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Fusion gene ID: 12251 |
FusionGeneSummary for EXO1_WDR64 |
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Fusion gene information | Fusion gene name: EXO1_WDR64 | Fusion gene ID: 12251 | Hgene | Tgene | Gene symbol | EXO1 | WDR64 | Gene ID | 9156 | 128025 |
Gene name | exonuclease 1 | WD repeat domain 64 | |
Synonyms | HEX1|hExoI | - | |
Cytomap | 1q43 | 1q43 | |
Type of gene | protein-coding | protein-coding | |
Description | exonuclease 1rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1 | WD repeat-containing protein 64 | |
Modification date | 20180527 | 20180329 | |
UniProtAcc | Q9UQ84 | B1ANS9 | |
Ensembl transtripts involved in fusion gene | ENST00000366548, ENST00000348581, ENST00000518483, ENST00000493702, | ENST00000437684, ENST00000366552, ENST00000461971, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: EXO1 [Title/Abstract] AND WDR64 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | EXO1 | GO:0006298 | mismatch repair | 14636568 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-61-2000-01A | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000366548 | ENST00000437684 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
In-frame | ENST00000366548 | ENST00000366552 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
5CDS-intron | ENST00000366548 | ENST00000461971 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
In-frame | ENST00000348581 | ENST00000437684 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
In-frame | ENST00000348581 | ENST00000366552 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
5CDS-intron | ENST00000348581 | ENST00000461971 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
In-frame | ENST00000518483 | ENST00000437684 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
In-frame | ENST00000518483 | ENST00000366552 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
5CDS-intron | ENST00000518483 | ENST00000461971 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
3UTR-3CDS | ENST00000493702 | ENST00000437684 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
3UTR-3CDS | ENST00000493702 | ENST00000366552 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
3UTR-intron | ENST00000493702 | ENST00000461971 | EXO1 | chr1 | 242013888 | + | WDR64 | chr1 | 241951151 | + |
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FusionProtFeatures for EXO1_WDR64 |
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Hgene | Tgene |
EXO1 | WDR64 |
5'->3' double-stranded DNA exonuclease which may alsopossess a cryptic 3'->5' double-stranded DNA exonuclease activity.Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5'or 3' to the mismatch. Also exhibits endonuclease activity against5'-overhanging flap structures similar to those generated bydisplacement synthesis when DNA polymerase encounters the 5'-endof a downstream Okazaki fragment. Required for somatichypermutation (SHM) and class switch recombination (CSR) ofimmunoglobulin genes. Essential for male and female meiosis.{ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837,ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105,ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184,ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842,ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194,ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 741_803 | 724 | 915 | Repeat | Note=WD 12 |
Tgene | >WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 804_857 | 724 | 915 | Repeat | Note=WD 13 |
Tgene | >WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 858_895 | 724 | 915 | Repeat | Note=WD 14 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >EXO1 | chr1:242013888 | chr1:241951151 | ENST00000348581 | + | 2 | 14 | 418_421 | 53 | 847 | Motif | Note=Nuclear localization signal |
Hgene | >EXO1 | chr1:242013888 | chr1:241951151 | ENST00000366548 | + | 4 | 16 | 418_421 | 53 | 847 | Motif | Note=Nuclear localization signal |
Hgene | >EXO1 | chr1:242013888 | chr1:241951151 | ENST00000518483 | + | 2 | 14 | 418_421 | 53 | 804 | Motif | Note=Nuclear localization signal |
Hgene | >EXO1 | chr1:242013888 | chr1:241951151 | ENST00000348581 | + | 2 | 14 | 138_229 | 53 | 847 | Region | Note=I-domain |
Hgene | >EXO1 | chr1:242013888 | chr1:241951151 | ENST00000348581 | + | 2 | 14 | 1_99 | 53 | 847 | Region | Note=N-domain |
Hgene | >EXO1 | chr1:242013888 | chr1:241951151 | ENST00000366548 | + | 4 | 16 | 138_229 | 53 | 847 | Region | Note=I-domain |
Hgene | >EXO1 | chr1:242013888 | chr1:241951151 | ENST00000366548 | + | 4 | 16 | 1_99 | 53 | 847 | Region | Note=N-domain |
Hgene | >EXO1 | chr1:242013888 | chr1:241951151 | ENST00000518483 | + | 2 | 14 | 138_229 | 53 | 804 | Region | Note=I-domain |
Hgene | >EXO1 | chr1:242013888 | chr1:241951151 | ENST00000518483 | + | 2 | 14 | 1_99 | 53 | 804 | Region | Note=N-domain |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 102_152 | 891 | 1082 | Repeat | Note=WD 1 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 153_198 | 891 | 1082 | Repeat | Note=WD 2 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 199_265 | 891 | 1082 | Repeat | Note=WD 3 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 266_314 | 891 | 1082 | Repeat | Note=WD 4 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 315_356 | 891 | 1082 | Repeat | Note=WD 5 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 357_400 | 891 | 1082 | Repeat | Note=WD 6 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 401_444 | 891 | 1082 | Repeat | Note=WD 7 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 445_488 | 891 | 1082 | Repeat | Note=WD 8 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 489_532 | 891 | 1082 | Repeat | Note=WD 9 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 533_631 | 891 | 1082 | Repeat | Note=WD 10 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 632_740 | 891 | 1082 | Repeat | Note=WD 11 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 741_803 | 891 | 1082 | Repeat | Note=WD 12 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 804_857 | 891 | 1082 | Repeat | Note=WD 13 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000366552 | + | 21 | 27 | 858_895 | 891 | 1082 | Repeat | Note=WD 14 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 102_152 | 724 | 915 | Repeat | Note=WD 1 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 153_198 | 724 | 915 | Repeat | Note=WD 2 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 199_265 | 724 | 915 | Repeat | Note=WD 3 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 266_314 | 724 | 915 | Repeat | Note=WD 4 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 315_356 | 724 | 915 | Repeat | Note=WD 5 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 357_400 | 724 | 915 | Repeat | Note=WD 6 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 401_444 | 724 | 915 | Repeat | Note=WD 7 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 445_488 | 724 | 915 | Repeat | Note=WD 8 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 489_532 | 724 | 915 | Repeat | Note=WD 9 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 533_631 | 724 | 915 | Repeat | Note=WD 10 |
Tgene | WDR64 | chr1:242013888 | chr1:241951151 | ENST00000437684 | + | 16 | 22 | 632_740 | 724 | 915 | Repeat | Note=WD 11 |
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FusionGeneSequence for EXO1_WDR64 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EXO1_WDR64 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
EXO1 | MSH2, MSH3, MLH1, PMS2, BLM, PMS1, YWHAZ, YWHAB, YWHAE, ATM, PCNA, YWHAH, YWHAG, SFN, YWHAQ, KPNB1, KPNA4, WDR83, CD14, COMT, LLGL2, MYEF2, ACTR5, KLC3, RBBP8, UBE2I, SENP6, DNA2, TRIM25 | WDR64 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000348581 | + | 2 | 14 | 388_490 | 53 | 847 | MLH1 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000348581 | + | 2 | 14 | 787_846 | 53 | 847 | MLH1 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000366548 | + | 4 | 16 | 388_490 | 53 | 847 | MLH1 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000366548 | + | 4 | 16 | 787_846 | 53 | 847 | MLH1 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000518483 | + | 2 | 14 | 388_490 | 53 | 804 | MLH1 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000518483 | + | 2 | 14 | 787_846 | 53 | 804 | MLH1 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000348581 | + | 2 | 14 | 600_846 | 53 | 847 | MSH2 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000366548 | + | 4 | 16 | 600_846 | 53 | 847 | MSH2 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000518483 | + | 2 | 14 | 600_846 | 53 | 804 | MSH2 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000348581 | + | 2 | 14 | 129_387 | 53 | 847 | MSH3 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000366548 | + | 4 | 16 | 129_387 | 53 | 847 | MSH3 |
Hgene | EXO1 | chr1:242013888 | chr1:241951151 | ENST00000518483 | + | 2 | 14 | 129_387 | 53 | 804 | MSH3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EXO1_WDR64 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for EXO1_WDR64 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | EXO1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | EXO1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |