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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12305

FusionGeneSummary for EXOSC10_MTOR

check button Fusion gene summary
Fusion gene informationFusion gene name: EXOSC10_MTOR
Fusion gene ID: 12305
HgeneTgene
Gene symbol

EXOSC10

MTOR

Gene ID

5394

2475

Gene nameexosome component 10mechanistic target of rapamycin kinase
SynonymsPM-Scl|PM/Scl-100|PMSCL|PMSCL2|RRP6|Rrp6p|p2|p3|p4FRAP|FRAP1|FRAP2|RAFT1|RAPT1|SKS
Cytomap

1p36.22

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionexosome component 10P100 polymyositis-scleroderma overlap syndrome-associated autoantigenautoantigen PM-SCLpolymyositis/scleroderma autoantigen 100 kDapolymyositis/scleroderma autoantigen 2serine/threonine-protein kinase mTORFK506 binding protein 12-rapamycin associated protein 2FK506-binding protein 12-rapamycin complex-associated protein 1FKBP-rapamycin associated proteinFKBP12-rapamycin complex-associated protein 1mammalian target o
Modification date2018052220180527
UniProtAcc

Q01780

P42345

Ensembl transtripts involved in fusion geneENST00000304457, ENST00000376936, 
ENST00000544779, ENST00000485606, 
ENST00000361445, ENST00000376838, 
ENST00000495435, 
Fusion gene scores* DoF score2 X 3 X 3=1811 X 12 X 7=924
# samples 316
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/924*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EXOSC10 [Title/Abstract] AND MTOR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMTOR

GO:0001558

regulation of cell growth

18762023

TgeneMTOR

GO:0001934

positive regulation of protein phosphorylation

20233713

TgeneMTOR

GO:0006468

protein phosphorylation

12150926|15467718|18925875

TgeneMTOR

GO:0009267

cellular response to starvation

28223137

TgeneMTOR

GO:0016242

negative regulation of macroautophagy

25327288

TgeneMTOR

GO:0016310

phosphorylation

11853878|25327288

TgeneMTOR

GO:0034198

cellular response to amino acid starvation

22424946

TgeneMTOR

GO:0038202

TORC1 signaling

28223137

TgeneMTOR

GO:0043200

response to amino acid

18497260

TgeneMTOR

GO:0045727

positive regulation of translation

18762023

TgeneMTOR

GO:0046777

protein autophosphorylation

15467718

TgeneMTOR

GO:0071230

cellular response to amino acid stimulus

22424946

TgeneMTOR

GO:0071233

cellular response to leucine

22424946

TgeneMTOR

GO:1990253

cellular response to leucine starvation

22424946


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVACCTCGA-OR-A5J7-01AEXOSC10chr1

11139768

-MTORchr1

11190834

-
TCGALDBRCATCGA-E9-A244-01AEXOSC10chr1

11140556

-MTORchr1

11177143

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000304457ENST00000361445EXOSC10chr1

11139768

-MTORchr1

11190834

-
5CDS-5UTRENST00000304457ENST00000376838EXOSC10chr1

11139768

-MTORchr1

11190834

-
5CDS-intronENST00000304457ENST00000495435EXOSC10chr1

11139768

-MTORchr1

11190834

-
In-frameENST00000376936ENST00000361445EXOSC10chr1

11139768

-MTORchr1

11190834

-
5CDS-5UTRENST00000376936ENST00000376838EXOSC10chr1

11139768

-MTORchr1

11190834

-
5CDS-intronENST00000376936ENST00000495435EXOSC10chr1

11139768

-MTORchr1

11190834

-
Frame-shiftENST00000544779ENST00000361445EXOSC10chr1

11139768

-MTORchr1

11190834

-
5CDS-5UTRENST00000544779ENST00000376838EXOSC10chr1

11139768

-MTORchr1

11190834

-
5CDS-intronENST00000544779ENST00000495435EXOSC10chr1

11139768

-MTORchr1

11190834

-
intron-3CDSENST00000485606ENST00000361445EXOSC10chr1

11139768

-MTORchr1

11190834

-
intron-5UTRENST00000485606ENST00000376838EXOSC10chr1

11139768

-MTORchr1

11190834

-
intron-intronENST00000485606ENST00000495435EXOSC10chr1

11139768

-MTORchr1

11190834

-
Frame-shiftENST00000304457ENST00000361445EXOSC10chr1

11140556

-MTORchr1

11177143

-
Frame-shiftENST00000304457ENST00000376838EXOSC10chr1

11140556

-MTORchr1

11177143

-
5CDS-intronENST00000304457ENST00000495435EXOSC10chr1

11140556

-MTORchr1

11177143

-
Frame-shiftENST00000376936ENST00000361445EXOSC10chr1

11140556

-MTORchr1

11177143

-
Frame-shiftENST00000376936ENST00000376838EXOSC10chr1

11140556

-MTORchr1

11177143

-
5CDS-intronENST00000376936ENST00000495435EXOSC10chr1

11140556

-MTORchr1

11177143

-
Frame-shiftENST00000544779ENST00000361445EXOSC10chr1

11140556

-MTORchr1

11177143

-
Frame-shiftENST00000544779ENST00000376838EXOSC10chr1

11140556

-MTORchr1

11177143

-
5CDS-intronENST00000544779ENST00000495435EXOSC10chr1

11140556

-MTORchr1

11177143

-
intron-3CDSENST00000485606ENST00000361445EXOSC10chr1

11140556

-MTORchr1

11177143

-
intron-3CDSENST00000485606ENST00000376838EXOSC10chr1

11140556

-MTORchr1

11177143

-
intron-intronENST00000485606ENST00000495435EXOSC10chr1

11140556

-MTORchr1

11177143

-

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FusionProtFeatures for EXOSC10_MTOR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EXOSC10

Q01780

MTOR

P42345

Putative catalytic component of the RNA exosome complexwhich has 3'->5' exoribonuclease activity and participates in amultitude of cellular RNA processing and degradation events. Inthe nucleus, the RNA exosome complex is involved in propermaturation of stable RNA species such as rRNA, snRNA and snoRNA,in the elimination of RNA processing by-products and non-coding'pervasive' transcripts, such as antisense RNA species andpromoter-upstream transcripts (PROMPTs), and of mRNAs withprocessing defects, thereby limiting or excluding their export tothe cytoplasm. The RNA exosome may be involved in Ig class switchrecombination (CSR) and/or Ig variable region somatichypermutation (SHM) by targeting AICDA deamination activity totranscribed dsDNA substrates. In the cytoplasm, the RNA exosomecomplex is involved in general mRNA turnover and specificallydegrades inherently unstable mRNAs containing AU-rich elements(AREs) within their 3' untranslated regions, and in RNAsurveillance pathways, preventing translation of aberrant mRNAs.It seems to be involved in degradation of histone mRNA. EXOSC10has 3'-5' exonuclease activity (By similarity). EXOSC10 isrequired for nucleolar localization of C1D and probably mediatesthe association of MTREX, C1D and MPP6 wth the RNA exosomeinvolved in the maturation of 5.8S rRNA. {ECO:0000250,ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498,ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563,ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938,ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273}. Serine/threonine protein kinase which is a centralregulator of cellular metabolism, growth and survival in responseto hormones, growth factors, nutrients, energy and stress signals.MTOR directly or indirectly regulates the phosphorylation of atleast 800 proteins. Functions as part of 2 structurally andfunctionally distinct signaling complexes mTORC1 and mTORC2 (mTORcomplex 1 and 2). Activated mTORC1 up-regulates protein synthesisby phosphorylating key regulators of mRNA translation and ribosomesynthesis. This includes phosphorylation of EIF4EBP1 and releaseof its inhibition toward the elongation initiation factor 4E(eiF4E). Moreover, phosphorylates and activates RPS6KB1 andRPS6KB2 that promote protein synthesis by modulating the activityof their downstream targets including ribosomal protein S6,eukaryotic translation initiation factor EIF4B, and the inhibitorof translation initiation PDCD4. Stimulates the pyrimidinebiosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, anddelayed regulation, through transcriptional enhancement of thepentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a laterstep in synthesis, this function is dependent on the mTORC1complex. Regulates ribosome synthesis by activating RNA polymeraseIII-dependent transcription through phosphorylation and inhibitionof MAF1 an RNA polymerase III-repressor. In parallel to proteinsynthesis, also regulates lipid synthesis through SREBF1/SREBP1and LPIN1. To maintain energy homeostasis mTORC1 may also regulatemitochondrial biogenesis through regulation of PPARGC1A. mTORC1also negatively regulates autophagy through phosphorylation ofULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventingactivation of ULK1. Also prevents autophagy throughphosphorylation of the autophagy inhibitor DAP. mTORC1 exerts afeedback control on upstream growth factor signaling that includesphosphorylation and activation of GRB10 a INSR-dependent signalingsuppressor. Among other potential targets mTORC1 may phosphorylateCLIP1 and regulate microtubules. As part of the mTORC2 complexMTOR may regulate other cellular processes including survival andorganization of the cytoskeleton. Plays a critical role in thephosphorylation at 'Ser-473' of AKT1, a pro-survival effector ofphosphoinositide 3-kinase, facilitating its activation by PDK1.mTORC2 may regulate the actin cytoskeleton, throughphosphorylation of PRKCA, PXN and activation of the Rho-typeguanine nucleotide exchange factors RHOA and RAC1A or RAC1B.mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'(PubMed:12087098, PubMed:12150925, PubMed:12150926,PubMed:12231510, PubMed:12718876, PubMed:14651849,PubMed:15268862, PubMed:15467718, PubMed:15545625,PubMed:15718470, PubMed:18497260, PubMed:18762023,PubMed:18925875, PubMed:20516213, PubMed:20537536,PubMed:21659604, PubMed:23429703, PubMed:23429704,PubMed:25799227, PubMed:26018084). Regulates osteoclastogenesis byadjusting the expression of CEBPB isoforms (By similarity).{ECO:0000250|UniProtKB:Q9JLN9, ECO:0000269|PubMed:12087098,ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12150926,ECO:0000269|PubMed:12231510, ECO:0000269|PubMed:12718876,ECO:0000269|PubMed:14651849, ECO:0000269|PubMed:15268862,ECO:0000269|PubMed:15467718, ECO:0000269|PubMed:15545625,ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:18497260,ECO:0000269|PubMed:18762023, ECO:0000269|PubMed:18925875,ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20537536,ECO:0000269|PubMed:21659604, ECO:0000269|PubMed:23429703,ECO:0000269|PubMed:23429704, ECO:0000269|PubMed:25799227,ECO:0000269|PubMed:26018084}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEXOSC10chr1:11139768chr1:11190834ENST00000304457-1424503_583583861DomainHRDC
HgeneEXOSC10chr1:11139768chr1:11190834ENST00000376936-1425503_583583886DomainHRDC
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37582182_251617882550DomainPI3K/PI4K
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37582517_254917882550DomainFATC
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581787_184617882550RepeatNote=TPR 13
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581898_193017882550RepeatNote=TPR 14
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581931_197017882550RepeatNote=TPR 15
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581971_200517882550RepeatNote=TPR 16

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581382_198217882550DomainFAT
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758100_13717882550RepeatNote=HEAT 3
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581029_106817882550RepeatNote=HEAT 25
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581069_110517882550RepeatNote=HEAT 26
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581106_114417882550RepeatNote=HEAT 27
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581145_118817882550RepeatNote=HEAT 28
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581189_122517882550RepeatNote=HEAT 29
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581226_127317882550RepeatNote=HEAT 30
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581274_131117882550RepeatNote=HEAT 31
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581312_134517882550RepeatNote=HEAT 32
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581346_138217882550RepeatNote=TPR 1
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581383_140817882550RepeatNote=TPR 2
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758138_17917882550RepeatNote=HEAT 4
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581409_144217882550RepeatNote=TPR 3
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581443_147317882550RepeatNote=TPR 4
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581474_150717882550RepeatNote=TPR 5
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581508_154117882550RepeatNote=TPR 6
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581542_157417882550RepeatNote=TPR 7
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581575_161417882550RepeatNote=TPR 8
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581615_164917882550RepeatNote=TPR 9
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581650_169317882550RepeatNote=TPR 10
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581694_173117882550RepeatNote=TPR 11
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-375816_5317882550RepeatNote=HEAT 1
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581732_178617882550RepeatNote=TPR 12
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758180_22017882550RepeatNote=HEAT 5
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758222_27617882550RepeatNote=HEAT 6
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758277_31317882550RepeatNote=HEAT 7
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758314_36417882550RepeatNote=HEAT 8
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758365_40917882550RepeatNote=HEAT 9
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758410_44517882550RepeatNote=HEAT 10
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758446_49417882550RepeatNote=HEAT 11
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758495_52917882550RepeatNote=HEAT 12
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758530_56317882550RepeatNote=HEAT 13
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-375855_9917882550RepeatNote=HEAT 2
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758564_59617882550RepeatNote=HEAT 14
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758597_63617882550RepeatNote=HEAT 15
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758637_68317882550RepeatNote=HEAT 16
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758686_72417882550RepeatNote=HEAT 17
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758727_76617882550RepeatNote=HEAT 18
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758769_81117882550RepeatNote=HEAT 19
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758814_85317882550RepeatNote=HEAT 20
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758857_89317882550RepeatNote=HEAT 21
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758894_94217882550RepeatNote=HEAT 22
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758943_98817882550RepeatNote=HEAT 23
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-3758989_102717882550RepeatNote=HEAT 24


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FusionGeneSequence for EXOSC10_MTOR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EXOSC10_MTOR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EXOSC10MPP6, UPF1, UPF2, UPF3A, HDGF, SIRT7, CUL3, CAND1, EXOSC4, DIS3, DIS3L, EXOSC3, EXOSC5, EXOSC9, ESR1, AICDA, EXOSC6, EXOSC7, EXOSC8, SKIV2L, CIB1, TOX4, SCRIB, PTGES2, RUVBL2, NOMO1, NOMO2, SSRP1, USP21, B9D1, FOXRED1, CHPF, IMMT, RPE, FERMT3, LCAT, ALDH1B1, DXO, XRN2, LSM2, LSM8, XRN1, EIF3M, TARDBP, USP16, RPA3, RPA2, RPA1, MOV10, NXF1, OBSL1, SUMO2, EXOSC1, EXOSC2, MPHOSPH6, HNRNPR, SKIV2L2, SSB, SUPT6H, UTP14A, NTRK1, KRAS, IFI16, HNRNPU, NPM1, RBM7, SNW1, CDC5L, NANOG, POU5F1, C1D, ZC3H18, RPL18A, NCL, FOXA1, BRCA1, MTF1MTORUBQLN1, RICTOR, RPTOR, FKBP1A, ABL1, EIF4EBP1, AKT1, MTOR, IRS1, LRPAP1, PRKAA1, PRKCD, RHEB, RPS6KB1, CLIP1, STAT1, EIF3B, EIF3C, EIF3F, GPHN, MAPKAP1, GDI2P1, PA2G4, PDK1, CFP, PLD2, PPP2R2A, RAP1A, STAT3, TERT, MLST8, FBXW7, TTI1, TELO2, DEPTOR, PRR5, PRKCA, RPL23, RPS6, RPL23A, RPL26, RPL5, GSK3B, C7orf25, CDC37, SEPT2, TERF1, SIRT7, USP9X, RUVBL2, RUVBL1, SQSTM1, RRAGC, MAPK8, AKT1S1, EIF4EBP2, ULK1, RRAGD, PML, STK38, BRCA1, DDB1, VCP, METAP2, TP53, SIRT1, PREX1, PREX2, LARS, PDIA3, HSPA4, AMBRA1, TRAF6, EGFR, YWHAQ, MTA2, FKBP8, GNB1, GNG2, GNB2, GNB3, GNB5, RRAGB, PRR5L, ILK, NCBP1, EIF4E, CHUK, IKBKB, IKBKG, NFKBIA, SGK1, GADD45A, RHEBL1, SHMT2, MOV10, NXF1, MAF1, NBN, LAMTOR2, BCL2L1, SUZ12, SUMO1, GTF3C1, PRKAR1A, YWHAZ, BSG, CD274, VSIG2, CA14, NT5E, CD244, LYPD3, RP2, SCN2B, HTR6, MLXIP, MLXIPL, DIAPH1, TRMT61A, XPO1, HNRNPD, LLGL2, YEATS4, SYNCRIP, SGTB, VPS16, NAF1, ASPM, BAG6, ZSCAN26, TRAF2, TNFAIP3, RAB1A, RAP2A, PARK2, BRAT1, MAP3K3, DCP2, MTMR3, ZNRF2, FBXO8, PDGFRA, PRKDC, CHEK1, KDM5C, IGF1R, SMAD4, TOP1, CASP8, PTEN, LEFTY1, SCN3B, VIPR2, NTRK3, NPY2R, CD83, TMEM206, DPEP1, HTT, THADA, SMDT1, XPO6, XPO4, MAP2K1, MAPK1, RABGGTB, FNTA, TUBA1A, WEE1, ESR1, TRIM25, SKP2, EP300


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37582258_229617882550MLST8


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMTORchr1:11139768chr1:11190834ENST00000361445-37581_65117882550NBN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EXOSC10_MTOR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMTORP42345DB01590EverolimusSerine/threonine-protein kinase mTORsmall moleculeapproved
TgeneMTORP42345DB06287TemsirolimusSerine/threonine-protein kinase mTORsmall moleculeapproved
TgeneMTORP42345DB00337PimecrolimusSerine/threonine-protein kinase mTORsmall moleculeapproved|investigational
TgeneMTORP42345DB00877SirolimusSerine/threonine-protein kinase mTORsmall moleculeapproved|investigational

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RelatedDiseases for EXOSC10_MTOR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMTORC0041696Unipolar Depression2PSYGENET
TgeneMTORC1269683Major Depressive Disorder2PSYGENET
TgeneMTORC0001418Adenocarcinoma1CTD_human
TgeneMTORC0007134Renal Cell Carcinoma1CTD_human
TgeneMTORC0007873Uterine Cervical Neoplasm1CTD_human
TgeneMTORC0020538Hypertensive disease1CTD_human
TgeneMTORC0025500Mesothelioma1CTD_human
TgeneMTORC0036341Schizophrenia1CTD_human
TgeneMTORC0149721Left Ventricular Hypertrophy1CTD_human
TgeneMTORC0235032Neurotoxicity Syndromes1CTD_human
TgeneMTORC0262584Carcinoma, Small Cell1CTD_human
TgeneMTORC0334634Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse1CTD_human
TgeneMTORC0588006Mild depression1PSYGENET
TgeneMTORC0919267ovarian neoplasm1CTD_human
TgeneMTORC1955869Malformations of Cortical Development1CTD_human
TgeneMTORC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneMTORC2239176Liver carcinoma1CTD_human
TgeneMTORC4225259SMITH-KINGSMORE SYNDROME1ORPHANET;UNIPROT