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Fusion gene ID: 12487 |
FusionGeneSummary for FAM114A1_TBC1D2B |
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Fusion gene information | Fusion gene name: FAM114A1_TBC1D2B | Fusion gene ID: 12487 | Hgene | Tgene | Gene symbol | FAM114A1 | TBC1D2B | Gene ID | 92689 | 23102 |
Gene name | family with sequence similarity 114 member A1 | TBC1 domain family member 2B | |
Synonyms | Noxp20 | - | |
Cytomap | 4p14 | 15q24.3-q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein NOXP20nervous system over-expressed protein 20 | TBC1 domain family member 2B | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8IWE2 | Q9UPU7 | |
Ensembl transtripts involved in fusion gene | ENST00000515037, ENST00000358869, ENST00000513966, | ENST00000300584, ENST00000409931, ENST00000492078, | |
Fusion gene scores | * DoF score | 8 X 7 X 6=336 | 3 X 3 X 1=9 |
# samples | 8 | 4 | |
** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FAM114A1 [Title/Abstract] AND TBC1D2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU753804 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000515037 | ENST00000300584 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
intron-intron | ENST00000515037 | ENST00000409931 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
intron-5UTR | ENST00000515037 | ENST00000492078 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
3UTR-intron | ENST00000358869 | ENST00000300584 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
3UTR-intron | ENST00000358869 | ENST00000409931 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
3UTR-5UTR | ENST00000358869 | ENST00000492078 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
intron-intron | ENST00000513966 | ENST00000300584 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
intron-intron | ENST00000513966 | ENST00000409931 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
intron-5UTR | ENST00000513966 | ENST00000492078 | FAM114A1 | chr4 | 38947165 | - | TBC1D2B | chr15 | 78291238 | + |
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FusionProtFeatures for FAM114A1_TBC1D2B |
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Hgene | Tgene |
FAM114A1 | TBC1D2B |
May play a role in neuronal cell development.{ECO:0000250}. | May act as a GTPase-activating protein. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM114A1_TBC1D2B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM114A1_TBC1D2B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM114A1_TBC1D2B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM114A1_TBC1D2B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |