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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12278

FusionGeneSummary for EXOC4_SUPT3H

check button Fusion gene summary
Fusion gene informationFusion gene name: EXOC4_SUPT3H
Fusion gene ID: 12278
HgeneTgene
Gene symbol

EXOC4

SUPT3H

Gene ID

60412

8464

Gene nameexocyst complex component 4SPT3 homolog, SAGA and STAGA complex component
SynonymsSEC8|SEC8L1|Sec8pSPT3|SPT3L
Cytomap

7q33

6p21.1

Type of geneprotein-codingprotein-coding
Descriptionexocyst complex component 4SEC8-like 1exocyst complex component Sec8transcription initiation protein SPT3 homologSPT3-like proteinsuppressor of Ty 3 homolog
Modification date2018052320180523
UniProtAcc

Q96A65

O75486

Ensembl transtripts involved in fusion geneENST00000253861, ENST00000539845, 
ENST00000393161, ENST00000545148, 
ENST00000460346, ENST00000541309, 
ENST00000371460, ENST00000371459, 
ENST00000371461, ENST00000306867, 
ENST00000371458, ENST00000459689, 
Fusion gene scores* DoF score17 X 13 X 8=176815 X 7 X 9=945
# samples 1615
** MAII scorelog2(16/1768*10)=-3.46597446450407
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/945*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EXOC4 [Title/Abstract] AND SUPT3H [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSUPT3H

GO:0016578

histone deubiquitination

18206972

TgeneSUPT3H

GO:0043966

histone H3 acetylation

11564863


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-86-8585-01AEXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000253861ENST00000371460EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000253861ENST00000371459EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000253861ENST00000371461EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000253861ENST00000306867EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000253861ENST00000371458EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
5CDS-intronENST00000253861ENST00000459689EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000539845ENST00000371460EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000539845ENST00000371459EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000539845ENST00000371461EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000539845ENST00000306867EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000539845ENST00000371458EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
5CDS-intronENST00000539845ENST00000459689EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000393161ENST00000371460EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000393161ENST00000371459EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000393161ENST00000371461EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000393161ENST00000306867EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
Frame-shiftENST00000393161ENST00000371458EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
5CDS-intronENST00000393161ENST00000459689EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000545148ENST00000371460EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000545148ENST00000371459EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000545148ENST00000371461EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000545148ENST00000306867EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000545148ENST00000371458EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-intronENST00000545148ENST00000459689EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000460346ENST00000371460EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000460346ENST00000371459EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000460346ENST00000371461EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000460346ENST00000306867EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000460346ENST00000371458EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-intronENST00000460346ENST00000459689EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000541309ENST00000371460EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000541309ENST00000371459EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000541309ENST00000371461EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000541309ENST00000306867EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-3CDSENST00000541309ENST00000371458EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-
intron-intronENST00000541309ENST00000459689EXOC4chr7

133164892

+SUPT3Hchr6

44797594

-

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FusionProtFeatures for EXOC4_SUPT3H


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EXOC4

Q96A65

SUPT3H

O75486

Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane.{ECO:0000250}. Probable transcriptional activator.{ECO:0000269|PubMed:9787080}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EXOC4_SUPT3H


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EXOC4_SUPT3H


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EXOC4MYC, DLG3, EXOC3, GRIN2B, DLG4, EXOC7, GTF2E2, DISC1, DTNBP1, CEP63, EXOC1, MYO5A, EXOC2, EXOC8, EXOC5, IQCB1, EGFR, ATG5, ATG12, BECN1, SNAP29, BSG, TPM1, SETDB1, EXOC6, NTRK1, MED4, SCLT1, OFD1, PCM1, CNTROB, FGFR1OP, CEP128, CEP44, CNTRL, ODF2, DYNLT1, TMEM17, SNW1, CDC5L, PTAR1, MTMR4, STX11, IKBIP, IL1R2, GGA1, APLNR, EXOC3L2, EXOC6B, TSSC1, RABEP2, VPS51, RABEP1, RALB, TRIM25SUPT3HMYC, TAF4, TAF5, KAT2A, TAF10, TRRAP, TAF6L, TAF5L, TADA3, TADA1, SF3B3, SUPT7L, TAF9, TAF12, DDB1, DDB2, ATXN7L3, USP22, ATXN7, TP53, KAT2B, MED1, MED16, MED17, MED13, MED12, PYGO2, TADA2B, CCDC101, SAP130, TADA2A, TCF3, HIST3H3, SUPT20H, SSSCA1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EXOC4_SUPT3H


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EXOC4_SUPT3H


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource