![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 12415 |
FusionGeneSummary for FADS1_CLDN1 |
![]() |
Fusion gene information | Fusion gene name: FADS1_CLDN1 | Fusion gene ID: 12415 | Hgene | Tgene | Gene symbol | FADS1 | CLDN1 | Gene ID | 3992 | 9076 |
Gene name | fatty acid desaturase 1 | claudin 1 | |
Synonyms | D5D|FADS6|FADSD5|LLCDL1|TU12 | CLD1|ILVASC|SEMP1 | |
Cytomap | 11q12.2 | 3q28 | |
Type of gene | protein-coding | protein-coding | |
Description | fatty acid desaturase 1delta(5) desaturasedelta-5 fatty acid desaturaselinoleoyl-CoA desaturase (delta-6-desaturase)-like 1 | claudin-1senescence-associated epithelial membrane protein 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O60427 | O95832 | |
Ensembl transtripts involved in fusion gene | ENST00000350997, ENST00000536991, ENST00000433932, ENST00000460649, ENST00000542506, ENST00000541683, | ENST00000295522, | |
Fusion gene scores | * DoF score | 6 X 7 X 2=84 | 3 X 3 X 2=18 |
# samples | 7 | 3 | |
** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: FADS1 [Title/Abstract] AND CLDN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FADS1 | GO:0006636 | unsaturated fatty acid biosynthetic process | 10601301 |
Hgene | FADS1 | GO:0009267 | cellular response to starvation | 10601301 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG289620 | FADS1 | chr11 | 61568978 | - | CLDN1 | chr3 | 190024669 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000350997 | ENST00000295522 | FADS1 | chr11 | 61568978 | - | CLDN1 | chr3 | 190024669 | - |
intron-3UTR | ENST00000536991 | ENST00000295522 | FADS1 | chr11 | 61568978 | - | CLDN1 | chr3 | 190024669 | - |
intron-3UTR | ENST00000433932 | ENST00000295522 | FADS1 | chr11 | 61568978 | - | CLDN1 | chr3 | 190024669 | - |
intron-3UTR | ENST00000460649 | ENST00000295522 | FADS1 | chr11 | 61568978 | - | CLDN1 | chr3 | 190024669 | - |
intron-3UTR | ENST00000542506 | ENST00000295522 | FADS1 | chr11 | 61568978 | - | CLDN1 | chr3 | 190024669 | - |
intron-3UTR | ENST00000541683 | ENST00000295522 | FADS1 | chr11 | 61568978 | - | CLDN1 | chr3 | 190024669 | - |
Top |
FusionProtFeatures for FADS1_CLDN1 |
![]() |
Hgene | Tgene |
FADS1 | CLDN1 |
Claudins function as major constituents of the tightjunction complexes that regulate the permeability of epithelia.While some claudin family members play essential roles in theformation of impermeable barriers, others mediate the permeabilityto ions and small molecules. Often, several claudin family membersare coexpressed and interact with each other, and this determinesthe overall permeability. CLDN1 is required to prevent theparacellular diffusion of small molecules through tight junctionsin the epidermis and is required for the normal barrier functionof the skin. Required for normal water homeostasis and to preventexcessive water loss through the skin, probably via an indirecteffect on the expression levels of other proteins, since CLDN1itself seems to be dispensable for water barrier formation inkeratinocyte tight junctions (PubMed:23407391).{ECO:0000269|PubMed:23407391}. (Microbial infection) Acts as a receptor for hepatitis Cvirus (HCV) in hepatocytes (PubMed:17325668, PubMed:20375010).Associates with CD81 and the CLDN1-CD81 receptor complex isessential for HCV entry into host cell (PubMed:20375010). Acts asa receptor for dengue virus (PubMed:24074594).{ECO:0000269|PubMed:17325668, ECO:0000269|PubMed:20375010,ECO:0000269|PubMed:24074594}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for FADS1_CLDN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for FADS1_CLDN1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for FADS1_CLDN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for FADS1_CLDN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FADS1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | FADS1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | FADS1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | FADS1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Tgene | CLDN1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Tgene | CLDN1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Tgene | CLDN1 | C0011616 | Contact Dermatitis | 1 | CTD_human |
Tgene | CLDN1 | C0014175 | Endometriosis | 1 | CTD_human |