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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12194

FusionGeneSummary for EVA1A_ANKRD17

check button Fusion gene summary
Fusion gene informationFusion gene name: EVA1A_ANKRD17
Fusion gene ID: 12194
HgeneTgene
Gene symbol

EVA1A

ANKRD17

Gene ID

84141

26057

Gene nameeva-1 homolog A, regulator of programmed cell deathankyrin repeat domain 17
SynonymsFAM176A|TMEM166GTAR|MASK2|NY-BR-16
Cytomap

2p12

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein eva-1 homolog Afamily with sequence similarity 176, member Aprotein FAM176Atransmembrane protein 166ankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16
Modification date2018052320180523
UniProtAcc

Q9H8M9

O75179

Ensembl transtripts involved in fusion geneENST00000490746, ENST00000393913, 
ENST00000233712, ENST00000410113, 
ENST00000410071, ENST00000410010, 
ENST00000358602, ENST00000509867, 
ENST00000330838, ENST00000514252, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 14 X 3=336
# samples 118
** MAII scorelog2(1/1*10)=3.32192809488736log2(18/336*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: EVA1A [Title/Abstract] AND ANKRD17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANKRD17

GO:0042742

defense response to bacterium

23711367

TgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

TgeneANKRD17

GO:0045087

innate immune response

23711367

TgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

TgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF177337EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000490746ENST00000358602EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000490746ENST00000509867EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000490746ENST00000330838EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000490746ENST00000514252EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000393913ENST00000358602EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000393913ENST00000509867EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000393913ENST00000330838EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000393913ENST00000514252EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000233712ENST00000358602EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000233712ENST00000509867EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000233712ENST00000330838EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000233712ENST00000514252EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410113ENST00000358602EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410113ENST00000509867EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410113ENST00000330838EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410113ENST00000514252EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410071ENST00000358602EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410071ENST00000509867EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410071ENST00000330838EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410071ENST00000514252EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410010ENST00000358602EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410010ENST00000509867EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410010ENST00000330838EVA1Achr2

75719618

-ANKRD17chr4

73999126

-
intron-intronENST00000410010ENST00000514252EVA1Achr2

75719618

-ANKRD17chr4

73999126

-

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FusionProtFeatures for EVA1A_ANKRD17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EVA1A

Q9H8M9

ANKRD17

O75179

Acts as a regulator of programmed cell death, mediatingboth autophagy and apoptosis. {ECO:0000269|PubMed:17492404,ECO:0000269|PubMed:19029833}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for EVA1A_ANKRD17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for EVA1A_ANKRD17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for EVA1A_ANKRD17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EVA1A_ANKRD17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource