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Fusion gene ID: 12361 |
FusionGeneSummary for EZH1_PDSS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EZH1_PDSS2 | Fusion gene ID: 12361 | Hgene | Tgene | Gene symbol | EZH1 | PDSS2 | Gene ID | 2145 | 57107 |
| Gene name | enhancer of zeste 1 polycomb repressive complex 2 subunit | decaprenyl diphosphate synthase subunit 2 | |
| Synonyms | KMT6B | C6orf210|COQ10D3|DLP1|bA59I9.3|hDLP1 | |
| Cytomap | 17q21.2 | 6q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase EZH1ENX-2enhancer of zeste homolog 1 | decaprenyl-diphosphate synthase subunit 2all-trans-decaprenyl-diphosphate synthase subunit 2decaprenyl pyrophosphate synthase subunit 2decaprenyl pyrophosphate synthetase subunit 2prenyl (decaprenyl) diphosphate synthase, subunit 2subunit 2 of decapr | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | Q92800 | Q86YH6 | |
| Ensembl transtripts involved in fusion gene | ENST00000428826, ENST00000415827, ENST00000435174, ENST00000592743, ENST00000585893, ENST00000590078, ENST00000590783, | ENST00000369037, ENST00000453874, ENST00000369031, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 7 X 5 X 6=210 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EZH1 [Title/Abstract] AND PDSS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PDSS2 | GO:0006744 | ubiquinone biosynthetic process | 16262699 |
| Tgene | PDSS2 | GO:0008299 | isoprenoid biosynthetic process | 16262699 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PCPG | TCGA-WB-A81F-01A | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000428826 | ENST00000369037 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| In-frame | ENST00000428826 | ENST00000453874 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| In-frame | ENST00000428826 | ENST00000369031 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| intron-3CDS | ENST00000415827 | ENST00000369037 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| intron-3CDS | ENST00000415827 | ENST00000453874 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| intron-3CDS | ENST00000415827 | ENST00000369031 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| Frame-shift | ENST00000435174 | ENST00000369037 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| Frame-shift | ENST00000435174 | ENST00000453874 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| Frame-shift | ENST00000435174 | ENST00000369031 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| Frame-shift | ENST00000592743 | ENST00000369037 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| Frame-shift | ENST00000592743 | ENST00000453874 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| Frame-shift | ENST00000592743 | ENST00000369031 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| In-frame | ENST00000585893 | ENST00000369037 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| In-frame | ENST00000585893 | ENST00000453874 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| In-frame | ENST00000585893 | ENST00000369031 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| Frame-shift | ENST00000590078 | ENST00000369037 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| Frame-shift | ENST00000590078 | ENST00000453874 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| Frame-shift | ENST00000590078 | ENST00000369031 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| intron-3CDS | ENST00000590783 | ENST00000369037 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| intron-3CDS | ENST00000590783 | ENST00000453874 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
| intron-3CDS | ENST00000590783 | ENST00000369031 | EZH1 | chr17 | 40879653 | - | PDSS2 | chr6 | 107595431 | - |
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FusionProtFeatures for EZH1_PDSS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EZH1 | PDSS2 |
| Supplies decaprenyl diphosphate, the precursor for theside chain of the isoprenoid quinones ubiquinone-10.{ECO:0000269|PubMed:16262699}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000428826 | - | 4 | 21 | 524_606 | 82 | 748 | Compositional bias | Note=Cys-rich |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000435174 | - | 4 | 19 | 524_606 | 23 | 609 | Compositional bias | Note=Cys-rich |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000585893 | - | 4 | 20 | 524_606 | 82 | 708 | Compositional bias | Note=Cys-rich |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000590078 | - | 3 | 20 | 524_606 | 12 | 678 | Compositional bias | Note=Cys-rich |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000592743 | - | 3 | 20 | 524_606 | 82 | 748 | Compositional bias | Note=Cys-rich |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000428826 | - | 4 | 21 | 504_606 | 82 | 748 | Domain | CXC |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000428826 | - | 4 | 21 | 613_728 | 82 | 748 | Domain | SET |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000435174 | - | 4 | 19 | 504_606 | 23 | 609 | Domain | CXC |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000435174 | - | 4 | 19 | 613_728 | 23 | 609 | Domain | SET |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000585893 | - | 4 | 20 | 504_606 | 82 | 708 | Domain | CXC |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000585893 | - | 4 | 20 | 613_728 | 82 | 708 | Domain | SET |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000590078 | - | 3 | 20 | 504_606 | 12 | 678 | Domain | CXC |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000590078 | - | 3 | 20 | 613_728 | 12 | 678 | Domain | SET |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000592743 | - | 3 | 20 | 504_606 | 82 | 748 | Domain | CXC |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000592743 | - | 3 | 20 | 613_728 | 82 | 748 | Domain | SET |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000428826 | - | 4 | 21 | 491_496 | 82 | 748 | Motif | Nuclear localization signal |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000435174 | - | 4 | 19 | 491_496 | 23 | 609 | Motif | Nuclear localization signal |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000585893 | - | 4 | 20 | 491_496 | 82 | 708 | Motif | Nuclear localization signal |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000590078 | - | 3 | 20 | 491_496 | 12 | 678 | Motif | Nuclear localization signal |
| Hgene | >EZH1 | chr17:40879653 | chr6:107595431 | ENST00000592743 | - | 3 | 20 | 491_496 | 82 | 748 | Motif | Nuclear localization signal |
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FusionGeneSequence for EZH1_PDSS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EZH1_ENST00000428826_chr17_40879653_-_PDSS2_ENST00000369037_chr6_107595431_-_338aa MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKSKKFGRDH GANSYCSPCTSWDSKFKXVAIIXWSTERHAIWKXNCYPEWRLSSSKCLQWTSSATEHQGCGTFSKCSYGLGTRSISXKFYFKGKLYHRXY WNIDLEGADFSLPWCLTSKELPSCNGISKAXCXGSEYGISVWEAHGHESXDKFXCPAFYXRKDQXLHDFXSKLSSCSLTSGISWKRFVDX >In-frame_EZH1_ENST00000428826_chr17_40879653_-_PDSS2_ENST00000453874_chr6_107595431_-_236aa MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKSKKFGRDH GANSYCSPCTSWDSKFKXVAIIXWSTERHAIWKXNCYPEWRLSSSKCLQWTSSATEHQGCGTFSKCSYGLGTRSISXKFYFKGSRKRKIG >In-frame_EZH1_ENST00000428826_chr17_40879653_-_PDSS2_ENST00000369031_chr6_107595431_-_179aa MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKSKKFGRDH >In-frame_EZH1_ENST00000585893_chr17_40879653_-_PDSS2_ENST00000369037_chr6_107595431_-_338aa MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKSKKFGRDH GANSYCSPCTSWDSKFKXVAIIXWSTERHAIWKXNCYPEWRLSSSKCLQWTSSATEHQGCGTFSKCSYGLGTRSISXKFYFKGKLYHRXY WNIDLEGADFSLPWCLTSKELPSCNGISKAXCXGSEYGISVWEAHGHESXDKFXCPAFYXRKDQXLHDFXSKLSSCSLTSGISWKRFVDX >In-frame_EZH1_ENST00000585893_chr17_40879653_-_PDSS2_ENST00000453874_chr6_107595431_-_236aa MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKSKKFGRDH GANSYCSPCTSWDSKFKXVAIIXWSTERHAIWKXNCYPEWRLSSSKCLQWTSSATEHQGCGTFSKCSYGLGTRSISXKFYFKGSRKRKIG >In-frame_EZH1_ENST00000585893_chr17_40879653_-_PDSS2_ENST00000369031_chr6_107595431_-_179aa MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQSMKPVSGHPFLKKSKKFGRDH |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EZH1_ENST00000428826_chr17_40879653_-_PDSS2_ENST00000369037_chr6_107595431_-_1015nt ATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAA CGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG AAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTCTCAAAAAGTCAAAGAAGTTTGGCAGAGATCAC GGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCACTGAAAGACATGCA ATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGAACACCAAGGTTGT GGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTCTACTTCAAAGGAAAGTTATATCACAGATGATAT TGGAATATCGACTTGGAAGGAGCAGACTTTTCTCTCCCATGGTGCCTTACTAGCAAAGAGCTGCCAAGCTGCAATGGAATTAGCAAAGCA TGATGCTGAGGTTCAGAATATGGCATTTCAGTATGGGAAGCACATGGCCATGAGTCATAAGATAAATTCTGATGTCCAGCCTTTTATTAA AGAAAAGACCAGTGACTCCATGACTTTTAATCTAAACTCAGCTCCTGTAGTCTTACATCAGGAATTTCTTGGAAGAGATTTGTGGATTAA ACAGATCGGAGAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTAT TGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCCTCGGAGGCCAGATCTGCTTTAGAAAACATTGT >In-frame_EZH1_ENST00000428826_chr17_40879653_-_PDSS2_ENST00000453874_chr6_107595431_-_709nt ATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAA CGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG AAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTCTCAAAAAGTCAAAGAAGTTTGGCAGAGATCAC GGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCACTGAAAGACATGCA ATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGAACACCAAGGTTGT GGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTCTACTTCAAAGGCTCAAGAAAAAGGAAGATTGGA CTATGCTAAGTTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGA >In-frame_EZH1_ENST00000428826_chr17_40879653_-_PDSS2_ENST00000369031_chr6_107595431_-_538nt ATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAA CGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG AAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTCTCAAAAAGTCAAAGAAGTTTGGCAGAGATCAC GGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCACTGAAAGACATGCA ATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGAACACCAAGTCATT >In-frame_EZH1_ENST00000585893_chr17_40879653_-_PDSS2_ENST00000369037_chr6_107595431_-_1015nt ATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAA CGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG AAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTCTCAAAAAGTCAAAGAAGTTTGGCAGAGATCAC GGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCACTGAAAGACATGCA ATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGAACACCAAGGTTGT GGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTCTACTTCAAAGGAAAGTTATATCACAGATGATAT TGGAATATCGACTTGGAAGGAGCAGACTTTTCTCTCCCATGGTGCCTTACTAGCAAAGAGCTGCCAAGCTGCAATGGAATTAGCAAAGCA TGATGCTGAGGTTCAGAATATGGCATTTCAGTATGGGAAGCACATGGCCATGAGTCATAAGATAAATTCTGATGTCCAGCCTTTTATTAA AGAAAAGACCAGTGACTCCATGACTTTTAATCTAAACTCAGCTCCTGTAGTCTTACATCAGGAATTTCTTGGAAGAGATTTGTGGATTAA ACAGATCGGAGAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTAT TGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCCTCGGAGGCCAGATCTGCTTTAGAAAACATTGT >In-frame_EZH1_ENST00000585893_chr17_40879653_-_PDSS2_ENST00000453874_chr6_107595431_-_709nt ATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAA CGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG AAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTCTCAAAAAGTCAAAGAAGTTTGGCAGAGATCAC GGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCACTGAAAGACATGCA ATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGAACACCAAGGTTGT GGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTCTACTTCAAAGGCTCAAGAAAAAGGAAGATTGGA CTATGCTAAGTTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGA >In-frame_EZH1_ENST00000585893_chr17_40879653_-_PDSS2_ENST00000369031_chr6_107595431_-_538nt ATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGAAATCTGAATACATGCGACTTCGACAACTTAAA CGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG AAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTCTCAAAAAGTCAAAGAAGTTTGGCAGAGATCAC GGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTGCAATCATCTGATGGTCCACTGAAAGACATGCA ATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAATGGACTAGCTCTGCTACAGAACACCAAGTCATT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EZH1_ENST00000428826_chr17_40879653_-_PDSS2_ENST00000369037_chr6_107595431_-_3199nt CCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAACA CTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGA AATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTC AAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTC TCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTG CAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAAT GGACTAGCTCTGCTACAGAACACCAAGGTTGTGGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTCT ACTTCAAAGGAAAGTTATATCACAGATGATATTGGAATATCGACTTGGAAGGAGCAGACTTTTCTCTCCCATGGTGCCTTACTAGCAAAG AGCTGCCAAGCTGCAATGGAATTAGCAAAGCATGATGCTGAGGTTCAGAATATGGCATTTCAGTATGGGAAGCACATGGCCATGAGTCAT AAGATAAATTCTGATGTCCAGCCTTTTATTAAAGAAAAGACCAGTGACTCCATGACTTTTAATCTAAACTCAGCTCCTGTAGTCTTACAT CAGGAATTTCTTGGAAGAGATTTGTGGATTAAACAGATCGGAGAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAGA ATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCC TCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTTGCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTAGC TGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCTTTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTATCA CATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTGCTACAAACAAAATTAGAAGAAAAAAAGGTCAAGCAGTTTTCACTTGTCACGCCA GAAGCACACTTGAGGCTGCAGTCGCAGAAATAATTAATGAGATTCGCTCCTGTGACCTCAGCAAATGGACAGGAAATAAGTCCTTATTGA TTGGACCGAGCCAGGGATGGCGCCAGGGCGGTGGCCTGTGGTTTTTCCTGCTAGAGAGGACAAAGCAAGTTGGAAGCTGCAGGTGTCAAG AGAAATGCTCTCAATACCAACCAGGGAGGATTGTCTAATCAAAAACTAGTGACCAATTTGTCATAATGGAGAGTAGTTCAATGGATTGAG AAAAATATGTTTTATTTGTTGGCTTGTAATTATGTCTCTGGATTATTATTATTTTTTTTTTAGATGTAGTTTTGCTCTTGTTGCCCAGGC TGGAGTGCAATGGTGCAGTTTTGACTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGAA TTACAGGCACCTGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTGGTCAGGCTAGTCTCGAACTCCT GACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTAGAGGCTTGAGCCACTGCACCTGGCCTCATGTCTCTGGATTTAT AATGCAGTATGAATATACTTTGTGCTTTATGGTTTTTATAATGTCTTTTTGGAGAAATTGCCGAAAAGTTGCCAAATACTTGAAGTAGGA GATTAAAATGTTATCAAATGTTAAATTGGTTATATTAGGAATAGTCTGTTTTTCTTTCCTGAAGATCAGTTTTTTTATTCAAACACATTT CAAAGAACCAAATTTTTTTTTTCTTTAAGGAAAAAGGAGCTTTTTTTCAAGTGAAATGTATTCATTTGTAATACTTTGGTTTAAGGCATA CTTTAATTTTTACGAGTTTCAGAAACAGAATTTTTGTACTAGGGAATTCATTGGTGAGAGTGTTCTTTTAACCTCAGAATGTCAAATTTT GGTCTTGAACCACAGACATCCAATTACAGAAAGAATATAAGCAATCTCACAGGCCTGCAATCGGACACTGTCTCTGTGTGGTTCATAGGA GATGATTTTTGAGGTTTGCACTCATGCAATTTGAGAACACCGTTGACAAGAAGGCTGAGTTTACATAAATGATCTAGATTGAAACTCAGC TACCTTTCTTCCTCATGTGGTGTAATTACAGCCCTATCTGGAGACAGCGAATACAGCAAACAGATTTTATTACCTAGTTCGCTCAAACAC TACATGAAGTTATTTTAGTTAAAGCCCTCCCCCAAAAGTTATAAAACCATTTTATCAGGGCCCAACATGTGGCATGCAATGAAGAGAAAA TGTAAAGCTACAGAGGTTAATGTATTGTATTATAAAATATTTTAAGTGTACTCAAAATATCATAATTGTACAGTTTATGCCACCATAATT TGAGGCCTATAGATTTAGCTTAAGAGAACACTGTTCTGTTTGAAATGCTTTCTGTCACTGAAATTGGCTTAATTAGTAACCATGGATAAG ATGCTTTAGATCAGACTAGGTTTTAATCATTAACTTCCACAAAGAAGTCATACTTTGCGTTAGGTGTGCTGGTTGGATGTGCAGGAACTT CAGCAAGCAGTAGGTTTTACTAAGCAGATGGTCGGGCACTGCAGGGCACCAGGCAGGATCCTAGGGCGCCTCTTATTCTGCGTTAGCATC TGGTTTGCTGTATGACCTTGCACAAGTCACTTCCTTCTGAGCCTCAATTTTCTCATCTGTACAATGAGATTCAAAAGTTGACCTGAAAGT >In-frame_EZH1_ENST00000428826_chr17_40879653_-_PDSS2_ENST00000453874_chr6_107595431_-_1004nt CCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAACA CTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGA AATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTC AAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTC TCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTG CAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAAT GGACTAGCTCTGCTACAGAACACCAAGGTTGTGGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTCT ACTTCAAAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGAC CTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCCTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTT GCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTAGCTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCT TTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTATCACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTG >In-frame_EZH1_ENST00000428826_chr17_40879653_-_PDSS2_ENST00000369031_chr6_107595431_-_894nt CCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAACA CTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTGA AATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTTC AAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTTC TCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTTG CAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAAT GGACTAGCTCTGCTACAGAACACCAAGTCATTTTCATTTAATGGACCTATTGCTATATATCAGATGGGAGACTGTGAGTCAGCCTGGATC TTGTCTAAACACCCAAGAGCATTGTCATGATGTCACTCCTGGAGGTTGTTCTATTAAGCATTAGTGATTTATACTTCCGGATAACCAGTG GCACAGATGTACTCTTTACATAGCTGATGTATTTCCTTATGTTAACTTTGTTTTCCTAAAGGCGTAAATATGTTGTTTAAAATGAAGTAT >In-frame_EZH1_ENST00000585893_chr17_40879653_-_PDSS2_ENST00000369037_chr6_107595431_-_3200nt ACCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAAC ACTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTG AAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTT CAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTT CTCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTT GCAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAA TGGACTAGCTCTGCTACAGAACACCAAGGTTGTGGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTC TACTTCAAAGGAAAGTTATATCACAGATGATATTGGAATATCGACTTGGAAGGAGCAGACTTTTCTCTCCCATGGTGCCTTACTAGCAAA GAGCTGCCAAGCTGCAATGGAATTAGCAAAGCATGATGCTGAGGTTCAGAATATGGCATTTCAGTATGGGAAGCACATGGCCATGAGTCA TAAGATAAATTCTGATGTCCAGCCTTTTATTAAAGAAAAGACCAGTGACTCCATGACTTTTAATCTAAACTCAGCTCCTGTAGTCTTACA TCAGGAATTTCTTGGAAGAGATTTGTGGATTAAACAGATCGGAGAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAG AATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCC CTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTTGCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTAG CTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCTTTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTATC ACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTGCTACAAACAAAATTAGAAGAAAAAAAGGTCAAGCAGTTTTCACTTGTCACGCC AGAAGCACACTTGAGGCTGCAGTCGCAGAAATAATTAATGAGATTCGCTCCTGTGACCTCAGCAAATGGACAGGAAATAAGTCCTTATTG ATTGGACCGAGCCAGGGATGGCGCCAGGGCGGTGGCCTGTGGTTTTTCCTGCTAGAGAGGACAAAGCAAGTTGGAAGCTGCAGGTGTCAA GAGAAATGCTCTCAATACCAACCAGGGAGGATTGTCTAATCAAAAACTAGTGACCAATTTGTCATAATGGAGAGTAGTTCAATGGATTGA GAAAAATATGTTTTATTTGTTGGCTTGTAATTATGTCTCTGGATTATTATTATTTTTTTTTTAGATGTAGTTTTGCTCTTGTTGCCCAGG CTGGAGTGCAATGGTGCAGTTTTGACTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGA ATTACAGGCACCTGCCACCACGCCTGGCTAATTTTGTATTTTTAGTAGAGATGGGGTTTCACTATGTTGGTCAGGCTAGTCTCGAACTCC TGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTAGAGGCTTGAGCCACTGCACCTGGCCTCATGTCTCTGGATTTA TAATGCAGTATGAATATACTTTGTGCTTTATGGTTTTTATAATGTCTTTTTGGAGAAATTGCCGAAAAGTTGCCAAATACTTGAAGTAGG AGATTAAAATGTTATCAAATGTTAAATTGGTTATATTAGGAATAGTCTGTTTTTCTTTCCTGAAGATCAGTTTTTTTATTCAAACACATT TCAAAGAACCAAATTTTTTTTTTCTTTAAGGAAAAAGGAGCTTTTTTTCAAGTGAAATGTATTCATTTGTAATACTTTGGTTTAAGGCAT ACTTTAATTTTTACGAGTTTCAGAAACAGAATTTTTGTACTAGGGAATTCATTGGTGAGAGTGTTCTTTTAACCTCAGAATGTCAAATTT TGGTCTTGAACCACAGACATCCAATTACAGAAAGAATATAAGCAATCTCACAGGCCTGCAATCGGACACTGTCTCTGTGTGGTTCATAGG AGATGATTTTTGAGGTTTGCACTCATGCAATTTGAGAACACCGTTGACAAGAAGGCTGAGTTTACATAAATGATCTAGATTGAAACTCAG CTACCTTTCTTCCTCATGTGGTGTAATTACAGCCCTATCTGGAGACAGCGAATACAGCAAACAGATTTTATTACCTAGTTCGCTCAAACA CTACATGAAGTTATTTTAGTTAAAGCCCTCCCCCAAAAGTTATAAAACCATTTTATCAGGGCCCAACATGTGGCATGCAATGAAGAGAAA ATGTAAAGCTACAGAGGTTAATGTATTGTATTATAAAATATTTTAAGTGTACTCAAAATATCATAATTGTACAGTTTATGCCACCATAAT TTGAGGCCTATAGATTTAGCTTAAGAGAACACTGTTCTGTTTGAAATGCTTTCTGTCACTGAAATTGGCTTAATTAGTAACCATGGATAA GATGCTTTAGATCAGACTAGGTTTTAATCATTAACTTCCACAAAGAAGTCATACTTTGCGTTAGGTGTGCTGGTTGGATGTGCAGGAACT TCAGCAAGCAGTAGGTTTTACTAAGCAGATGGTCGGGCACTGCAGGGCACCAGGCAGGATCCTAGGGCGCCTCTTATTCTGCGTTAGCAT CTGGTTTGCTGTATGACCTTGCACAAGTCACTTCCTTCTGAGCCTCAATTTTCTCATCTGTACAATGAGATTCAAAAGTTGACCTGAAAG >In-frame_EZH1_ENST00000585893_chr17_40879653_-_PDSS2_ENST00000453874_chr6_107595431_-_1005nt ACCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAAC ACTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTG AAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTT CAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTT CTCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTT GCAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAA TGGACTAGCTCTGCTACAGAACACCAAGGTTGTGGAACTTTTAGCAAGTGCTCTTATGGACTTGGTACAAGGAGTATATCATGAAAATTC TACTTCAAAGGCTCAAGAAAAAGGAAGATTGGACTATGCTAAGTTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGA CCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCCTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTT TGCTGTGACCAGATTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTAGCTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGC TTTCACGATGCGTTAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTATCACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACT >In-frame_EZH1_ENST00000585893_chr17_40879653_-_PDSS2_ENST00000369031_chr6_107595431_-_895nt ACCCGCGGCTCGGGATGGAGGCTGGACACCTGTTCTGCTGTTGTGTCCTGCCATTCTCCTGAAGAACAGAGGCACACTGTAAAACCCAAC ACTTCCCCTTGCATTCTATAAGATTACAGCAAGATGGAAATACCAAATCCCCCTACCTCCAAATGTATCACTTACTGGAAAAGAAAAGTG AAATCTGAATACATGCGACTTCGACAACTTAAACGGCTTCAGGCAAATATGGGTGCAAAGGCTTTGTATGTGGCAAATTTTGCAAAGGTT CAAGAAAAAACCCAGATCCTCAATGAAGAATGGAAGAAGCTTCGTGTCCAACCTGTTCAGTCAATGAAGCCTGTGAGTGGACACCCTTTT CTCAAAAAGTCAAAGAAGTTTGGCAGAGATCACGGAGCTAATTCATATTGCTCTCCTTGTACATCGTGGGATAGTAAATTTAAATGAGTT GCAATCATCTGATGGTCCACTGAAAGACATGCAATTTGGAAATAAAATTGCTATCCTGAGTGGAGACTTTCTTCTAGCAAATGCCTGCAA TGGACTAGCTCTGCTACAGAACACCAAGTCATTTTCATTTAATGGACCTATTGCTATATATCAGATGGGAGACTGTGAGTCAGCCTGGAT CTTGTCTAAACACCCAAGAGCATTGTCATGATGTCACTCCTGGAGGTTGTTCTATTAAGCATTAGTGATTTATACTTCCGGATAACCAGT GGCACAGATGTACTCTTTACATAGCTGATGTATTTCCTTATGTTAACTTTGTTTTCCTAAAGGCGTAAATATGTTGTTTAAAATGAAGTA |
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FusionGenePPI for EZH1_PDSS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EZH1 | ZMYND11, E2F6, EZH1, EZH2, SUZ12, EED, GATA4, JARID2, PHF1, PHF19 | PDSS2 | ELAVL1, APP, OXLD1, ACAD9, SDHA, THEM4, FDPS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EZH1_PDSS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EZH1_PDSS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PDSS2 | C3553358 | COENZYME Q10 DEFICIENCY, PRIMARY, 3 | 1 | UNIPROT |
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