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Fusion gene ID: 12328 |
FusionGeneSummary for EXT1_RSF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EXT1_RSF1 | Fusion gene ID: 12328 | Hgene | Tgene | Gene symbol | EXT1 | RSF1 | Gene ID | 2131 | 51773 |
| Gene name | exostosin glycosyltransferase 1 | remodeling and spacing factor 1 | |
| Synonyms | EXT|LGCR|LGS|TRPS2|TTV | HBXAP|RSF-1|XAP8|p325 | |
| Cytomap | 8q24.11 | 11q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exostosin-1Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferaseLanger-Giedion syndrome chromosome regionN-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferaseexostoses (multiple) 1glucuronosyl-N-acetylgluc | remodeling and spacing factor 1HBV pX-associated protein 8hepatitis B virus x-associated proteinp325 subunit of RSF chromatin-remodeling complex | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q16394 | Q96T23 | |
| Ensembl transtripts involved in fusion gene | ENST00000378204, | ENST00000308488, ENST00000360355, ENST00000480887, ENST00000530604, | |
| Fusion gene scores | * DoF score | 11 X 8 X 12=1056 | 10 X 8 X 7=560 |
| # samples | 19 | 11 | |
| ** MAII score | log2(19/1056*10)=-2.47453851102751 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/560*10)=-2.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EXT1 [Title/Abstract] AND RSF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EXT1 | GO:0006024 | glycosaminoglycan biosynthetic process | 12907669 |
| Hgene | EXT1 | GO:0015012 | heparan sulfate proteoglycan biosynthetic process | 9620772|10639137 |
| Hgene | EXT1 | GO:0033692 | cellular polysaccharide biosynthetic process | 12907669 |
| Tgene | RSF1 | GO:0006334 | nucleosome assembly | 12972596 |
| Tgene | RSF1 | GO:0006338 | chromatin remodeling | 9836642 |
| Tgene | RSF1 | GO:0006352 | DNA-templated transcription, initiation | 9836642 |
| Tgene | RSF1 | GO:0016584 | nucleosome positioning | 9836642 |
| Tgene | RSF1 | GO:0043392 | negative regulation of DNA binding | 12972596 |
| Tgene | RSF1 | GO:0045892 | negative regulation of transcription, DNA-templated | 11944984 |
| Tgene | RSF1 | GO:0045893 | positive regulation of transcription, DNA-templated | 11788598 |
| Tgene | RSF1 | GO:0050434 | positive regulation of viral transcription | 11788598 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A1EN-01A | EXT1 | chr8 | 118825111 | - | RSF1 | chr11 | 77451981 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000378204 | ENST00000308488 | EXT1 | chr8 | 118825111 | - | RSF1 | chr11 | 77451981 | - |
| In-frame | ENST00000378204 | ENST00000360355 | EXT1 | chr8 | 118825111 | - | RSF1 | chr11 | 77451981 | - |
| 5CDS-intron | ENST00000378204 | ENST00000480887 | EXT1 | chr8 | 118825111 | - | RSF1 | chr11 | 77451981 | - |
| 5CDS-intron | ENST00000378204 | ENST00000530604 | EXT1 | chr8 | 118825111 | - | RSF1 | chr11 | 77451981 | - |
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FusionProtFeatures for EXT1_RSF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EXT1 | RSF1 |
| Glycosyltransferase required for the biosynthesis ofheparan-sulfate. The EXT1/EXT2 complex possesses substantiallyhigher glycosyltransferase activity than EXT1 or EXT2 alone.Appears to be a tumor suppressor. Required for the exosomalrelease of SDCBP, CD63 and syndecan (PubMed:22660413).{ECO:0000269|PubMed:11518722, ECO:0000269|PubMed:22660413}. | Required for assembly of regular nucleosome arrays bythe RSF chromatin-remodeling complex (PubMed:12972596).Facilitates transcription of hepatitis B virus (HBV) genes by thepX transcription activator. In case of infection by HBV, togetherwith pX, it represses TNF-alpha induced NF-kappa-B transcriptionactivation. Represses transcription when artificially recruited tochromatin by fusion to a heterogeneous DNA binding domain(PubMed:11944984, PubMed:11788598). {ECO:0000269|PubMed:11788598,ECO:0000269|PubMed:11944984, ECO:0000269|PubMed:12972596}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | EXT1 | chr8:118825111 | chr11:77451981 | ENST00000378204 | - | 8 | 11 | 544_549 | 574 | 747 | Region | Substrate binding |
| Hgene | EXT1 | chr8:118825111 | chr11:77451981 | ENST00000378204 | - | 8 | 11 | 565_567 | 574 | 747 | Region | Substrate binding |
| Hgene | EXT1 | chr8:118825111 | chr11:77451981 | ENST00000378204 | - | 8 | 11 | 1_7 | 574 | 747 | Topological domain | Cytoplasmic |
| Hgene | EXT1 | chr8:118825111 | chr11:77451981 | ENST00000378204 | - | 8 | 11 | 8_28 | 574 | 747 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000308488 | - | 2 | 16 | 942_1012 | 124 | 1442 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000360355 | - | 1 | 15 | 942_1012 | 93 | 1411 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000480887 | - | 0 | 11 | 942_1012 | -354 | 1190 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000308488 | - | 2 | 16 | 1080_1083 | 124 | 1442 | Compositional bias | Note=Poly-Ala |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000308488 | - | 2 | 16 | 1146_1243 | 124 | 1442 | Compositional bias | Note=Arg-rich |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000308488 | - | 2 | 16 | 1286_1292 | 124 | 1442 | Compositional bias | Note=Poly-Glu |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000308488 | - | 2 | 16 | 1419_1424 | 124 | 1442 | Compositional bias | Note=Poly-Glu |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000308488 | - | 2 | 16 | 226_372 | 124 | 1442 | Compositional bias | Note=Glu-rich |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000308488 | - | 2 | 16 | 875_884 | 124 | 1442 | Compositional bias | Note=Poly-Glu |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000360355 | - | 1 | 15 | 1080_1083 | 93 | 1411 | Compositional bias | Note=Poly-Ala |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000360355 | - | 1 | 15 | 1146_1243 | 93 | 1411 | Compositional bias | Note=Arg-rich |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000360355 | - | 1 | 15 | 1286_1292 | 93 | 1411 | Compositional bias | Note=Poly-Glu |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000360355 | - | 1 | 15 | 1419_1424 | 93 | 1411 | Compositional bias | Note=Poly-Glu |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000360355 | - | 1 | 15 | 226_372 | 93 | 1411 | Compositional bias | Note=Glu-rich |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000360355 | - | 1 | 15 | 875_884 | 93 | 1411 | Compositional bias | Note=Poly-Glu |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000480887 | - | 0 | 11 | 1080_1083 | -354 | 1190 | Compositional bias | Note=Poly-Ala |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000480887 | - | 0 | 11 | 1146_1243 | -354 | 1190 | Compositional bias | Note=Arg-rich |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000480887 | - | 0 | 11 | 1286_1292 | -354 | 1190 | Compositional bias | Note=Poly-Glu |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000480887 | - | 0 | 11 | 1419_1424 | -354 | 1190 | Compositional bias | Note=Poly-Glu |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000480887 | - | 0 | 11 | 226_372 | -354 | 1190 | Compositional bias | Note=Glu-rich |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000480887 | - | 0 | 11 | 875_884 | -354 | 1190 | Compositional bias | Note=Poly-Glu |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000480887 | - | 0 | 11 | 17_84 | -354 | 1190 | Domain | Note=DDT |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000308488 | - | 2 | 16 | 891_941 | 124 | 1442 | Zinc finger | PHD-type |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000360355 | - | 1 | 15 | 891_941 | 93 | 1411 | Zinc finger | PHD-type |
| Tgene | >RSF1 | chr8:118825111 | chr11:77451981 | ENST00000480887 | - | 0 | 11 | 891_941 | -354 | 1190 | Zinc finger | PHD-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >EXT1 | chr8:118825111 | chr11:77451981 | ENST00000378204 | - | 8 | 11 | 650_654 | 574 | 747 | Region | Substrate binding |
| Hgene | >EXT1 | chr8:118825111 | chr11:77451981 | ENST00000378204 | - | 8 | 11 | 688_701 | 574 | 747 | Region | Substrate binding |
| Hgene | >EXT1 | chr8:118825111 | chr11:77451981 | ENST00000378204 | - | 8 | 11 | 29_746 | 574 | 747 | Topological domain | Lumenal |
| Tgene | RSF1 | chr8:118825111 | chr11:77451981 | ENST00000308488 | - | 2 | 16 | 17_84 | 124 | 1442 | Domain | Note=DDT |
| Tgene | RSF1 | chr8:118825111 | chr11:77451981 | ENST00000360355 | - | 1 | 15 | 17_84 | 93 | 1411 | Domain | Note=DDT |
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FusionGeneSequence for EXT1_RSF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_EXT1_ENST00000378204_chr8_118825111_-_RSF1_ENST00000308488_chr11_77451981_-_1892aa MQAKKRYFILLSAGSCLALLFYFGGLQFRASRSHSRREEHSGRNGLHHPSPDHFWPRFPDALRPFVPWDQLENEDSSVHISPRQKRDANS SIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQS LHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFLKFNTIPPLRKYMLVFKGKR YLTGIGSDTRNALYHVHNGEDVVLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVML SNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPG GLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVVVIE GESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQ DDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANV LEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSS HEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDER VAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETS LDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSP PSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASE NTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEE STALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLP NHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFS EDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRA AAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKK YSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSED DELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEED FENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQ >In-frame_EXT1_ENST00000378204_chr8_118825111_-_RSF1_ENST00000360355_chr11_77451981_-_1892aa MQAKKRYFILLSAGSCLALLFYFGGLQFRASRSHSRREEHSGRNGLHHPSPDHFWPRFPDALRPFVPWDQLENEDSSVHISPRQKRDANS SIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQS LHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFLKFNTIPPLRKYMLVFKGKR YLTGIGSDTRNALYHVHNGEDVVLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVML SNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPG GLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVVVIE GESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEYLCECQFDDNLKFKNIINEEDADTMRLQPIGRDKDGLMYWYQLDQDHNVRMYIEEQ DDQDGSSWKCIVRNRNELAETLALLKAQIDPVLLKNSSQQDNSSRESPSLEDEETKKEEETPKQEEQKESEKMKSEEQPMDLENRSTANV LEETTVKKEKEDEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKENVKPIKVEVKECRADPKDTKSSMEKPVAQEPERIEFGGNIKSS HEITEKSTEETEKLKNDQQAKIPLKKREIKLSDDFDSPVKGPLCKSVTPTKEFLKDEIKQEEETCKRISTITALGHEGKQLVNGEVSDER VAPNFKTEPIETKFYETKEESYSPSKDRNIITEGNGTESLNSVITSMKTGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETS LDSSEMAKDLSSKTALSSTESCTMKGEEKSPKTKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTLESEKPGSPEAAETSP PSNIIDHCEKLASEKEVVECQSTSTVGGQSVKKVDLETLKEDSEFTKVEMDNLDNAQTSGIEEPSETKGSMQKSKFKYKLVPEEETTASE NTEITSERQKEGIKLTIRISSRKKKPDSPPKVLEPENKQEKTEKEEEKTNVGRTLRRSPRISRPTAKVAEIRDQKADKKRGEGEDEVEEE STALQKTDKKEILKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGSEKSSAASEEEEEKESEEAILADDDEPCKKCGLP NHPELILLCDSCDSGYHTACLRPPLMIIPDGEWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFS EDQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGKDISTITGHRGKDISTILDEERKENKRPQRA AAARRKKRRRLNDLDSDSNLDEEESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKK YSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSED DELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKPSRKRLHRIETDEEESCDNAHGDANQPARDSQPRVLPSEQESTKKPYRIESDEEED FENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDYVCNSEQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_EXT1_ENST00000378204_chr8_118825111_-_RSF1_ENST00000308488_chr11_77451981_-_5676nt ATGCAGGCCAAAAAACGCTATTTCATCCTGCTCTCAGCTGGCTCTTGTCTCGCCCTTTTGTTTTATTTCGGAGGCTTGCAGTTTAGGGCA TCGAGGAGCCACAGCCGGAGAGAAGAACACAGCGGTAGGAATGGCTTGCACCACCCCAGTCCGGATCATTTCTGGCCCCGCTTCCCGGAC GCTCTGCGCCCCTTCGTTCCTTGGGATCAATTGGAAAACGAGGATTCCAGCGTGCACATTTCCCCCCGGCAGAAGCGAGATGCCAACTCC AGCATCTACAAAGGCAAGAAGTGCCGCATGGAGTCCTGCTTCGATTTCACCCTTTGCAAGAAAAACGGCTTCAAAGTCTACGTATACCCA CAGCAAAAAGGGGAGAAAATCGCCGAAAGTTACCAAAACATTCTAGCGGCCATCGAGGGCTCCAGGTTCTACACCTCGGACCCCAGCCAG GCGTGCCTCTTTGTCCTGAGTCTGGATACTTTAGACAGAGACCAGTTGTCACCTCAGTATGTGCACAATTTGAGATCCAAAGTGCAGAGT CTCCACTTGTGGAACAATGGTAGGAATCATTTAATTTTTAATTTATATTCCGGCACTTGGCCTGACTACACCGAGGACGTGGGGTTTGAC ATCGGCCAGGCGATGCTGGCCAAAGCCAGCATCAGTACTGAAAACTTCCGACCCAACTTTGATGTTTCTATTCCCCTCTTTTCTAAGGAT CATCCCAGGACAGGAGGGGAGAGGGGGTTTTTGAAGTTCAACACCATCCCTCCTCTCAGGAAGTACATGCTGGTATTCAAGGGGAAGAGG TACCTGACAGGGATAGGATCAGACACCAGGAATGCCTTATATCACGTCCATAACGGGGAGGACGTTGTGCTCCTCACCACCTGCAAGCAT GGCAAAGACTGGCAAAAGCACAAGGATTCTCGCTGTGACAGAGACAACACCGAGTATGAGAAGTATGATTATCGGGAAATGCTGCACAAT GCCACTTTCTGTCTGGTTCCTCGTGGTCGCAGGCTTGGGTCCTTCAGATTCCTGGAGGCTTTGCAGGCTGCCTGCGTCCCTGTGATGCTC AGCAATGGATGGGAGTTGCCATTCTCTGAAGTGATTAATTGGAACCAAGCTGCCGTCATAGGCGATGAGAGATTGTTATTACAGATTCCT TCTACAATCAGGTCTATTCATCAGGATAAAATCCTAGCACTTAGACAGCAGACACAATTCTTGTGGGAGGCTTATTTTTCTTCAGTTGAG AAGATTGTATTAACTACACTAGAGATTATTCAGGACAGAATATTCAAGCACATATCACGTAACAGTTTAATATGGAACAAACATCCTGGA GGATTGTTCGTACTACCACAGTATTCATCTTATCTGGGAGATTTTCCTTACTACTATGCTAATTTAGGTTTAAAGCCCCCCTCCAAATTC ACTGCAGTCATCCATGCGGTGACCCCCCTGGTCTCTCAGTCCCAGCCAGTGTTGAAGCTTCTCGTGGCTGCAGCCAAGTCCCAGTACTGT GCCCAGATCATAGTTCTATGGAATTGTGACAAGCCCCTACCAGCCAAACACCGCTGGCCTGCCACTGCTGTGCCTGTCGTCGTCATTGAA GGAGAGAGCAAGGTTATGAGCAGCCGTTTTCTGCCCTACGACAACATCATCACAGACGCCGTGCTCAGCCTTGACGAGGACACGGTGCTT TCAACAACAGAGTACCTCTGTGAGTGTCAGTTTGATGACAATCTCAAATTCAAGAATATTATTAATGAGGAGGATGCCGATACTATGCGT CTCCAGCCAATTGGTCGAGACAAAGATGGCCTCATGTACTGGTACCAATTGGATCAAGATCACAATGTCAGAATGTACATAGAAGAACAA GATGATCAAGATGGCTCTTCATGGAAATGCATTGTCAGAAATCGAAACGAGTTGGCTGAGACTCTTGCACTCCTGAAAGCACAAATTGAT CCTGTACTATTGAAAAACTCTAGCCAACAAGACAACTCTTCTCGGGAAAGTCCCAGCTTAGAGGATGAGGAGACTAAAAAAGAGGAAGAA ACACCTAAACAAGAGGAACAGAAAGAAAGTGAAAAGATGAAAAGTGAGGAGCAGCCTATGGATTTAGAAAACCGTTCTACAGCCAATGTT CTAGAAGAGACTACTGTGAAAAAAGAAAAAGAAGATGAAAAGGAACTTGTGAAACTGCCAGTCATAGTGAAGCTAGAAAAACCTTTGCCA GAAAATGAAGAAAAAAAGATTATCAAAGAAGAAAGTGATTCCTTCAAGGAAAATGTCAAACCCATTAAAGTTGAGGTGAAGGAATGTAGA GCAGATCCTAAAGATACCAAAAGTAGCATGGAGAAGCCAGTGGCACAGGAGCCTGAAAGGATCGAATTTGGTGGCAATATTAAATCTTCT CACGAAATTACTGAGAAATCTACTGAAGAAACTGAGAAACTTAAAAATGACCAGCAGGCCAAGATACCACTAAAAAAACGAGAAATTAAA CTGAGTGATGATTTTGACAGTCCAGTCAAGGGACCTTTGTGTAAATCAGTTACTCCAACAAAAGAGTTTTTGAAAGATGAAATAAAACAA GAGGAAGAGACTTGTAAAAGGATCTCTACAATCACTGCTTTGGGTCATGAAGGGAAACAGCTGGTAAATGGAGAAGTTAGTGATGAAAGG GTAGCTCCAAATTTTAAGACAGAACCAATAGAGACAAAGTTTTATGAGACAAAGGAAGAGAGCTATAGCCCCTCTAAGGACAGAAATATC ATCACGGAGGGAAATGGAACAGAGTCCTTAAATTCTGTCATAACAAGTATGAAAACAGGTGAGCTTGAGAAAGAAACAGCCCCTTTGAGG AAAGATGCAGATAGTTCAATATCAGTCTTAGAGATCCATAGTCAAAAAGCACAAATAGAGGAACCCGATCCTCCAGAAATGGAAACTTCT CTTGATTCTTCTGAGATGGCAAAAGATCTCTCTTCAAAAACTGCTTTATCTTCCACCGAGTCGTGTACCATGAAAGGTGAAGAGAAGTCT CCCAAAACTAAGAAGGATAAGCGCCCACCAATCCTAGAATGTCTTGAAAAGTTAGAGAAGTCCAAAAAGACTTTTCTTGATAAGGACGCA CAAAGATTGAGTCCAATACCAGAAGAAGTTCCAAAGAGTACTCTAGAGTCAGAAAAGCCTGGCTCTCCTGAGGCAGCTGAAACTTCTCCA CCATCTAATATCATTGACCACTGTGAGAAACTAGCCTCAGAAAAAGAAGTGGTAGAATGCCAGAGTACAAGTACTGTTGGTGGCCAGTCT GTGAAAAAAGTAGACCTAGAAACCCTAAAAGAGGATTCTGAGTTCACAAAGGTAGAAATGGATAATCTGGACAATGCCCAGACCTCTGGC ATAGAGGAGCCTTCTGAGACAAAGGGTTCTATGCAAAAAAGCAAATTCAAATATAAGTTGGTTCCTGAAGAAGAAACCACTGCCTCAGAA AATACAGAGATAACCTCTGAAAGGCAGAAAGAGGGCATCAAATTAACAATCAGGATATCAAGTCGGAAAAAGAAGCCCGATTCTCCCCCC AAAGTTCTAGAACCAGAAAACAAGCAAGAGAAGACAGAAAAGGAAGAGGAGAAAACAAATGTGGGTCGTACTTTAAGAAGATCTCCAAGA ATATCTAGACCCACTGCAAAAGTGGCTGAGATCAGAGATCAGAAAGCTGATAAAAAAAGAGGGGAAGGAGAAGATGAGGTGGAAGAAGAG TCAACAGCTTTGCAAAAAACTGACAAAAAGGAAATTTTGAAAAAATCAGAGAAAGATACAAATTCTAAAGTAAGCAAGGTAAAACCCAAA GGCAAAGTTCGATGGACTGGTTCTCGGACACGTGGCAGATGGAAATATTCCAGCAATGATGAAAGTGAAGGGTCTGGCAGTGAAAAATCA TCTGCAGCTTCAGAAGAGGAGGAAGAAAAGGAAAGTGAAGAAGCCATCCTAGCAGATGATGATGAACCATGCAAAAAATGTGGCCTTCCA AACCATCCTGAGCTAATTCTTCTGTGTGACTCTTGCGATAGTGGATACCATACTGCCTGCCTTCGCCCTCCTCTGATGATCATCCCAGAT GGAGAATGGTTCTGCCCACCTTGCCAACATAAACTGCTCTGTGAAAAATTAGAGGAACAGTTGCAGGATTTGGATGTTGCCTTAAAGAAG AAAGAGCGTGCCGAACGAAGAAAAGAACGCTTGGTGTATGTTGGTATCAGTATTGAAAACATCATTCCTCCACAAGAGCCAGACTTTTCT GAAGATCAAGAAGAAAAGAAAAAAGATTCAAAAAAATCCAAAGCAAACTTGCTTGAAAGGAGGTCAACAAGAACAAGGAAATGTATAAGC TACAGATTTGATGAGTTTGATGAAGCAATTGATGAAGCTATTGAAGATGACATCAAAGAAGCCGATGGAGGAGGAGTTGGCCGAGGAAAA GATATCTCCACCATCACAGGTCATCGTGGGAAAGACATCTCTACTATTTTGGATGAAGAAAGAAAAGAAAATAAACGACCCCAGAGGGCA GCTGCTGCTCGAAGGAAGAAACGCCGGCGATTAAATGATCTGGACAGTGATAGCAACCTGGATGAAGAAGAGAGCGAGGATGAATTCAAG ATCAGTGATGGATCTCAAGATGAGTTTGTTGTGTCTGATGAAAACCCAGATGAAAGTGAAGAAGATCCGCCATCTAATGATGACAGTGAC ACTGACTTTTGTAGCCGTAGACTGAGGCGACACCCCTCTCGGCCAATGAGGCAGAGCAGGCGTTTGCGAAGAAAGACCCCAAAGAAAAAA TATTCCGATGATGATGAAGAGGAGGAATCTGAGGAGAATAGTAGAGACTCTGAAAGTGACTTCAGTGATGATTTTAGTGATGATTTTGTA GAAACTCGGCGAAGGCGGTCAAGGAGAAATCAGAAAAGACAAATTAACTACAAAGAAGACTCAGAAAGTGACGGTTCCCAGAAGAGTTTG CGACGTGGTAAAGAAATAAGGCGAGTACACAAGCGAAGACTTTCCAGCTCAGAGAGTGAAGAGAGCTATTTGTCCAAGAACTCTGAAGAT GATGAGCTAGCTAAAGAATCAAAGCGGTCAGTTCGAAAGCGGGGCCGAAGCACAGACGAGTATTCAGAAGCAGATGAGGAGGAGGAGGAA GAGGAAGGCAAACCATCCCGCAAACGGCTACACCGGATTGAGACGGATGAGGAGGAGAGTTGTGACAATGCTCATGGAGATGCAAATCAG CCTGCCCGTGACAGCCAGCCTAGGGTCCTGCCCTCAGAACAAGAGAGCACCAAGAAGCCCTACCGGATAGAAAGTGATGAGGAAGAGGAC TTTGAAAATGTAGGCAAAGTGGGGAGCCCATTGGACTATAGCTTAGTGGACTTACCTTCAACCAATGGACAGAGCCCTGGCAAAGCCATT GAGAACTTGATTGGCAAGCCTACTGAGAAGTCTCAGACCCCCAAGGACAACAGCACAGCCAGTGCAAGCCTAGCCTCCAATGGGACAAGT GGTGGGCAGGAGGCAGGAGCACCAGAAGAGGAGGAAGATGAGCTTTTGAGAGTGACTGACCTTGTTGATTATGTCTGTAACAGTGAACAG >In-frame_EXT1_ENST00000378204_chr8_118825111_-_RSF1_ENST00000360355_chr11_77451981_-_5676nt ATGCAGGCCAAAAAACGCTATTTCATCCTGCTCTCAGCTGGCTCTTGTCTCGCCCTTTTGTTTTATTTCGGAGGCTTGCAGTTTAGGGCA TCGAGGAGCCACAGCCGGAGAGAAGAACACAGCGGTAGGAATGGCTTGCACCACCCCAGTCCGGATCATTTCTGGCCCCGCTTCCCGGAC GCTCTGCGCCCCTTCGTTCCTTGGGATCAATTGGAAAACGAGGATTCCAGCGTGCACATTTCCCCCCGGCAGAAGCGAGATGCCAACTCC AGCATCTACAAAGGCAAGAAGTGCCGCATGGAGTCCTGCTTCGATTTCACCCTTTGCAAGAAAAACGGCTTCAAAGTCTACGTATACCCA CAGCAAAAAGGGGAGAAAATCGCCGAAAGTTACCAAAACATTCTAGCGGCCATCGAGGGCTCCAGGTTCTACACCTCGGACCCCAGCCAG GCGTGCCTCTTTGTCCTGAGTCTGGATACTTTAGACAGAGACCAGTTGTCACCTCAGTATGTGCACAATTTGAGATCCAAAGTGCAGAGT CTCCACTTGTGGAACAATGGTAGGAATCATTTAATTTTTAATTTATATTCCGGCACTTGGCCTGACTACACCGAGGACGTGGGGTTTGAC ATCGGCCAGGCGATGCTGGCCAAAGCCAGCATCAGTACTGAAAACTTCCGACCCAACTTTGATGTTTCTATTCCCCTCTTTTCTAAGGAT CATCCCAGGACAGGAGGGGAGAGGGGGTTTTTGAAGTTCAACACCATCCCTCCTCTCAGGAAGTACATGCTGGTATTCAAGGGGAAGAGG TACCTGACAGGGATAGGATCAGACACCAGGAATGCCTTATATCACGTCCATAACGGGGAGGACGTTGTGCTCCTCACCACCTGCAAGCAT GGCAAAGACTGGCAAAAGCACAAGGATTCTCGCTGTGACAGAGACAACACCGAGTATGAGAAGTATGATTATCGGGAAATGCTGCACAAT GCCACTTTCTGTCTGGTTCCTCGTGGTCGCAGGCTTGGGTCCTTCAGATTCCTGGAGGCTTTGCAGGCTGCCTGCGTCCCTGTGATGCTC AGCAATGGATGGGAGTTGCCATTCTCTGAAGTGATTAATTGGAACCAAGCTGCCGTCATAGGCGATGAGAGATTGTTATTACAGATTCCT TCTACAATCAGGTCTATTCATCAGGATAAAATCCTAGCACTTAGACAGCAGACACAATTCTTGTGGGAGGCTTATTTTTCTTCAGTTGAG AAGATTGTATTAACTACACTAGAGATTATTCAGGACAGAATATTCAAGCACATATCACGTAACAGTTTAATATGGAACAAACATCCTGGA GGATTGTTCGTACTACCACAGTATTCATCTTATCTGGGAGATTTTCCTTACTACTATGCTAATTTAGGTTTAAAGCCCCCCTCCAAATTC ACTGCAGTCATCCATGCGGTGACCCCCCTGGTCTCTCAGTCCCAGCCAGTGTTGAAGCTTCTCGTGGCTGCAGCCAAGTCCCAGTACTGT GCCCAGATCATAGTTCTATGGAATTGTGACAAGCCCCTACCAGCCAAACACCGCTGGCCTGCCACTGCTGTGCCTGTCGTCGTCATTGAA GGAGAGAGCAAGGTTATGAGCAGCCGTTTTCTGCCCTACGACAACATCATCACAGACGCCGTGCTCAGCCTTGACGAGGACACGGTGCTT TCAACAACAGAGTACCTCTGTGAGTGTCAGTTTGATGACAATCTCAAATTCAAGAATATTATTAATGAGGAGGATGCCGATACTATGCGT CTCCAGCCAATTGGTCGAGACAAAGATGGCCTCATGTACTGGTACCAATTGGATCAAGATCACAATGTCAGAATGTACATAGAAGAACAA GATGATCAAGATGGCTCTTCATGGAAATGCATTGTCAGAAATCGAAACGAGTTGGCTGAGACTCTTGCACTCCTGAAAGCACAAATTGAT CCTGTACTATTGAAAAACTCTAGCCAACAAGACAACTCTTCTCGGGAAAGTCCCAGCTTAGAGGATGAGGAGACTAAAAAAGAGGAAGAA ACACCTAAACAAGAGGAACAGAAAGAAAGTGAAAAGATGAAAAGTGAGGAGCAGCCTATGGATTTAGAAAACCGTTCTACAGCCAATGTT CTAGAAGAGACTACTGTGAAAAAAGAAAAAGAAGATGAAAAGGAACTTGTGAAACTGCCAGTCATAGTGAAGCTAGAAAAACCTTTGCCA GAAAATGAAGAAAAAAAGATTATCAAAGAAGAAAGTGATTCCTTCAAGGAAAATGTCAAACCCATTAAAGTTGAGGTGAAGGAATGTAGA GCAGATCCTAAAGATACCAAAAGTAGCATGGAGAAGCCAGTGGCACAGGAGCCTGAAAGGATCGAATTTGGTGGCAATATTAAATCTTCT CACGAAATTACTGAGAAATCTACTGAAGAAACTGAGAAACTTAAAAATGACCAGCAGGCCAAGATACCACTAAAAAAACGAGAAATTAAA CTGAGTGATGATTTTGACAGTCCAGTCAAGGGACCTTTGTGTAAATCAGTTACTCCAACAAAAGAGTTTTTGAAAGATGAAATAAAACAA GAGGAAGAGACTTGTAAAAGGATCTCTACAATCACTGCTTTGGGTCATGAAGGGAAACAGCTGGTAAATGGAGAAGTTAGTGATGAAAGG GTAGCTCCAAATTTTAAGACAGAACCAATAGAGACAAAGTTTTATGAGACAAAGGAAGAGAGCTATAGCCCCTCTAAGGACAGAAATATC ATCACGGAGGGAAATGGAACAGAGTCCTTAAATTCTGTCATAACAAGTATGAAAACAGGTGAGCTTGAGAAAGAAACAGCCCCTTTGAGG AAAGATGCAGATAGTTCAATATCAGTCTTAGAGATCCATAGTCAAAAAGCACAAATAGAGGAACCCGATCCTCCAGAAATGGAAACTTCT CTTGATTCTTCTGAGATGGCAAAAGATCTCTCTTCAAAAACTGCTTTATCTTCCACCGAGTCGTGTACCATGAAAGGTGAAGAGAAGTCT CCCAAAACTAAGAAGGATAAGCGCCCACCAATCCTAGAATGTCTTGAAAAGTTAGAGAAGTCCAAAAAGACTTTTCTTGATAAGGACGCA CAAAGATTGAGTCCAATACCAGAAGAAGTTCCAAAGAGTACTCTAGAGTCAGAAAAGCCTGGCTCTCCTGAGGCAGCTGAAACTTCTCCA CCATCTAATATCATTGACCACTGTGAGAAACTAGCCTCAGAAAAAGAAGTGGTAGAATGCCAGAGTACAAGTACTGTTGGTGGCCAGTCT GTGAAAAAAGTAGACCTAGAAACCCTAAAAGAGGATTCTGAGTTCACAAAGGTAGAAATGGATAATCTGGACAATGCCCAGACCTCTGGC ATAGAGGAGCCTTCTGAGACAAAGGGTTCTATGCAAAAAAGCAAATTCAAATATAAGTTGGTTCCTGAAGAAGAAACCACTGCCTCAGAA AATACAGAGATAACCTCTGAAAGGCAGAAAGAGGGCATCAAATTAACAATCAGGATATCAAGTCGGAAAAAGAAGCCCGATTCTCCCCCC AAAGTTCTAGAACCAGAAAACAAGCAAGAGAAGACAGAAAAGGAAGAGGAGAAAACAAATGTGGGTCGTACTTTAAGAAGATCTCCAAGA ATATCTAGACCCACTGCAAAAGTGGCTGAGATCAGAGATCAGAAAGCTGATAAAAAAAGAGGGGAAGGAGAAGATGAGGTGGAAGAAGAG TCAACAGCTTTGCAAAAAACTGACAAAAAGGAAATTTTGAAAAAATCAGAGAAAGATACAAATTCTAAAGTAAGCAAGGTAAAACCCAAA GGCAAAGTTCGATGGACTGGTTCTCGGACACGTGGCAGATGGAAATATTCCAGCAATGATGAAAGTGAAGGGTCTGGCAGTGAAAAATCA TCTGCAGCTTCAGAAGAGGAGGAAGAAAAGGAAAGTGAAGAAGCCATCCTAGCAGATGATGATGAACCATGCAAAAAATGTGGCCTTCCA AACCATCCTGAGCTAATTCTTCTGTGTGACTCTTGCGATAGTGGATACCATACTGCCTGCCTTCGCCCTCCTCTGATGATCATCCCAGAT GGAGAATGGTTCTGCCCACCTTGCCAACATAAACTGCTCTGTGAAAAATTAGAGGAACAGTTGCAGGATTTGGATGTTGCCTTAAAGAAG AAAGAGCGTGCCGAACGAAGAAAAGAACGCTTGGTGTATGTTGGTATCAGTATTGAAAACATCATTCCTCCACAAGAGCCAGACTTTTCT GAAGATCAAGAAGAAAAGAAAAAAGATTCAAAAAAATCCAAAGCAAACTTGCTTGAAAGGAGGTCAACAAGAACAAGGAAATGTATAAGC TACAGATTTGATGAGTTTGATGAAGCAATTGATGAAGCTATTGAAGATGACATCAAAGAAGCCGATGGAGGAGGAGTTGGCCGAGGAAAA GATATCTCCACCATCACAGGTCATCGTGGGAAAGACATCTCTACTATTTTGGATGAAGAAAGAAAAGAAAATAAACGACCCCAGAGGGCA GCTGCTGCTCGAAGGAAGAAACGCCGGCGATTAAATGATCTGGACAGTGATAGCAACCTGGATGAAGAAGAGAGCGAGGATGAATTCAAG ATCAGTGATGGATCTCAAGATGAGTTTGTTGTGTCTGATGAAAACCCAGATGAAAGTGAAGAAGATCCGCCATCTAATGATGACAGTGAC ACTGACTTTTGTAGCCGTAGACTGAGGCGACACCCCTCTCGGCCAATGAGGCAGAGCAGGCGTTTGCGAAGAAAGACCCCAAAGAAAAAA TATTCCGATGATGATGAAGAGGAGGAATCTGAGGAGAATAGTAGAGACTCTGAAAGTGACTTCAGTGATGATTTTAGTGATGATTTTGTA GAAACTCGGCGAAGGCGGTCAAGGAGAAATCAGAAAAGACAAATTAACTACAAAGAAGACTCAGAAAGTGACGGTTCCCAGAAGAGTTTG CGACGTGGTAAAGAAATAAGGCGAGTACACAAGCGAAGACTTTCCAGCTCAGAGAGTGAAGAGAGCTATTTGTCCAAGAACTCTGAAGAT GATGAGCTAGCTAAAGAATCAAAGCGGTCAGTTCGAAAGCGGGGCCGAAGCACAGACGAGTATTCAGAAGCAGATGAGGAGGAGGAGGAA GAGGAAGGCAAACCATCCCGCAAACGGCTACACCGGATTGAGACGGATGAGGAGGAGAGTTGTGACAATGCTCATGGAGATGCAAATCAG CCTGCCCGTGACAGCCAGCCTAGGGTCCTGCCCTCAGAACAAGAGAGCACCAAGAAGCCCTACCGGATAGAAAGTGATGAGGAAGAGGAC TTTGAAAATGTAGGCAAAGTGGGGAGCCCATTGGACTATAGCTTAGTGGACTTACCTTCAACCAATGGACAGAGCCCTGGCAAAGCCATT GAGAACTTGATTGGCAAGCCTACTGAGAAGTCTCAGACCCCCAAGGACAACAGCACAGCCAGTGCAAGCCTAGCCTCCAATGGGACAAGT GGTGGGCAGGAGGCAGGAGCACCAGAAGAGGAGGAAGATGAGCTTTTGAGAGTGACTGACCTTGTTGATTATGTCTGTAACAGTGAACAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_EXT1_ENST00000378204_chr8_118825111_-_RSF1_ENST00000308488_chr11_77451981_-_13404nt GTGTAAGTGTAACATTCAGAACCGGGTAACATTCGGCGACCGAACGCGGCGGTCGGCAGCGTTCGCGCGGGGGCCTGCGAAGCGCTGCTC GGGGCCGGCACTGCCCGCGGGGAGGACGCGCCGCCGCCGCCACCCAGCGCCGCCGCCGCCGCCGCCTCCAGCCGGGCCGCCGCGCGTCCC GGGGGCCGGCCCCGCGAGCGCAGGAGTAAACACCGCCGGAGTCTTGGAGCCGCTGCAGAAGGGAATAAAGAGAGATGCAGGGATTTGTGA GGTTACGGCGCCCCAGCTGCAAGATGCACTAGCCGGCTGAACCCGGGATCGGCTGACTTGTTGGAACCGGAGTGCTCTGCACGGAGAGTG GTGGATGAGTTGAAGTTGCCTTCCCGGGGCTCATTTTCCACGCTGCCGAGAGGAATCCGAGAGGCAAGGCAATCACTTCGTCTTGCCATT GATTGGGTATCGGGAGCTTTTTTTTTCTCCCCTCTCTCTTTCTTTTCCTCCGTCTTGTTGCATGCAAGAAAATTACAGTCCGCTGCTCGC CCGCCCTGGGTGCGAGATATTCAGCCCCGCTCTCTCCCGTGCATTGTGCAACCCAAAGATGAAAGACCGAAGGGGAGAAAGTTAAAGAAA TCGCCCACATGCGCTGGATCAGTCCACGGCTTGGGGAAAGGCATCCAGAGAAGGTGGGAGCGGAGAGTTTGAAGTCTTTACAGGCGGGAA GATGGCGGACTGGAGCTGAAAGTGTTGATTGGGAAACTTGGGTGATTCTTGTGTTTATTTACAATCCTCTTGACCCAGGCAGGACACATG CAGGCCAAAAAACGCTATTTCATCCTGCTCTCAGCTGGCTCTTGTCTCGCCCTTTTGTTTTATTTCGGAGGCTTGCAGTTTAGGGCATCG AGGAGCCACAGCCGGAGAGAAGAACACAGCGGTAGGAATGGCTTGCACCACCCCAGTCCGGATCATTTCTGGCCCCGCTTCCCGGACGCT CTGCGCCCCTTCGTTCCTTGGGATCAATTGGAAAACGAGGATTCCAGCGTGCACATTTCCCCCCGGCAGAAGCGAGATGCCAACTCCAGC ATCTACAAAGGCAAGAAGTGCCGCATGGAGTCCTGCTTCGATTTCACCCTTTGCAAGAAAAACGGCTTCAAAGTCTACGTATACCCACAG CAAAAAGGGGAGAAAATCGCCGAAAGTTACCAAAACATTCTAGCGGCCATCGAGGGCTCCAGGTTCTACACCTCGGACCCCAGCCAGGCG TGCCTCTTTGTCCTGAGTCTGGATACTTTAGACAGAGACCAGTTGTCACCTCAGTATGTGCACAATTTGAGATCCAAAGTGCAGAGTCTC CACTTGTGGAACAATGGTAGGAATCATTTAATTTTTAATTTATATTCCGGCACTTGGCCTGACTACACCGAGGACGTGGGGTTTGACATC GGCCAGGCGATGCTGGCCAAAGCCAGCATCAGTACTGAAAACTTCCGACCCAACTTTGATGTTTCTATTCCCCTCTTTTCTAAGGATCAT CCCAGGACAGGAGGGGAGAGGGGGTTTTTGAAGTTCAACACCATCCCTCCTCTCAGGAAGTACATGCTGGTATTCAAGGGGAAGAGGTAC CTGACAGGGATAGGATCAGACACCAGGAATGCCTTATATCACGTCCATAACGGGGAGGACGTTGTGCTCCTCACCACCTGCAAGCATGGC AAAGACTGGCAAAAGCACAAGGATTCTCGCTGTGACAGAGACAACACCGAGTATGAGAAGTATGATTATCGGGAAATGCTGCACAATGCC ACTTTCTGTCTGGTTCCTCGTGGTCGCAGGCTTGGGTCCTTCAGATTCCTGGAGGCTTTGCAGGCTGCCTGCGTCCCTGTGATGCTCAGC AATGGATGGGAGTTGCCATTCTCTGAAGTGATTAATTGGAACCAAGCTGCCGTCATAGGCGATGAGAGATTGTTATTACAGATTCCTTCT ACAATCAGGTCTATTCATCAGGATAAAATCCTAGCACTTAGACAGCAGACACAATTCTTGTGGGAGGCTTATTTTTCTTCAGTTGAGAAG ATTGTATTAACTACACTAGAGATTATTCAGGACAGAATATTCAAGCACATATCACGTAACAGTTTAATATGGAACAAACATCCTGGAGGA TTGTTCGTACTACCACAGTATTCATCTTATCTGGGAGATTTTCCTTACTACTATGCTAATTTAGGTTTAAAGCCCCCCTCCAAATTCACT GCAGTCATCCATGCGGTGACCCCCCTGGTCTCTCAGTCCCAGCCAGTGTTGAAGCTTCTCGTGGCTGCAGCCAAGTCCCAGTACTGTGCC CAGATCATAGTTCTATGGAATTGTGACAAGCCCCTACCAGCCAAACACCGCTGGCCTGCCACTGCTGTGCCTGTCGTCGTCATTGAAGGA GAGAGCAAGGTTATGAGCAGCCGTTTTCTGCCCTACGACAACATCATCACAGACGCCGTGCTCAGCCTTGACGAGGACACGGTGCTTTCA ACAACAGAGTACCTCTGTGAGTGTCAGTTTGATGACAATCTCAAATTCAAGAATATTATTAATGAGGAGGATGCCGATACTATGCGTCTC CAGCCAATTGGTCGAGACAAAGATGGCCTCATGTACTGGTACCAATTGGATCAAGATCACAATGTCAGAATGTACATAGAAGAACAAGAT GATCAAGATGGCTCTTCATGGAAATGCATTGTCAGAAATCGAAACGAGTTGGCTGAGACTCTTGCACTCCTGAAAGCACAAATTGATCCT GTACTATTGAAAAACTCTAGCCAACAAGACAACTCTTCTCGGGAAAGTCCCAGCTTAGAGGATGAGGAGACTAAAAAAGAGGAAGAAACA CCTAAACAAGAGGAACAGAAAGAAAGTGAAAAGATGAAAAGTGAGGAGCAGCCTATGGATTTAGAAAACCGTTCTACAGCCAATGTTCTA GAAGAGACTACTGTGAAAAAAGAAAAAGAAGATGAAAAGGAACTTGTGAAACTGCCAGTCATAGTGAAGCTAGAAAAACCTTTGCCAGAA AATGAAGAAAAAAAGATTATCAAAGAAGAAAGTGATTCCTTCAAGGAAAATGTCAAACCCATTAAAGTTGAGGTGAAGGAATGTAGAGCA GATCCTAAAGATACCAAAAGTAGCATGGAGAAGCCAGTGGCACAGGAGCCTGAAAGGATCGAATTTGGTGGCAATATTAAATCTTCTCAC GAAATTACTGAGAAATCTACTGAAGAAACTGAGAAACTTAAAAATGACCAGCAGGCCAAGATACCACTAAAAAAACGAGAAATTAAACTG AGTGATGATTTTGACAGTCCAGTCAAGGGACCTTTGTGTAAATCAGTTACTCCAACAAAAGAGTTTTTGAAAGATGAAATAAAACAAGAG GAAGAGACTTGTAAAAGGATCTCTACAATCACTGCTTTGGGTCATGAAGGGAAACAGCTGGTAAATGGAGAAGTTAGTGATGAAAGGGTA GCTCCAAATTTTAAGACAGAACCAATAGAGACAAAGTTTTATGAGACAAAGGAAGAGAGCTATAGCCCCTCTAAGGACAGAAATATCATC ACGGAGGGAAATGGAACAGAGTCCTTAAATTCTGTCATAACAAGTATGAAAACAGGTGAGCTTGAGAAAGAAACAGCCCCTTTGAGGAAA GATGCAGATAGTTCAATATCAGTCTTAGAGATCCATAGTCAAAAAGCACAAATAGAGGAACCCGATCCTCCAGAAATGGAAACTTCTCTT GATTCTTCTGAGATGGCAAAAGATCTCTCTTCAAAAACTGCTTTATCTTCCACCGAGTCGTGTACCATGAAAGGTGAAGAGAAGTCTCCC AAAACTAAGAAGGATAAGCGCCCACCAATCCTAGAATGTCTTGAAAAGTTAGAGAAGTCCAAAAAGACTTTTCTTGATAAGGACGCACAA AGATTGAGTCCAATACCAGAAGAAGTTCCAAAGAGTACTCTAGAGTCAGAAAAGCCTGGCTCTCCTGAGGCAGCTGAAACTTCTCCACCA TCTAATATCATTGACCACTGTGAGAAACTAGCCTCAGAAAAAGAAGTGGTAGAATGCCAGAGTACAAGTACTGTTGGTGGCCAGTCTGTG AAAAAAGTAGACCTAGAAACCCTAAAAGAGGATTCTGAGTTCACAAAGGTAGAAATGGATAATCTGGACAATGCCCAGACCTCTGGCATA GAGGAGCCTTCTGAGACAAAGGGTTCTATGCAAAAAAGCAAATTCAAATATAAGTTGGTTCCTGAAGAAGAAACCACTGCCTCAGAAAAT ACAGAGATAACCTCTGAAAGGCAGAAAGAGGGCATCAAATTAACAATCAGGATATCAAGTCGGAAAAAGAAGCCCGATTCTCCCCCCAAA GTTCTAGAACCAGAAAACAAGCAAGAGAAGACAGAAAAGGAAGAGGAGAAAACAAATGTGGGTCGTACTTTAAGAAGATCTCCAAGAATA TCTAGACCCACTGCAAAAGTGGCTGAGATCAGAGATCAGAAAGCTGATAAAAAAAGAGGGGAAGGAGAAGATGAGGTGGAAGAAGAGTCA ACAGCTTTGCAAAAAACTGACAAAAAGGAAATTTTGAAAAAATCAGAGAAAGATACAAATTCTAAAGTAAGCAAGGTAAAACCCAAAGGC AAAGTTCGATGGACTGGTTCTCGGACACGTGGCAGATGGAAATATTCCAGCAATGATGAAAGTGAAGGGTCTGGCAGTGAAAAATCATCT GCAGCTTCAGAAGAGGAGGAAGAAAAGGAAAGTGAAGAAGCCATCCTAGCAGATGATGATGAACCATGCAAAAAATGTGGCCTTCCAAAC CATCCTGAGCTAATTCTTCTGTGTGACTCTTGCGATAGTGGATACCATACTGCCTGCCTTCGCCCTCCTCTGATGATCATCCCAGATGGA GAATGGTTCTGCCCACCTTGCCAACATAAACTGCTCTGTGAAAAATTAGAGGAACAGTTGCAGGATTTGGATGTTGCCTTAAAGAAGAAA GAGCGTGCCGAACGAAGAAAAGAACGCTTGGTGTATGTTGGTATCAGTATTGAAAACATCATTCCTCCACAAGAGCCAGACTTTTCTGAA GATCAAGAAGAAAAGAAAAAAGATTCAAAAAAATCCAAAGCAAACTTGCTTGAAAGGAGGTCAACAAGAACAAGGAAATGTATAAGCTAC AGATTTGATGAGTTTGATGAAGCAATTGATGAAGCTATTGAAGATGACATCAAAGAAGCCGATGGAGGAGGAGTTGGCCGAGGAAAAGAT ATCTCCACCATCACAGGTCATCGTGGGAAAGACATCTCTACTATTTTGGATGAAGAAAGAAAAGAAAATAAACGACCCCAGAGGGCAGCT GCTGCTCGAAGGAAGAAACGCCGGCGATTAAATGATCTGGACAGTGATAGCAACCTGGATGAAGAAGAGAGCGAGGATGAATTCAAGATC AGTGATGGATCTCAAGATGAGTTTGTTGTGTCTGATGAAAACCCAGATGAAAGTGAAGAAGATCCGCCATCTAATGATGACAGTGACACT GACTTTTGTAGCCGTAGACTGAGGCGACACCCCTCTCGGCCAATGAGGCAGAGCAGGCGTTTGCGAAGAAAGACCCCAAAGAAAAAATAT TCCGATGATGATGAAGAGGAGGAATCTGAGGAGAATAGTAGAGACTCTGAAAGTGACTTCAGTGATGATTTTAGTGATGATTTTGTAGAA ACTCGGCGAAGGCGGTCAAGGAGAAATCAGAAAAGACAAATTAACTACAAAGAAGACTCAGAAAGTGACGGTTCCCAGAAGAGTTTGCGA CGTGGTAAAGAAATAAGGCGAGTACACAAGCGAAGACTTTCCAGCTCAGAGAGTGAAGAGAGCTATTTGTCCAAGAACTCTGAAGATGAT GAGCTAGCTAAAGAATCAAAGCGGTCAGTTCGAAAGCGGGGCCGAAGCACAGACGAGTATTCAGAAGCAGATGAGGAGGAGGAGGAAGAG GAAGGCAAACCATCCCGCAAACGGCTACACCGGATTGAGACGGATGAGGAGGAGAGTTGTGACAATGCTCATGGAGATGCAAATCAGCCT GCCCGTGACAGCCAGCCTAGGGTCCTGCCCTCAGAACAAGAGAGCACCAAGAAGCCCTACCGGATAGAAAGTGATGAGGAAGAGGACTTT GAAAATGTAGGCAAAGTGGGGAGCCCATTGGACTATAGCTTAGTGGACTTACCTTCAACCAATGGACAGAGCCCTGGCAAAGCCATTGAG AACTTGATTGGCAAGCCTACTGAGAAGTCTCAGACCCCCAAGGACAACAGCACAGCCAGTGCAAGCCTAGCCTCCAATGGGACAAGTGGT GGGCAGGAGGCAGGAGCACCAGAAGAGGAGGAAGATGAGCTTTTGAGAGTGACTGACCTTGTTGATTATGTCTGTAACAGTGAACAGTTA TAAGACTTTTTTTCCATTTTTGTGCTAATTTATTCCACGGTAGCTCTCACACCAGCGGGCCAGTTATTAAAAGCTGTTTAATTTTTCCTA GAAAACTCCACTACAGAATGACTTTTAGAAGAAAAATTTCAACAAATCCTGAAGTCTTTCTGTGAAGTGACCAGTTCTGAACTTTGAAGA TAAATAATTGCTGTAAATTCCTTTTGATTTTCTTTTTCCAGGTTCATGGTCCTTGGTAATTTCATTCATGGAAAAAAATCTTATTATAAT AACAACAAAGATTTGTATATTTTTGACTTTATATTTCCTGAGCTCTCCTGACTTTGTGAAAAAGGGTGGATGAAAATGCATTCCGAATCT GTGAGGGCCCAAAACAGAATTTAGGGGTGGGTGAAAGCACTTGTGCTTTAGCTTTTTCATATTAAATATATATTATATTTAAACATTCAT GGCATAGATGATGATTTACAGACAATTTAAAAGTTCAAGTCTGTACTGTTACAGTTTGAGAATTGTAGATAACATCATACATAAGTCATT TAGTAACAGCCTTTGTGAAATGAACTTGTTTACTATTGGAGATAACCACACTTAATAAAGAAGAGACAGTGAAAGTACCATCATAATTAA CCTAAATTTTTGTTATAGCAGAGTTTCTTGTTTAAAAAAAAATAAAATCATCTGAAAAGCATTTGTACAGTAAAATGTATAATGAAGCTT TGCCAACCAGACTGTGCTAGCAACAAATTTTTTTAAATAAGCTTTATGCAGTGGTAATAAGGTGGCCTCAAATATATTGTGTCTGATGGA GAGTTATTAGTGAAATGAATGTGGTCTTTCTTAAGGCCTGGGTGGACTGTAAACTTTGCCAATAGTATAACTCTTGTCTTCTGGCCACTT GATGTTTAAATATCTGAAATATCATTTTGAAAAAAATACATCTATATATAACATACATGAAGAGATGCTAAGCTGACAGTGATATTTTAG CACATTTGAAGACTGGGAAGAGATTTTCAGGTGAATTTTAACTGGTCTATTCTTGCCCTTAGTATCTACTTCAAATTGAAGTCTACAAAC AAAGCAGTTCCTTTGGGAGGTTTTTAGTTTGAGTTTTAGCGTGTGTGTGTGTTTGTGTGTGTGCGTGTGCGTGTGTGTGTGTGTTGGAAT TTCCTATCTGCCTGGATATATTAGCAGAGTTTGAATGTAGTTTTGGCCTTTGGCCATTAGACTTCTATTAAAATTCATTAATAGTCATAC AACCAACATAGAGTTGAATGAGAACTGCCGATGTAATTAATAGGCATGACATCCATTTCAAACATCTCAACACTTTAAAGAAAAGCCCTT TGTTTCAAGAAAAAAGGGTTTGTAACTAACTAAATACCTAACATGTAATTGACACTAAAATATGAACTTTGTCTTATTTAGTTTCTGTTA TAGCTGTAAAATTTCAGGCAGAGCCATAACATTGTACAGAGTGTAGCACTTGTGATTAAACCTAGCCTGTTAAATCCTGAAACCTTCAAC CATTACTTCTGTGAATACTTTAGCCCTGGGATTTGGGTTTTTCTGTTCCGGTGTTGTGTCTGTTGCCGGCAATGGACACACCATATCTGC TGCTGGCCCAAGGAACGTCATTAATTTTTCTTTCCAAATTAAGTATTATGTGCTAGTCAGTGTATAGTAAAGCACTTCTCTTTTTTATTA CTAAAAAGCTGGCATTAGATTTGCATTATAAATACCTCTCTAGGAACTTTATACTCCTTTTCCTTCTTCAACAGGTATTGCCCTTAAATC TTATCTTTTGGCCTTGAAAGTTTATAGCTATTGTTTTTCAGTTGTTCGTTGTTTTGTTTTGTTTCACTTTAGTTCTGTAGTACCTGCCCA TTAATATTTTTGCTTTGATTCTAGCAATGTGTATGTATCTGTATAAAAAATAAAATAATGAAAGCAACCTAAAAATAGGATGCACCAATA GCATGTGGTTCCAAGTAAGTTGTGATTTTTATTTTGAGACAGTGTTCCACTGGAAGGGAGGGAAGGGCTTACATTCACAGACAGTAAAGC AGGGCTGTGTAAGGAGCTACATTTACTTAACAGTCTCCTTTCCAGCTAGGTTTGTTTTATTTATTTGCAAGTCAGCTAAGAATTAACCTT TTAAACCATCTAAAACAGGCAAGCAATATAAAGATTTCTACTAGTGCAAGGTAAGTGGTTTGAATATACAAGTGCCCTTTCCTGCCACCC AGTCTCACTACCGTTTTAGTCCTGCAGCTGGGTAAAGCCACTATTGTGTGGAAACTCTCCCATGTGCCCTGTCTCTACCTCTGGACACAC CAGCTCCTTCTTCCACCTATTCTATTCCTCAGTTAAGCCAAGTGATCAGAAGTAGTATTAAATGGGTAGATAATTTTAACAGGATGCCTA ATGTGAAATAAGGAGTTATTTTTACTCTTCTACTATAGAAAGCCTAAGGTAATTCTTACCATCTCAAAGACTGAGTATTCCATTTAGGTT TGGAGACCACTTGTGCTGTGCTGCCTGATATTTACCAAACTTGAATAAGTGTTCGTCAACTTGATAGTGAATGTACCCCTTCTCACCTTA TATTTTGATTAAATCAATTAACTATAGGTCATCTACCAAGAATGTAATCCAAGCGGTTGATAAAACATTATTAGGCAGATAGATTATTGA TTATTAAATTTTGAGCAGTGCAAAAACGGTTTTGCTGCTTGGAGTTCAGATTCAGTCCCTCAAAGAGTTTATGATCACTGAAATACACTC TGAAGGTATTCTGAAGAAGTTAAAAAATTTTAGAAAACGAAATGTTCTGTATACAAAGACAATACAGTCACTACGAACTGCAGAAAGTAT AGGAAAGCAGTAATTGATGTAGAGTTTAGACAGTCTTGGATCTTTTTTAGAGCACTAACCATGGATTTAGACTCAAAATAGCTGCTACAT AATAGAGCCCTTTAATAATTTAAACCCCCCTTGTTGAAATACAAGTTGGACTCCCAGTGTCAAACTCTAGACTGTAGCTAATGTATTAAA GGGAGATGTAGATTAATATTCAGTATATTTAGTTTGCAATTTCTGAAAAGGTTTGAAAACTAGTCAGCTTTTCACACAGCAGAAGCTTTG AACTGAAATATGTGTGAAAAGGACGCAGACTGAAAACGTTTTGGTTTTGTACATCAGTGCTGATGAAATTAGTGTAAAACATTTTCCATC ATTGGCACATTACTGCAAAATGATGGCAGAGATATTTTCAAGAATGTACATCAAGTTATATTTCCTTGACATCCTTTTTTCAATTGGTCA AGGTTACAGATTCAGAGGATAAAGGGTAGTTTCATTTAGAATAAATTCATGTCTACTGGCAATCTATATATAAAAGTGACCTGCCCAAGA ACCAAAAACTTTAAATGCTAATGAAGCTTTTGAAAAATAATTTTTAAACAAATTAATTTTAAAAGGGTGTTACACGTACCCAGTTTTTAC TTTTTAGTTGATGAAACCCATCCTATAATATACATTTGAGCAAAGTACACATATTAAGAAAAACATGGACATTTACTTGTTTAATAGTCA AAATGATGAGGAAATGTTAGCTGTTTTTAAGTGGGACTGGTGGGGTGTCCTTTGTCACAAGGAATGCTTTTTTAGCTTGTTTGTGGGCAT AAGAGATGTTAACCCTTTGCTGATTCTACCACACAACTGTAAAGAACCTAATGAATCTACAAGTTTAATATTCAGAAAAAGCTAGGAACT CCGCTCTTTACCAGTACAGTGGAACAGGCCCGTTATTCAAGGTGATGCCTCACAGCTATAGAACAACTATTCAAAGACCCAGAGTTAAAT GGTACATGTGTATATGTGTGTGTGTGTGTGCACACGCACACACTTCAGATAAGTATCAGAAAAAATAAAAATGAATCCATCATTAACTTG AAAGAAATAAGATGGCTGCATTGCAACAGATACAAATATTATGAACATCATTTAATTACAGAAAATCTAGACAACAGTTTCTCCTGATGT TTGACATTCTCAAAATATATTCCTCATTCTCGAAGAAGCAGAGAATGCCAAGGCTGCATATCTGCTGTAATCTACCTAGCCCTCTTCTGC TTAATATGATCCATTATTGAATCTTCTCAGATTAAAATCCATTCCTATATCATCTACCTTTCCCAAAGTGTGTGCCTGTAAACCTACCTT GGAAGTGGCAAGTTAACTGATTTTTTTGTGTCATTTTTATACCAATCCTTAAGGTCAAAGCCTTTTGCTATCAATGTATTTAAACTGAGT TGCTATATGTTCACTAATTTGTTTTCAAAATGTTTTGCTCCAACTTAAATTATCTTTTAACATCTTTTGAGTGCCAAGAATTGCTAAGTA ACTGTAATATGTTGAAGAGAGTAATTGCCAAGCAAGCAGTCATAAGCCAAAATGTAATGAGCTTAGTATATAACCACTTTAGAGTATACA CTCACCACTTTTTGTATTCATTCATGCAAACCCTCCTGGAAGTCGATTAGAAGAGGATCCAATTTGTGGACCTTTTTTCCTCCTTTTGGA CACCTGAGCACAATTTTTTTTTTCCTTTCATATTTATACCACTTTGGAAAATTCAGTAAACCCAATTCTGGCACATCATAATGGTTTCAG TTAGTGAAGATGTTTATTTTAATAACTTTAAAATATGACTATCCTATACATAAGTTATATAAGAGGGCATAACAATAGATGAGTAGAAAT TTATAAAATTTCTTGGATATTTTGAATGAGAAAAAAACATTTTTAAAGGAATTTTGTTTTTTCCTTTTTTGGCCAAACCGGTACAAGTTA GAAAGTGTGCTAAGGACTGAATACTTGCCTCGTGCTTTTTGCCACTGGATGATGTAAGTTAAGAATGGAATTGTTAATCCTAAGTATATA TTTTCTTGACTTTCATCAGTTTCTAAAGAAATCTAATTTAAGTGTTTTGCGGTTTTGTTTGATCTGTATTTATTGAGTTCTGGTCATAGA CCAGCAGCTTGCACGTCATGCTCATGAACAGCCAGAACATAGTTATTGGGGAACTTCATGGCTCAAAACCTTCTGAATCATTTAACTTAT TTTGTATGTTGCAAAAAAAAAAAAAAAGTTTATTTTGCTTGAGAGTCACCTTTTTTTAAAAAAAATAACTGTACAGCTTTTAAGGGATGG GAGGTGGGAAAATACCCTAAAATAGGATGTAGATTTTTTACAATTGTGTTTATGCTAGATCATCTACAGGTGCATTATGTAATTAAACCT AAAATTGTTTAAAAATTTGTGCCATGTCTTTTTCATTCTCCTGCCCTTTAGCAGAATTGGTGCATGTCAACTGCTATGTGGACAAGCCTT GAAATTAGAGTAACAAGCCCTGTCTCCAAAGCTTTAAGGTCACTGCATGAAAATTGCACACACACACACACACACACACACATCTAGCTT ATATTAGTAAATGGATTTTCAGGATCAGAACAGCTACAGTAGCCCAGATTTGGCTGTTAACAGCATATTCTTACAGCACATGATTTTTGT GATGCCTAACTAGGGTATTCTCAATGTTAGTCTGGTGTTCTATTCTCTTTCAAAGTAGCTTCTTGAGATGGTATCTGTTGTAGCTTGCCC AAACCTGCCATGAGGTTGTGTGTACACTTTGAAAGGGTATGTCCTATGCTAAGATGGTGGTAGAGCAGGGCTTGATTTTAATCTATTCAT ATAAAAGAAGGAAAAAACTAGAATTGGTCTATTTGGTTATTCAGTGGACTTAATTCCACAGGAATAGTTGTCTGCTGAAGCGTGGCAGCA AGAGAAGTCAAATTCAAGTTTCAGTTCCTTCCTTATTCACTAAGTATTTTGAAATCTTGTAGAACTTCTGATTCTAGCACAGTCTTTTAC ATGGCACATTTTACCATGGTATATTCACAGCTTCGTTTAAATGTCAGTACTTTTTCCCATCTGATAATTTTGCCATTCTAATTTCTCACC TTTGTAGTACAAGTGTATTCTTGAAAATAATTAAATTCATCTAAGTGTGTCATAATTTCAATCAAAGCTATATTCATGTGTTGCCAGCGT CAGTTTTTTGCTATCCTCATTCAGAAGGGAAGCCTGCAGATCATGAGTTTCCATATGAAGAATACAAATTCCACATAAAAATTTATAAAT GGTATCTTTAGAATTTTGATTTAAAGTAATAGCTGGAATTCAGGGACTGATCAGAATGCCTCTTGAATTTTCCAACATGCTTATATGAAA TGCTTTATTTTCCTATGCGTTAAAAAAAATATTCCTGGAATAGGTTCTCAGAATGTTTTATTTGGTTTCTAGGAGATGAGATTTAAAGCA GAAGCTCCAAGATTGGCATAAAACTAACTCTTGAGGTAATCAGGACCATGCTGTTAGTCAAATAGAAGCTGGAGTGCTCTCTGTCACATA ATGTACTGCATGTGTGTGGGGGTGGGGGGGCAGGGAAGATCAGAAAACTGGAAATGTAATTCTGATAACACGCAAAGTAAATTGTGCATT AAAAGTATGGGAATTCTTGGTAGCTTAAAGCTTCAGGGGTTAACTTCAGTGTATGAACACCTAGTGTGTTAGAATTGCAGTGCATAGTTG TTTAAATACAATATTCCTTGTAAGTGACAACCAAAATATGTTGTGGCTGGTGCCAGTATTTTTGTTAATGAAATGTTCAGTGTCTCACTA CAGTCTGATCAGAACTCTTGGTGTTATAAGCCAGGCCTAAAGCCATTTTATAGCTATTGGCCTAATTGTGTAACTTTTTCTTTCAAAATG >In-frame_EXT1_ENST00000378204_chr8_118825111_-_RSF1_ENST00000360355_chr11_77451981_-_7170nt GTGTAAGTGTAACATTCAGAACCGGGTAACATTCGGCGACCGAACGCGGCGGTCGGCAGCGTTCGCGCGGGGGCCTGCGAAGCGCTGCTC GGGGCCGGCACTGCCCGCGGGGAGGACGCGCCGCCGCCGCCACCCAGCGCCGCCGCCGCCGCCGCCTCCAGCCGGGCCGCCGCGCGTCCC GGGGGCCGGCCCCGCGAGCGCAGGAGTAAACACCGCCGGAGTCTTGGAGCCGCTGCAGAAGGGAATAAAGAGAGATGCAGGGATTTGTGA GGTTACGGCGCCCCAGCTGCAAGATGCACTAGCCGGCTGAACCCGGGATCGGCTGACTTGTTGGAACCGGAGTGCTCTGCACGGAGAGTG GTGGATGAGTTGAAGTTGCCTTCCCGGGGCTCATTTTCCACGCTGCCGAGAGGAATCCGAGAGGCAAGGCAATCACTTCGTCTTGCCATT GATTGGGTATCGGGAGCTTTTTTTTTCTCCCCTCTCTCTTTCTTTTCCTCCGTCTTGTTGCATGCAAGAAAATTACAGTCCGCTGCTCGC CCGCCCTGGGTGCGAGATATTCAGCCCCGCTCTCTCCCGTGCATTGTGCAACCCAAAGATGAAAGACCGAAGGGGAGAAAGTTAAAGAAA TCGCCCACATGCGCTGGATCAGTCCACGGCTTGGGGAAAGGCATCCAGAGAAGGTGGGAGCGGAGAGTTTGAAGTCTTTACAGGCGGGAA GATGGCGGACTGGAGCTGAAAGTGTTGATTGGGAAACTTGGGTGATTCTTGTGTTTATTTACAATCCTCTTGACCCAGGCAGGACACATG CAGGCCAAAAAACGCTATTTCATCCTGCTCTCAGCTGGCTCTTGTCTCGCCCTTTTGTTTTATTTCGGAGGCTTGCAGTTTAGGGCATCG AGGAGCCACAGCCGGAGAGAAGAACACAGCGGTAGGAATGGCTTGCACCACCCCAGTCCGGATCATTTCTGGCCCCGCTTCCCGGACGCT CTGCGCCCCTTCGTTCCTTGGGATCAATTGGAAAACGAGGATTCCAGCGTGCACATTTCCCCCCGGCAGAAGCGAGATGCCAACTCCAGC ATCTACAAAGGCAAGAAGTGCCGCATGGAGTCCTGCTTCGATTTCACCCTTTGCAAGAAAAACGGCTTCAAAGTCTACGTATACCCACAG CAAAAAGGGGAGAAAATCGCCGAAAGTTACCAAAACATTCTAGCGGCCATCGAGGGCTCCAGGTTCTACACCTCGGACCCCAGCCAGGCG TGCCTCTTTGTCCTGAGTCTGGATACTTTAGACAGAGACCAGTTGTCACCTCAGTATGTGCACAATTTGAGATCCAAAGTGCAGAGTCTC CACTTGTGGAACAATGGTAGGAATCATTTAATTTTTAATTTATATTCCGGCACTTGGCCTGACTACACCGAGGACGTGGGGTTTGACATC GGCCAGGCGATGCTGGCCAAAGCCAGCATCAGTACTGAAAACTTCCGACCCAACTTTGATGTTTCTATTCCCCTCTTTTCTAAGGATCAT CCCAGGACAGGAGGGGAGAGGGGGTTTTTGAAGTTCAACACCATCCCTCCTCTCAGGAAGTACATGCTGGTATTCAAGGGGAAGAGGTAC CTGACAGGGATAGGATCAGACACCAGGAATGCCTTATATCACGTCCATAACGGGGAGGACGTTGTGCTCCTCACCACCTGCAAGCATGGC AAAGACTGGCAAAAGCACAAGGATTCTCGCTGTGACAGAGACAACACCGAGTATGAGAAGTATGATTATCGGGAAATGCTGCACAATGCC ACTTTCTGTCTGGTTCCTCGTGGTCGCAGGCTTGGGTCCTTCAGATTCCTGGAGGCTTTGCAGGCTGCCTGCGTCCCTGTGATGCTCAGC AATGGATGGGAGTTGCCATTCTCTGAAGTGATTAATTGGAACCAAGCTGCCGTCATAGGCGATGAGAGATTGTTATTACAGATTCCTTCT ACAATCAGGTCTATTCATCAGGATAAAATCCTAGCACTTAGACAGCAGACACAATTCTTGTGGGAGGCTTATTTTTCTTCAGTTGAGAAG ATTGTATTAACTACACTAGAGATTATTCAGGACAGAATATTCAAGCACATATCACGTAACAGTTTAATATGGAACAAACATCCTGGAGGA TTGTTCGTACTACCACAGTATTCATCTTATCTGGGAGATTTTCCTTACTACTATGCTAATTTAGGTTTAAAGCCCCCCTCCAAATTCACT GCAGTCATCCATGCGGTGACCCCCCTGGTCTCTCAGTCCCAGCCAGTGTTGAAGCTTCTCGTGGCTGCAGCCAAGTCCCAGTACTGTGCC CAGATCATAGTTCTATGGAATTGTGACAAGCCCCTACCAGCCAAACACCGCTGGCCTGCCACTGCTGTGCCTGTCGTCGTCATTGAAGGA GAGAGCAAGGTTATGAGCAGCCGTTTTCTGCCCTACGACAACATCATCACAGACGCCGTGCTCAGCCTTGACGAGGACACGGTGCTTTCA ACAACAGAGTACCTCTGTGAGTGTCAGTTTGATGACAATCTCAAATTCAAGAATATTATTAATGAGGAGGATGCCGATACTATGCGTCTC CAGCCAATTGGTCGAGACAAAGATGGCCTCATGTACTGGTACCAATTGGATCAAGATCACAATGTCAGAATGTACATAGAAGAACAAGAT GATCAAGATGGCTCTTCATGGAAATGCATTGTCAGAAATCGAAACGAGTTGGCTGAGACTCTTGCACTCCTGAAAGCACAAATTGATCCT GTACTATTGAAAAACTCTAGCCAACAAGACAACTCTTCTCGGGAAAGTCCCAGCTTAGAGGATGAGGAGACTAAAAAAGAGGAAGAAACA CCTAAACAAGAGGAACAGAAAGAAAGTGAAAAGATGAAAAGTGAGGAGCAGCCTATGGATTTAGAAAACCGTTCTACAGCCAATGTTCTA GAAGAGACTACTGTGAAAAAAGAAAAAGAAGATGAAAAGGAACTTGTGAAACTGCCAGTCATAGTGAAGCTAGAAAAACCTTTGCCAGAA AATGAAGAAAAAAAGATTATCAAAGAAGAAAGTGATTCCTTCAAGGAAAATGTCAAACCCATTAAAGTTGAGGTGAAGGAATGTAGAGCA GATCCTAAAGATACCAAAAGTAGCATGGAGAAGCCAGTGGCACAGGAGCCTGAAAGGATCGAATTTGGTGGCAATATTAAATCTTCTCAC GAAATTACTGAGAAATCTACTGAAGAAACTGAGAAACTTAAAAATGACCAGCAGGCCAAGATACCACTAAAAAAACGAGAAATTAAACTG AGTGATGATTTTGACAGTCCAGTCAAGGGACCTTTGTGTAAATCAGTTACTCCAACAAAAGAGTTTTTGAAAGATGAAATAAAACAAGAG GAAGAGACTTGTAAAAGGATCTCTACAATCACTGCTTTGGGTCATGAAGGGAAACAGCTGGTAAATGGAGAAGTTAGTGATGAAAGGGTA GCTCCAAATTTTAAGACAGAACCAATAGAGACAAAGTTTTATGAGACAAAGGAAGAGAGCTATAGCCCCTCTAAGGACAGAAATATCATC ACGGAGGGAAATGGAACAGAGTCCTTAAATTCTGTCATAACAAGTATGAAAACAGGTGAGCTTGAGAAAGAAACAGCCCCTTTGAGGAAA GATGCAGATAGTTCAATATCAGTCTTAGAGATCCATAGTCAAAAAGCACAAATAGAGGAACCCGATCCTCCAGAAATGGAAACTTCTCTT GATTCTTCTGAGATGGCAAAAGATCTCTCTTCAAAAACTGCTTTATCTTCCACCGAGTCGTGTACCATGAAAGGTGAAGAGAAGTCTCCC AAAACTAAGAAGGATAAGCGCCCACCAATCCTAGAATGTCTTGAAAAGTTAGAGAAGTCCAAAAAGACTTTTCTTGATAAGGACGCACAA AGATTGAGTCCAATACCAGAAGAAGTTCCAAAGAGTACTCTAGAGTCAGAAAAGCCTGGCTCTCCTGAGGCAGCTGAAACTTCTCCACCA TCTAATATCATTGACCACTGTGAGAAACTAGCCTCAGAAAAAGAAGTGGTAGAATGCCAGAGTACAAGTACTGTTGGTGGCCAGTCTGTG AAAAAAGTAGACCTAGAAACCCTAAAAGAGGATTCTGAGTTCACAAAGGTAGAAATGGATAATCTGGACAATGCCCAGACCTCTGGCATA GAGGAGCCTTCTGAGACAAAGGGTTCTATGCAAAAAAGCAAATTCAAATATAAGTTGGTTCCTGAAGAAGAAACCACTGCCTCAGAAAAT ACAGAGATAACCTCTGAAAGGCAGAAAGAGGGCATCAAATTAACAATCAGGATATCAAGTCGGAAAAAGAAGCCCGATTCTCCCCCCAAA GTTCTAGAACCAGAAAACAAGCAAGAGAAGACAGAAAAGGAAGAGGAGAAAACAAATGTGGGTCGTACTTTAAGAAGATCTCCAAGAATA TCTAGACCCACTGCAAAAGTGGCTGAGATCAGAGATCAGAAAGCTGATAAAAAAAGAGGGGAAGGAGAAGATGAGGTGGAAGAAGAGTCA ACAGCTTTGCAAAAAACTGACAAAAAGGAAATTTTGAAAAAATCAGAGAAAGATACAAATTCTAAAGTAAGCAAGGTAAAACCCAAAGGC AAAGTTCGATGGACTGGTTCTCGGACACGTGGCAGATGGAAATATTCCAGCAATGATGAAAGTGAAGGGTCTGGCAGTGAAAAATCATCT GCAGCTTCAGAAGAGGAGGAAGAAAAGGAAAGTGAAGAAGCCATCCTAGCAGATGATGATGAACCATGCAAAAAATGTGGCCTTCCAAAC CATCCTGAGCTAATTCTTCTGTGTGACTCTTGCGATAGTGGATACCATACTGCCTGCCTTCGCCCTCCTCTGATGATCATCCCAGATGGA GAATGGTTCTGCCCACCTTGCCAACATAAACTGCTCTGTGAAAAATTAGAGGAACAGTTGCAGGATTTGGATGTTGCCTTAAAGAAGAAA GAGCGTGCCGAACGAAGAAAAGAACGCTTGGTGTATGTTGGTATCAGTATTGAAAACATCATTCCTCCACAAGAGCCAGACTTTTCTGAA GATCAAGAAGAAAAGAAAAAAGATTCAAAAAAATCCAAAGCAAACTTGCTTGAAAGGAGGTCAACAAGAACAAGGAAATGTATAAGCTAC AGATTTGATGAGTTTGATGAAGCAATTGATGAAGCTATTGAAGATGACATCAAAGAAGCCGATGGAGGAGGAGTTGGCCGAGGAAAAGAT ATCTCCACCATCACAGGTCATCGTGGGAAAGACATCTCTACTATTTTGGATGAAGAAAGAAAAGAAAATAAACGACCCCAGAGGGCAGCT GCTGCTCGAAGGAAGAAACGCCGGCGATTAAATGATCTGGACAGTGATAGCAACCTGGATGAAGAAGAGAGCGAGGATGAATTCAAGATC AGTGATGGATCTCAAGATGAGTTTGTTGTGTCTGATGAAAACCCAGATGAAAGTGAAGAAGATCCGCCATCTAATGATGACAGTGACACT GACTTTTGTAGCCGTAGACTGAGGCGACACCCCTCTCGGCCAATGAGGCAGAGCAGGCGTTTGCGAAGAAAGACCCCAAAGAAAAAATAT TCCGATGATGATGAAGAGGAGGAATCTGAGGAGAATAGTAGAGACTCTGAAAGTGACTTCAGTGATGATTTTAGTGATGATTTTGTAGAA ACTCGGCGAAGGCGGTCAAGGAGAAATCAGAAAAGACAAATTAACTACAAAGAAGACTCAGAAAGTGACGGTTCCCAGAAGAGTTTGCGA CGTGGTAAAGAAATAAGGCGAGTACACAAGCGAAGACTTTCCAGCTCAGAGAGTGAAGAGAGCTATTTGTCCAAGAACTCTGAAGATGAT GAGCTAGCTAAAGAATCAAAGCGGTCAGTTCGAAAGCGGGGCCGAAGCACAGACGAGTATTCAGAAGCAGATGAGGAGGAGGAGGAAGAG GAAGGCAAACCATCCCGCAAACGGCTACACCGGATTGAGACGGATGAGGAGGAGAGTTGTGACAATGCTCATGGAGATGCAAATCAGCCT GCCCGTGACAGCCAGCCTAGGGTCCTGCCCTCAGAACAAGAGAGCACCAAGAAGCCCTACCGGATAGAAAGTGATGAGGAAGAGGACTTT GAAAATGTAGGCAAAGTGGGGAGCCCATTGGACTATAGCTTAGTGGACTTACCTTCAACCAATGGACAGAGCCCTGGCAAAGCCATTGAG AACTTGATTGGCAAGCCTACTGAGAAGTCTCAGACCCCCAAGGACAACAGCACAGCCAGTGCAAGCCTAGCCTCCAATGGGACAAGTGGT GGGCAGGAGGCAGGAGCACCAGAAGAGGAGGAAGATGAGCTTTTGAGAGTGACTGACCTTGTTGATTATGTCTGTAACAGTGAACAGTTA TAAGACTTTTTTTCCATTTTTGTGCTAATTTATTCCACGGTAGCTCTCACACCAGCGGGCCAGTTATTAAAAGCTGTTTAATTTTTCCTA GAAAACTCCACTACAGAATGACTTTTAGAAGAAAAATTTCAACAAATCCTGAAGTCTTTCTGTGAAGTGACCAGTTCTGAACTTTGAAGA TAAATAATTGCTGTAAATTCCTTTTGATTTTCTTTTTCCAGGTTCATGGTCCTTGGTAATTTCATTCATGGAAAAAAATCTTATTATAAT AACAACAAAGATTTGTATATTTTTGACTTTATATTTCCTGAGCTCTCCTGACTTTGTGAAAAAGGGTGGATGAAAATGCATTCCGAATCT GTGAGGGCCCAAAACAGAATTTAGGGGTGGGTGAAAGCACTTGTGCTTTAGCTTTTTCATATTAAATATATATTATATTTAAACATTCAT GGCATAGATGATGATTTACAGACAATTTAAAAGTTCAAGTCTGTACTGTTACAGTTTGAGAATTGTAGATAACATCATACATAAGTCATT TAGTAACAGCCTTTGTGAAATGAACTTGTTTACTATTGGAGATAACCACACTTAATAAAGAAGAGACAGTGAAAGTACCATCATAATTAA 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FusionGenePPI for EXT1_RSF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EXT1 | CNTF, OSTF1, EXT1, EXT2, TRAP1, PEX19, SYNE4, PLAUR, PTCH1, ERGIC3, NAAA, SCGB2A2, B4GAT1, MPPE1, CRP, SYP, GAA, SLC39A5, TFR2, NRROS, TOR1AIP2, CD79B, FBXW7, NOTCH1 | RSF1 | NFKB1, SMARCA5, CENPA, SIRT7, SP1, COPS6, CSNK2A1, HIST1H2BG, HIST1H3A, EWSR1, MARK2, ATXN3, KAT6A, MCM2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EXT1_RSF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EXT1_RSF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EXT1 | C0015306 | Hereditary Multiple Exostoses | 8 | CTD_human;HPO;ORPHANET;UNIPROT |
| Hgene | EXT1 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | EXT1 | C0008479 | Chondrosarcoma | 1 | CTD_human;HPO;ORPHANET;UNIPROT |
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