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Fusion gene ID: 12357 |
FusionGeneSummary for EYS_SCARB2 |
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Fusion gene information | Fusion gene name: EYS_SCARB2 | Fusion gene ID: 12357 | Hgene | Tgene | Gene symbol | EYS | SCARB2 | Gene ID | 346007 | 950 |
Gene name | eyes shut homolog (Drosophila) | scavenger receptor class B member 2 | |
Synonyms | C6orf178|C6orf179|C6orf180|EGFL10|EGFL11|RP25|SPAM|bA166P24.2|bA307F22.3|bA74E24.1|dJ1018A4.2|dJ22I17.2|dJ303F19.1 | AMRF|CD36L2|EPM4|HLGP85|LGP85|LIMP-2|LIMPII|SR-BII | |
Cytomap | 6q12 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog | lysosome membrane protein 285 kDa lysosomal membrane sialoglycoprotein85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q5T1H1 | Q14108 | |
Ensembl transtripts involved in fusion gene | ENST00000503581, ENST00000370621, ENST00000370616, ENST00000393380, ENST00000342421, ENST00000370618, ENST00000486069, | ENST00000264896, ENST00000452464, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 4 X 3=60 |
# samples | 3 | 5 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: EYS [Title/Abstract] AND SCARB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AV711464 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000503581 | ENST00000264896 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-intron | ENST00000503581 | ENST00000452464 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-3UTR | ENST00000370621 | ENST00000264896 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-intron | ENST00000370621 | ENST00000452464 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-3UTR | ENST00000370616 | ENST00000264896 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-intron | ENST00000370616 | ENST00000452464 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-3UTR | ENST00000393380 | ENST00000264896 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-intron | ENST00000393380 | ENST00000452464 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-3UTR | ENST00000342421 | ENST00000264896 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-intron | ENST00000342421 | ENST00000452464 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-3UTR | ENST00000370618 | ENST00000264896 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-intron | ENST00000370618 | ENST00000452464 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-3UTR | ENST00000486069 | ENST00000264896 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
intron-intron | ENST00000486069 | ENST00000452464 | EYS | chr6 | 64489077 | + | SCARB2 | chr4 | 77080626 | - |
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FusionProtFeatures for EYS_SCARB2 |
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Hgene | Tgene |
EYS | SCARB2 |
Acts as a lysosomal receptor for glucosylceramidase(GBA) targeting. {ECO:0000269|PubMed:18022370}. (Microbial infection) Acts as a receptor for enterovirus71. {ECO:0000269|PubMed:19543282}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EYS_SCARB2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EYS_SCARB2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EYS_SCARB2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EYS_SCARB2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EYS | C1864446 | Retinitis Pigmentosa 25 | 2 | CTD_human;UNIPROT |
Hgene | EYS | C0035334 | Retinitis Pigmentosa | 1 | CTD_human;ORPHANET |
Tgene | SCARB2 | C0751779 | Action Myoclonus-Renal Failure Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |