765

P04233

Ensembl transtripts involved in fusion geneENST00000411641, ENST00000273784, 
ENST00000377795, ENST00000353334, 
ENST00000524315, ENST00000009530, 
Fusion gene scores* DoF score4 X 3 X 2=2416 X 15 X 5=1200
# samples 427
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(27/1200*10)=-2.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AHSG [Title/Abstract] AND CD74 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAHSG

GO:0006953

acute-phase response

12153747

HgeneAHSG

GO:0050766

positive regulation of phagocytosis

12725640

TgeneCD74

GO:0001516

prostaglandin biosynthetic process

12782713

TgeneCD74

GO:0001934

positive regulation of protein phosphorylation

24942581

TgeneCD74

GO:0002792

negative regulation of peptide secretion

19849849

TgeneCD74

GO:0007165

signal transduction

12782713

TgeneCD74

GO:0008283

cell proliferation

12782713

TgeneCD74

GO:0033674

positive regulation of kinase activity

24942581

TgeneCD74

GO:0043066

negative regulation of apoptotic process

12782713

TgeneCD74

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

24942581

TgeneCD74

GO:0043410

positive regulation of MAPK cascade

24942581

TgeneCD74

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

17045821

TgeneCD74

GO:0045657

positive regulation of monocyte differentiation

24942581

TgeneCD74

GO:0045893

positive regulation of transcription, DNA-templated

24942581

TgeneCD74

GO:0046598

positive regulation of viral entry into host cell

24942581

TgeneCD74

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

17045821

TgeneCD74

GO:0051290

protein heterotetramerization

24942581

TgeneCD74

GO:0070374

positive regulation of ERK1 and ERK2 cascade

17045821|24942581


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI133275AHSGchr3

186338913

-CD74chr5

149781594

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000411641ENST00000377795AHSGchr3

186338913

-CD74chr5

149781594

-
3UTR-3UTRENST00000411641ENST00000353334AHSGchr3

186338913

-CD74chr5

149781594

-
3UTR-intronENST00000411641ENST00000524315AHSGchr3

186338913

-CD74chr5

149781594

-
3UTR-intronENST00000411641ENST00000009530AHSGchr3

186338913

-CD74chr5

149781594

-
3UTR-3UTRENST00000273784ENST00000377795AHSGchr3

186338913

-CD74chr5

149781594

-
3UTR-3UTRENST00000273784ENST00000353334AHSGchr3

186338913

-CD74chr5

149781594

-
3UTR-intronENST00000273784ENST00000524315AHSGchr3

186338913

-CD74chr5

149781594

-
3UTR-intronENST00000273784ENST00000009530AHSGchr3

186338913

-CD74chr5

149781594

-

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FusionProtFeatures for AHSG_CD74


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHSG

P02765

CD74

P04233

Promotes endocytosis, possesses opsonic properties andinfluences the mineral phase of bone. Shows affinity for calciumand barium ions.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AHSG_CD74


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AHSG_CD74


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AHSG_CD74


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneAHSGP02765DB01593ZincAlpha-2-HS-glycoproteinsmall moleculeapproved|investigational

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RelatedDiseases for AHSG_CD74


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAHSGC0006663Calcinosis1CTD_human
TgeneCD74C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneCD74C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCD74C0162557Liver Failure, Acute1CTD_human
TgeneCD74C1458155Mammary Neoplasms1CTD_human