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Fusion gene ID: 12383 |
FusionGeneSummary for EZR_SNX9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EZR_SNX9 | Fusion gene ID: 12383 | Hgene | Tgene | Gene symbol | EZR | SNX9 | Gene ID | 7430 | 51429 |
| Gene name | ezrin | sorting nexin 9 | |
| Synonyms | CVIL|CVL|HEL-S-105|VIL2 | SDP1|SH3PX1|SH3PXD3A|WISP | |
| Cytomap | 6q25.3 | 6q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin) | sorting nexin-9SH3 and PX domain-containing protein 1SH3 and PX domain-containing protein 3AWiskott-Aldrich syndrome protein (WASP) interactor protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P15311 | Q9Y5X1 | |
| Ensembl transtripts involved in fusion gene | ENST00000337147, ENST00000367075, ENST00000392177, ENST00000476189, | ENST00000392185, | |
| Fusion gene scores | * DoF score | 14 X 13 X 5=910 | 7 X 7 X 5=245 |
| # samples | 17 | 8 | |
| ** MAII score | log2(17/910*10)=-2.42033179894836 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/245*10)=-1.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EZR [Title/Abstract] AND SNX9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EZR | GO:0048015 | phosphatidylinositol-mediated signaling | 25591774 |
| Hgene | EZR | GO:0051017 | actin filament bundle assembly | 10793131 |
| Tgene | SNX9 | GO:0032461 | positive regulation of protein oligomerization | 15703209 |
| Tgene | SNX9 | GO:0043547 | positive regulation of GTPase activity | 15703209 |
| Tgene | SNX9 | GO:0045860 | positive regulation of protein kinase activity | 18388313 |
| Tgene | SNX9 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 18353773 |
| Tgene | SNX9 | GO:0060988 | lipid tube assembly | 17948057 |
| Tgene | SNX9 | GO:0097320 | plasma membrane tubulation | 18388313 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-VP-A875-01A | EZR | chr6 | 159239114 | - | SNX9 | chr6 | 158317859 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000337147 | ENST00000392185 | EZR | chr6 | 159239114 | - | SNX9 | chr6 | 158317859 | + |
| Frame-shift | ENST00000367075 | ENST00000392185 | EZR | chr6 | 159239114 | - | SNX9 | chr6 | 158317859 | + |
| In-frame | ENST00000392177 | ENST00000392185 | EZR | chr6 | 159239114 | - | SNX9 | chr6 | 158317859 | + |
| 5UTR-3CDS | ENST00000476189 | ENST00000392185 | EZR | chr6 | 159239114 | - | SNX9 | chr6 | 158317859 | + |
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FusionProtFeatures for EZR_SNX9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EZR | SNX9 |
| Probably involved in connections of major cytoskeletalstructures to the plasma membrane. In epithelial cells, requiredfor the formation of microvilli and membrane ruffles on the apicalpole. Along with PLEKHG6, required for normal macropinocytosis.{ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268,ECO:0000269|PubMed:19111582}. | Involved in endocytosis and intracellular vesicletrafficking, both during interphase and at the end of mitosis.Required for efficient progress through mitosis and cytokinesis.Required for normal formation of the cleavage furrow at the end ofmitosis. Plays a role in endocytosis via clathrin-coated pits, butalso clathrin-independent, actin-dependent fluid-phaseendocytosis. Plays a role in macropinocytosis. Promotesinternalization of TNFR. Promotes degradation of EGFR after EGFsignaling. Stimulates the GTPase activity of DNM1. Promotes DNM1oligomerization. Promotes activation of the Arp2/3 complex byWASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched inphosphatidylinositol 4,5-bisphosphate and promotes membranetubulation. Has lower affinity for membranes enriched inphosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118,ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209,ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057,ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313,ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SNX9 | chr6:159239114 | chr6:158317859 | ENST00000392185 | + | 3 | 18 | 250_361 | 100 | 596 | Domain | PX |
| Tgene | >SNX9 | chr6:159239114 | chr6:158317859 | ENST00000392185 | + | 3 | 18 | 392_595 | 100 | 596 | Domain | Note=BAR |
| Tgene | >SNX9 | chr6:159239114 | chr6:158317859 | ENST00000392185 | + | 3 | 18 | 201_213 | 100 | 596 | Region | Note=Critical for tubulation activity |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EZR | chr6:159239114 | chr6:158317859 | ENST00000337147 | - | 1 | 13 | 2_295 | 4 | 587 | Domain | FERM |
| Hgene | >EZR | chr6:159239114 | chr6:158317859 | ENST00000367075 | - | 2 | 14 | 2_295 | 4 | 587 | Domain | FERM |
| Hgene | >EZR | chr6:159239114 | chr6:158317859 | ENST00000337147 | - | 1 | 13 | 115_120 | 4 | 587 | Motif | [IL]-x-C-x-x-[DE] motif |
| Hgene | >EZR | chr6:159239114 | chr6:158317859 | ENST00000367075 | - | 2 | 14 | 115_120 | 4 | 587 | Motif | [IL]-x-C-x-x-[DE] motif |
| Tgene | SNX9 | chr6:159239114 | chr6:158317859 | ENST00000392185 | + | 3 | 18 | 1_62 | 100 | 596 | Domain | SH3 |
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FusionGeneSequence for EZR_SNX9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EZR_ENST00000337147_chr6_159239114_-_SNX9_ENST00000392185_chr6_158317859_+_500aa MPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKDSESADA GGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTP TNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEKEWKTGK RKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQG ETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKRVSIMSY >In-frame_EZR_ENST00000392177_chr6_159239114_-_SNX9_ENST00000392185_chr6_158317859_+_500aa MPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDDDDWDEDWDGPKSSSYFKDSESADA GGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDCVVADPRKGSKMYGLKSYIEYQLTP TNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHPVISESEVFQQFLNFRDEKEWKTGK RKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLPKEYQKIGKALQSLATVFSSSGYQG ETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDKLVATSKITLQDKQNMVKRVSIMSY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EZR_ENST00000337147_chr6_159239114_-_SNX9_ENST00000392185_chr6_158317859_+_1500nt ATGCCGAAACCAGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGAGTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAAGGCTGGGGG GCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCAACAACTGGGACACTGCCTTCGGCCACCCCCAGGCCTACCAAGGA CCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGGATGGGCCCAAATCCTCTTCCTACTTTAAGGATTCAGAGTCAGCTGATGCA GGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCATCCATGAAAATTCCCCTTAACAAATTTCCTGGATTTGCGAAACCTGGCACG GAACAGTATTTGTTGGCCAAACAACTAGCAAAACCCAAAGAGAAAATTCCCATCATTGTTGGAGATTATGGCCCAATGTGGGTTTATCCT ACCTCTACTTTTGACTGTGTGGTAGCAGATCCCAGGAAAGGCTCCAAAATGTATGGTCTAAAGAGCTACATCGAATATCAGCTAACACCT ACTAACACTAATCGATCTGTAAACCACAGGTATAAGCACTTTGACTGGTTATATGAGCGTCTCCTGGTTAAGTTTGGGTCAGCCATTCCA ATCCCTTCTCTTCCAGACAAACAAGTCACAGGCCGCTTTGAAGAGGAATTTATCAAAATGCGCATGGAGAGACTTCAGGCCTGGATGACC AGGATGTGTCGCCATCCAGTAATCTCAGAAAGTGAAGTTTTCCAGCAGTTCCTAAATTTCCGAGATGAGAAGGAATGGAAAACTGGAAAG AGGAAGGCCGAGAGAGATGAGCTGGCGGGAGTCATGATATTTTCCACCATGGAACCAGAGGCACCTGACTTGGACTTAGTAGAAATAGAG CAGAAGTGCGAGGCTGTGGGGAAGTTCACCAAGGCCATGGATGACGGCGTGAAGGAGCTGCTGACGGTGGGGCAGGAGCACTGGAAGCGC TGCACGGGCCCATTACCCAAGGAATATCAGAAGATAGGAAAGGCCTTGCAGAGTTTGGCCACAGTGTTCAGTTCCAGTGGCTATCAAGGT GAAACAGATCTCAATGATGCAATAACAGAAGCAGGAAAGACTTATGAAGAAATTGCCAGTCTCGTGGCAGAACAGCCAAAGAAAGATCTC CATTTCCTGATGGAATGTAATCACGAGTATAAAGGTTTTCTTGGCTGCTTCCCTGACATCATTGGCACTCACAAGGGAGCAATAGAAAAA GTGAAAGAAAGTGACAAACTAGTTGCAACAAGTAAAATCACCCTACAAGACAAACAGAACATGGTGAAGAGAGTCAGCATCATGTCTTAC GCGTTGCAAGCTGAGATGAATCACTTTCACAGTAACCGGATCTATGATTACAACAGTGTCATCCGCCTGTACCTGGAGCAGCAAGTGCAA >In-frame_EZR_ENST00000392177_chr6_159239114_-_SNX9_ENST00000392185_chr6_158317859_+_1500nt ATGCCGAAACCAGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGAGTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAAGGCTGGGGG GCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCAACAACTGGGACACTGCCTTCGGCCACCCCCAGGCCTACCAAGGA CCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGGATGGGCCCAAATCCTCTTCCTACTTTAAGGATTCAGAGTCAGCTGATGCA GGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCATCCATGAAAATTCCCCTTAACAAATTTCCTGGATTTGCGAAACCTGGCACG GAACAGTATTTGTTGGCCAAACAACTAGCAAAACCCAAAGAGAAAATTCCCATCATTGTTGGAGATTATGGCCCAATGTGGGTTTATCCT ACCTCTACTTTTGACTGTGTGGTAGCAGATCCCAGGAAAGGCTCCAAAATGTATGGTCTAAAGAGCTACATCGAATATCAGCTAACACCT ACTAACACTAATCGATCTGTAAACCACAGGTATAAGCACTTTGACTGGTTATATGAGCGTCTCCTGGTTAAGTTTGGGTCAGCCATTCCA ATCCCTTCTCTTCCAGACAAACAAGTCACAGGCCGCTTTGAAGAGGAATTTATCAAAATGCGCATGGAGAGACTTCAGGCCTGGATGACC AGGATGTGTCGCCATCCAGTAATCTCAGAAAGTGAAGTTTTCCAGCAGTTCCTAAATTTCCGAGATGAGAAGGAATGGAAAACTGGAAAG AGGAAGGCCGAGAGAGATGAGCTGGCGGGAGTCATGATATTTTCCACCATGGAACCAGAGGCACCTGACTTGGACTTAGTAGAAATAGAG CAGAAGTGCGAGGCTGTGGGGAAGTTCACCAAGGCCATGGATGACGGCGTGAAGGAGCTGCTGACGGTGGGGCAGGAGCACTGGAAGCGC TGCACGGGCCCATTACCCAAGGAATATCAGAAGATAGGAAAGGCCTTGCAGAGTTTGGCCACAGTGTTCAGTTCCAGTGGCTATCAAGGT GAAACAGATCTCAATGATGCAATAACAGAAGCAGGAAAGACTTATGAAGAAATTGCCAGTCTCGTGGCAGAACAGCCAAAGAAAGATCTC CATTTCCTGATGGAATGTAATCACGAGTATAAAGGTTTTCTTGGCTGCTTCCCTGACATCATTGGCACTCACAAGGGAGCAATAGAAAAA GTGAAAGAAAGTGACAAACTAGTTGCAACAAGTAAAATCACCCTACAAGACAAACAGAACATGGTGAAGAGAGTCAGCATCATGTCTTAC GCGTTGCAAGCTGAGATGAATCACTTTCACAGTAACCGGATCTATGATTACAACAGTGTCATCCGCCTGTACCTGGAGCAGCAAGTGCAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EZR_ENST00000337147_chr6_159239114_-_SNX9_ENST00000392185_chr6_158317859_+_3873nt GGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCTGCTGGA TAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGA GTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAAGGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCA ACAACTGGGACACTGCCTTCGGCCACCCCCAGGCCTACCAAGGACCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGGATGGGC CCAAATCCTCTTCCTACTTTAAGGATTCAGAGTCAGCTGATGCAGGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCATCCATGA AAATTCCCCTTAACAAATTTCCTGGATTTGCGAAACCTGGCACGGAACAGTATTTGTTGGCCAAACAACTAGCAAAACCCAAAGAGAAAA TTCCCATCATTGTTGGAGATTATGGCCCAATGTGGGTTTATCCTACCTCTACTTTTGACTGTGTGGTAGCAGATCCCAGGAAAGGCTCCA AAATGTATGGTCTAAAGAGCTACATCGAATATCAGCTAACACCTACTAACACTAATCGATCTGTAAACCACAGGTATAAGCACTTTGACT GGTTATATGAGCGTCTCCTGGTTAAGTTTGGGTCAGCCATTCCAATCCCTTCTCTTCCAGACAAACAAGTCACAGGCCGCTTTGAAGAGG AATTTATCAAAATGCGCATGGAGAGACTTCAGGCCTGGATGACCAGGATGTGTCGCCATCCAGTAATCTCAGAAAGTGAAGTTTTCCAGC AGTTCCTAAATTTCCGAGATGAGAAGGAATGGAAAACTGGAAAGAGGAAGGCCGAGAGAGATGAGCTGGCGGGAGTCATGATATTTTCCA CCATGGAACCAGAGGCACCTGACTTGGACTTAGTAGAAATAGAGCAGAAGTGCGAGGCTGTGGGGAAGTTCACCAAGGCCATGGATGACG GCGTGAAGGAGCTGCTGACGGTGGGGCAGGAGCACTGGAAGCGCTGCACGGGCCCATTACCCAAGGAATATCAGAAGATAGGAAAGGCCT TGCAGAGTTTGGCCACAGTGTTCAGTTCCAGTGGCTATCAAGGTGAAACAGATCTCAATGATGCAATAACAGAAGCAGGAAAGACTTATG AAGAAATTGCCAGTCTCGTGGCAGAACAGCCAAAGAAAGATCTCCATTTCCTGATGGAATGTAATCACGAGTATAAAGGTTTTCTTGGCT GCTTCCCTGACATCATTGGCACTCACAAGGGAGCAATAGAAAAAGTGAAAGAAAGTGACAAACTAGTTGCAACAAGTAAAATCACCCTAC AAGACAAACAGAACATGGTGAAGAGAGTCAGCATCATGTCTTACGCGTTGCAAGCTGAGATGAATCACTTTCACAGTAACCGGATCTATG ATTACAACAGTGTCATCCGCCTGTACCTGGAGCAGCAAGTGCAATTTTACGAAACGATTGCAGAAAAGCTGAGGCAGGCCCTCAGCCGCT TTCCAGTGATGTAGGACAGAACGGGCCTTGAAGAGAATGCCGCGTGCTTTCTCCTGACTTGGGGCAATGCAATTCAAAACTTTTTTTCCC CTATTATTCAGAAAAAAAAGGAAACAAAACCAAAAAGAAAGAGTTGCAAAAAACTGCATTTATTTTATTAGCCACCCTAAATGCGTCAGT TATTTAGGGATGGTCTTTTGTTCATTTCCGCATCCATTATTTAAACCAGTGGAAATTGTCTCTATTTTTGGAAAGTACTTAAAAGTTACC AGAATTTTCAATGGAAAATGAGGGGTTTCTCCCCACTGATATTTTACATAGAGTCATAATTTATATGTCTTATAAATTATAAGTCTTATA TAATTTATAAGTCTCCCACAATCTTCCAGTTCTTACCCAGTGTCAGATAATTAATTACTAATTACTTTCTTAAAAACATGAACTATGCCA GAATAAAAAATATCTATGTTTGTATATTTTTATAACTCCTTTCAGTCCTCTGGGGCTCCTGTCATTGAGGGAAGTCGTTACGCCTTTCAC TGCCACAGTTACAGCTCAAGTGCTTACACTTCAAGAGGGAGGACGCTGGGGGCCCCTGGGGCTGCTAGTGCCATCGTGGTGTGTGGCAGG TGGGCCATCCCATGTCCCTCCAGGGGGACCCCACAGCCTGGCAGATGAGCAGATACCCCTGGCCACCCATGTCCTCAGCGACATTTCTGA TGTGCTGCTCTTATGTGAGGACCAGTGCTTTCTCTCTTTGCACTTCCTTCCTAATCTTGGTTAAGGCATGTTTTATGCCATGAAGAATAC ATTAGAAGAATTGAGGGACTTTGTAGAGAATTTTGTGGCTTTGGTCCAACGGGTGAGTGGCTGTGCGGAGGCCTGTGTTCGGGAGGGCCT GGGAGAAGGAGGGCACCCAGCACCCCGGCGTCTCTGGCCCTTTCTTATTCTTTGGCTCCTCATCCACCGTGATGAGAAGCGCTGCTGTGG CCACGGCACACTGCTTGGCTTGGGTGGCGGGTTCATGGCCAGTTGGTGTCATCAGCAAAGAGAAAAAGCACAGGTTAGCTCCCCATTAGA TGGAAAAGTGTAGGGACTGAGAAGGGCTGCAGCCTCAGCAGTGTACAGAGTCCCCGGCGCTCTGAGGTTGGAGAGAAAGAACAGACCAGC GCCCTTCCCGACTACATCCGAAACTTCACACAGGGTGTTTCTGAGCACCAGCACTTCCAGCGCTTCACTTAACGGCATAAAGCAAAACAG GACCTTGGCACACCGTCAGCTCGAACTCAACACTGGCAGCCACCGTCTCACCCCTGCGGAGGAGCGCTCCCGTCTCCCACAGGTGCCTTA CCGCGTTCCCTCCCGCTGCTTTCATTTTTCTGACCTAATAATTACGGGAAATGGAAAGTCTGGGCCAGCATCAATAAAATGACACCAAAA ATAAGTAGATGAAATCAAATGAATATGAGAACATCTTGTTCTTCAATATCACGGGTTTTTGTTAATGTTTCATAAGTAATTCTCCCCACT TGATTTTTCTTCTATAAAATCCCATAGAACAATGTTTATGCTATAGCCATTTAATATATGTACAAATTGTAAAGAATATGTATAAATGTT TTACACGAATGTAAGAGCATGTAGAAGCCAACATATAAATAAATTGTTTAAAAAAACTGTACAGTAAATTCTCAAAGCACTTTTTCAAAA CACTTTTTGGACTTTGTGTGTGATTTTTGTTGTTGTTGTTAAGTACTTTTTATTCCAGCTGCTGAAAATGGTCCAGGTAATGAATTCTTC CCCAAATCCTATTTCTTCTGACATGAATTCATCATTTCAGTTCCGTAGGTCAGTGTTGCGGTCCGGGAAGCGTATCATAACCACCTGGGA GTTGCCAAGAAGCAGACAGTCTCCCAGTGTCTGACTCTCGGATATTTGGATTTGACTGGTGTGAGGCAAAGTGAAAAAGGGATGGGGGAA ATGGAGATGGCACGGGCTCCTCAGAGCGTGGTAGCCGACTGTGAGGAAAAGCAGAGGGAATGTGAAAGAAAATAAGAGAATCCACGGGAT TTGATGCCTGGAAGATTCTCCTTCAAGTGGCAACATGGCATATATATCCTTCTCCGGGGAGTCACATGCACCATTTGGTTCTTAGATACG TTGATGTTTTGATTTTTAATGATTTGTATCAACCTGTAGGTACCACAGAAGAGCTGTAGTCATACAATCACATAACTTTTACAAATATAG >In-frame_EZR_ENST00000392177_chr6_159239114_-_SNX9_ENST00000392185_chr6_158317859_+_3879nt GTGTCGGGCGCGGCAGGAGGACGAGGCAGGGCGGGCGGGCGCTCTAAGGGTTCTGCTCTGACTCCAGGTTGGGACAGCGTCTTCGCTGCT GCTGGATAGTCGTGTTTTCGGGGATCGAGGATACTCACCAGAAACCGAAAATGCCGAAACCAGTTGGCAGTGGCAATGACCCCTGGTCAG CCTGGAGTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAAGGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACA CTCCCAACAACTGGGACACTGCCTTCGGCCACCCCCAGGCCTACCAAGGACCAGCAACTGGTGATGATGATGACTGGGATGAAGACTGGG ATGGGCCCAAATCCTCTTCCTACTTTAAGGATTCAGAGTCAGCTGATGCAGGCGGCGCTCAGCGAGGAAACAGTCGTGCTAGTTCCTCAT CCATGAAAATTCCCCTTAACAAATTTCCTGGATTTGCGAAACCTGGCACGGAACAGTATTTGTTGGCCAAACAACTAGCAAAACCCAAAG AGAAAATTCCCATCATTGTTGGAGATTATGGCCCAATGTGGGTTTATCCTACCTCTACTTTTGACTGTGTGGTAGCAGATCCCAGGAAAG GCTCCAAAATGTATGGTCTAAAGAGCTACATCGAATATCAGCTAACACCTACTAACACTAATCGATCTGTAAACCACAGGTATAAGCACT TTGACTGGTTATATGAGCGTCTCCTGGTTAAGTTTGGGTCAGCCATTCCAATCCCTTCTCTTCCAGACAAACAAGTCACAGGCCGCTTTG AAGAGGAATTTATCAAAATGCGCATGGAGAGACTTCAGGCCTGGATGACCAGGATGTGTCGCCATCCAGTAATCTCAGAAAGTGAAGTTT TCCAGCAGTTCCTAAATTTCCGAGATGAGAAGGAATGGAAAACTGGAAAGAGGAAGGCCGAGAGAGATGAGCTGGCGGGAGTCATGATAT TTTCCACCATGGAACCAGAGGCACCTGACTTGGACTTAGTAGAAATAGAGCAGAAGTGCGAGGCTGTGGGGAAGTTCACCAAGGCCATGG ATGACGGCGTGAAGGAGCTGCTGACGGTGGGGCAGGAGCACTGGAAGCGCTGCACGGGCCCATTACCCAAGGAATATCAGAAGATAGGAA AGGCCTTGCAGAGTTTGGCCACAGTGTTCAGTTCCAGTGGCTATCAAGGTGAAACAGATCTCAATGATGCAATAACAGAAGCAGGAAAGA CTTATGAAGAAATTGCCAGTCTCGTGGCAGAACAGCCAAAGAAAGATCTCCATTTCCTGATGGAATGTAATCACGAGTATAAAGGTTTTC TTGGCTGCTTCCCTGACATCATTGGCACTCACAAGGGAGCAATAGAAAAAGTGAAAGAAAGTGACAAACTAGTTGCAACAAGTAAAATCA CCCTACAAGACAAACAGAACATGGTGAAGAGAGTCAGCATCATGTCTTACGCGTTGCAAGCTGAGATGAATCACTTTCACAGTAACCGGA TCTATGATTACAACAGTGTCATCCGCCTGTACCTGGAGCAGCAAGTGCAATTTTACGAAACGATTGCAGAAAAGCTGAGGCAGGCCCTCA GCCGCTTTCCAGTGATGTAGGACAGAACGGGCCTTGAAGAGAATGCCGCGTGCTTTCTCCTGACTTGGGGCAATGCAATTCAAAACTTTT TTTCCCCTATTATTCAGAAAAAAAAGGAAACAAAACCAAAAAGAAAGAGTTGCAAAAAACTGCATTTATTTTATTAGCCACCCTAAATGC GTCAGTTATTTAGGGATGGTCTTTTGTTCATTTCCGCATCCATTATTTAAACCAGTGGAAATTGTCTCTATTTTTGGAAAGTACTTAAAA GTTACCAGAATTTTCAATGGAAAATGAGGGGTTTCTCCCCACTGATATTTTACATAGAGTCATAATTTATATGTCTTATAAATTATAAGT CTTATATAATTTATAAGTCTCCCACAATCTTCCAGTTCTTACCCAGTGTCAGATAATTAATTACTAATTACTTTCTTAAAAACATGAACT ATGCCAGAATAAAAAATATCTATGTTTGTATATTTTTATAACTCCTTTCAGTCCTCTGGGGCTCCTGTCATTGAGGGAAGTCGTTACGCC TTTCACTGCCACAGTTACAGCTCAAGTGCTTACACTTCAAGAGGGAGGACGCTGGGGGCCCCTGGGGCTGCTAGTGCCATCGTGGTGTGT GGCAGGTGGGCCATCCCATGTCCCTCCAGGGGGACCCCACAGCCTGGCAGATGAGCAGATACCCCTGGCCACCCATGTCCTCAGCGACAT TTCTGATGTGCTGCTCTTATGTGAGGACCAGTGCTTTCTCTCTTTGCACTTCCTTCCTAATCTTGGTTAAGGCATGTTTTATGCCATGAA GAATACATTAGAAGAATTGAGGGACTTTGTAGAGAATTTTGTGGCTTTGGTCCAACGGGTGAGTGGCTGTGCGGAGGCCTGTGTTCGGGA GGGCCTGGGAGAAGGAGGGCACCCAGCACCCCGGCGTCTCTGGCCCTTTCTTATTCTTTGGCTCCTCATCCACCGTGATGAGAAGCGCTG CTGTGGCCACGGCACACTGCTTGGCTTGGGTGGCGGGTTCATGGCCAGTTGGTGTCATCAGCAAAGAGAAAAAGCACAGGTTAGCTCCCC ATTAGATGGAAAAGTGTAGGGACTGAGAAGGGCTGCAGCCTCAGCAGTGTACAGAGTCCCCGGCGCTCTGAGGTTGGAGAGAAAGAACAG ACCAGCGCCCTTCCCGACTACATCCGAAACTTCACACAGGGTGTTTCTGAGCACCAGCACTTCCAGCGCTTCACTTAACGGCATAAAGCA AAACAGGACCTTGGCACACCGTCAGCTCGAACTCAACACTGGCAGCCACCGTCTCACCCCTGCGGAGGAGCGCTCCCGTCTCCCACAGGT GCCTTACCGCGTTCCCTCCCGCTGCTTTCATTTTTCTGACCTAATAATTACGGGAAATGGAAAGTCTGGGCCAGCATCAATAAAATGACA CCAAAAATAAGTAGATGAAATCAAATGAATATGAGAACATCTTGTTCTTCAATATCACGGGTTTTTGTTAATGTTTCATAAGTAATTCTC CCCACTTGATTTTTCTTCTATAAAATCCCATAGAACAATGTTTATGCTATAGCCATTTAATATATGTACAAATTGTAAAGAATATGTATA AATGTTTTACACGAATGTAAGAGCATGTAGAAGCCAACATATAAATAAATTGTTTAAAAAAACTGTACAGTAAATTCTCAAAGCACTTTT TCAAAACACTTTTTGGACTTTGTGTGTGATTTTTGTTGTTGTTGTTAAGTACTTTTTATTCCAGCTGCTGAAAATGGTCCAGGTAATGAA TTCTTCCCCAAATCCTATTTCTTCTGACATGAATTCATCATTTCAGTTCCGTAGGTCAGTGTTGCGGTCCGGGAAGCGTATCATAACCAC CTGGGAGTTGCCAAGAAGCAGACAGTCTCCCAGTGTCTGACTCTCGGATATTTGGATTTGACTGGTGTGAGGCAAAGTGAAAAAGGGATG GGGGAAATGGAGATGGCACGGGCTCCTCAGAGCGTGGTAGCCGACTGTGAGGAAAAGCAGAGGGAATGTGAAAGAAAATAAGAGAATCCA CGGGATTTGATGCCTGGAAGATTCTCCTTCAAGTGGCAACATGGCATATATATCCTTCTCCGGGGAGTCACATGCACCATTTGGTTCTTA GATACGTTGATGTTTTGATTTTTAATGATTTGTATCAACCTGTAGGTACCACAGAAGAGCTGTAGTCATACAATCACATAACTTTTACAA |
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FusionGenePPI for EZR_SNX9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EZR | PRKAB1, HLA-B, GABARAPL2, MCC, BID, TNFRSF10B, FAS, MSN, RHOA, ARHGDIA, FADD, FASLG, MAPK8, CASP10, CASP8, TNFRSF1A, AHNAK, PPL, SPTA1, PRX, S100P, SCYL3, SLC9A3R2, NF2, EZR, PTK2, L1CAM, TSC1, PIK3R1, ICAM1, ICAM2, ICAM3, VCAM1, ADORA2B, IQGAP1, CLIC5, CD44, PALLD, SLC9A3R1, PRKCA, SELP, DLG1, CFTR, SELL, SDC2, SPN, CTNNB1, CDH1, PHLPP2, DCC, ELAVL1, WWP1, ISG15, BRCA1, RDX, ACTN1, DGKQ, ARPC3, FN1, GZMM, BAG3, MPP3, WFDC1, MDM2, MAPK10, FBXO6, ASB6, CROCC, FH, FKBP9, GNPDA1, GTF3C4, H2AFZ, HEXA, HEXB, PDCD10, PDCD6IP, UBA1, IPO5, MC1R, OGFOD1, PYGL, RIC8A, TRNT1, UBE2R2, XPNPEP1, CUL7, OBSL1, VPS11, ACAA2, AKR1B1, CALR, CLIC4, ECE2, EIF5A2, EIF5AL1, ENO1, ENO2, AURKA, GDI2, TPD52, FABP5, GPX4, HSD17B10, HSPA4, HSPA4L, HSPE1, HSPH1, ISYNA1, LCP1, OAT, P4HB, PDXK, PGD, PLS1, PLS3, PPA2, RCN1, SHMT2, STIP1, TAGLN2, TKT, TPD52L2, TXNRD2, UCHL3, WDR1, NTRK1, SCARNA22, PTTG1, PPME1, NOLC1, B4GALT7, TIMM13, EGFR, MCM2, U2AF2, ERBB2, MRPL12, MISP, TSPAN33, PTPRQ, LASP1, DNM1L, FOXA1, TRIM25, HEY1 | SNX9 | ADAM15, MPP6, DNM2, CLTC, ADAM9, ITCH, SIRT7, KHDRBS1, SNX33, CUL3, COPS5, TNK2, FASLG, SNX9, MED28, CFTR, DNM1, WASL, OBSL1, EGFR, DPPA4, AURKA, NTRK1, FBF1, NPHP1, HDAC1, GTSE1, NAF1, FOXG1, FOXK2, MCM2, CDH1, SYNJ1, DNM3, AP2A1, FCHSD1, MLYCD, AP2M1, AP2A2, AP1B1, HNRNPK, AP2B1, CPNE5, RNGTT, OCRL, BRCA1, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | EZR | chr6:159239114 | chr6:158317859 | ENST00000337147 | - | 1 | 13 | 244_586 | 4 | 587 | SCYL3 |
| Hgene | EZR | chr6:159239114 | chr6:158317859 | ENST00000367075 | - | 2 | 14 | 244_586 | 4 | 587 | SCYL3 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EZR_SNX9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EZR_SNX9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EZR | C0033578 | Prostatic Neoplasms | 3 | CTD_human |
| Hgene | EZR | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | EZR | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| Hgene | EZR | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| Hgene | EZR | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | EZR | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
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