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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12319

FusionGeneSummary for EXOSC9_MAPK10

check button Fusion gene summary
Fusion gene informationFusion gene name: EXOSC9_MAPK10
Fusion gene ID: 12319
HgeneTgene
Gene symbol

EXOSC9

MAPK10

Gene ID

5393

5602

Gene nameexosome component 9mitogen-activated protein kinase 10
SynonymsPM/Scl-75|PMSCL1|RRP45|Rrp45p|p5|p6JNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPK
Cytomap

4q27

4q21.3

Type of geneprotein-codingprotein-coding
Descriptionexosome complex component RRP45P75 polymyositis-scleroderma overlap syndrome associated autoantigenPMSCL autoantigen, 75kDautoantigen PM/Scl 1exosome complex exonuclease RRP45polymyositis/scleroderma autoantigen 1, 75kDamitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3
Modification date2018052320180524
UniProtAcc

Q06265

P53779

Ensembl transtripts involved in fusion geneENST00000243498, ENST00000509980, 
ENST00000379663, ENST00000512454, 
ENST00000395169, ENST00000359221, 
ENST00000361569, ENST00000395166, 
ENST00000449047, ENST00000395161, 
ENST00000513839, ENST00000395157, 
ENST00000395160, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 6=150
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EXOSC9 [Title/Abstract] AND MAPK10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-2Y-A9GZ-01AEXOSC9chr4

122728777

+MAPK10chr4

86952584

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000243498ENST00000395169EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000243498ENST00000359221EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000243498ENST00000361569EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000243498ENST00000395166EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000243498ENST00000449047EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000243498ENST00000395161EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
5CDS-intronENST00000243498ENST00000513839EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
5CDS-intronENST00000243498ENST00000395157EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
5CDS-intronENST00000243498ENST00000395160EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
3UTR-3CDSENST00000509980ENST00000395169EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
3UTR-3CDSENST00000509980ENST00000359221EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
3UTR-3CDSENST00000509980ENST00000361569EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
3UTR-3CDSENST00000509980ENST00000395166EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
3UTR-3CDSENST00000509980ENST00000449047EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
3UTR-3CDSENST00000509980ENST00000395161EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
3UTR-intronENST00000509980ENST00000513839EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
3UTR-intronENST00000509980ENST00000395157EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
3UTR-intronENST00000509980ENST00000395160EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000379663ENST00000395169EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000379663ENST00000359221EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000379663ENST00000361569EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000379663ENST00000395166EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000379663ENST00000449047EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000379663ENST00000395161EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
5CDS-intronENST00000379663ENST00000513839EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
5CDS-intronENST00000379663ENST00000395157EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
5CDS-intronENST00000379663ENST00000395160EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000512454ENST00000395169EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000512454ENST00000359221EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000512454ENST00000361569EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000512454ENST00000395166EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000512454ENST00000449047EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
Frame-shiftENST00000512454ENST00000395161EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
5CDS-intronENST00000512454ENST00000513839EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
5CDS-intronENST00000512454ENST00000395157EXOSC9chr4

122728777

+MAPK10chr4

86952584

-
5CDS-intronENST00000512454ENST00000395160EXOSC9chr4

122728777

+MAPK10chr4

86952584

-

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FusionProtFeatures for EXOSC9_MAPK10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EXOSC9

Q06265

MAPK10

P53779

Non-catalytic component of the RNA exosome complex whichhas 3'->5' exoribonuclease activity and participates in amultitude of cellular RNA processing and degradation events. Inthe nucleus, the RNA exosome complex is involved in propermaturation of stable RNA species such as rRNA, snRNA and snoRNA,in the elimination of RNA processing by-products and non-coding'pervasive' transcripts, such as antisense RNA species andpromoter-upstream transcripts (PROMPTs), and of mRNAs withprocessing defects, thereby limiting or excluding their export tothe cytoplasm. The RNA exosome may be involved in Ig class switchrecombination (CSR) and/or Ig variable region somatichypermutation (SHM) by targeting AICDA deamination activity totranscribed dsDNA substrates. In the cytoplasm, the RNA exosomecomplex is involved in general mRNA turnover and specificallydegrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNAsurveillance pathways, preventing translation of aberrant mRNAs.It seems to be involved in degradation of histone mRNA. Thecatalytic inactive RNA exosome core complex of 9 subunits (Exo-9)is proposed to play a pivotal role in the binding and presentationof RNA for ribonucleolysis, and to serve as a scaffold for theassociation with catalytic subunits and accessory proteins orcomplexes. EXOSC9 binds to ARE-containing RNAs.{ECO:0000269|PubMed:11782436, ECO:0000269|PubMed:16455498,ECO:0000269|PubMed:16912217, ECO:0000269|PubMed:17545563}. Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation,migration and programmed cell death. Extracellular stimuli such asproinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)signaling pathway. In this cascade, two dual specificity kinasesMAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activateMAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number oftranscription factors, primarily components of AP-1 such as JUNand ATF2 and thus regulates AP-1 transcriptional activity. Playsregulatory roles in the signaling pathways during neuronalapoptosis. Phosphorylates the neuronal microtubule regulatorSTMN2. Acts in the regulation of the amyloid-beta precursorprotein/APP signaling during neuronal differentiation byphosphorylating APP. Participates also in neurite growth in spiralganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimerand plays a role in the photic regulation of the circadian clock(PubMed:22441692). {ECO:0000269|PubMed:11718727,ECO:0000269|PubMed:22441692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EXOSC9_MAPK10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EXOSC9_MAPK10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EXOSC9UBE2I, CUL3, COPS5, CAND1, CHMP4B, EXOSC4, DIS3, DIS3L, EXOSC3, EXOSC2, EXOSC5, EXOSC10, CSNK2A1, AICDA, MPG, ZDHHC17, OBSL1, SUMO2, EXOSC7, EXOSC8, EXOSC1, EXOSC6, PSMA2, PSMA6, PSMA7, STAG1, STAG2, MPHOSPH6, PSMA5, NTRK1, EEF1G, HP, RBM7, NOP56, TKT, TRIP12, C1D, HBS1L, ZNF106, SLC35E1, KIAA1804, DAB2IP, FAM111B, YBX1, USP37, LUM, RSRC1, SLIT2, LRRC47, NCL, FOXA1MAPK10MAPK8IP3, GTF3C1, UNC119, ARRB2, ARRB1, SH3BP5, DUSP1, DUSP10, DUSP16, TP53, MAPK8IP2, MCL1, CREBBP, CEP290, KIF26A, HDAC9, HDAC1, PLIN2, MAP2K4, CDKN1B, JUN, APP, ATF2, ELK1, PKMYT1, MAPK10, CDKN2A, CDKN2C, GCH1, RELA, HAX1, TNIP1, MAPK9, MSN, EZR, RDX, WDR62, IMPDH2, DDX5, LDHA, CCT7, CCT6B, CCT2, DDI1, DUSP9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EXOSC9_MAPK10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EXOSC9_MAPK10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource