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Fusion gene ID: 12486 |
FusionGeneSummary for FAM114A1_QSOX1 |
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Fusion gene information | Fusion gene name: FAM114A1_QSOX1 | Fusion gene ID: 12486 | Hgene | Tgene | Gene symbol | FAM114A1 | QSOX1 | Gene ID | 92689 | 5768 |
Gene name | family with sequence similarity 114 member A1 | quiescin sulfhydryl oxidase 1 | |
Synonyms | Noxp20 | Q6|QSCN6 | |
Cytomap | 4p14 | 1q25.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein NOXP20nervous system over-expressed protein 20 | sulfhydryl oxidase 1quiescin Q6 sulfhydryl oxidase 1testis tissue sperm-binding protein Li 62nthiol oxidase 1 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8IWE2 | O00391 | |
Ensembl transtripts involved in fusion gene | ENST00000515037, ENST00000358869, ENST00000513966, | ENST00000367602, ENST00000367600, | |
Fusion gene scores | * DoF score | 8 X 7 X 6=336 | 5 X 6 X 2=60 |
# samples | 8 | 6 | |
** MAII score | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
Context | PubMed: FAM114A1 [Title/Abstract] AND QSOX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF996657 | FAM114A1 | chr4 | 38870162 | + | QSOX1 | chr1 | 180139210 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000515037 | ENST00000367602 | FAM114A1 | chr4 | 38870162 | + | QSOX1 | chr1 | 180139210 | - |
intron-intron | ENST00000515037 | ENST00000367600 | FAM114A1 | chr4 | 38870162 | + | QSOX1 | chr1 | 180139210 | - |
5UTR-intron | ENST00000358869 | ENST00000367602 | FAM114A1 | chr4 | 38870162 | + | QSOX1 | chr1 | 180139210 | - |
5UTR-intron | ENST00000358869 | ENST00000367600 | FAM114A1 | chr4 | 38870162 | + | QSOX1 | chr1 | 180139210 | - |
intron-intron | ENST00000513966 | ENST00000367602 | FAM114A1 | chr4 | 38870162 | + | QSOX1 | chr1 | 180139210 | - |
intron-intron | ENST00000513966 | ENST00000367600 | FAM114A1 | chr4 | 38870162 | + | QSOX1 | chr1 | 180139210 | - |
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FusionProtFeatures for FAM114A1_QSOX1 |
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Hgene | Tgene |
FAM114A1 | QSOX1 |
May play a role in neuronal cell development.{ECO:0000250}. | Catalyzes the oxidation of sulfhydryl groups in peptideand protein thiols to disulfides with the reduction of oxygen tohydrogen peroxide. May contribute to disulfide bond formation in avariety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.{ECO:0000269|PubMed:10542195, ECO:0000269|PubMed:10708601,ECO:0000269|PubMed:12176051, ECO:0000269|PubMed:16806532,ECO:0000269|PubMed:17331072, ECO:0000269|PubMed:18393449}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAM114A1_QSOX1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FAM114A1_QSOX1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAM114A1_QSOX1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAM114A1_QSOX1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | QSOX1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |