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Fusion gene ID: 12417 |
FusionGeneSummary for FADS1_TGOLN2 |
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Fusion gene information | Fusion gene name: FADS1_TGOLN2 | Fusion gene ID: 12417 | Hgene | Tgene | Gene symbol | FADS1 | TGOLN2 | Gene ID | 3992 | 10618 |
Gene name | fatty acid desaturase 1 | trans-golgi network protein 2 | |
Synonyms | D5D|FADS6|FADSD5|LLCDL1|TU12 | TGN38|TGN46|TGN48|TGN51|TTGN2 | |
Cytomap | 11q12.2 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | fatty acid desaturase 1delta(5) desaturasedelta-5 fatty acid desaturaselinoleoyl-CoA desaturase (delta-6-desaturase)-like 1 | trans-Golgi network integral membrane protein 2TGN38 homologtrans-Golgi network protein (46, 48, 51kD isoforms)trans-Golgi network protein TGN51 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O60427 | O43493 | |
Ensembl transtripts involved in fusion gene | ENST00000350997, ENST00000536991, ENST00000433932, ENST00000460649, ENST00000542506, ENST00000541683, | ENST00000282120, ENST00000377386, ENST00000398263, ENST00000409232, ENST00000409015, ENST00000444342, | |
Fusion gene scores | * DoF score | 6 X 7 X 2=84 | 8 X 8 X 1=64 |
# samples | 7 | 8 | |
** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/64*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FADS1 [Title/Abstract] AND TGOLN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FADS1 | GO:0006636 | unsaturated fatty acid biosynthetic process | 10601301 |
Hgene | FADS1 | GO:0009267 | cellular response to starvation | 10601301 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB143399 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000350997 | ENST00000282120 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000350997 | ENST00000377386 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000350997 | ENST00000398263 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000350997 | ENST00000409232 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000350997 | ENST00000409015 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000350997 | ENST00000444342 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000536991 | ENST00000282120 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000536991 | ENST00000377386 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000536991 | ENST00000398263 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000536991 | ENST00000409232 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000536991 | ENST00000409015 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000536991 | ENST00000444342 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000433932 | ENST00000282120 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000433932 | ENST00000377386 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000433932 | ENST00000398263 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000433932 | ENST00000409232 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000433932 | ENST00000409015 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000433932 | ENST00000444342 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000460649 | ENST00000282120 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000460649 | ENST00000377386 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000460649 | ENST00000398263 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000460649 | ENST00000409232 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000460649 | ENST00000409015 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000460649 | ENST00000444342 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000542506 | ENST00000282120 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000542506 | ENST00000377386 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000542506 | ENST00000398263 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000542506 | ENST00000409232 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000542506 | ENST00000409015 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000542506 | ENST00000444342 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000541683 | ENST00000282120 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000541683 | ENST00000377386 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-3UTR | ENST00000541683 | ENST00000398263 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000541683 | ENST00000409232 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000541683 | ENST00000409015 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
intron-intron | ENST00000541683 | ENST00000444342 | FADS1 | chr11 | 61569629 | + | TGOLN2 | chr2 | 85545424 | - |
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FusionProtFeatures for FADS1_TGOLN2 |
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Hgene | Tgene |
FADS1 | TGOLN2 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FADS1_TGOLN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FADS1_TGOLN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FADS1_TGOLN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FADS1_TGOLN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FADS1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | FADS1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | FADS1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | FADS1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | TGOLN2 | C0040128 | Thyroid Diseases | 1 | CTD_human |
Tgene | TGOLN2 | C0525045 | Mood Disorders | 1 | PSYGENET |