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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12447

FusionGeneSummary for FAIM_SLAIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: FAIM_SLAIN1
Fusion gene ID: 12447
HgeneTgene
Gene symbol

FAIM

SLAIN1

Gene ID

55179

122060

Gene nameFas apoptotic inhibitory moleculeSLAIN motif family member 1
SynonymsFAIM1C13orf32
Cytomap

3q22.3

13q22.3

Type of geneprotein-codingprotein-coding
Descriptionfas apoptotic inhibitory molecule 1SLAIN motif-containing protein 1
Modification date2018051920180519
UniProtAcc

Q9NVQ4

Q8ND83

Ensembl transtripts involved in fusion geneENST00000338446, ENST00000360570, 
ENST00000393035, ENST00000393034, 
ENST00000464668, 
ENST00000466548, 
ENST00000418532, ENST00000488699, 
ENST00000267219, ENST00000351546, 
ENST00000465831, ENST00000314070, 
ENST00000358679, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 4 X 2=32
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FAIM [Title/Abstract] AND SLAIN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1W07321FAIMchr3

138352063

-SLAIN1chr13

78320728

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000338446ENST00000466548FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000338446ENST00000418532FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000338446ENST00000488699FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000338446ENST00000267219FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000338446ENST00000351546FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3UTRENST00000338446ENST00000465831FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-intronENST00000338446ENST00000314070FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-intronENST00000338446ENST00000358679FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000360570ENST00000466548FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000360570ENST00000418532FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000360570ENST00000488699FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000360570ENST00000267219FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000360570ENST00000351546FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3UTRENST00000360570ENST00000465831FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-intronENST00000360570ENST00000314070FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-intronENST00000360570ENST00000358679FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393035ENST00000466548FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393035ENST00000418532FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393035ENST00000488699FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393035ENST00000267219FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393035ENST00000351546FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3UTRENST00000393035ENST00000465831FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-intronENST00000393035ENST00000314070FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-intronENST00000393035ENST00000358679FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393034ENST00000466548FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393034ENST00000418532FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393034ENST00000488699FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393034ENST00000267219FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3CDSENST00000393034ENST00000351546FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-3UTRENST00000393034ENST00000465831FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-intronENST00000393034ENST00000314070FAIMchr3

138352063

-SLAIN1chr13

78320728

-
3UTR-intronENST00000393034ENST00000358679FAIMchr3

138352063

-SLAIN1chr13

78320728

-
intron-3CDSENST00000464668ENST00000466548FAIMchr3

138352063

-SLAIN1chr13

78320728

-
intron-3CDSENST00000464668ENST00000418532FAIMchr3

138352063

-SLAIN1chr13

78320728

-
intron-3CDSENST00000464668ENST00000488699FAIMchr3

138352063

-SLAIN1chr13

78320728

-
intron-3CDSENST00000464668ENST00000267219FAIMchr3

138352063

-SLAIN1chr13

78320728

-
intron-3CDSENST00000464668ENST00000351546FAIMchr3

138352063

-SLAIN1chr13

78320728

-
intron-3UTRENST00000464668ENST00000465831FAIMchr3

138352063

-SLAIN1chr13

78320728

-
intron-intronENST00000464668ENST00000314070FAIMchr3

138352063

-SLAIN1chr13

78320728

-
intron-intronENST00000464668ENST00000358679FAIMchr3

138352063

-SLAIN1chr13

78320728

-

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FusionProtFeatures for FAIM_SLAIN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAIM

Q9NVQ4

SLAIN1

Q8ND83

Plays a role as an inducible effector molecule thatmediates Fas resistance produced by surface Ig engagement in Bcells. {ECO:0000250}. Microtubule plus-end tracking protein that might beinvolved in the regulation of cytoplasmic microtubule dynamics,microtubule organization and microtubule elongation.{ECO:0000269|PubMed:21646404}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAIM_SLAIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAIM_SLAIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAIM_SLAIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FAIM_SLAIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource