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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1239

FusionGeneSummary for AHRR_AVIL

check button Fusion gene summary
Fusion gene informationFusion gene name: AHRR_AVIL
Fusion gene ID: 1239
HgeneTgene
Gene symbol

AHRR

AVIL

Gene ID

57491

10677

Gene namearyl-hydrocarbon receptor repressoradvillin
SynonymsAHH|AHHR|bHLHe77ADVIL|DOC6|p92
Cytomap

5p15.33

12q14.1

Type of geneprotein-codingprotein-coding
Descriptionaryl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressoradvillin
Modification date2018052320180519
UniProtAcc

A9YTQ3

O75366

Ensembl transtripts involved in fusion geneENST00000505113, ENST00000316418, 
ENST00000512529, ENST00000515206, 
ENST00000506456, 		ENST00000537081, 
ENST00000257861, ENST00000550083, 
Fusion gene scores* DoF score4 X 2 X 3=2415 X 10 X 6=900
# samples 416
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/900*10)=-2.49185309632967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AHRR [Title/Abstract] AND AVIL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A2IZ-01AAHRRchr5

376831

+AVILchr12

58193703

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000505113ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
In-frameENST00000505113ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
5CDS-intronENST00000505113ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-
In-frameENST00000316418ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
In-frameENST00000316418ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
5CDS-intronENST00000316418ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000512529ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000512529ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
intron-intronENST00000512529ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000515206ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000515206ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
intron-intronENST00000515206ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000506456ENST00000537081AHRRchr5

376831

+AVILchr12

58193703

-
intron-3CDSENST00000506456ENST00000257861AHRRchr5

376831

+AVILchr12

58193703

-
intron-intronENST00000506456ENST00000550083AHRRchr5

376831

+AVILchr12

58193703

-

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FusionProtFeatures for AHRR_AVIL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHRR

A9YTQ3

AVIL

O75366

Mediates dioxin toxicity and is involved in regulationof cell growth and differentiation. Represses the transcriptionactivity of AHR by competing with this transcription factor forheterodimer formation with the ARNT and subsequently binding tothe xenobiotic response element (XRE) sequence present in thepromoter regulatory region of variety of genes. Represses CYP1A1by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/orHDAC5. Autoregulates its expression by associating with its ownXRE site. {ECO:0000269|PubMed:17890447,ECO:0000269|PubMed:18172554}. Ca(2+)-regulated actin-binding protein. May have aunique function in the morphogenesis of neuronal cells which formganglia. Required for SREC1-mediated regulation of neurite-likeoutgrowth. Plays a role in regenerative sensory axon outgrowth andremodeling processes after peripheral injury in neonates. Involvedin the formation of long fine actin-containing filopodia-likestructures in fibroblast. Plays a role in ciliogenesis.{ECO:0000269|PubMed:20393563}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAHRRchr5:376831chr12:58193703ENST00000316418+41228_81121720DomainbHLH
HgeneAHRRchr5:376831chr12:58193703ENST00000505113+41128_81121702DomainbHLH
TgeneAVILchr5:376831chr12:58193703ENST00000257861-1619753_819740820DomainHP
TgeneAVILchr5:376831chr12:58193703ENST00000537081-1619753_819733813DomainHP
TgeneAVILchr5:376831chr12:58193703ENST00000537081-1619731_819733813RegionHeadpiece

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAHRRchr5:376831chr12:58193703ENST00000316418+412112_182121720DomainPAS
HgeneAHRRchr5:376831chr12:58193703ENST00000505113+411112_182121702DomainPAS
HgeneAHRRchr5:376831chr12:58193703ENST00000316418+412551_701121720RegionNeeded for transcriptional repression
HgeneAHRRchr5:376831chr12:58193703ENST00000505113+411551_701121702RegionNeeded for transcriptional repression
TgeneAVILchr5:376831chr12:58193703ENST00000257861-1619109_116740820RegionPolyphosphoinositide binding
TgeneAVILchr5:376831chr12:58193703ENST00000257861-1619135_143740820RegionPolyphosphoinositide binding
TgeneAVILchr5:376831chr12:58193703ENST00000257861-16191_731740820RegionCore
TgeneAVILchr5:376831chr12:58193703ENST00000257861-1619731_819740820RegionHeadpiece
TgeneAVILchr5:376831chr12:58193703ENST00000537081-1619109_116733813RegionPolyphosphoinositide binding
TgeneAVILchr5:376831chr12:58193703ENST00000537081-1619135_143733813RegionPolyphosphoinositide binding
TgeneAVILchr5:376831chr12:58193703ENST00000537081-16191_731733813RegionCore
TgeneAVILchr5:376831chr12:58193703ENST00000257861-1619145_185740820RepeatNote=Gelsolin-like 2
TgeneAVILchr5:376831chr12:58193703ENST00000257861-161924_73740820RepeatNote=Gelsolin-like 1
TgeneAVILchr5:376831chr12:58193703ENST00000257861-1619262_306740820RepeatNote=Gelsolin-like 3
TgeneAVILchr5:376831chr12:58193703ENST00000257861-1619403_454740820RepeatNote=Gelsolin-like 4
TgeneAVILchr5:376831chr12:58193703ENST00000257861-1619525_565740820RepeatNote=Gelsolin-like 5
TgeneAVILchr5:376831chr12:58193703ENST00000257861-1619628_669740820RepeatNote=Gelsolin-like 6
TgeneAVILchr5:376831chr12:58193703ENST00000537081-1619145_185733813RepeatNote=Gelsolin-like 2
TgeneAVILchr5:376831chr12:58193703ENST00000537081-161924_73733813RepeatNote=Gelsolin-like 1
TgeneAVILchr5:376831chr12:58193703ENST00000537081-1619262_306733813RepeatNote=Gelsolin-like 3
TgeneAVILchr5:376831chr12:58193703ENST00000537081-1619403_454733813RepeatNote=Gelsolin-like 4
TgeneAVILchr5:376831chr12:58193703ENST00000537081-1619525_565733813RepeatNote=Gelsolin-like 5
TgeneAVILchr5:376831chr12:58193703ENST00000537081-1619628_669733813RepeatNote=Gelsolin-like 6


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FusionGeneSequence for AHRR_AVIL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_AHRR_ENST00000505113_chr5_376831_+_AVIL_ENST00000537081_chr12_58193703_-_201aa
MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ
SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLEDMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG

>In-frame_AHRR_ENST00000505113_chr5_376831_+_AVIL_ENST00000257861_chr12_58193703_-_201aa
MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ
SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLEDMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG

>In-frame_AHRR_ENST00000316418_chr5_376831_+_AVIL_ENST00000537081_chr12_58193703_-_201aa
MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ
SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLEDMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG

>In-frame_AHRR_ENST00000316418_chr5_376831_+_AVIL_ENST00000257861_chr12_58193703_-_201aa
MPRTMIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ
SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLEDMKNATLSLNSNDSEPKYYPIAVLLKNQNQELPEDVNPAKKENYLSEQDFVSVFGITRG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_AHRR_ENST00000505113_chr5_376831_+_AVIL_ENST00000537081_chr12_58193703_-_603nt
ATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCCGGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGG
GCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACGCCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGAC
ATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCAGTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAG
AGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTG
GAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAAT
CAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGG

>In-frame_AHRR_ENST00000505113_chr5_376831_+_AVIL_ENST00000257861_chr12_58193703_-_603nt
ATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCCGGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGG
GCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACGCCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGAC
ATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCAGTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAG
AGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTG
GAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAAT
CAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGG

>In-frame_AHRR_ENST00000316418_chr5_376831_+_AVIL_ENST00000537081_chr12_58193703_-_603nt
ATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCCGGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGG
GCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACGCCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGAC
ATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCAGTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAG
AGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTG
GAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAAT
CAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGG

>In-frame_AHRR_ENST00000316418_chr5_376831_+_AVIL_ENST00000257861_chr12_58193703_-_603nt
ATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCCGGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGG
GCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACGCCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGAC
ATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCAGTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAG
AGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCTGTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTG
GAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTGAGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAAT
CAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACCTCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_AHRR_ENST00000505113_chr5_376831_+_AVIL_ENST00000537081_chr12_58193703_-_1147nt
GGCACGTGGACTCCCTTTAATCCAGTGACTGTCAGGTCGATCATATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCC
GGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACG
CCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCA
GTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCT
GTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTG
AGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACC
TCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAG
AAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAAGGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATC
CACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAATAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGC
ATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAA
ACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAACAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGA
CCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCTATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAA

>In-frame_AHRR_ENST00000505113_chr5_376831_+_AVIL_ENST00000257861_chr12_58193703_-_647nt
GGCACGTGGACTCCCTTTAATCCAGTGACTGTCAGGTCGATCATATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCC
GGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACG
CCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCA
GTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCT
GTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTG
AGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACC
TCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAG

>In-frame_AHRR_ENST00000316418_chr5_376831_+_AVIL_ENST00000537081_chr12_58193703_-_1147nt
GGCACGTGGACTCCCTTTAATCCAGTGACTGTCAGGTCGATCATATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCC
GGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACG
CCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCA
GTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCT
GTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTG
AGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACC
TCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAG
AAAAGGGGCTTTTCTAAAGCAAGAAGGCCTATACCTATTGCAAGGCCACAGAAAAGAGCAGATAGTGCCAATATCAGGAAATAATTTATC
CACCAATTTCTGCCTGACATTCAGCTACTTAATTTAGATATAATAGAGTCTGCAAATCACGGCATGTTCTCCATTTTTTCTCATCCTTGC
ATTCCTTGCTTGTTATATACCTAAAATGTTAACCATATAGTTTTTGGGTTTTGTGGCCCTCTAGCTAAAGCCTCAGCAGAAAGCACTAAA
ACTGCATAAATCTGGAGAAATCAAAAGAAAGAGAACCAAAAAACAATGCTTAAAATGTTTAATAACTTTATGTTTAATATTATACCAGGA
CCTACCTTTGTTTTCAATTTTAAGATGATTATTTCTAAAATCTATTTAGCCTGTAAATCATTGAAATCATATATGCACTCCATAGGCAAA

>In-frame_AHRR_ENST00000316418_chr5_376831_+_AVIL_ENST00000257861_chr12_58193703_-_647nt
GGCACGTGGACTCCCTTTAATCCAGTGACTGTCAGGTCGATCATATGCCGAGGACGATGATCCCGCCGGGGGAGTGCACGTACGCGGGCC
GGAAGCGGAGGAGGCCCCTGCAGAAACAGAGGCCCGCCGTGGGGGCAGAGAAGTCCAACCCCTCCAAGCGACACCGGGACCGCCTCAACG
CCGAGTTGGACCACCTGGCCAGCCTGCTGCCGTTCCCGCCTGACATCATCTCCAAGCTGGACAAGCTTTCTGTCCTGCGCCTCAGTGTCA
GTTACCTCCGGGTGAAGAGCTTCTTCCAAGTCGTGCAGGAGCAGAGCTCACGGCAGCCTGCGGCCGGCGCCCCCTCGCCCGGAGACAGCT
GTCCTCTTGCAGGGTCTGCCGTGCTGGAGGGAAGGCTGCTGTTGGAGGACATGAAGAATGCAACCCTCTCCCTGAATTCTAATGACAGTG
AGCCAAAATATTACCCTATAGCAGTTCTGTTGAAAAACCAGAATCAGGAGCTGCCTGAGGATGTAAACCCTGCCAAAAAGGAGAATTACC
TCTCTGAACAGGACTTTGTGTCTGTGTTTGGCATCACAAGAGGGCAATTTGCAGCTCTGCCTGGCTGGAAACAGCTCCAAATGAAGAAAG


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FusionGenePPI for AHRR_AVIL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AHRRARNT, ESR1, HDAC4, HDAC5, ANKRA2AVILCRK, RBSN, DDX11, DUS3L, FIGNL1, SCYL1, DOCK7, VIL1, TMOD2, RICTOR, RIPK4, DCTN6, MCM8, THUMPD3, BRIP1, MYO5C, ALMS1, MYO1F, TUBA4A, TUBB8, MYO1B, MYO5A, USP47, C14orf80, TUBB3, DDX11L8, WDR59, BBS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AHRR_AVIL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AHRR_AVIL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource