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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12407

FusionGeneSummary for FAAH_FAAH

check button Fusion gene summary
Fusion gene informationFusion gene name: FAAH_FAAH
Fusion gene ID: 12407
HgeneTgene
Gene symbol

FAAH

FAAH

Gene ID

79152

79152

Gene namefatty acid 2-hydroxylasefatty acid 2-hydroxylase
SynonymsFAAH|FAH1|FAXDC1|SCS7|SPG35FAAH|FAH1|FAXDC1|SCS7|SPG35
Cytomap

16q23.1

16q23.1

Type of geneprotein-codingprotein-coding
Descriptionfatty acid 2-hydroxylasefatty acid alpha-hydroxylasefatty acid hydroxylase domain containing 1spastic paraplegia 35 (autosomal recessive)fatty acid 2-hydroxylasefatty acid alpha-hydroxylasefatty acid hydroxylase domain containing 1spastic paraplegia 35 (autosomal recessive)
Modification date2018052320180523
UniProtAcc

O00519

O00519

Ensembl transtripts involved in fusion geneENST00000243167, ENST00000493735, 
ENST00000243167, ENST00000493735, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: FAAH [Title/Abstract] AND FAAH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF766834FAAHchr1

46879292

+FAAHchr1

46879145

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000243167ENST00000243167FAAHchr1

46879292

+FAAHchr1

46879145

-
3UTR-intronENST00000243167ENST00000493735FAAHchr1

46879292

+FAAHchr1

46879145

-
intron-3CDSENST00000493735ENST00000243167FAAHchr1

46879292

+FAAHchr1

46879145

-
intron-intronENST00000493735ENST00000493735FAAHchr1

46879292

+FAAHchr1

46879145

-

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FusionProtFeatures for FAAH_FAAH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAAH

O00519

FAAH

O00519

Degrades bioactive fatty acid amides like oleamide, theendogenous cannabinoid, anandamide and myristic amide to theircorresponding acids, thereby serving to terminate the signalingfunctions of these molecules. Hydrolyzes polyunsaturated substrateanandamide preferentially as compared to monounsaturatedsubstrates. {ECO:0000269|PubMed:17015445}. Degrades bioactive fatty acid amides like oleamide, theendogenous cannabinoid, anandamide and myristic amide to theircorresponding acids, thereby serving to terminate the signalingfunctions of these molecules. Hydrolyzes polyunsaturated substrateanandamide preferentially as compared to monounsaturatedsubstrates. {ECO:0000269|PubMed:17015445}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for FAAH_FAAH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for FAAH_FAAH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for FAAH_FAAH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFAAHO00519DB00316AcetaminophenFatty-acid amide hydrolase 1small moleculeapproved
HgeneFAAHO00519DB00599ThiopentalFatty-acid amide hydrolase 1small moleculeapproved|vet_approved
TgeneFAAHO00519DB00316AcetaminophenFatty-acid amide hydrolase 1small moleculeapproved
TgeneFAAHO00519DB00599ThiopentalFatty-acid amide hydrolase 1small moleculeapproved|vet_approved

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RelatedDiseases for FAAH_FAAH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAAHC0024809Marijuana Abuse3PSYGENET
HgeneFAAHC0028754Obesity2CTD_human
HgeneFAAHC0038587Substance Withdrawal Syndrome2CTD_human
HgeneFAAHC0236969Substance-Related Disorders2CTD_human
HgeneFAAHC0006870Cannabis Dependence1PSYGENET
HgeneFAAHC0020179Huntington Disease1CTD_human
HgeneFAAHC0032962Pregnancy Complications1CTD_human
HgeneFAAHC0033975Psychotic Disorders1PSYGENET
HgeneFAAHC0036341Schizophrenia1PSYGENET
HgeneFAAHC0036572Seizures1CTD_human
HgeneFAAHC0041696Unipolar Depression1PSYGENET
HgeneFAAHC0349204Nonorganic psychosis1PSYGENET
HgeneFAAHC0525045Mood Disorders1PSYGENET
HgeneFAAHC1269683Major Depressive Disorder1PSYGENET
TgeneFAAHC0024809Marijuana Abuse3PSYGENET
TgeneFAAHC0028754Obesity2CTD_human
TgeneFAAHC0038587Substance Withdrawal Syndrome2CTD_human
TgeneFAAHC0236969Substance-Related Disorders2CTD_human
TgeneFAAHC0006870Cannabis Dependence1PSYGENET
TgeneFAAHC0020179Huntington Disease1CTD_human
TgeneFAAHC0032962Pregnancy Complications1CTD_human
TgeneFAAHC0033975Psychotic Disorders1PSYGENET
TgeneFAAHC0036341Schizophrenia1PSYGENET
TgeneFAAHC0036572Seizures1CTD_human
TgeneFAAHC0041696Unipolar Depression1PSYGENET
TgeneFAAHC0349204Nonorganic psychosis1PSYGENET
TgeneFAAHC0525045Mood Disorders1PSYGENET
TgeneFAAHC1269683Major Depressive Disorder1PSYGENET