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Fusion gene ID: 12254 |
FusionGeneSummary for EXOC1_IDO1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EXOC1_IDO1 | Fusion gene ID: 12254 | Hgene | Tgene | Gene symbol | EXOC1 | IDO1 | Gene ID | 55763 | 3620 |
| Gene name | exocyst complex component 1 | indoleamine 2,3-dioxygenase 1 | |
| Synonyms | BM-102|SEC3|SEC3L1|SEC3P | IDO|IDO-1|INDO | |
| Cytomap | 4q12 | 8p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | exocyst complex component 1SEC3-like 1exocyst complex component Sec3 | indoleamine 2,3-dioxygenase 1indolamine 2,3 dioxygenaseindole 2,3-dioxygenaseindoleamine-pyrrole 2,3-dioxygenase | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9NV70 | P14902 | |
| Ensembl transtripts involved in fusion gene | ENST00000381295, ENST00000346134, ENST00000349598, | ENST00000522495, ENST00000518237, | |
| Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 4 X 4 X 4=64 |
| # samples | 4 | 4 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EXOC1 [Title/Abstract] AND IDO1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | EXOC1 | GO:0048015 | phosphatidylinositol-mediated signaling | 25591774 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-97-8179-01A | EXOC1 | chr4 | 56768704 | + | IDO1 | chr8 | 39780071 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000381295 | ENST00000522495 | EXOC1 | chr4 | 56768704 | + | IDO1 | chr8 | 39780071 | + |
| Frame-shift | ENST00000381295 | ENST00000518237 | EXOC1 | chr4 | 56768704 | + | IDO1 | chr8 | 39780071 | + |
| Frame-shift | ENST00000346134 | ENST00000522495 | EXOC1 | chr4 | 56768704 | + | IDO1 | chr8 | 39780071 | + |
| Frame-shift | ENST00000346134 | ENST00000518237 | EXOC1 | chr4 | 56768704 | + | IDO1 | chr8 | 39780071 | + |
| Frame-shift | ENST00000349598 | ENST00000522495 | EXOC1 | chr4 | 56768704 | + | IDO1 | chr8 | 39780071 | + |
| Frame-shift | ENST00000349598 | ENST00000518237 | EXOC1 | chr4 | 56768704 | + | IDO1 | chr8 | 39780071 | + |
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FusionProtFeatures for EXOC1_IDO1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EXOC1 | IDO1 |
| Component of the exocyst complex involved in the dockingof exocytic vesicles with fusion sites on the plasma membrane. (Microbial infection) Has an antiviral effect againstflaviviruses by affecting viral RNA transcription and translationthrough the sequestration of elongation factor 1-alpha (EEF1A1).This results in decreased viral RNA synthesis and decreased viralprotein translation. {ECO:0000269|PubMed:19889084}. | Catalyzes the first and rate limiting step of thecatabolism of the essential amino acid tryptophan along thekynurenine pathway (PubMed:17671174). Involved in the peripheralimmune tolerance, contributing to maintain homeostasis bypreventing autoimmunity or immunopathology that would result fromuncontrolled and overreacting immune responses (PubMed:25691885).Tryptophan shortage inhibits T lymphocytes division andaccumulation of tryptophan catabolites induces T-cell apoptosisand differentiation of regulatory T-cells (PubMed:25691885). Actsas a suppressor of anti-tumor immunity (PubMed:23103127,PubMed:25157255, PubMed:14502282, PubMed:25691885). Limits thegrowth of intracellular pathogens by depriving tryptophan(PubMed:25691885). Protects the fetus from maternal immunerejection (PubMed:25691885). {ECO:0000269|PubMed:14502282,ECO:0000269|PubMed:17671174, ECO:0000303|PubMed:23103127,ECO:0000303|PubMed:25157255, ECO:0000303|PubMed:25691885}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EXOC1_IDO1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EXOC1_IDO1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EXOC1 | CDC5L, DISC1, TRAF3IP1, TRIO, DST, LUC7L2, EXOC4, SYBU, SPTAN1, SFR1, CCSER2, CCDC93, CCDC88A, KDM1A, NUF2, MACF1, SRGAP2, GOLGA4, SH3BP5, CEP295, KIAA1551, KIF5A, TRIM9, KANSL1, COLEC12, IQCB1, KIAA0226, RB1CC1, ATG14, SNAP29, BSG, CD274, THAP7, KIR2DS2, CA14, DTNBP1, TMEFF1, SCN2B, EXOC2, EXOC3, NTRK1, MED4, SNW1, EXOC6, NCKAP5L, TUFT1, GRIPAP1, CLOCK, FKBP15, PTRF, BLOC1S4, IKBIP, RABEP2, RABGAP1L, NDC80, PHF21A, IL1R2, EXOC6B, EXOC8, VPS53, RABGEF1, CCDC6, CCDC132, TRIM32, EXOC5, KXD1, GIT2, POTEE, ARHGEF7, SNAPIN, VPS51, BLOC1S2, EXOC7, USP4, THAP11, TSKS, JUN, TSSC1, TNFRSF8, CCHCR1, SIKE1, GIT1, KIF5B, RABEP1, NUP54, TNIP1, GOLGA5, COG6, KIF5C, STRN3, STRN, APLNR, PCNT, CCDC122, EDNRB, ZWINT, VTI1B, TMED1, RALB, MTNR1A | IDO1 | PPP1R16A, TERF2IP, APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EXOC1_IDO1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | IDO1 | P14902 | DB00435 | Nitric Oxide | Indoleamine 2,3-dioxygenase 1 | small molecule | approved |
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RelatedDiseases for EXOC1_IDO1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | IDO1 | C0011570 | Mental Depression | 4 | PSYGENET |
| Tgene | IDO1 | C0011581 | Depressive disorder | 4 | PSYGENET |
| Tgene | IDO1 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | IDO1 | C0021368 | Inflammation | 1 | CTD_human |
| Tgene | IDO1 | C0027643 | Neoplasm Recurrence, Local | 1 | CTD_human |
| Tgene | IDO1 | C0028754 | Obesity | 1 | CTD_human |
| Tgene | IDO1 | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | IDO1 | C0178417 | Anhedonia | 1 | PSYGENET |
| Tgene | IDO1 | C0338715 | Drug-induced depressive state | 1 | PSYGENET |
| Tgene | IDO1 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |
| Tgene | IDO1 | C0581391 | Chronic depression | 1 | PSYGENET |
| Tgene | IDO1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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