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Fusion gene ID: 12188 |
FusionGeneSummary for ETV6_PLEKHG6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ETV6_PLEKHG6 | Fusion gene ID: 12188 | Hgene | Tgene | Gene symbol | ETV6 | PLEKHG6 | Gene ID | 2120 | 55200 |
| Gene name | ETS variant 6 | pleckstrin homology and RhoGEF domain containing G6 | |
| Synonyms | TEL|TEL/ABL|THC5 | MyoGEF | |
| Cytomap | 12p13.2 | 12p13.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor ETV6ETS translocation variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene) | pleckstrin homology domain-containing family G member 6PH domain-containing family G member 6myosin II interacting GEFmyosin interacting guanine nucleotide exchange factorpleckstrin homology domain containing, family G (with RhoGef domain) member 6 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P41212 | Q3KR16 | |
| Ensembl transtripts involved in fusion gene | ENST00000396373, ENST00000544715, | ENST00000011684, ENST00000536531, ENST00000396988, ENST00000449001, ENST00000538208, ENST00000304581, | |
| Fusion gene scores | * DoF score | 23 X 26 X 11=6578 | 2 X 2 X 2=8 |
| # samples | 47 | 2 | |
| ** MAII score | log2(47/6578*10)=-3.8069163462704 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ETV6 [Title/Abstract] AND PLEKHG6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ETV6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10514502 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-62-A46O-01A | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000396373 | ENST00000011684 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| In-frame | ENST00000396373 | ENST00000536531 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| In-frame | ENST00000396373 | ENST00000396988 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| In-frame | ENST00000396373 | ENST00000449001 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| 5CDS-intron | ENST00000396373 | ENST00000538208 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| 5CDS-intron | ENST00000396373 | ENST00000304581 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| 3UTR-3CDS | ENST00000544715 | ENST00000011684 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| 3UTR-3CDS | ENST00000544715 | ENST00000536531 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| 3UTR-3CDS | ENST00000544715 | ENST00000396988 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| 3UTR-3CDS | ENST00000544715 | ENST00000449001 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| 3UTR-intron | ENST00000544715 | ENST00000538208 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
| 3UTR-intron | ENST00000544715 | ENST00000304581 | ETV6 | chr12 | 11803094 | + | PLEKHG6 | chr12 | 6424171 | + |
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FusionProtFeatures for ETV6_PLEKHG6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ETV6 | PLEKHG6 |
| Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignanttransformation. {ECO:0000269|PubMed:25581430}. | Guanine nucleotide exchange factor activating the smallGTPase RHOA, which, in turn, induces myosin filament formation.Also activates RHOG. Does not activate RAC1, or to a much lowerextent than RHOA and RHOG. Part of a functional unit, involvingPLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrowingression during cytokinesis. In epithelial cells, required forthe formation of microvilli and membrane ruffles on the apicalpole. Along with EZR, required for normal macropinocytosis.{ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000011684 | + | 2 | 16 | 364_367 | 98 | 791 | Compositional bias | Note=Poly-Ala |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000011684 | + | 2 | 16 | 714_718 | 98 | 791 | Compositional bias | Note=Poly-Glu |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000304581 | + | 0 | 4 | 364_367 | -34 | 321 | Compositional bias | Note=Poly-Ala |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000304581 | + | 0 | 4 | 714_718 | -34 | 321 | Compositional bias | Note=Poly-Glu |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000396988 | + | 2 | 16 | 364_367 | 98 | 791 | Compositional bias | Note=Poly-Ala |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000396988 | + | 2 | 16 | 714_718 | 98 | 791 | Compositional bias | Note=Poly-Glu |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000449001 | + | 1 | 15 | 364_367 | 66 | 759 | Compositional bias | Note=Poly-Ala |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000449001 | + | 1 | 15 | 714_718 | 66 | 759 | Compositional bias | Note=Poly-Glu |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000011684 | + | 2 | 16 | 161_353 | 98 | 791 | Domain | DH |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000011684 | + | 2 | 16 | 409_509 | 98 | 791 | Domain | PH |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000304581 | + | 0 | 4 | 161_353 | -34 | 321 | Domain | DH |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000304581 | + | 0 | 4 | 409_509 | -34 | 321 | Domain | PH |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000396988 | + | 2 | 16 | 161_353 | 98 | 791 | Domain | DH |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000396988 | + | 2 | 16 | 409_509 | 98 | 791 | Domain | PH |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000449001 | + | 1 | 15 | 161_353 | 66 | 759 | Domain | DH |
| Tgene | >PLEKHG6 | chr12:11803094 | chr12:6424171 | ENST00000449001 | + | 1 | 15 | 409_509 | 66 | 759 | Domain | PH |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ETV6 | chr12:11803094 | chr12:6424171 | ENST00000396373 | + | 1 | 8 | 339_420 | 11 | 453 | DNA binding | ETS |
| Hgene | >ETV6 | chr12:11803094 | chr12:6424171 | ENST00000396373 | + | 1 | 8 | 40_124 | 11 | 453 | Domain | PNT |
