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Fusion gene ID: 12434 |
FusionGeneSummary for FAF1_PTRH2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAF1_PTRH2 | Fusion gene ID: 12434 | Hgene | Tgene | Gene symbol | FAF1 | PTRH2 | Gene ID | 11124 | 51651 |
| Gene name | Fas associated factor 1 | peptidyl-tRNA hydrolase 2 | |
| Synonyms | CGI-03|HFAF1s|UBXD12|UBXN3A|hFAF1 | BIT1|CFAP37|CGI-147|IMNEPD|PTH|PTH 2|PTH2 | |
| Cytomap | 1p32.3 | 17q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | FAS-associated factor 1Fas (TNFRSF6) associated factor 1TNFRSF6-associated factor 1UBX domain protein 3AUBX domain-containing protein 12UBX domain-containing protein 3A | peptidyl-tRNA hydrolase 2, mitochondrialbcl-2 inhibitor of transcription 1cilia and flagella associated protein 37 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9UNN5 | Q9Y3E5 | |
| Ensembl transtripts involved in fusion gene | ENST00000396153, ENST00000371778, ENST00000545823, ENST00000472808, | ENST00000393038, ENST00000537860, ENST00000409433, ENST00000470557, ENST00000579915, | |
| Fusion gene scores | * DoF score | 15 X 10 X 8=1200 | 6 X 4 X 5=120 |
| # samples | 21 | 7 | |
| ** MAII score | log2(21/1200*10)=-2.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FAF1 [Title/Abstract] AND PTRH2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FAF1 | GO:0010942 | positive regulation of cell death | 15596450 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A0DX-01A | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000396153 | ENST00000393038 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| Frame-shift | ENST00000396153 | ENST00000537860 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| In-frame | ENST00000396153 | ENST00000409433 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| In-frame | ENST00000396153 | ENST00000470557 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| 5CDS-intron | ENST00000396153 | ENST00000579915 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| In-frame | ENST00000371778 | ENST00000393038 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| Frame-shift | ENST00000371778 | ENST00000537860 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| Frame-shift | ENST00000371778 | ENST00000409433 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| Frame-shift | ENST00000371778 | ENST00000470557 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| 5CDS-intron | ENST00000371778 | ENST00000579915 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-3CDS | ENST00000545823 | ENST00000393038 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-3CDS | ENST00000545823 | ENST00000537860 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-3CDS | ENST00000545823 | ENST00000409433 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-3CDS | ENST00000545823 | ENST00000470557 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-intron | ENST00000545823 | ENST00000579915 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-3CDS | ENST00000472808 | ENST00000393038 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-3CDS | ENST00000472808 | ENST00000537860 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-3CDS | ENST00000472808 | ENST00000409433 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-3CDS | ENST00000472808 | ENST00000470557 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
| intron-intron | ENST00000472808 | ENST00000579915 | FAF1 | chr1 | 51121114 | - | PTRH2 | chr17 | 57775339 | - |
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FusionProtFeatures for FAF1_PTRH2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAF1 | PTRH2 |
| Ubiquitin-binding protein (PubMed:19722279). Requiredfor the progression of DNA replication forks by targeting DNAreplication licensing factor CDT1 for degradation(PubMed:26842564). Potentiates but cannot initiate FAS-inducedapoptosis (By similarity). {ECO:0000250|UniProtKB:P54731,ECO:0000269|PubMed:19722279, ECO:0000269|PubMed:26842564}. | The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.{ECO:0000250}. Promotes caspase-independent apoptosis by regulating thefunction of two transcriptional regulators, AES and TLE1.{ECO:0000269|PubMed:15006356}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FAF1_PTRH2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FAF1_ENST00000396153_chr1_51121114_-_PTRH2_ENST00000409433_chr17_57775339_-_428aa MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPS RQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSS SHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMPSKSLVMEYLAHPSTLGLAVG VACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPEMLKQWEYCG >In-frame_FAF1_ENST00000396153_chr1_51121114_-_PTRH2_ENST00000470557_chr17_57775339_-_248aa MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPS RQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSS >In-frame_FAF1_ENST00000371778_chr1_51121114_-_PTRH2_ENST00000393038_chr17_57775339_-_428aa MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSEYGGETIPGPAFNPASHPASAPTSSSSSAFRPVMPS RQIVERQPRMLDFRVEYRDRNVDVVLEDTCTVGEIKQILENELQIPVSKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSS SHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTIQEVKRNVYDLTSIPVRHQLWEGWPTSATDDSMPSKSLVMEYLAHPSTLGLAVG VACGMCLGWSLRVCFGMLPKSKTSKTHTDTESEASILGDSGEYKMILVVRNDLKMGKGKVAAQCSHAAVSAYKQIQRRNPEMLKQWEYCG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FAF1_ENST00000396153_chr1_51121114_-_PTRH2_ENST00000409433_chr17_57775339_-_1284nt ATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTT GAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGAATATGGAGGTGAGACC ATACCAGGACCTGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCATCC AGGCAGATTGTAGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGTACTTGAAGACACCTGT ACTGTTGGAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTG GAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCATCT AGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAAC TTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGG CCAACTTCTGCTACAGACGACTCAATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTCATCCCAGTACACTCGGCTTGGCTGTTGGA GTTGCTTGTGGCATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAAGCAAGACGAGCAAGACACACACAGATACT GAAAGTGAAGCAAGCATCTTGGGAGACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAAATGACTTAAAGATGGGAAAAGGGAAAGTG GCTGCCCAGTGCTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGAAATCCTGAAATGCTCAAACAATGGGAATACTGTGGC CAGCCCAAGGTGGTGGTCAAAGCTCCTGATGAAGAAACCCTGATTGCATTATTGGCCCATGCAAAAATGCTGGGACTGACTGTAAGTTTA ATTCAAGATGCTGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGGATTGGGCCAGGACCAGCAGACCTAATTGACAAAGTC >In-frame_FAF1_ENST00000396153_chr1_51121114_-_PTRH2_ENST00000470557_chr17_57775339_-_744nt ATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTT GAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGAATATGGAGGTGAGACC ATACCAGGACCTGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCATCC AGGCAGATTGTAGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGTACTTGAAGACACCTGT ACTGTTGGAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTG GAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCATCT AGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAAC TTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGG >In-frame_FAF1_ENST00000371778_chr1_51121114_-_PTRH2_ENST00000393038_chr17_57775339_-_1284nt ATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTT GAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGAATATGGAGGTGAGACC ATACCAGGACCTGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCATCC AGGCAGATTGTAGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGTACTTGAAGACACCTGT ACTGTTGGAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTG GAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCATCT AGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAAC TTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGG CCAACTTCTGCTACAGACGACTCAATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTCATCCCAGTACACTCGGCTTGGCTGTTGGA GTTGCTTGTGGCATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAAGCAAGACGAGCAAGACACACACAGATACT GAAAGTGAAGCAAGCATCTTGGGAGACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAAATGACTTAAAGATGGGAAAAGGGAAAGTG GCTGCCCAGTGCTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGAAATCCTGAAATGCTCAAACAATGGGAATACTGTGGC CAGCCCAAGGTGGTGGTCAAAGCTCCTGATGAAGAAACCCTGATTGCATTATTGGCCCATGCAAAAATGCTGGGACTGACTGTAAGTTTA ATTCAAGATGCTGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGGATTGGGCCAGGACCAGCAGACCTAATTGACAAAGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FAF1_ENST00000396153_chr1_51121114_-_PTRH2_ENST00000409433_chr17_57775339_-_1867nt AGGGGCGGAGGCGGCGGCCAGGGAGGAAGCGGAGGAGGCGGAGGCGGCCGCGGCGTTCGCCCGCCCGCTCGCTCGCTCGGTTTCCCCGCC CCCGCCGGGCTTAACGCCGCTGAAGGTATCCGGGTGCGCGCTGTCGCAACCTGCCCTCATCCTGGCCCGCGACTGTAAGACCGGACCCAC ATCCAGACCAATCTTCCTGTCCGGGCTGCTGCGACGCGGGCTCCGCAGGTTGCAGGCGGGCGGCCGGGGCGCCTGAAGGTTACCGAGTGC ATGAGCGCCTAGCGCTTCCCGCGCTGCCCCGCCCGCTGGCCCGCCGACCCGCCCGCCGGCTCGCCCGCCAGCCCCTCGGCGCCCGGCGGC GGCGGCGGCGGTGGCGGCGACGGTCGCAGGAGGTGCCGTCTGCCTCCCAGGTGCGCGCTTCGCTCCCGGAGCCGCGGAACTCGGCGGCCG CCATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGC TTGAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGAATATGGAGGTGAGA CCATACCAGGACCTGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCAT CCAGGCAGATTGTAGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGTACTTGAAGACACCT GTACTGTTGGAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATG TGGAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCAT CTAGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGA ACTTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCT GGCCAACTTCTGCTACAGACGACTCAATGCCCTCCAAATCCTTGGTTATGGAATATTTGGCTCATCCCAGTACACTCGGCTTGGCTGTTG GAGTTGCTTGTGGCATGTGCCTGGGCTGGAGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAAGCAAGACGAGCAAGACACACACAGATA CTGAAAGTGAAGCAAGCATCTTGGGAGACAGCGGGGAGTACAAGATGATTCTTGTGGTTCGAAATGACTTAAAGATGGGAAAAGGGAAAG TGGCTGCCCAGTGCTCTCATGCTGCTGTTTCAGCCTACAAGCAGATTCAAAGAAGAAATCCTGAAATGCTCAAACAATGGGAATACTGTG GCCAGCCCAAGGTGGTGGTCAAAGCTCCTGATGAAGAAACCCTGATTGCATTATTGGCCCATGCAAAAATGCTGGGACTGACTGTAAGTT TAATTCAAGATGCTGGACGTACTCAGATTGCACCAGGCTCTCAAACTGTCCTAGGGATTGGGCCAGGACCAGCAGACCTAATTGACAAAG TCACTGGTCACCTAAAACTTTACTAGGTGGACTTTGATATGACAACAACCCCTCCATCACAAGTGTTTGAAGCCTGTCAGATTCTAACAA >In-frame_FAF1_ENST00000396153_chr1_51121114_-_PTRH2_ENST00000470557_chr17_57775339_-_4643nt AGGGGCGGAGGCGGCGGCCAGGGAGGAAGCGGAGGAGGCGGAGGCGGCCGCGGCGTTCGCCCGCCCGCTCGCTCGCTCGGTTTCCCCGCC CCCGCCGGGCTTAACGCCGCTGAAGGTATCCGGGTGCGCGCTGTCGCAACCTGCCCTCATCCTGGCCCGCGACTGTAAGACCGGACCCAC ATCCAGACCAATCTTCCTGTCCGGGCTGCTGCGACGCGGGCTCCGCAGGTTGCAGGCGGGCGGCCGGGGCGCCTGAAGGTTACCGAGTGC ATGAGCGCCTAGCGCTTCCCGCGCTGCCCCGCCCGCTGGCCCGCCGACCCGCCCGCCGGCTCGCCCGCCAGCCCCTCGGCGCCCGGCGGC GGCGGCGGCGGTGGCGGCGACGGTCGCAGGAGGTGCCGTCTGCCTCCCAGGTGCGCGCTTCGCTCCCGGAGCCGCGGAACTCGGCGGCCG CCATGGCGTCCAACATGGACCGGGAGATGATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGC TTGAACAAAATAATTGGGACTTAGTGGCAGCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGAATATGGAGGTGAGA CCATACCAGGACCTGCATTTAATCCAGCAAGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCAT CCAGGCAGATTGTAGAAAGGCAACCTCGGATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGTACTTGAAGACACCT GTACTGTTGGAGAGATTAAACAGATTCTAGAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATG TGGAAGACAGTACGGTCCTAAAATCTCTACACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCAT CTAGTCATGCTGGTGCCCTGCAGGAGTCATTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGA ACTTCTCAGGAAGCAGTACTATTCAAGAGGTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCT GGCCAACTTCTGCTACAGACGACTCAAAATCAAAACCCTATGCATCGCTCTAAGTCTTTCCAGTTTACTTTCATTACACCTGTTCTTCAA CAGCATGTCTAGATAAATAGCATGCATCACTTTATTGTCCATAAATCAGTCTTTGATAATACAGGTTGCTTTTTATCAGGTAGGCCAAAA GAGAAAAATGTAATAACACAGGTTGCATGGTCTATCATGTCAAACATTCTTACCCTTATCCTAAATTCCCTTGTACCACTGTGTCTTGGG GCGTGCTCCTGGCATAATTTAAACTTGGATACATCCAACTACCATTTCAGTAGGAGGGGAGAGCAAAGGATGAGTGTGGATGGAGGTTAG TTTGTATGTCTGGAGGAAGTGATTAGTAGTTTTAGTCTTTTGGCTTCTAAGTACTACTGGAGAAAATCACAAATAGTATGTTGCCATTAA AAAGTCATCATTAATCTTAACCATGCTTTCAATATTCCTCTGCAATCCTGCCATATTTTGCCACACCTTTTATTTCCGCCTTTCTCTTCT CTACTCCATTTTAACTTCTGTCTGAGCTCCTTCCCTCAGGGGGAATACTTTCCTGCCTTCAAATCCGTGGACCTACTTGATTTAAAACTG AAATTGGGAAAGGTGTCCCTTTTCCTTTCCAAAACCACATCCCTTTATAAAGTCTTTCTCTATCTTGAGCATTTACCTGCCTTTCTTCTG GCTTCATCCTATTAACATTTAAATATGCTTATCCTTTCTTCTTAGGAGAAAAAAAAAATTGCTTTCCTCTGTGTCGCCTTATATCCATTG CTTTTTCTTTTTGCTCTATCTCTTGACCCCACCTCAAACGAATTTCTGCCCCACCAAAGACAGTAACCCCTTTTATGTTAAAATTAGTGG AAAGAATGTTAATATAATGCCCTAACTTTAAAGAAGAACATAAAGGAAATTTATAAGTACTTCCAGGGCTGTCATCTATGCCGTGCCAAT CATGCAGTGCACAATTCCAAGGGCACCACTTTACATTACAAATACAGTGCATTACAAATATAGTGGCCCCATGTTTATAAATGCTTAGAT AATACTCCACTAGAAAAAGAAACTGATAGTTGCTTGCCACATAGAAGCACTGTGAATCCAGCAGCCTCATTTGTAGACTGATATAAGTGT CTTATTGGTGACTCAAATATTATGAACAGCTTTGCCGAAGTAGCAAGATTTTCTAAAATAATAAAGGATGACATTCCTTTGTTTTATGAT AGCTACACTTCTGGAAAATTCAGTATGGACAGTCTCCGACTTAGGATTTTTCAACTTTAGGATGGTGTGAAAGAGACACCCATTCAGTAG AAACTGTACTTCGAGTTTTGCATTTTGATCTTTTCCTGGCCTAGTGATAATGTGGTACAGTACACTCTTGTGATGCTGGGCAGCGGCAGC GAGCCACAGCTCCCAGTCACCCATGTGATCACGGGAATCAACAACCCATCCTCTACCGTGTACTGTGTTGTCAGCTTTTTTGGATATTGT GTTTTGTGTTTTCACATTCCATCATGTCTACAAAATGTCCATCAGTGTCTCCTGTTTCTGGTGAGATGAAGAAGAGGAAGGCAATTACTC TTGAAATGAAACTCAAGATAATTGCCCAGCATGAAGGTGGCAAGCCAGTAATGGCCATTGCACGTGAGTTAGGACTTTGGCAATCCACGA TTTCAACCATCTTAAGGGATAAGAAGCAAATCAGTGATGCAGCGAAATCGTCAGCATCAGTTAAATCCACTGTCATCACAAAGAAAAGGG CTGGACCAATTGATGATATGGAAAAATTACTTGTTATGTGGATGGAAGACCAGATACAGAAGCGTATACCACTTAGCCTACTGATGATCC AGGCTAAGGCAAGAAGTCTTTTTAATATGCTAAAAGACCGTGCCAGTGATCCTACATATACACAAATGTTTAAAGCAAGTCATGGATGGT TCCAGCGCTTCAAAAGGCGTCATAATTTTCACAATGTAAAGATCACTGGTGAGGCAGCACGTGCTGGTAATGAAGGTGCCATAGCTTTTA AGGAACAGCTGCATAGGATAATTATGGCTAAAGATCTTTGCAATAAGGAGCTGATTGCACTGGAGGAAGAAAGAGGTAAAGGCGTTGAGG CAGTGGAAGAAGTTACACCCACGGCACCTAGAAAGTTCACAGCAAAGAAACTGGCAGAGGCATTTGCTGCTATCAGCAGTGGCCTACACG TTAGAAGAAATGGACGTCAATTACGAGAGATTCGCCACAGTTGACAGGCGCAGATACAGGATGCTCTTGCTTGCTACAGAGAAATATATA GTGAAAAGAAGAAACAAGCTGTACGGTCAAAACTTGGTATCTTCCTGAAGAACAACACTATGCTTGCTAAACCATCAACTAGTGTTGATG TCCCAATGCCTTCTACCACCTATTCTCGATGTTCATCAGAAGAGAGAGAAATTGAGGACCCTGTTGCATCCCCATCATCCAGCAATTAAT TCTATTTCAGTGCTTCAAACATTTTTCAGGACCACTGTGCTTTCAGCTGTGTAAATTAATGGTGAGTACCCATACAACCATTGTTTTCCA CTTACAGTATTCAATAAATTACAGGAGATATTCAACACTATTATAAAAGAGCCTCGTGTTAGATGATTTTTGTCCAACTGTAGGCTAATG TAAGTGTTCTGAGCACATTTAAGGTAGGCTAGGCTAAGTCATGATATTCTGTAGGTGTATTAAATGCATTTTTGGCTTACAGTATTTTCA ATTAATTGGGTTAATTGGGATATAACCCCATGGAAAATTGAGGAGCACCTGTACATAGTAAAACTATGCAAAAAATATTTTGTGTTCTTA AGTAAAATGATGTTGAGTTCTCATCTCAGTTATTAAGTTTTTCAGCTGCACTCACGTCCAATGGGACAACTCTTCATTTTGTAAGGTTTT TAGCATCCTTGCTCAGGCTTAGTAAATTTCAGTAGTGCACCTCACTCCAGGCCCATTAATGTGACAGTGAGGTTCTTCTGAGGGTAACTG ATTTGATACCATCTCCACTGAGAACCACTGCATTGTGAAAACACCGATTAGCACTGTATTCCAGGAAAGGGTTATTTTTGGTTTCTTTAA ATCTTAGGCATCTTGGTAAAACGGAACATCTCCACAAGACTAAGGGAAGACTGAGGAATAGAGTTTTTGAACTTTATGCAACTTCGTTTA CATCAAGATTCAAAATGACCTAAACTGTTTCATGTGGATGCTTGAATCTTTTCTAGTACACTGGTGGTGGGCAAGAGGGTGTTGGAAACA GGGTGCAGGCATAAGATCAAAGGTGTGTTTTGCCTTTTTTCTGGATGACCATTAAGTGTATAGTCAAAATGTTTCTCTGATAAGCCTATA >In-frame_FAF1_ENST00000371778_chr1_51121114_-_PTRH2_ENST00000393038_chr17_57775339_-_1480nt AACGCCGCTGAAGGTATCCGGGTGCGCGCTTCGCTCCCGGAGCCGCGGAACTCGGCGGCCGCCATGGCGTCCAACATGGACCGGGAGATG ATCCTGGCGGATTTTCAGGCATGTACTGGCATTGAAAACATTGACGAAGCTATTACATTGCTTGAACAAAATAATTGGGACTTAGTGGCA GCTATCAATGGTGTAATACCACAGGAAAATGGCATTCTACAAAGTGAATATGGAGGTGAGACCATACCAGGACCTGCATTTAATCCAGCA AGTCATCCAGCTTCAGCTCCTACTTCCTCTTCTTCTTCAGCGTTTCGACCTGTAATGCCATCCAGGCAGATTGTAGAAAGGCAACCTCGG ATGCTGGACTTCAGGGTTGAATACAGAGACAGAAATGTTGATGTGGTACTTGAAGACACCTGTACTGTTGGAGAGATTAAACAGATTCTA GAAAATGAACTTCAGATACCTGTGTCCAAAATGCTGTTAAAAGGCTGGAAGACGGGAGATGTGGAAGACAGTACGGTCCTAAAATCTCTA CACTTGCCAAAAAACAACAGTCTTTATGTCCTTACACCAGATTTGCCACCACCTTCATCATCTAGTCATGCTGGTGCCCTGCAGGAGTCA TTAAATCAAAACTTCATGCTGATCATCACCCACCGAGAAGTCCAGCGGGAGTACAACCTGAACTTCTCAGGAAGCAGTACTATTCAAGAG GTAAAGAGAAATGTGTATGACCTTACAAGTATCCCCGTTCGCCACCAATTATGGGAGGGCTGGCCAACTTCTGCTACAGACGACTCAATG CCCTCCAAATCCTTGGTTATGGAATATTTGGCTCATCCCAGTACACTCGGCTTGGCTGTTGGAGTTGCTTGTGGCATGTGCCTGGGCTGG AGCCTTCGAGTATGCTTTGGGATGCTCCCCAAAAGCAAGACGAGCAAGACACACACAGATACTGAAAGTGAAGCAAGCATCTTGGGAGAC AGCGGGGAGTACAAGATGATTCTTGTGGTTCGAAATGACTTAAAGATGGGAAAAGGGAAAGTGGCTGCCCAGTGCTCTCATGCTGCTGTT TCAGCCTACAAGCAGATTCAAAGAAGAAATCCTGAAATGCTCAAACAATGGGAATACTGTGGCCAGCCCAAGGTGGTGGTCAAAGCTCCT GATGAAGAAACCCTGATTGCATTATTGGCCCATGCAAAAATGCTGGGACTGACTGTAAGTTTAATTCAAGATGCTGGACGTACTCAGATT GCACCAGGCTCTCAAACTGTCCTAGGGATTGGGCCAGGACCAGCAGACCTAATTGACAAAGTCACTGGTCACCTAAAACTTTACTAGGTG GACTTTGATATGACAACAACCCCTCCATCACAAGTGTTTGAAGCCTGTCAGATTCTAACAACAAAAGCTGAATTTCTTCACCCAACTTAA |
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FusionGenePPI for FAF1_PTRH2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FAF1 | ASCC2, FAS, CSNK2B, G3BP1, RAE1, CASP8, CTNNB1, VCP, NPLOC4, UFD1L, CUL1, CUL2, CUL3, UBR1, HIF1A, ALPP, VCPIP1, SKP1, FBXW11, KLHL22, KBTBD7, WDR26, AMFR, UBR2, UBR4, PJA2, CDC73, TAF1D, RAP1B, UROD, TK1, ANXA1, DNAJB11, CDKN1A, TNNT1, SIRT6, HSD17B10, RCC1, NR1H2, ANXA7, TSC22D1, NR4A1, ITGB1BP1, IGF2, RAD23A, BTRC, NGLY1, UBC, HSPA4, RELA, HSPA8, FADD, IKBKB, NLRP3, NLRP2, NLRP7, NLRP12, NUDT21, SKIL, CARM1, CARS, FAM114A1, FARSB, GART, HIRIP3, HIST1H4A, HSPH1, ILK, PLOD2, PPM1G, PPP2R5C, PRMT3, PUF60, RANBP3, RPL24, SAMHD1, SEC23A, SET, SF1, SWAP70, TLN1, TROVE2, UGP2, XPO7, VAPA, VAPB, UBL4A, ASNA1, GET4, BAG6, RPN2, DDOST, FAF1, CD40, MAGIX, TCEAL1, CBX3, DNAJA1, ZC3H15, NTRK1, RAP1A, CDT1, IPO5, WDR24, YTHDF1, CDC5L, KCTD10, YTHDF3, WDR59, MMAB, NUP98, MYCBP2, USP11, NSFL1C, UBXN7, UBXN1, ASPSCR1, HSPA2, MIOS, UBXN6, BTBD9, KCTD13, TNFAIP1, UBXN2B, BHLHA15, CHCHD10, CLEC3A, PRCC, TRIM25, XIAP | PTRH2 | AES, ATP6V0A1, ATP6V0A2, ATP6V1D, STT3B, FLOT1, RPS2, LAMTOR3, RPS15, JUP, CD55, ABCC2, FLOT2, GADD45GIP1, PTK2, PHYHIP, ARHGEF10, DLK1, FAM63B, TNFRSF10B, CLEC5A, CLTC, COQ9, CHCHD2, DUSP22, DUSP6, DUSP8, DUSP9, EYA3, TLR5, CHRM3, CD7, SLC6A15, HTR2C, SIGLEC10, SLC18A1, HTR3A, SCGB2A2, TEX29, GPR21, YIPF3, HMOX2, SLC39A12, MED21, GRPR, PTPN1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAF1_PTRH2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FAF1_PTRH2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PTRH2 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | PTRH2 | C4015728 | NEUROLOGIC, ENDOCRINE, AND PANCREATIC DISEASE, MULTISYSTEM, INFANTILE-ONSET | 1 | ORPHANET;UNIPROT |
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