FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 12251

FusionGeneSummary for EXO1_WDR64

check button Fusion gene summary
Fusion gene informationFusion gene name: EXO1_WDR64
Fusion gene ID: 12251
HgeneTgene
Gene symbol

EXO1

WDR64

Gene ID

9156

128025

Gene nameexonuclease 1WD repeat domain 64
SynonymsHEX1|hExoI-
Cytomap

1q43

1q43

Type of geneprotein-codingprotein-coding
Descriptionexonuclease 1rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1WD repeat-containing protein 64
Modification date2018052720180329
UniProtAcc

Q9UQ84

B1ANS9

Ensembl transtripts involved in fusion geneENST00000366548, ENST00000348581, 
ENST00000518483, ENST00000493702, 
ENST00000437684, ENST00000366552, 
ENST00000461971, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: EXO1 [Title/Abstract] AND WDR64 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEXO1

GO:0006298

mismatch repair

14636568


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-2000-01AEXO1chr1

242013888

+WDR64chr1

241951151

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000366548ENST00000437684EXO1chr1

242013888

+WDR64chr1

241951151

+
In-frameENST00000366548ENST00000366552EXO1chr1

242013888

+WDR64chr1

241951151

+
5CDS-intronENST00000366548ENST00000461971EXO1chr1

242013888

+WDR64chr1

241951151

+
In-frameENST00000348581ENST00000437684EXO1chr1

242013888

+WDR64chr1

241951151

+
In-frameENST00000348581ENST00000366552EXO1chr1

242013888

+WDR64chr1

241951151

+
5CDS-intronENST00000348581ENST00000461971EXO1chr1

242013888

+WDR64chr1

241951151

+
In-frameENST00000518483ENST00000437684EXO1chr1

242013888

+WDR64chr1

241951151

+
In-frameENST00000518483ENST00000366552EXO1chr1

242013888

+WDR64chr1

241951151

+
5CDS-intronENST00000518483ENST00000461971EXO1chr1

242013888

+WDR64chr1

241951151

+
3UTR-3CDSENST00000493702ENST00000437684EXO1chr1

242013888

+WDR64chr1

241951151

+
3UTR-3CDSENST00000493702ENST00000366552EXO1chr1

242013888

+WDR64chr1

241951151

+
3UTR-intronENST00000493702ENST00000461971EXO1chr1

242013888

+WDR64chr1

241951151

+

Top

FusionProtFeatures for EXO1_WDR64


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EXO1

Q9UQ84

WDR64

B1ANS9

5'->3' double-stranded DNA exonuclease which may alsopossess a cryptic 3'->5' double-stranded DNA exonuclease activity.Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5'or 3' to the mismatch. Also exhibits endonuclease activity against5'-overhanging flap structures similar to those generated bydisplacement synthesis when DNA polymerase encounters the 5'-endof a downstream Okazaki fragment. Required for somatichypermutation (SHM) and class switch recombination (CSR) ofimmunoglobulin genes. Essential for male and female meiosis.{ECO:0000269|PubMed:10364235, ECO:0000269|PubMed:10608837,ECO:0000269|PubMed:11809771, ECO:0000269|PubMed:11842105,ECO:0000269|PubMed:12414623, ECO:0000269|PubMed:12704184,ECO:0000269|PubMed:14636568, ECO:0000269|PubMed:14676842,ECO:0000269|PubMed:15225546, ECO:0000269|PubMed:15886194,ECO:0000269|PubMed:16143102, ECO:0000269|PubMed:9685493}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622741_803724915RepeatNote=WD 12
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622804_857724915RepeatNote=WD 13
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622858_895724915RepeatNote=WD 14

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEXO1chr1:242013888chr1:241951151ENST00000348581+214418_42153847MotifNote=Nuclear localization signal
HgeneEXO1chr1:242013888chr1:241951151ENST00000366548+416418_42153847MotifNote=Nuclear localization signal
HgeneEXO1chr1:242013888chr1:241951151ENST00000518483+214418_42153804MotifNote=Nuclear localization signal
HgeneEXO1chr1:242013888chr1:241951151ENST00000348581+214138_22953847RegionNote=I-domain
HgeneEXO1chr1:242013888chr1:241951151ENST00000348581+2141_9953847RegionNote=N-domain
HgeneEXO1chr1:242013888chr1:241951151ENST00000366548+416138_22953847RegionNote=I-domain
HgeneEXO1chr1:242013888chr1:241951151ENST00000366548+4161_9953847RegionNote=N-domain
HgeneEXO1chr1:242013888chr1:241951151ENST00000518483+214138_22953804RegionNote=I-domain
HgeneEXO1chr1:242013888chr1:241951151ENST00000518483+2141_9953804RegionNote=N-domain
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127102_1528911082RepeatNote=WD 1
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127153_1988911082RepeatNote=WD 2
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127199_2658911082RepeatNote=WD 3
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127266_3148911082RepeatNote=WD 4
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127315_3568911082RepeatNote=WD 5
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127357_4008911082RepeatNote=WD 6
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127401_4448911082RepeatNote=WD 7
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127445_4888911082RepeatNote=WD 8
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127489_5328911082RepeatNote=WD 9
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127533_6318911082RepeatNote=WD 10
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127632_7408911082RepeatNote=WD 11
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127741_8038911082RepeatNote=WD 12
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127804_8578911082RepeatNote=WD 13
TgeneWDR64chr1:242013888chr1:241951151ENST00000366552+2127858_8958911082RepeatNote=WD 14
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622102_152724915RepeatNote=WD 1
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622153_198724915RepeatNote=WD 2
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622199_265724915RepeatNote=WD 3
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622266_314724915RepeatNote=WD 4
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622315_356724915RepeatNote=WD 5
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622357_400724915RepeatNote=WD 6
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622401_444724915RepeatNote=WD 7
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622445_488724915RepeatNote=WD 8
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622489_532724915RepeatNote=WD 9
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622533_631724915RepeatNote=WD 10
TgeneWDR64chr1:242013888chr1:241951151ENST00000437684+1622632_740724915RepeatNote=WD 11


Top

FusionGeneSequence for EXO1_WDR64


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for EXO1_WDR64


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
EXO1MSH2, MSH3, MLH1, PMS2, BLM, PMS1, YWHAZ, YWHAB, YWHAE, ATM, PCNA, YWHAH, YWHAG, SFN, YWHAQ, KPNB1, KPNA4, WDR83, CD14, COMT, LLGL2, MYEF2, ACTR5, KLC3, RBBP8, UBE2I, SENP6, DNA2, TRIM25WDR64


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneEXO1chr1:242013888chr1:241951151ENST00000348581+214388_49053847MLH1
HgeneEXO1chr1:242013888chr1:241951151ENST00000348581+214787_84653847MLH1
HgeneEXO1chr1:242013888chr1:241951151ENST00000366548+416388_49053847MLH1
HgeneEXO1chr1:242013888chr1:241951151ENST00000366548+416787_84653847MLH1
HgeneEXO1chr1:242013888chr1:241951151ENST00000518483+214388_49053804MLH1
HgeneEXO1chr1:242013888chr1:241951151ENST00000518483+214787_84653804MLH1
HgeneEXO1chr1:242013888chr1:241951151ENST00000348581+214600_84653847MSH2
HgeneEXO1chr1:242013888chr1:241951151ENST00000366548+416600_84653847MSH2
HgeneEXO1chr1:242013888chr1:241951151ENST00000518483+214600_84653804MSH2
HgeneEXO1chr1:242013888chr1:241951151ENST00000348581+214129_38753847MSH3
HgeneEXO1chr1:242013888chr1:241951151ENST00000366548+416129_38753847MSH3
HgeneEXO1chr1:242013888chr1:241951151ENST00000518483+214129_38753804MSH3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for EXO1_WDR64


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for EXO1_WDR64


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneEXO1C0009404Colorectal Neoplasms1CTD_human
HgeneEXO1C1458155Mammary Neoplasms1CTD_human