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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1225

FusionGeneSummary for AHNAK_GPNMB

check button Fusion gene summary
Fusion gene informationFusion gene name: AHNAK_GPNMB
Fusion gene ID: 1225
HgeneTgene
Gene symbol

AHNAK

GPNMB

Gene ID

79026

10457

Gene nameAHNAK nucleoproteinglycoprotein nmb
SynonymsAHNAKRS|PM227HGFIN|NMB|PLCA3
Cytomap

11q12.3

7p15.3

Type of geneprotein-codingprotein-coding
Descriptionneuroblast differentiation-associated protein AHNAKAHNAK-relateddesmoyokintransmembrane glycoprotein NMBglycoprotein (transmembrane) nmbglycoprotein nmb-like proteinglycoprotein nonmetastatic melanoma protein Bhematopoietic growth factor inducible neurokinin-1osteoactivintransmembrane glycoprotein HGFIN
Modification date2018052320180523
UniProtAcc

Q09666

Q14956

Ensembl transtripts involved in fusion geneENST00000530124, ENST00000257247, 
ENST00000525875, ENST00000378024, 
ENST00000258733, ENST00000381990, 
ENST00000409458, ENST00000539136, 
ENST00000453162, ENST00000478451, 
Fusion gene scores* DoF score20 X 15 X 9=27003 X 3 X 3=27
# samples 223
** MAII scorelog2(22/2700*10)=-3.61738397841353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AHNAK [Title/Abstract] AND GPNMB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGPNMB

GO:0001818

negative regulation of cytokine production

19350579

TgeneGPNMB

GO:0001934

positive regulation of protein phosphorylation

22891158

TgeneGPNMB

GO:0030335

positive regulation of cell migration

20711474

TgeneGPNMB

GO:0031954

positive regulation of protein autophosphorylation

19350579

TgeneGPNMB

GO:0034103

regulation of tissue remodeling

25010402

TgeneGPNMB

GO:0042130

negative regulation of T cell proliferation

19350579

TgeneGPNMB

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

19350579


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG435349AHNAKchr11

62291575

-GPNMBchr7

23314595

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000530124ENST00000258733AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-3UTRENST00000530124ENST00000381990AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000530124ENST00000409458AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000530124ENST00000539136AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000530124ENST00000453162AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000530124ENST00000478451AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-3UTRENST00000257247ENST00000258733AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-3UTRENST00000257247ENST00000381990AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000257247ENST00000409458AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000257247ENST00000539136AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000257247ENST00000453162AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000257247ENST00000478451AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-3UTRENST00000525875ENST00000258733AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-3UTRENST00000525875ENST00000381990AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000525875ENST00000409458AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000525875ENST00000539136AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000525875ENST00000453162AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000525875ENST00000478451AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-3UTRENST00000378024ENST00000258733AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-3UTRENST00000378024ENST00000381990AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000378024ENST00000409458AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000378024ENST00000539136AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000378024ENST00000453162AHNAKchr11

62291575

-GPNMBchr7

23314595

+
intron-intronENST00000378024ENST00000478451AHNAKchr11

62291575

-GPNMBchr7

23314595

+

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FusionProtFeatures for AHNAK_GPNMB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHNAK

Q09666

GPNMB

Q14956

May be required for neuronal cell differentiation. Could be a melanogenic enzyme. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AHNAK_GPNMB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AHNAK_GPNMB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AHNAK_GPNMB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AHNAK_GPNMB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAHNAKC0007134Renal Cell Carcinoma1CTD_human
HgeneAHNAKC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneAHNAKC0263454Chloracne1CTD_human
TgeneGPNMBC0009404Colorectal Neoplasms2CTD_human
TgeneGPNMBC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGPNMBC0162557Liver Failure, Acute1CTD_human
TgeneGPNMBC1458155Mammary Neoplasms1CTD_human
TgeneGPNMBC2609414Acute kidney injury1CTD_human