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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12400

FusionGeneSummary for F3_C11orf80

check button Fusion gene summary
Fusion gene informationFusion gene name: F3_C11orf80
Fusion gene ID: 12400
HgeneTgene
Gene symbol

F3

C11orf80

Gene ID

2152

79703

Gene namecoagulation factor III, tissue factorchromosome 11 open reading frame 80
SynonymsCD142|TF|TFATOP6BL|TOPOVIBL
Cytomap

1p21.3

11q13.2

Type of geneprotein-codingprotein-coding
Descriptiontissue factorcoagulation factor III (thromboplastin, tissue factor)type 2 DNA topoisomerase 6 subunit B-liketype 2 DNA topoisomerase VI subunit B-like
Modification date2018052720180523
UniProtAcc

P13726

Ensembl transtripts involved in fusion geneENST00000334047, ENST00000370207, 
ENST00000480356, 
ENST00000346672, 
ENST00000360962, ENST00000527634, 
ENST00000540737, ENST00000532565, 
ENST00000525449, ENST00000527368, 
Fusion gene scores* DoF score3 X 3 X 2=1812 X 7 X 8=672
# samples 415
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(15/672*10)=-2.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: F3 [Title/Abstract] AND C11orf80 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneF3

GO:0001938

positive regulation of endothelial cell proliferation

17898544

HgeneF3

GO:0002541

activation of plasma proteins involved in acute inflammatory response

17469850

HgeneF3

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

17898544

HgeneF3

GO:0007596

blood coagulation

8632006|24998411

HgeneF3

GO:0010641

positive regulation of platelet-derived growth factor receptor signaling pathway

17991872

HgeneF3

GO:0016485

protein processing

24998411

HgeneF3

GO:0045766

positive regulation of angiogenesis

17898544


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-D6-6517-01AF3chr1

95007093

-C11orf80chr11

66583524

+
TCGALDHNSCTCGA-F7-A620-01AF3chr1

95007093

-C11orf80chr11

66583524

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000334047ENST00000346672F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000334047ENST00000360962F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000334047ENST00000527634F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000334047ENST00000540737F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000334047ENST00000532565F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000334047ENST00000525449F3chr1

95007093

-C11orf80chr11

66583524

+
5CDS-intronENST00000334047ENST00000527368F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000370207ENST00000346672F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000370207ENST00000360962F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000370207ENST00000527634F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000370207ENST00000540737F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000370207ENST00000532565F3chr1

95007093

-C11orf80chr11

66583524

+
Frame-shiftENST00000370207ENST00000525449F3chr1

95007093

-C11orf80chr11

66583524

+
5CDS-intronENST00000370207ENST00000527368F3chr1

95007093

-C11orf80chr11

66583524

+
5UTR-3CDSENST00000480356ENST00000346672F3chr1

95007093

-C11orf80chr11

66583524

+
5UTR-3CDSENST00000480356ENST00000360962F3chr1

95007093

-C11orf80chr11

66583524

+
5UTR-3CDSENST00000480356ENST00000527634F3chr1

95007093

-C11orf80chr11

66583524

+
5UTR-3CDSENST00000480356ENST00000540737F3chr1

95007093

-C11orf80chr11

66583524

+
5UTR-3CDSENST00000480356ENST00000532565F3chr1

95007093

-C11orf80chr11

66583524

+
5UTR-3CDSENST00000480356ENST00000525449F3chr1

95007093

-C11orf80chr11

66583524

+
5UTR-intronENST00000480356ENST00000527368F3chr1

95007093

-C11orf80chr11

66583524

+

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FusionProtFeatures for F3_C11orf80


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
F3

P13726

C11orf80

Initiates blood coagulation by forming a complex withcirculating factor VII or VIIa. The [TF:VIIa] complex activatesfactors IX or X by specific limited protolysis. TF plays a role innormal hemostasis by initiating the cell-surface assembly andpropagation of the coagulation protease cascade.{ECO:0000269|PubMed:12652293}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for F3_C11orf80


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for F3_C11orf80


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
F3F7, FLNA, PLG, ELAVL1, DAD1, TM9SF4, RAB13, STX12, UBE2D1, UBE2D2, UBE2D3, UBE2D4, PPP2R4C11orf80


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for F3_C11orf80


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneF3P13726DB00036Coagulation factor VIIa Recombinant HumanTissue factorbiotechapproved

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RelatedDiseases for F3_C11orf80


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneF3C0012739Disseminated Intravascular Coagulation3CTD_human
HgeneF3C0040053Thrombosis2CTD_human
HgeneF3C0023487Acute Promyelocytic Leukemia1CTD_human
HgeneF3C0023890Liver Cirrhosis1CTD_human
HgeneF3C0027726Nephrotic Syndrome1CTD_human
HgeneF3C0034155Purpura, Thrombotic Thrombocytopenic1CTD_human
HgeneF3C0042487Venous Thrombosis1CTD_human
HgeneF3C0151744Myocardial Ischemia1CTD_human
HgeneF3C1458155Mammary Neoplasms1CTD_human