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Fusion gene ID: 12263 |
FusionGeneSummary for EXOC2_SH3RF3 |
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Fusion gene information | Fusion gene name: EXOC2_SH3RF3 | Fusion gene ID: 12263 | Hgene | Tgene | Gene symbol | EXOC2 | SH3RF3 | Gene ID | 55770 | 344558 |
Gene name | exocyst complex component 2 | SH3 domain containing ring finger 3 | |
Synonyms | SEC5|SEC5L1|Sec5p | POSH2|SH3MD4 | |
Cytomap | 6p25.3 | 2q13 | |
Type of gene | protein-coding | protein-coding | |
Description | exocyst complex component 2SEC5-like 1exocyst complex component Sec5 | SH3 domain-containing RING finger protein 3SH3 multiple domains 4plenty of SH3s-2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q96KP1 | Q8TEJ3 | |
Ensembl transtripts involved in fusion gene | ENST00000230449, ENST00000448181, ENST00000475028, | ENST00000309415, | |
Fusion gene scores | * DoF score | 7 X 4 X 7=196 | 4 X 4 X 2=32 |
# samples | 7 | 4 | |
** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: EXOC2 [Title/Abstract] AND SH3RF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-C8-A12U-01A | EXOC2 | chr6 | 693019 | - | SH3RF3 | chr2 | 109964130 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000230449 | ENST00000309415 | EXOC2 | chr6 | 693019 | - | SH3RF3 | chr2 | 109964130 | + |
5UTR-3CDS | ENST00000448181 | ENST00000309415 | EXOC2 | chr6 | 693019 | - | SH3RF3 | chr2 | 109964130 | + |
5UTR-3CDS | ENST00000475028 | ENST00000309415 | EXOC2 | chr6 | 693019 | - | SH3RF3 | chr2 | 109964130 | + |
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FusionProtFeatures for EXOC2_SH3RF3 |
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Hgene | Tgene |
EXOC2 | SH3RF3 |
Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane. | Has E3 ubiquitin-protein ligase activity.{ECO:0000269|PubMed:20696164}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EXOC2_SH3RF3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EXOC2_SH3RF3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EXOC2 | EXOC8, RALB, RALA, SERGEF, VPS53, EXOC4, EXOC3, EXOC7, EXOC5, EXOC6, GET4, ESX1, TBK1, BECN1, USP33, KIAA0226, ATG14, PIK3C3, ULK1, SHMT2, MOV10, NXF1, BSG, LPAR6, PTGER3, SCN2B, SCARA3, HTR6, EXOC1, PGM1, SPTBN2, NTRK1, RANBP9, SNW1, CDC5L, PTAR1, IL1R2, EDNRB, APLNR, CHRM3, EXOC6B, CDKN2A | SH3RF3 | RAC1, CDC42, PAK2, ADAM15, YWHAB, KCTD3, KIF13B, CGN, ZBTB21, KSR1, GIGYF1, LPIN3, LRFN1, RTKN, DENND4C, MAST3, DENND1A, SH3PXD2A, SRGAP2, PPM1H, TANC2, PTPN13, RALGPS2, EIF4E2, SIPA1L1, NF1, CDC25C, CBY1, GIGYF2, LIMA1, MAGI1, HDAC4, TESK2, DCLK1, MAPKAP1, INPP5E, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EXOC2_SH3RF3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EXOC2_SH3RF3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SH3RF3 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |