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Fusion gene ID: 12238 |
FusionGeneSummary for EWSR1_NR4A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: EWSR1_NR4A3 | Fusion gene ID: 12238 | Hgene | Tgene | Gene symbol | EWSR1 | NR4A3 | Gene ID | 2130 | 8013 |
| Gene name | EWS RNA binding protein 1 | nuclear receptor subfamily 4 group A member 3 | |
| Synonyms | EWS|EWS-FLI1|bK984G1.4 | CHN|CSMF|MINOR|NOR1|TEC | |
| Cytomap | 22q12.2 | 9q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene | nuclear receptor subfamily 4 group A member 3chondrosarcoma, extraskeletal myxoid, fused to EWSmitogen-induced nuclear orphan receptorneuron-derived orphan receptor 1nuclear hormone receptor NOR-1translocated in extraskeletal chondrosarcoma | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | Q01844 | Q92570 | |
| Ensembl transtripts involved in fusion gene | ENST00000332050, ENST00000397938, ENST00000406548, ENST00000331029, ENST00000414183, ENST00000333395, ENST00000332035, | ENST00000338488, ENST00000395097, ENST00000330847, | |
| Fusion gene scores | * DoF score | 17 X 31 X 5=2635 | 6 X 6 X 4=144 |
| # samples | 53 | 10 | |
| ** MAII score | log2(53/2635*10)=-2.31373869707402 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/144*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: EWSR1 [Title/Abstract] AND NR4A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NR4A3 | GO:0010828 | positive regulation of glucose transmembrane transport | 24022864 |
| Tgene | NR4A3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20558821 |
| Tgene | NR4A3 | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 23554459 |
| Tgene | NR4A3 | GO:0048660 | regulation of smooth muscle cell proliferation | 25852083 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AF524261 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + | ||
| ChiTaRS3.1 | S81242 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000332050 | ENST00000338488 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000332050 | ENST00000395097 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000332050 | ENST00000330847 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000397938 | ENST00000338488 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000397938 | ENST00000395097 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000397938 | ENST00000330847 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000406548 | ENST00000338488 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000406548 | ENST00000395097 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000406548 | ENST00000330847 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| intron-intron | ENST00000331029 | ENST00000338488 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| intron-intron | ENST00000331029 | ENST00000395097 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| intron-intron | ENST00000331029 | ENST00000330847 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000414183 | ENST00000338488 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000414183 | ENST00000395097 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000414183 | ENST00000330847 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| intron-intron | ENST00000333395 | ENST00000338488 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| intron-intron | ENST00000333395 | ENST00000395097 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| intron-intron | ENST00000333395 | ENST00000330847 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000332035 | ENST00000338488 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000332035 | ENST00000395097 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-intron | ENST00000332035 | ENST00000330847 | EWSR1 | chr22 | 29688159 | + | NR4A3 | chr9 | 102589010 | + |
| 5CDS-5UTR | ENST00000332050 | ENST00000338488 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000332050 | ENST00000395097 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-intron | ENST00000332050 | ENST00000330847 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000397938 | ENST00000338488 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000397938 | ENST00000395097 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-intron | ENST00000397938 | ENST00000330847 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000406548 | ENST00000338488 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000406548 | ENST00000395097 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-intron | ENST00000406548 | ENST00000330847 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000331029 | ENST00000338488 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000331029 | ENST00000395097 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-intron | ENST00000331029 | ENST00000330847 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000414183 | ENST00000338488 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000414183 | ENST00000395097 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-intron | ENST00000414183 | ENST00000330847 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000333395 | ENST00000338488 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000333395 | ENST00000395097 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-intron | ENST00000333395 | ENST00000330847 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000332035 | ENST00000338488 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-5UTR | ENST00000332035 | ENST00000395097 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
| 5CDS-intron | ENST00000332035 | ENST00000330847 | EWSR1 | chr22 | 29683123 | + | NR4A3 | chr9 | 102587941 | + |
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FusionProtFeatures for EWSR1_NR4A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| EWSR1 | NR4A3 |
| Might normally function as a transcriptional repressor.EWS-fusion-proteins (EFPS) may play a role in the tumorigenicprocess. They may disturb gene expression by mimicking, orinterfering with the normal function of CTD-POLII within thetranscription initiation complex. They may also contribute to anaberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for EWSR1_NR4A3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for EWSR1_NR4A3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| EWSR1 | PRTFDC1, ZDHHC3, MSC, SLC22A24, MYO1F, KXD1, KHDRBS2, DNAJB3, FASN, NLE1, MNS1, PRUNE2, WWP2, NDUFB1, BNIP3L, NSUN4, KRR1, WWP1, RMND5B, SLC1A1, RASL11B, DFFA, WDR37, RPS15A, CPSF6, C11orf16, YY1AP1, RNF183, MTCP1, TULP2, RBPMS, KEL, MYOZ2, FAM131C, HMGA1, NPPB, HERPUD1, CD177, RPL31, VPS72, ACTL6A, RAD23A, MAGEA11, CFDP1, DMRTB1, CXADR, ZNF165, SSBP2, TPGS2, RAB37, CETP, NDUFV1, DYNLL2, NBPF3, CEACAM5, GPBP1L1, SERP2, GNPDA1, C19orf57, ELAVL3, ELAVL4, LILRA3, BAD, CCDC7, MRPS18B, CUEDC2, CNST, TSPAN3, CCDC91, TRIM37, NINL, NTNG2, CPSF7, PGLS, EPT1, MYL6, SMAD4, TMSB4Y, TRPV5, MVK, MAPK1IP1L, MDFI, MTMR9, PLSCR1, RALYL, PDHX, C10orf12, RHOXF2, MATK, SALL2, AGT, KCNMB1, SUV39H2, SMNDC1, ARHGDIA, PUF60, GSK3B, ILK, CD2BP2, BARD1, CREBBP, BTK, SF1, SNRPC, ELK1, PTK2B, CALM1, POU4F1, EZH2, IRF3, TONSL, RFX3, HLTF, SUPT4H1, ZNF184, HIST1H2BN, BLZF1, HDAC3, FXR2, HMGN4, POLR3A, ECD, ZBTB1, SCMH1, SUZ12, E2F8, TRIM5, ZNF383, DHX9, SMN1, PCM1, RAD21, NDRG1, CEBPA, ELAVL1, SIRT7, HNRNPA1, TSG101, TP53, POLR2A, YBX1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, KCND3, ATN1, ATXN3, ERCC5, HBP1, HSPA2, PCBP1, USP7, SRSF5, TMEM126A, SAP30BP, GORASP2, MBD3, MRPS9, HAX1, SFXN1, ITGA5, TCIRG1, RNF168, GEMIN5, HAS1, MTCH1, NDUFA5, MCAT, MRPL57, HDAC2, ESR1, FN1, VCAM1, ITGA4, CD81, PRMT1, SF3B4, EP300, PRRC2A, EWSR1, FUS, ITGB5, NONO, TRAF3, HNRNPUL1, EPAS1, CHERP, CDK12, ITCH, WBP4, RPA3, RPA2, RPA1, HSPA5, RIOK2, TRAF1, TRAF2, SEC24D, TFG, SEC24A, SSBP3, PRR13, ATPAF2, PEF1, JUN, CUL7, OBSL1, CCDC8, RNF2, BMI1, EGFR, ABL1, SRPK1, ABCE1, PRMT8, RPS6KB2, ACAA2, ACAT1, EIF4H, ANXA2, HIP1R, PICALM, POR, NTRK1, SCARNA22, NPM1, KRT2, PRDX2, S100A9, YWHAZ, DDX17, PCLO, ANXA6, SEC24C, GIPC1, CSRP2, FHL1, HNRNPA3, CTTN, MARCKSL1, PARP1, SERPINB3, CCDC50, KIF2A, KRT6B, HIST1H1D, STK38, H2AFV, PACSIN2, U2AF1, RSL24D1, XRCC5, ESYT3, RPL29, SDF2L1, LRP1B, MSN, SEC23A, RPL7A, SNX18, PPIL1, RPS27A, IGHM, SUMO3, GTF2I, RUVBL1, KRT16, RBM8A, RPL8, SRSF9, ZC3HAV1L, GAPDH, ETV3, IGF2R, COL5A2, HNRNPD, ANP32B, WAC, TFAP2A, TTN, CBR3, ARGLU1, HNRNPAB, SRRT, ATP1B3, COPS7B, PRR12, ATF3, NOMO3, NOMO1, NOMO2, EYA3, C1orf198, MAZ, U2AF2, SSB, TRA2B, C1orf52, HMGB1, HMGB1P10, RPRD1A, HNRNPH3, EIF5A2, C1orf131, SEC13, MAPRE1, CSTF2T, SRSF3, LENG1, UPF1, HDGFRP2, RPS10P7, RPS10P11, RPS10, RPS10P13, RPS10P4, RPS10P22, DACH1, ANO1, NCOR1, MLX, SUMO1P3, SUMO1, WIZ, PFDN6, ARFIP2, ZHX3, EEF1B2, MBIP, BAG6, DENND2A, PRCC, SRSF1, EIF4ENIF1, SPTAN1, CDCA8, PLS3, API5P1, API5, PSMA4, DNTTIP1, AKAP8, NCOA3, SMTN, FBRS, SMARCE1, ERC1, WBP11, SPTBN1, NFRKB, OLA1, ZNF207, R3HDM1, TRIM33, SAFB, UBFD1, SRSF7, SRSF2, GATA6, VDAC1P1, VDAC1, IL16, GMNN, ILF2, MED4, QKI, VCL, MFAP1, SNAP29, PADI1, BCL9, BCL9L, PKM, GPATCH11, CASC3, PSMC6, CACYBP, RPL12P6, RPL12P32, RPL12P14, RPL12, RPL12P2, RPL12P35, RPL12P19, TPI1, TPI1P1, CHAF1A, MIA3, CIC, SDCBP, CA2, FKBP3, ACE, NKX2-5, CSTF2, PFDN2, UBTF, FAM207A, LOC729774, BRD8, C12orf45, C1orf35, TCF20, SOD1, SPAG7, MED8, ETS2, ALDOC, FKBP4, INCENP, CEP85, CECR2, TFE3, SUPT16HP1, SUPT16H, MAPT, HTATSF1, RPS18P12, RPS18P5, KPNA2, TMX1, CKAP4, HSPE1, COPRS, PTGES3, LAMP2, ERLIN2, CTNNBL1, TOMM22, NRBF2, C9orf78, NCOA6, MED26, RANBP1, LOC389842, LOC727803, HMGB3, CANX, PUS7, RPSAP19, RPSA, RPSAP18, RPSAP58, RPSAP15, RPSAP8, RPSAP9, RPSAP12, RPSAP29, RPSAP61, ARHGAP17, USF1, PSIP1, SNRPEP2, SNRPE, NUDT5, PPM1G, OTUB1, AHCY, COPS3, NSMCE2, SAE1, PROSER1, GRWD1, CREB5, TAF9B, RBM33, EDF1, PGK1, FAM114A2, SRRM1, RAD23B, CIAPIN1, CIAPIN1P, LRRC59, PABPN1, KMT2A, RPRD1B, GPATCH8, CCDC43, DGCR14, PPP1R2, ERICH1, EIF5A, EIF5AL1, BAG3, PCNA, SOX7, PNISR, FAM168A, MED15, SRSF11, SIRT1, RSF1, MAML1, HPRT1, SPDL1, CRTC3, CEP55, CDV3, ALYREF, RNF40, STOML2, DGCR8, NUCKS1, UBN2, PSMD7, WNT10A, HMBS, KHDRBS1, VBP1, NCSTN, CDCA2, SFSWAP, ZRANB2, DDB1, RBBP6, ZEB1, SRSF6, LOC644422, EIF2S1, RFX5, RPS19, RPS19P3, TALDO1, CWC15, CDCA5, LOC645086, C11orf58, TXN, STX12, PHRF1, BSG, TAF4, SH3GL1, LIN37, HRNR, FAM192A, RRBP1, KIAA0907, GOLGB1, PAX9, P4HB, CHMP5, LDHB, CALR, SUMO2P1, SUMO2, PDIA6, AHSA1, EN2, CCDC124, RPLP0P6, RPLP0P2, RPLP0P3, RPLP0, NIPBL, PDLIM4, PRKCSH, C15orf39, HNRNPDL, PDIA4, NUP210, RPLP2P3, RPLP2, PRDX4, DAZAP1, UBE2T, PHAX, AMOT, MARCKS, LOC284685, SMARCC1, BCORL1, RFC4, GLRX3, ANP32E, HYOU1, NPM3, ATF7IP, SARNP, TRA2A, HDGF, STIP1, PELP1, KCTD12, GLO1, PCF11, CLIC1, DNAJC8, RNF114, SLC4A1AP, FAM50A, GTF2A1, PRPF40A, CDC37, PPIAP22, PPIA, SMARCC2, MEGF11, KIAA1143, DENR, LAMP1, MYBL2, PITX1, UBE2MP1, UBE2M, CHTF8, OTX1, NACA, FNBP4, GTF2F2, GLTSCR1, GTF2E1, PQBP1, EMD, RNF113A, GPALPP1, SNRPA, RRP15, RPS25, RPS25P8, GMEB2, LNPEP, DNAJB1, IGBP1P1, IGBP1, HINT1, ARID1A, PPIB, ANXA11, MATR3, PPARGC1A, MCM2, UBASH3B, SFPQ, CAPN13, HEY1, BRCA1 | NR4A3 | SIX3, KDM5B, TRIM28, COPS5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for EWSR1_NR4A3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | NR4A3 | Q92570 | DB01254 | Dasatinib | Nuclear receptor subfamily 4 group A member 3 | small molecule | approved|investigational |
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RelatedDiseases for EWSR1_NR4A3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | EWSR1 | C0553580 | Ewings sarcoma | 3 | CTD_human;HPO;ORPHANET |
| Hgene | EWSR1 | C0206663 | Neuroectodermal Tumor, Primitive | 1 | CTD_human |
| Tgene | NR4A3 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
| Tgene | NR4A3 | C0020443 | Hypercholesterolemia | 1 | CTD_human |
| Tgene | NR4A3 | C0021655 | Insulin Resistance | 1 | CTD_human |
| Tgene | NR4A3 | C3495559 | Juvenile arthritis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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