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Fusion gene ID: 12410 |
FusionGeneSummary for FABP2_MBOAT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FABP2_MBOAT2 | Fusion gene ID: 12410 | Hgene | Tgene | Gene symbol | FABP2 | MBOAT2 | Gene ID | 2169 | 129642 |
| Gene name | fatty acid binding protein 2 | membrane bound O-acyltransferase domain containing 2 | |
| Synonyms | FABPI|I-FABP | LPAAT|LPCAT4|LPEAT|LPLAT 2|OACT2 | |
| Cytomap | 4q26 | 2p25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fatty acid-binding protein, intestinalfatty acid binding protein 2, intestinalintestinal-type fatty acid-binding protein | lysophospholipid acyltransferase 21-acylglycerophosphate O-acyltransferase1-acylglycerophosphoethanolamine O-acyltransferaseO-acyltransferase (membrane bound) domain containing 2lyso-PA acyltransferaselyso-PE acyltransferaselysophosphatidic acid acy | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P12104 | Q6ZWT7 | |
| Ensembl transtripts involved in fusion gene | ENST00000274024, | ENST00000305997, ENST00000486484, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 4=100 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: FABP2 [Title/Abstract] AND MBOAT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BP270882 | FABP2 | chr4 | 120240727 | - | MBOAT2 | chr2 | 9003534 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000274024 | ENST00000305997 | FABP2 | chr4 | 120240727 | - | MBOAT2 | chr2 | 9003534 | - |
| intron-intron | ENST00000274024 | ENST00000486484 | FABP2 | chr4 | 120240727 | - | MBOAT2 | chr2 | 9003534 | - |
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FusionProtFeatures for FABP2_MBOAT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FABP2 | MBOAT2 |
| FABP are thought to play a role in the intracellulartransport of long-chain fatty acids and their acyl-CoA esters.FABP2 is probably involved in triglyceride-rich lipoproteinsynthesis. Binds saturated long-chain fatty acids with a highaffinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasisby functioning as a lipid sensor. | Acyltransferase which mediates the conversion oflysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity).Catalyzes also the acylation of lysophosphatidic acid (LPA) intophosphatidic acid (PA) (LPAAT activity). Has also a very weaklysophosphatidylcholine acyltransferase (LPCAT activity). Prefersoleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases(LPLATs) catalyze the reacylation step of the phospholipidremodeling pathway also known as the Lands cycle.{ECO:0000269|PubMed:18772128}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for FABP2_MBOAT2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for FABP2_MBOAT2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FABP2_MBOAT2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | FABP2 | P12104 | DB01050 | Ibuprofen | Fatty acid-binding protein, intestinal | small molecule | approved |
| Hgene | FABP2 | P12104 | DB09213 | Dexibuprofen | Fatty acid-binding protein, intestinal | small molecule | approved|investigational |
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RelatedDiseases for FABP2_MBOAT2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FABP2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
| Hgene | FABP2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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