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Fusion gene ID: 12274 |
FusionGeneSummary for EXOC4_PTAFR |
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Fusion gene information | Fusion gene name: EXOC4_PTAFR | Fusion gene ID: 12274 | Hgene | Tgene | Gene symbol | EXOC4 | PTAFR | Gene ID | 60412 | 5724 |
Gene name | exocyst complex component 4 | platelet activating factor receptor | |
Synonyms | SEC8|SEC8L1|Sec8p | PAFR | |
Cytomap | 7q33 | 1p35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | exocyst complex component 4SEC8-like 1exocyst complex component Sec8 | platelet-activating factor receptorPAF-R | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96A65 | P25105 | |
Ensembl transtripts involved in fusion gene | ENST00000253861, ENST00000539845, ENST00000393161, ENST00000545148, ENST00000460346, ENST00000541309, | ENST00000373857, ENST00000539896, ENST00000305392, | |
Fusion gene scores | * DoF score | 17 X 13 X 8=1768 | 1 X 1 X 1=1 |
# samples | 16 | 1 | |
** MAII score | log2(16/1768*10)=-3.46597446450407 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: EXOC4 [Title/Abstract] AND PTAFR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PTAFR | GO:0048015 | phosphatidylinositol-mediated signaling | 1657923 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-05-4398-01A | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000253861 | ENST00000373857 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
5CDS-5UTR | ENST00000253861 | ENST00000539896 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
5CDS-5UTR | ENST00000253861 | ENST00000305392 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
5CDS-5UTR | ENST00000539845 | ENST00000373857 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
5CDS-5UTR | ENST00000539845 | ENST00000539896 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
5CDS-5UTR | ENST00000539845 | ENST00000305392 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
intron-5UTR | ENST00000393161 | ENST00000373857 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
intron-5UTR | ENST00000393161 | ENST00000539896 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
intron-5UTR | ENST00000393161 | ENST00000305392 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
5CDS-5UTR | ENST00000545148 | ENST00000373857 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
5CDS-5UTR | ENST00000545148 | ENST00000539896 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
5CDS-5UTR | ENST00000545148 | ENST00000305392 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
3UTR-5UTR | ENST00000460346 | ENST00000373857 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
3UTR-5UTR | ENST00000460346 | ENST00000539896 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
3UTR-5UTR | ENST00000460346 | ENST00000305392 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
intron-5UTR | ENST00000541309 | ENST00000373857 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
intron-5UTR | ENST00000541309 | ENST00000539896 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
intron-5UTR | ENST00000541309 | ENST00000305392 | EXOC4 | chr7 | 133314894 | + | PTAFR | chr1 | 28477570 | - |
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FusionProtFeatures for EXOC4_PTAFR |
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Hgene | Tgene |
EXOC4 | PTAFR |
Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane.{ECO:0000250}. | Receptor for platelet activating factor, a chemotacticphospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate itsaction via a G protein that activates a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:1281995,ECO:0000269|PubMed:1374385, ECO:0000269|PubMed:1656963,ECO:0000269|PubMed:1657923}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EXOC4_PTAFR |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EXOC4_PTAFR |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EXOC4 | MYC, DLG3, EXOC3, GRIN2B, DLG4, EXOC7, GTF2E2, DISC1, DTNBP1, CEP63, EXOC1, MYO5A, EXOC2, EXOC8, EXOC5, IQCB1, EGFR, ATG5, ATG12, BECN1, SNAP29, BSG, TPM1, SETDB1, EXOC6, NTRK1, MED4, SCLT1, OFD1, PCM1, CNTROB, FGFR1OP, CEP128, CEP44, CNTRL, ODF2, DYNLT1, TMEM17, SNW1, CDC5L, PTAR1, MTMR4, STX11, IKBIP, IL1R2, GGA1, APLNR, EXOC3L2, EXOC6B, TSSC1, RABEP2, VPS51, RABEP1, RALB, TRIM25 | PTAFR | ARRB2, PTK2, JAK2, TYK2, ARRB1, CLTC, CALM1, GTPBP3, GORAB, SPATA24 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EXOC4_PTAFR |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PTAFR | P25105 | DB09166 | Etizolam | Platelet-activating factor receptor | small molecule | approved |
Tgene | PTAFR | P25105 | DB11614 | Rupatadine | Platelet-activating factor receptor | small molecule | approved |
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RelatedDiseases for EXOC4_PTAFR |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PTAFR | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PTAFR | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |