FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12485

FusionGeneSummary for FAM114A1_KCNIP4

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM114A1_KCNIP4
Fusion gene ID: 12485
HgeneTgene
Gene symbol

FAM114A1

KCNIP4

Gene ID

92689

80333

Gene namefamily with sequence similarity 114 member A1potassium voltage-gated channel interacting protein 4
SynonymsNoxp20CALP|KCHIP4
Cytomap

4p14

4p15.31-p15.2

Type of geneprotein-codingprotein-coding
Descriptionprotein NOXP20nervous system over-expressed protein 20Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein
Modification date2018051920180523
UniProtAcc

Q8IWE2

Q6PIL6

Ensembl transtripts involved in fusion geneENST00000515037, ENST00000358869, 
ENST00000513966, 		ENST00000382148, 
ENST00000447367, ENST00000382150, 
ENST00000382152, ENST00000509207, 
ENST00000382149, ENST00000359001, 
Fusion gene scores* DoF score8 X 7 X 6=33612 X 7 X 9=756
# samples 813
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/756*10)=-2.53987461119262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM114A1 [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-2A-A8W1-01AFAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000515037ENST00000382148FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000515037ENST00000447367FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000515037ENST00000382150FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000515037ENST00000382152FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000515037ENST00000509207FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000515037ENST00000382149FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000515037ENST00000359001FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
5UTR-intronENST00000358869ENST00000382148FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
5UTR-intronENST00000358869ENST00000447367FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
5UTR-intronENST00000358869ENST00000382150FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
5UTR-intronENST00000358869ENST00000382152FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
5UTR-intronENST00000358869ENST00000509207FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
5UTR-intronENST00000358869ENST00000382149FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
5UTR-intronENST00000358869ENST00000359001FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000513966ENST00000382148FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000513966ENST00000447367FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000513966ENST00000382150FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000513966ENST00000382152FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000513966ENST00000509207FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000513966ENST00000382149FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-
intron-intronENST00000513966ENST00000359001FAM114A1chr4

38870167

+KCNIP4chr4

21764655

-

Top

FusionProtFeatures for FAM114A1_KCNIP4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM114A1

Q8IWE2

KCNIP4

Q6PIL6

May play a role in neuronal cell development.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for FAM114A1_KCNIP4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for FAM114A1_KCNIP4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
FAM114A1AKT1S1, FAF1, PPAT, TLN1, HSPA4, N4BP1, RSU1, SEC24D, TARS, THUMPD3, RAB2A, SPG21, AGTRAP, RAB2B, CMTM5, TENC1, MIRLET7A1KCNIP4KCNIP2, PSEN2, PSEN1, APP, KCNIP1, SCGB1D1, MTX1, LACRT, ZG16B, PRR4, HLA-DRA, KLK4, TFPI, ECE2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for FAM114A1_KCNIP4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for FAM114A1_KCNIP4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource