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Fusion gene ID: 12408 |
FusionGeneSummary for FAAH_RAD54L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: FAAH_RAD54L | Fusion gene ID: 12408 | Hgene | Tgene | Gene symbol | FAAH | RAD54L | Gene ID | 79152 | 8438 |
| Gene name | fatty acid 2-hydroxylase | RAD54 like | |
| Synonyms | FAAH|FAH1|FAXDC1|SCS7|SPG35 | HR54|RAD54A|hHR54|hRAD54 | |
| Cytomap | 16q23.1 | 1p34.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | fatty acid 2-hydroxylasefatty acid alpha-hydroxylasefatty acid hydroxylase domain containing 1spastic paraplegia 35 (autosomal recessive) | DNA repair and recombination protein RAD54-likeRAD54 homolog | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O00519 | Q92698 | |
| Ensembl transtripts involved in fusion gene | ENST00000243167, ENST00000493735, | ENST00000442598, ENST00000371975, ENST00000473251, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: FAAH [Title/Abstract] AND RAD54L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-NJ-A4YF-01A | FAAH | chr1 | 46872040 | + | RAD54L | chr1 | 46733131 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000243167 | ENST00000442598 | FAAH | chr1 | 46872040 | + | RAD54L | chr1 | 46733131 | + |
| In-frame | ENST00000243167 | ENST00000371975 | FAAH | chr1 | 46872040 | + | RAD54L | chr1 | 46733131 | + |
| 5CDS-3UTR | ENST00000243167 | ENST00000473251 | FAAH | chr1 | 46872040 | + | RAD54L | chr1 | 46733131 | + |
| 3UTR-3CDS | ENST00000493735 | ENST00000442598 | FAAH | chr1 | 46872040 | + | RAD54L | chr1 | 46733131 | + |
| 3UTR-3CDS | ENST00000493735 | ENST00000371975 | FAAH | chr1 | 46872040 | + | RAD54L | chr1 | 46733131 | + |
| 3UTR-3UTR | ENST00000493735 | ENST00000473251 | FAAH | chr1 | 46872040 | + | RAD54L | chr1 | 46733131 | + |
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FusionProtFeatures for FAAH_RAD54L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FAAH | RAD54L |
| Degrades bioactive fatty acid amides like oleamide, theendogenous cannabinoid, anandamide and myristic amide to theircorresponding acids, thereby serving to terminate the signalingfunctions of these molecules. Hydrolyzes polyunsaturated substrateanandamide preferentially as compared to monounsaturatedsubstrates. {ECO:0000269|PubMed:17015445}. | Involved in DNA repair and mitotic recombination.Functions in the recombinational DNA repair (RAD52) pathway.Dissociates RAD51 from nucleoprotein filaments formed on dsDNA.Could be involved in the turnover of RAD51 protein-dsDNA filaments(By similarity). May play also an essential role in telomerelength maintenance and telomere capping in mammalian cells.{ECO:0000250, ECO:0000269|PubMed:11459989,ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:9774452}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | FAAH | chr1:46872040 | chr1:46733131 | ENST00000243167 | + | 7 | 15 | 238_241 | 317 | 580 | Region | Substrate binding |
| Hgene | FAAH | chr1:46872040 | chr1:46733131 | ENST00000243167 | + | 7 | 15 | 9_29 | 317 | 580 | Transmembrane | Helical |
| Tgene | >RAD54L | chr1:46872040 | chr1:46733131 | ENST00000371975 | + | 7 | 18 | 500_653 | 297 | 748 | Domain | Helicase C-terminal |
| Tgene | >RAD54L | chr1:46872040 | chr1:46733131 | ENST00000442598 | + | 8 | 19 | 500_653 | 297 | 748 | Domain | Helicase C-terminal |
| Tgene | >RAD54L | chr1:46872040 | chr1:46733131 | ENST00000371975 | + | 7 | 18 | 296_299 | 297 | 748 | Motif | Note=DEGH box |
| Tgene | >RAD54L | chr1:46872040 | chr1:46733131 | ENST00000442598 | + | 8 | 19 | 296_299 | 297 | 748 | Motif | Note=DEGH box |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >FAAH | chr1:46872040 | chr1:46733131 | ENST00000243167 | + | 7 | 15 | 404_433 | 317 | 580 | Intramembrane | Ontology_term=ECO:0000250 |
| Hgene | >FAAH | chr1:46872040 | chr1:46733131 | ENST00000243167 | + | 7 | 15 | 30_403 | 317 | 580 | Topological domain | Cytoplasmic |
| Hgene | >FAAH | chr1:46872040 | chr1:46733131 | ENST00000243167 | + | 7 | 15 | 434_579 | 317 | 580 | Topological domain | Cytoplasmic |
| Tgene | RAD54L | chr1:46872040 | chr1:46733131 | ENST00000371975 | + | 7 | 18 | 170_345 | 297 | 748 | Domain | Helicase ATP-binding |
| Tgene | RAD54L | chr1:46872040 | chr1:46733131 | ENST00000442598 | + | 8 | 19 | 170_345 | 297 | 748 | Domain | Helicase ATP-binding |
| Tgene | RAD54L | chr1:46872040 | chr1:46733131 | ENST00000371975 | + | 7 | 18 | 183_190 | 297 | 748 | Nucleotide binding | ATP |
| Tgene | RAD54L | chr1:46872040 | chr1:46733131 | ENST00000442598 | + | 8 | 19 | 183_190 | 297 | 748 | Nucleotide binding | ATP |
| Tgene | RAD54L | chr1:46872040 | chr1:46733131 | ENST00000371975 | + | 7 | 18 | 2_9 | 297 | 748 | Region | Required for chromatin remodeling%2C strand pairing activities and coupling of ATPase activity |
| Tgene | RAD54L | chr1:46872040 | chr1:46733131 | ENST00000442598 | + | 8 | 19 | 2_9 | 297 | 748 | Region | Required for chromatin remodeling%2C strand pairing activities and coupling of ATPase activity |
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FusionGeneSequence for FAAH_RAD54L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_FAAH_ENST00000243167_chr1_46872040_+_RAD54L_ENST00000442598_chr1_46733131_+_768aa MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRE LAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCV YGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH FVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQ AKPAEELLEGKMSVSSLSSITSLKKLCNHPALIYDKCVEEEDGFVGALDLFPPGYSSKALEPQLSGKMLVLDYILAVTRSRSSDKVVLVS NYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRD GQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFILDEASLSDTHDRLHCRRCVNSRQIRPPPDGSDCT >In-frame_FAAH_ENST00000243167_chr1_46872040_+_RAD54L_ENST00000371975_chr1_46733131_+_768aa MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRE LAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCV YGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEGHRLKNSENQTYQALDSLNTSRRVLISGTPIQNDLLEYFSLVH FVNSGILGTAHEFKKHFELPILKGRDAAASEADRQLGEERLRELTSIVNRCLIRRTSDILSKYLPVKIEQVVCCRLTPLQTELYKRFLRQ AKPAEELLEGKMSVSSLSSITSLKKLCNHPALIYDKCVEEEDGFVGALDLFPPGYSSKALEPQLSGKMLVLDYILAVTRSRSSDKVVLVS NYTQTLDLFEKLCRARRYLYVRLDGTMSIKKRAKVVERFNSPSSPDFVFMLSSKAGGCGLNLIGANRLVMFDPDWNPANDEQAMARVWRD GQKKTCYIYRLLSAGTIEEKIFQRQSHKKALSSCVVDEEQDVERHFSLGELKELFILDEASLSDTHDRLHCRRCVNSRQIRPPPDGSDCT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_FAAH_ENST00000243167_chr1_46872040_+_RAD54L_ENST00000442598_chr1_46733131_+_2304nt ATGGTGCAGTACGAGCTGTGGGCCGCGCTGCCTGGCGCCTCCGGGGTCGCCCTGGCCTGCTGCTTCGTGGCGGCGGCCGTGGCCCTGCGC TGGTCCGGGCGCCGGACGGCGCGGGGCGCGGTGGTCCGGGCGCGACAGAGGCAGCGAGCGGGCCTGGAGAACATGGACAGGGCGGCGCAG CGCTTCCGGCTCCAGAACCCAGACCTGGACTCAGAGGCGCTGCTAGCCCTGCCCCTGCCTCAGCTGGTGCAGAAGTTACACAGTAGAGAG CTGGCCCCTGAGGCCGTGCTCTTCACCTATGTGGGAAAGGCCTGGGAAGTGAACAAAGGGACCAACTGTGTGACCTCCTATCTGGCTGAC TGTGAGACTCAGCTGTCTCAGGCCCCAAGGCAGGGCCTGCTCTATGGCGTCCCTGTGAGCCTCAAGGAGTGCTTCACCTACAAGGGCCAG GACTCCACGCTGGGCTTGAGCCTGAATGAAGGGGTGCCGGCGGAGTGCGACAGCGTAGTGGTGCATGTGCTGAAGCTGCAGGGTGCCGTG CCCTTCGTGCACACCAATGTTCCACAGTCCATGTTCAGCTATGACTGCAGTAACCCCCTCTTTGGCCAGACCGTGAACCCATGGAAGTCC TCCAAAAGCCCAGGGGGCTCCTCAGGGGGTGAAGGGGCCCTCATCGGGTCTGGAGGCTCCCCCCTGGGCTTAGGCACTGATATCGGAGGC AGCATCCGCTTCCCCTCCTCCTTCTGCGGCATCTGCGGCCTCAAGCCCACAGGGAACCGCCTCAGCAAGAGTGGCCTGAAGGGCTGTGTC TATGGACAGGAGGCAGTGCGTCTCTCCGTGGGCCCCATGGCCCGGGACGTGGAGAGCCTGGCACTGTGCCTGCGAGCCCTGCTGTGTGAG GACATGTTCCGCTTGGACCCCACTGTGCCTCCCTTGCCCTTCAGAGAAGAGGGACACAGGCTCAAGAACTCTGAGAATCAGACTTACCAA GCCCTGGACAGCTTGAACACCAGCCGGCGGGTGCTCATCTCCGGAACTCCCATCCAGAATGATCTGCTTGAGTATTTCAGCTTGGTACAT TTTGTTAATTCCGGCATCCTAGGGACTGCCCATGAATTCAAGAAGCATTTTGAATTGCCAATTTTGAAGGGTCGAGACGCTGCTGCTAGT GAGGCAGACAGGCAGCTAGGAGAGGAGCGGCTGCGGGAGCTCACCAGCATTGTGAATAGATGCCTGATACGGAGGACTTCTGATATCCTT TCTAAATATCTGCCTGTGAAGATTGAGCAGGTCGTTTGTTGTAGGCTGACACCCCTTCAGACTGAGTTATACAAGAGGTTTCTGAGACAA GCCAAACCGGCAGAAGAATTGCTTGAGGGCAAGATGAGTGTGTCTTCCCTTTCTTCCATCACCTCGCTAAAGAAGCTTTGTAATCATCCA GCTCTAATCTATGATAAGTGTGTGGAAGAGGAGGATGGCTTTGTGGGTGCCTTGGACCTCTTCCCTCCTGGTTACAGCTCTAAGGCCCTG GAGCCCCAGCTGTCAGGTAAGATGCTGGTCCTGGATTATATTCTGGCGGTGACCCGAAGCCGTAGCAGTGACAAAGTAGTGCTGGTGTCG AATTACACCCAGACTTTGGATCTCTTTGAGAAGCTGTGCCGTGCCCGAAGGTACTTATACGTCCGCCTGGATGGCACGATGTCCATTAAG AAGCGAGCCAAGGTTGTAGAACGCTTCAATAGTCCATCGAGCCCTGACTTTGTCTTCATGCTGAGCAGCAAAGCTGGGGGCTGTGGCCTC AATCTCATTGGGGCTAACCGGCTGGTCATGTTTGACCCTGACTGGAACCCAGCCAATGATGAACAAGCCATGGCCCGGGTCTGGCGAGAT GGTCAAAAGAAGACTTGCTATATCTACCGCCTGCTGTCTGCAGGGACCATTGAGGAGAAGATCTTCCAGCGTCAGAGCCACAAGAAGGCA CTGAGCAGCTGTGTGGTGGATGAGGAGCAGGATGTAGAGCGCCACTTCTCTCTGGGCGAGTTGAAGGAGCTGTTTATCCTGGATGAAGCT AGCCTCAGTGACACACATGACAGGTTGCACTGCCGACGTTGTGTCAACAGCCGTCAGATCCGGCCACCCCCTGATGGTTCTGACTGCACT TCAGACCTGGCAGGGTGGAACCACTGCACTGATAAGTGGGGGCTCCGGGATGAGGTACTCCAGGCTGCCTGGGATGCTGCCTCCACTGCC >In-frame_FAAH_ENST00000243167_chr1_46872040_+_RAD54L_ENST00000371975_chr1_46733131_+_2304nt ATGGTGCAGTACGAGCTGTGGGCCGCGCTGCCTGGCGCCTCCGGGGTCGCCCTGGCCTGCTGCTTCGTGGCGGCGGCCGTGGCCCTGCGC TGGTCCGGGCGCCGGACGGCGCGGGGCGCGGTGGTCCGGGCGCGACAGAGGCAGCGAGCGGGCCTGGAGAACATGGACAGGGCGGCGCAG CGCTTCCGGCTCCAGAACCCAGACCTGGACTCAGAGGCGCTGCTAGCCCTGCCCCTGCCTCAGCTGGTGCAGAAGTTACACAGTAGAGAG CTGGCCCCTGAGGCCGTGCTCTTCACCTATGTGGGAAAGGCCTGGGAAGTGAACAAAGGGACCAACTGTGTGACCTCCTATCTGGCTGAC TGTGAGACTCAGCTGTCTCAGGCCCCAAGGCAGGGCCTGCTCTATGGCGTCCCTGTGAGCCTCAAGGAGTGCTTCACCTACAAGGGCCAG GACTCCACGCTGGGCTTGAGCCTGAATGAAGGGGTGCCGGCGGAGTGCGACAGCGTAGTGGTGCATGTGCTGAAGCTGCAGGGTGCCGTG CCCTTCGTGCACACCAATGTTCCACAGTCCATGTTCAGCTATGACTGCAGTAACCCCCTCTTTGGCCAGACCGTGAACCCATGGAAGTCC TCCAAAAGCCCAGGGGGCTCCTCAGGGGGTGAAGGGGCCCTCATCGGGTCTGGAGGCTCCCCCCTGGGCTTAGGCACTGATATCGGAGGC AGCATCCGCTTCCCCTCCTCCTTCTGCGGCATCTGCGGCCTCAAGCCCACAGGGAACCGCCTCAGCAAGAGTGGCCTGAAGGGCTGTGTC TATGGACAGGAGGCAGTGCGTCTCTCCGTGGGCCCCATGGCCCGGGACGTGGAGAGCCTGGCACTGTGCCTGCGAGCCCTGCTGTGTGAG GACATGTTCCGCTTGGACCCCACTGTGCCTCCCTTGCCCTTCAGAGAAGAGGGACACAGGCTCAAGAACTCTGAGAATCAGACTTACCAA GCCCTGGACAGCTTGAACACCAGCCGGCGGGTGCTCATCTCCGGAACTCCCATCCAGAATGATCTGCTTGAGTATTTCAGCTTGGTACAT TTTGTTAATTCCGGCATCCTAGGGACTGCCCATGAATTCAAGAAGCATTTTGAATTGCCAATTTTGAAGGGTCGAGACGCTGCTGCTAGT GAGGCAGACAGGCAGCTAGGAGAGGAGCGGCTGCGGGAGCTCACCAGCATTGTGAATAGATGCCTGATACGGAGGACTTCTGATATCCTT TCTAAATATCTGCCTGTGAAGATTGAGCAGGTCGTTTGTTGTAGGCTGACACCCCTTCAGACTGAGTTATACAAGAGGTTTCTGAGACAA GCCAAACCGGCAGAAGAATTGCTTGAGGGCAAGATGAGTGTGTCTTCCCTTTCTTCCATCACCTCGCTAAAGAAGCTTTGTAATCATCCA GCTCTAATCTATGATAAGTGTGTGGAAGAGGAGGATGGCTTTGTGGGTGCCTTGGACCTCTTCCCTCCTGGTTACAGCTCTAAGGCCCTG GAGCCCCAGCTGTCAGGTAAGATGCTGGTCCTGGATTATATTCTGGCGGTGACCCGAAGCCGTAGCAGTGACAAAGTAGTGCTGGTGTCG AATTACACCCAGACTTTGGATCTCTTTGAGAAGCTGTGCCGTGCCCGAAGGTACTTATACGTCCGCCTGGATGGCACGATGTCCATTAAG AAGCGAGCCAAGGTTGTAGAACGCTTCAATAGTCCATCGAGCCCTGACTTTGTCTTCATGCTGAGCAGCAAAGCTGGGGGCTGTGGCCTC AATCTCATTGGGGCTAACCGGCTGGTCATGTTTGACCCTGACTGGAACCCAGCCAATGATGAACAAGCCATGGCCCGGGTCTGGCGAGAT GGTCAAAAGAAGACTTGCTATATCTACCGCCTGCTGTCTGCAGGGACCATTGAGGAGAAGATCTTCCAGCGTCAGAGCCACAAGAAGGCA CTGAGCAGCTGTGTGGTGGATGAGGAGCAGGATGTAGAGCGCCACTTCTCTCTGGGCGAGTTGAAGGAGCTGTTTATCCTGGATGAAGCT AGCCTCAGTGACACACATGACAGGTTGCACTGCCGACGTTGTGTCAACAGCCGTCAGATCCGGCCACCCCCTGATGGTTCTGACTGCACT TCAGACCTGGCAGGGTGGAACCACTGCACTGATAAGTGGGGGCTCCGGGATGAGGTACTCCAGGCTGCCTGGGATGCTGCCTCCACTGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_FAAH_ENST00000243167_chr1_46872040_+_RAD54L_ENST00000442598_chr1_46733131_+_2579nt AGTCCGGGTTTTGCGGCGGAGCGGGCGGGCTGCGCGTGCGGCGGCTTCAACTGTCGCGGTAGGCAGCAGCAGGCTGAAGGGATCATGGTG CAGTACGAGCTGTGGGCCGCGCTGCCTGGCGCCTCCGGGGTCGCCCTGGCCTGCTGCTTCGTGGCGGCGGCCGTGGCCCTGCGCTGGTCC GGGCGCCGGACGGCGCGGGGCGCGGTGGTCCGGGCGCGACAGAGGCAGCGAGCGGGCCTGGAGAACATGGACAGGGCGGCGCAGCGCTTC CGGCTCCAGAACCCAGACCTGGACTCAGAGGCGCTGCTAGCCCTGCCCCTGCCTCAGCTGGTGCAGAAGTTACACAGTAGAGAGCTGGCC CCTGAGGCCGTGCTCTTCACCTATGTGGGAAAGGCCTGGGAAGTGAACAAAGGGACCAACTGTGTGACCTCCTATCTGGCTGACTGTGAG ACTCAGCTGTCTCAGGCCCCAAGGCAGGGCCTGCTCTATGGCGTCCCTGTGAGCCTCAAGGAGTGCTTCACCTACAAGGGCCAGGACTCC ACGCTGGGCTTGAGCCTGAATGAAGGGGTGCCGGCGGAGTGCGACAGCGTAGTGGTGCATGTGCTGAAGCTGCAGGGTGCCGTGCCCTTC GTGCACACCAATGTTCCACAGTCCATGTTCAGCTATGACTGCAGTAACCCCCTCTTTGGCCAGACCGTGAACCCATGGAAGTCCTCCAAA AGCCCAGGGGGCTCCTCAGGGGGTGAAGGGGCCCTCATCGGGTCTGGAGGCTCCCCCCTGGGCTTAGGCACTGATATCGGAGGCAGCATC CGCTTCCCCTCCTCCTTCTGCGGCATCTGCGGCCTCAAGCCCACAGGGAACCGCCTCAGCAAGAGTGGCCTGAAGGGCTGTGTCTATGGA CAGGAGGCAGTGCGTCTCTCCGTGGGCCCCATGGCCCGGGACGTGGAGAGCCTGGCACTGTGCCTGCGAGCCCTGCTGTGTGAGGACATG TTCCGCTTGGACCCCACTGTGCCTCCCTTGCCCTTCAGAGAAGAGGGACACAGGCTCAAGAACTCTGAGAATCAGACTTACCAAGCCCTG GACAGCTTGAACACCAGCCGGCGGGTGCTCATCTCCGGAACTCCCATCCAGAATGATCTGCTTGAGTATTTCAGCTTGGTACATTTTGTT AATTCCGGCATCCTAGGGACTGCCCATGAATTCAAGAAGCATTTTGAATTGCCAATTTTGAAGGGTCGAGACGCTGCTGCTAGTGAGGCA GACAGGCAGCTAGGAGAGGAGCGGCTGCGGGAGCTCACCAGCATTGTGAATAGATGCCTGATACGGAGGACTTCTGATATCCTTTCTAAA TATCTGCCTGTGAAGATTGAGCAGGTCGTTTGTTGTAGGCTGACACCCCTTCAGACTGAGTTATACAAGAGGTTTCTGAGACAAGCCAAA CCGGCAGAAGAATTGCTTGAGGGCAAGATGAGTGTGTCTTCCCTTTCTTCCATCACCTCGCTAAAGAAGCTTTGTAATCATCCAGCTCTA ATCTATGATAAGTGTGTGGAAGAGGAGGATGGCTTTGTGGGTGCCTTGGACCTCTTCCCTCCTGGTTACAGCTCTAAGGCCCTGGAGCCC CAGCTGTCAGGTAAGATGCTGGTCCTGGATTATATTCTGGCGGTGACCCGAAGCCGTAGCAGTGACAAAGTAGTGCTGGTGTCGAATTAC ACCCAGACTTTGGATCTCTTTGAGAAGCTGTGCCGTGCCCGAAGGTACTTATACGTCCGCCTGGATGGCACGATGTCCATTAAGAAGCGA GCCAAGGTTGTAGAACGCTTCAATAGTCCATCGAGCCCTGACTTTGTCTTCATGCTGAGCAGCAAAGCTGGGGGCTGTGGCCTCAATCTC ATTGGGGCTAACCGGCTGGTCATGTTTGACCCTGACTGGAACCCAGCCAATGATGAACAAGCCATGGCCCGGGTCTGGCGAGATGGTCAA AAGAAGACTTGCTATATCTACCGCCTGCTGTCTGCAGGGACCATTGAGGAGAAGATCTTCCAGCGTCAGAGCCACAAGAAGGCACTGAGC AGCTGTGTGGTGGATGAGGAGCAGGATGTAGAGCGCCACTTCTCTCTGGGCGAGTTGAAGGAGCTGTTTATCCTGGATGAAGCTAGCCTC AGTGACACACATGACAGGTTGCACTGCCGACGTTGTGTCAACAGCCGTCAGATCCGGCCACCCCCTGATGGTTCTGACTGCACTTCAGAC CTGGCAGGGTGGAACCACTGCACTGATAAGTGGGGGCTCCGGGATGAGGTACTCCAGGCTGCCTGGGATGCTGCCTCCACTGCCATCACC TTCGTCTTCCACCAGCGTTCTCATGAGGAGCAGCGGGGCCTCCGCTGATAACCAGCTGGTCTGGGTGTAGCTCTTAGAGGAAGGAGATAG GGAAAAGGGGCTCCTTGCTCCACAGGGCCCTGTTGAATTTTGTTCTCTGGGAGAAAATCATCAAGAAGGGCTGCATGATGTTTGCCCAAA >In-frame_FAAH_ENST00000243167_chr1_46872040_+_RAD54L_ENST00000371975_chr1_46733131_+_2578nt AGTCCGGGTTTTGCGGCGGAGCGGGCGGGCTGCGCGTGCGGCGGCTTCAACTGTCGCGGTAGGCAGCAGCAGGCTGAAGGGATCATGGTG CAGTACGAGCTGTGGGCCGCGCTGCCTGGCGCCTCCGGGGTCGCCCTGGCCTGCTGCTTCGTGGCGGCGGCCGTGGCCCTGCGCTGGTCC GGGCGCCGGACGGCGCGGGGCGCGGTGGTCCGGGCGCGACAGAGGCAGCGAGCGGGCCTGGAGAACATGGACAGGGCGGCGCAGCGCTTC CGGCTCCAGAACCCAGACCTGGACTCAGAGGCGCTGCTAGCCCTGCCCCTGCCTCAGCTGGTGCAGAAGTTACACAGTAGAGAGCTGGCC CCTGAGGCCGTGCTCTTCACCTATGTGGGAAAGGCCTGGGAAGTGAACAAAGGGACCAACTGTGTGACCTCCTATCTGGCTGACTGTGAG ACTCAGCTGTCTCAGGCCCCAAGGCAGGGCCTGCTCTATGGCGTCCCTGTGAGCCTCAAGGAGTGCTTCACCTACAAGGGCCAGGACTCC ACGCTGGGCTTGAGCCTGAATGAAGGGGTGCCGGCGGAGTGCGACAGCGTAGTGGTGCATGTGCTGAAGCTGCAGGGTGCCGTGCCCTTC GTGCACACCAATGTTCCACAGTCCATGTTCAGCTATGACTGCAGTAACCCCCTCTTTGGCCAGACCGTGAACCCATGGAAGTCCTCCAAA AGCCCAGGGGGCTCCTCAGGGGGTGAAGGGGCCCTCATCGGGTCTGGAGGCTCCCCCCTGGGCTTAGGCACTGATATCGGAGGCAGCATC CGCTTCCCCTCCTCCTTCTGCGGCATCTGCGGCCTCAAGCCCACAGGGAACCGCCTCAGCAAGAGTGGCCTGAAGGGCTGTGTCTATGGA CAGGAGGCAGTGCGTCTCTCCGTGGGCCCCATGGCCCGGGACGTGGAGAGCCTGGCACTGTGCCTGCGAGCCCTGCTGTGTGAGGACATG TTCCGCTTGGACCCCACTGTGCCTCCCTTGCCCTTCAGAGAAGAGGGACACAGGCTCAAGAACTCTGAGAATCAGACTTACCAAGCCCTG GACAGCTTGAACACCAGCCGGCGGGTGCTCATCTCCGGAACTCCCATCCAGAATGATCTGCTTGAGTATTTCAGCTTGGTACATTTTGTT AATTCCGGCATCCTAGGGACTGCCCATGAATTCAAGAAGCATTTTGAATTGCCAATTTTGAAGGGTCGAGACGCTGCTGCTAGTGAGGCA GACAGGCAGCTAGGAGAGGAGCGGCTGCGGGAGCTCACCAGCATTGTGAATAGATGCCTGATACGGAGGACTTCTGATATCCTTTCTAAA TATCTGCCTGTGAAGATTGAGCAGGTCGTTTGTTGTAGGCTGACACCCCTTCAGACTGAGTTATACAAGAGGTTTCTGAGACAAGCCAAA CCGGCAGAAGAATTGCTTGAGGGCAAGATGAGTGTGTCTTCCCTTTCTTCCATCACCTCGCTAAAGAAGCTTTGTAATCATCCAGCTCTA ATCTATGATAAGTGTGTGGAAGAGGAGGATGGCTTTGTGGGTGCCTTGGACCTCTTCCCTCCTGGTTACAGCTCTAAGGCCCTGGAGCCC CAGCTGTCAGGTAAGATGCTGGTCCTGGATTATATTCTGGCGGTGACCCGAAGCCGTAGCAGTGACAAAGTAGTGCTGGTGTCGAATTAC ACCCAGACTTTGGATCTCTTTGAGAAGCTGTGCCGTGCCCGAAGGTACTTATACGTCCGCCTGGATGGCACGATGTCCATTAAGAAGCGA GCCAAGGTTGTAGAACGCTTCAATAGTCCATCGAGCCCTGACTTTGTCTTCATGCTGAGCAGCAAAGCTGGGGGCTGTGGCCTCAATCTC ATTGGGGCTAACCGGCTGGTCATGTTTGACCCTGACTGGAACCCAGCCAATGATGAACAAGCCATGGCCCGGGTCTGGCGAGATGGTCAA AAGAAGACTTGCTATATCTACCGCCTGCTGTCTGCAGGGACCATTGAGGAGAAGATCTTCCAGCGTCAGAGCCACAAGAAGGCACTGAGC AGCTGTGTGGTGGATGAGGAGCAGGATGTAGAGCGCCACTTCTCTCTGGGCGAGTTGAAGGAGCTGTTTATCCTGGATGAAGCTAGCCTC AGTGACACACATGACAGGTTGCACTGCCGACGTTGTGTCAACAGCCGTCAGATCCGGCCACCCCCTGATGGTTCTGACTGCACTTCAGAC CTGGCAGGGTGGAACCACTGCACTGATAAGTGGGGGCTCCGGGATGAGGTACTCCAGGCTGCCTGGGATGCTGCCTCCACTGCCATCACC TTCGTCTTCCACCAGCGTTCTCATGAGGAGCAGCGGGGCCTCCGCTGATAACCAGCTGGTCTGGGTGTAGCTCTTAGAGGAAGGAGATAG GGAAAAGGGGCTCCTTGCTCCACAGGGCCCTGTTGAATTTTGTTCTCTGGGAGAAAATCATCAAGAAGGGCTGCATGATGTTTGCCCAAA |
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FusionGenePPI for FAAH_RAD54L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| FAAH | MME, NOTCH2NL | RAD54L | HECW2, WDYHV1, LIMK1, NCK1, SGTB, BAG6 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for FAAH_RAD54L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | FAAH | O00519 | DB00316 | Acetaminophen | Fatty-acid amide hydrolase 1 | small molecule | approved |
| Hgene | FAAH | O00519 | DB00599 | Thiopental | Fatty-acid amide hydrolase 1 | small molecule | approved|vet_approved |
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RelatedDiseases for FAAH_RAD54L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | FAAH | C0024809 | Marijuana Abuse | 3 | PSYGENET |
| Hgene | FAAH | C0028754 | Obesity | 2 | CTD_human |
| Hgene | FAAH | C0038587 | Substance Withdrawal Syndrome | 2 | CTD_human |
| Hgene | FAAH | C0236969 | Substance-Related Disorders | 2 | CTD_human |
| Hgene | FAAH | C0006870 | Cannabis Dependence | 1 | PSYGENET |
| Hgene | FAAH | C0020179 | Huntington Disease | 1 | CTD_human |
| Hgene | FAAH | C0032962 | Pregnancy Complications | 1 | CTD_human |
| Hgene | FAAH | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | FAAH | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | FAAH | C0036572 | Seizures | 1 | CTD_human |
| Hgene | FAAH | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Hgene | FAAH | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
| Hgene | FAAH | C0525045 | Mood Disorders | 1 | PSYGENET |
| Hgene | FAAH | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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