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FusionGeneSequence for ETV6_PLEKHG6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000011684_chr12_6424171_+_704aa MSETPAQCSIKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRV KQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQG EEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD KAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRES PSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELR DIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEE >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000536531_chr12_6424171_+_409aa MSETPAQCSIKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRV KQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQG EEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000396988_chr12_6424171_+_704aa MSETPAQCSIKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRV KQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQG EEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD KAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRES PSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELR DIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEE >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000449001_chr12_6424171_+_704aa MSETPAQCSIKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRV KQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQG EEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD KAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRES PSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELR DIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000011684_chr12_6424171_+_2112nt ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGG ATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAGGGAG CTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTG AGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGAGACC CTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCG GGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCGAGTG AAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCT GGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAGGAGC CCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGC GAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAACCTG CGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGA GTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGCGGAC AAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCACCTC ACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCAGGCC CAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGAGTCC CCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCCCCAC CTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGGCACC CCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACTCCGG GACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGGAGGC AGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCACAGG GCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGAAGAA GAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCTGGCC AGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCCCCAC >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000536531_chr12_6424171_+_1227nt ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGG ATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAGGGAG CTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTG AGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGAGACC CTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCG GGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCGAGTG AAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCT GGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAGGAGC CCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGC GAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAACCTG CGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGA GTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGCGGAC AAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAGTACGTCCTTCCTTCAGGGAGTC >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000396988_chr12_6424171_+_2112nt ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGG ATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAGGGAG CTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTG AGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGAGACC CTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCG GGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCGAGTG AAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCT GGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAGGAGC CCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGC GAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAACCTG CGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGA GTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGCGGAC AAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCACCTC ACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCAGGCC CAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGAGTCC CCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCCCCAC CTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGGCACC CCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACTCCGG GACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGGAGGC AGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCACAGG GCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGAAGAA GAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCTGGCC AGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCCCCAC >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000449001_chr12_6424171_+_2112nt ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGG ATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAGGGAG CTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTG AGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGAGACC CTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCG GGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCGAGTG AAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCT GGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAGGAGC CCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGC GAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAACCTG CGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGA GTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGCGGAC AAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCACCTC ACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCAGGCC CAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGAGTCC CCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCCCCAC CTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGGCACC CCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACTCCGG GACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGGAGGC AGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCACAGG GCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGAAGAA GAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCTGGCC AGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCCCCAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000011684_chr12_6424171_+_2746nt GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTT TGGGATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAG GGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTA CGTGAGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGA GACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGC CTCGGGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCG AGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCG CTCTGGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAG GAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCA GGGCGAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAA CCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGT GCGAGTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGC GGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCA CCTCACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCA GGCCCAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGA GTCCCCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCC CCACCTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGG CACCCCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACT CCGGGACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGG AGGCAGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCA CAGGGCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGA AGAAGAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCT GGCCAGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCC CCACATCATTCAGCTGGACACCCCTCTGTCCGCATCAGAGGTATGAGGAATGCAGAGGACCTTTGGCATGCATCTCTCCCAGAGGAGATC TCTCCCCAGTAGTGCTGGTCACCCTCCGGCATCTGTGACTCTACCTCAAGGACCACATTTCCCAAAGGAAGCCTGGCCCAGGCACCCTGC CTCCTGCTCTGTTTGGGGATCAAGAACTGTAAATTTATGTATCATAGGTGCACCTGAGCCCCACAGAAAGTTGTGCATAAAAATGACTGC CCTGGCTGGGCATGGCTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATCCCTTGAGCCCAGGAGTTCCAGACCAGCCTGG >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000536531_chr12_6424171_+_1517nt GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTT TGGGATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAG GGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTA CGTGAGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGA GACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGC CTCGGGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCG AGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCG CTCTGGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAG GAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCA GGGCGAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAA CCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGT GCGAGTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGC GGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAGTACGTCCTTCCTTCAGGG >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000396988_chr12_6424171_+_2746nt GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTT TGGGATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAG GGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTA CGTGAGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGA GACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGC CTCGGGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCG AGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCG CTCTGGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAG GAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCA GGGCGAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAA CCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGT GCGAGTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGC GGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCA CCTCACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCA GGCCCAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGA GTCCCCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCC CCACCTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGG CACCCCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACT CCGGGACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGG AGGCAGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCA CAGGGCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGA AGAAGAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCT GGCCAGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCC CCACATCATTCAGCTGGACACCCCTCTGTCCGCATCAGAGGTATGAGGAATGCAGAGGACCTTTGGCATGCATCTCTCCCAGAGGAGATC TCTCCCCAGTAGTGCTGGTCACCCTCCGGCATCTGTGACTCTACCTCAAGGACCACATTTCCCAAAGGAAGCCTGGCCCAGGCACCCTGC CTCCTGCTCTGTTTGGGGATCAAGAACTGTAAATTTATGTATCATAGGTGCACCTGAGCCCCACAGAAAGTTGTGCATAAAAATGACTGC CCTGGCTGGGCATGGCTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATCCCTTGAGCCCAGGAGTTCCAGACCAGCCTGG >In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000449001_chr12_6424171_+_2726nt GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTT TGGGATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAG GGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTA CGTGAGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGA GACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGC CTCGGGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCG AGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCG CTCTGGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAG GAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCA GGGCGAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAA CCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGT GCGAGTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGC GGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCA CCTCACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCA GGCCCAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGA GTCCCCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCC CCACCTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGG CACCCCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACT CCGGGACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGG AGGCAGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCA CAGGGCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGA AGAAGAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCT GGCCAGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCC CCACATCATTCAGCTGGACACCCCTCTGTCCGCATCAGAGGTATGAGGAATGCAGAGGACCTTTGGCATGCATCTCTCCCAGAGGAGATC TCTCCCCAGTAGTGCTGGTCACCCTCCGGCATCTGTGACTCTACCTCAAGGACCACATTTCCCAAAGGAAGCCTGGCCCAGGCACCCTGC CTCCTGCTCTGTTTGGGGATCAAGAACTGTAAATTTATGTATCATAGGTGCACCTGAGCCCCACAGAAAGTTGTGCATAAAAATGACTGC CCTGGCTGGGCATGGCTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATCCCTTGAGCCCAGGAGTTCCAGACCAGCCTGG |
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FusionGenePPI for ETV6_PLEKHG6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ETV6 | KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2 | PLEKHG6 | CEP55, PCDHGA5, BPIFA2, CST1, C9orf41, CST5, PIGR, IGJ, ZG16B, GSN, ACTB, AMY1C, ACTA2, LIMA1, TMOD2, IKBIP, IGHA1, TMOD1, CST4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ETV6_PLEKHG6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ETV6_PLEKHG6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ETV6 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 3 | CTD_human |
| Hgene | ETV6 | C0040034 | Thrombocytopenia | 2 | CTD_human;HPO |
| Hgene | ETV6 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Hgene | ETV6 | C0376545 | Hematologic Neoplasms | 1 | CTD_human |
| Hgene | ETV6 | C1838656 | Macrocytosis, Familial | 1 | CTD_human |
| Hgene | ETV6 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Hgene | ETV6 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Hgene | ETV6 | C4015537 | THROMBOCYTOPENIA 5 | 1 | UNIPROT |
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