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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12417

FusionGeneSummary for FADS1_TGOLN2

check button Fusion gene summary
Fusion gene informationFusion gene name: FADS1_TGOLN2
Fusion gene ID: 12417
HgeneTgene
Gene symbol

FADS1

TGOLN2

Gene ID

3992

10618

Gene namefatty acid desaturase 1trans-golgi network protein 2
SynonymsD5D|FADS6|FADSD5|LLCDL1|TU12TGN38|TGN46|TGN48|TGN51|TTGN2
Cytomap

11q12.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionfatty acid desaturase 1delta(5) desaturasedelta-5 fatty acid desaturaselinoleoyl-CoA desaturase (delta-6-desaturase)-like 1trans-Golgi network integral membrane protein 2TGN38 homologtrans-Golgi network protein (46, 48, 51kD isoforms)trans-Golgi network protein TGN51
Modification date2018051920180523
UniProtAcc

O60427

O43493

Ensembl transtripts involved in fusion geneENST00000350997, ENST00000536991, 
ENST00000433932, ENST00000460649, 
ENST00000542506, ENST00000541683, 
ENST00000282120, ENST00000377386, 
ENST00000398263, ENST00000409232, 
ENST00000409015, ENST00000444342, 
Fusion gene scores* DoF score6 X 7 X 2=848 X 8 X 1=64
# samples 78
** MAII scorelog2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/64*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FADS1 [Title/Abstract] AND TGOLN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFADS1

GO:0006636

unsaturated fatty acid biosynthetic process

10601301

HgeneFADS1

GO:0009267

cellular response to starvation

10601301


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB143399FADS1chr11

61569629

+TGOLN2chr2

85545424

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000350997ENST00000282120FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000350997ENST00000377386FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000350997ENST00000398263FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000350997ENST00000409232FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000350997ENST00000409015FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000350997ENST00000444342FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000536991ENST00000282120FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000536991ENST00000377386FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000536991ENST00000398263FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000536991ENST00000409232FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000536991ENST00000409015FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000536991ENST00000444342FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000433932ENST00000282120FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000433932ENST00000377386FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000433932ENST00000398263FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000433932ENST00000409232FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000433932ENST00000409015FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000433932ENST00000444342FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000460649ENST00000282120FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000460649ENST00000377386FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000460649ENST00000398263FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000460649ENST00000409232FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000460649ENST00000409015FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000460649ENST00000444342FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000542506ENST00000282120FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000542506ENST00000377386FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000542506ENST00000398263FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000542506ENST00000409232FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000542506ENST00000409015FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000542506ENST00000444342FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000541683ENST00000282120FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000541683ENST00000377386FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-3UTRENST00000541683ENST00000398263FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000541683ENST00000409232FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000541683ENST00000409015FADS1chr11

61569629

+TGOLN2chr2

85545424

-
intron-intronENST00000541683ENST00000444342FADS1chr11

61569629

+TGOLN2chr2

85545424

-

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FusionProtFeatures for FADS1_TGOLN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FADS1

O60427

TGOLN2

O43493


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FADS1_TGOLN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FADS1_TGOLN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FADS1_TGOLN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for FADS1_TGOLN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFADS1C0009404Colorectal Neoplasms1CTD_human
HgeneFADS1C0036341Schizophrenia1PSYGENET
HgeneFADS1C0038356Stomach Neoplasms1CTD_human
HgeneFADS1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneTGOLN2C0040128Thyroid Diseases1CTD_human
TgeneTGOLN2C0525045Mood Disorders1PSYGENET