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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 12188

FusionGeneSummary for ETV6_PLEKHG6

check button Fusion gene summary
Fusion gene informationFusion gene name: ETV6_PLEKHG6
Fusion gene ID: 12188
HgeneTgene
Gene symbol

ETV6

PLEKHG6

Gene ID

2120

55200

Gene nameETS variant 6pleckstrin homology and RhoGEF domain containing G6
SynonymsTEL|TEL/ABL|THC5MyoGEF
Cytomap

12p13.2

12p13.31

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS translocation variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)pleckstrin homology domain-containing family G member 6PH domain-containing family G member 6myosin II interacting GEFmyosin interacting guanine nucleotide exchange factorpleckstrin homology domain containing, family G (with RhoGef domain) member 6
Modification date2018052320180519
UniProtAcc

P41212

Q3KR16

Ensembl transtripts involved in fusion geneENST00000396373, ENST00000544715, 
ENST00000011684, ENST00000536531, 
ENST00000396988, ENST00000449001, 
ENST00000538208, ENST00000304581, 
Fusion gene scores* DoF score23 X 26 X 11=65782 X 2 X 2=8
# samples 472
** MAII scorelog2(47/6578*10)=-3.8069163462704
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ETV6 [Title/Abstract] AND PLEKHG6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-62-A46O-01AETV6chr12

11803094

+PLEKHG6chr12

6424171

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000396373ENST00000011684ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
In-frameENST00000396373ENST00000536531ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
In-frameENST00000396373ENST00000396988ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
In-frameENST00000396373ENST00000449001ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
5CDS-intronENST00000396373ENST00000538208ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
5CDS-intronENST00000396373ENST00000304581ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
3UTR-3CDSENST00000544715ENST00000011684ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
3UTR-3CDSENST00000544715ENST00000536531ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
3UTR-3CDSENST00000544715ENST00000396988ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
3UTR-3CDSENST00000544715ENST00000449001ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
3UTR-intronENST00000544715ENST00000538208ETV6chr12

11803094

+PLEKHG6chr12

6424171

+
3UTR-intronENST00000544715ENST00000304581ETV6chr12

11803094

+PLEKHG6chr12

6424171

+

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FusionProtFeatures for ETV6_PLEKHG6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

PLEKHG6

Q3KR16

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignanttransformation. {ECO:0000269|PubMed:25581430}. Guanine nucleotide exchange factor activating the smallGTPase RHOA, which, in turn, induces myosin filament formation.Also activates RHOG. Does not activate RAC1, or to a much lowerextent than RHOA and RHOG. Part of a functional unit, involvingPLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrowingression during cytokinesis. In epithelial cells, required forthe formation of microvilli and membrane ruffles on the apicalpole. Along with EZR, required for normal macropinocytosis.{ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000011684+216364_36798791Compositional biasNote=Poly-Ala
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000011684+216714_71898791Compositional biasNote=Poly-Glu
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000304581+04364_367-34321Compositional biasNote=Poly-Ala
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000304581+04714_718-34321Compositional biasNote=Poly-Glu
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000396988+216364_36798791Compositional biasNote=Poly-Ala
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000396988+216714_71898791Compositional biasNote=Poly-Glu
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000449001+115364_36766759Compositional biasNote=Poly-Ala
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000449001+115714_71866759Compositional biasNote=Poly-Glu
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000011684+216161_35398791DomainDH
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000011684+216409_50998791DomainPH
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000304581+04161_353-34321DomainDH
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000304581+04409_509-34321DomainPH
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000396988+216161_35398791DomainDH
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000396988+216409_50998791DomainPH
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000449001+115161_35366759DomainDH
TgenePLEKHG6chr12:11803094chr12:6424171ENST00000449001+115409_50966759DomainPH

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneETV6chr12:11803094chr12:6424171ENST00000396373+18339_42011453DNA bindingETS
HgeneETV6chr12:11803094chr12:6424171ENST00000396373+1840_12411453DomainPNT


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FusionGeneSequence for ETV6_PLEKHG6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000011684_chr12_6424171_+_704aa
MSETPAQCSIKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV
RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRV
KQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQG
EEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD
KAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRES
PSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELR
DIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEE

>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000536531_chr12_6424171_+_409aa
MSETPAQCSIKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV
RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRV
KQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQG
EEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD

>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000396988_chr12_6424171_+_704aa
MSETPAQCSIKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV
RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRV
KQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQG
EEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD
KAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRES
PSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELR
DIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEE

>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000449001_chr12_6424171_+_704aa
MSETPAQCSIKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYV
RKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRV
KQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQG
EEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKAD
KAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRES
PSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELR
DIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000011684_chr12_6424171_+_2112nt
ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGG
ATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAGGGAG
CTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTG
AGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGAGACC
CTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCG
GGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCGAGTG
AAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCT
GGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAGGAGC
CCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGC
GAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAACCTG
CGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGA
GTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGCGGAC
AAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCACCTC
ACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCAGGCC
CAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGAGTCC
CCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCCCCAC
CTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGGCACC
CCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACTCCGG
GACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGGAGGC
AGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCACAGG
GCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGAAGAA
GAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCTGGCC
AGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCCCCAC

>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000536531_chr12_6424171_+_1227nt
ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGG
ATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAGGGAG
CTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTG
AGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGAGACC
CTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCG
GGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCGAGTG
AAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCT
GGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAGGAGC
CCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGC
GAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAACCTG
CGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGA
GTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGCGGAC
AAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAGTACGTCCTTCCTTCAGGGAGTC

>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000396988_chr12_6424171_+_2112nt
ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGG
ATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAGGGAG
CTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTG
AGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGAGACC
CTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCG
GGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCGAGTG
AAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCT
GGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAGGAGC
CCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGC
GAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAACCTG
CGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGA
GTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGCGGAC
AAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCACCTC
ACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCAGGCC
CAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGAGTCC
CCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCCCCAC
CTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGGCACC
CCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACTCCGG
GACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGGAGGC
AGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCACAGG
GCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGAAGAA
GAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCTGGCC
AGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCCCCAC

>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000449001_chr12_6424171_+_2112nt
ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTTTGGG
ATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAGGGAG
CTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTACGTG
AGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGAGACC
CTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGCCTCG
GGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCGAGTG
AAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCGCTCT
GGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAGGAGC
CCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCAGGGC
GAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAACCTG
CGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGTGCGA
GTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGCGGAC
AAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCACCTC
ACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCAGGCC
CAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGAGTCC
CCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCCCCAC
CTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGGCACC
CCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACTCCGG
GACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGGAGGC
AGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCACAGG
GCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGAAGAA
GAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCTGGCC
AGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCCCCAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000011684_chr12_6424171_+_2746nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTT
TGGGATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAG
GGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTA
CGTGAGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGA
GACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGC
CTCGGGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCG
AGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCG
CTCTGGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAG
GAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCA
GGGCGAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAA
CCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGT
GCGAGTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGC
GGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCA
CCTCACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCA
GGCCCAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGA
GTCCCCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCC
CCACCTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGG
CACCCCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACT
CCGGGACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGG
AGGCAGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCA
CAGGGCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGA
AGAAGAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCT
GGCCAGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCC
CCACATCATTCAGCTGGACACCCCTCTGTCCGCATCAGAGGTATGAGGAATGCAGAGGACCTTTGGCATGCATCTCTCCCAGAGGAGATC
TCTCCCCAGTAGTGCTGGTCACCCTCCGGCATCTGTGACTCTACCTCAAGGACCACATTTCCCAAAGGAAGCCTGGCCCAGGCACCCTGC
CTCCTGCTCTGTTTGGGGATCAAGAACTGTAAATTTATGTATCATAGGTGCACCTGAGCCCCACAGAAAGTTGTGCATAAAAATGACTGC
CCTGGCTGGGCATGGCTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATCCCTTGAGCCCAGGAGTTCCAGACCAGCCTGG

>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000536531_chr12_6424171_+_1517nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTT
TGGGATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAG
GGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTA
CGTGAGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGA
GACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGC
CTCGGGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCG
AGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCG
CTCTGGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAG
GAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCA
GGGCGAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAA
CCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGT
GCGAGTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGC
GGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAGTACGTCCTTCCTTCAGGG

>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000396988_chr12_6424171_+_2746nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTT
TGGGATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAG
GGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTA
CGTGAGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGA
GACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGC
CTCGGGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCG
AGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCG
CTCTGGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAG
GAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCA
GGGCGAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAA
CCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGT
GCGAGTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGC
GGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCA
CCTCACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCA
GGCCCAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGA
GTCCCCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCC
CCACCTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGG
CACCCCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACT
CCGGGACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGG
AGGCAGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCA
CAGGGCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGA
AGAAGAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCT
GGCCAGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCC
CCACATCATTCAGCTGGACACCCCTCTGTCCGCATCAGAGGTATGAGGAATGCAGAGGACCTTTGGCATGCATCTCTCCCAGAGGAGATC
TCTCCCCAGTAGTGCTGGTCACCCTCCGGCATCTGTGACTCTACCTCAAGGACCACATTTCCCAAAGGAAGCCTGGCCCAGGCACCCTGC
CTCCTGCTCTGTTTGGGGATCAAGAACTGTAAATTTATGTATCATAGGTGCACCTGAGCCCCACAGAAAGTTGTGCATAAAAATGACTGC
CCTGGCTGGGCATGGCTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATCCCTTGAGCCCAGGAGTTCCAGACCAGCCTGG

>In-frame_ETV6_ENST00000396373_chr12_11803094_+_PLEKHG6_ENST00000449001_chr12_6424171_+_2726nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGGAACTCACCAAGGCCCATGAGCTGGAGGTGAGGCTGCACACTTTCAGCATGTT
TGGGATGCCCCGGCTGCCCCCTGAGGACCGGCGGCACTGGGAGATAGGAGAGGGTGGCGACAGTGGCCTGACCATCGAGAAGTCCTGGAG
GGAGCTGGTGCCTGGGCACAAGGAGATGAGCCAGGAGCTCTGCCACCAACAGGAGGCCCTGTGGGAGCTCCTGACCACCGAGCTGATCTA
CGTGAGAAAGCTCAAGATCATGACTGATCTGCTAGCCGCCGGCCTGCTGAACCTGCAGCGAGTGGGACTGCTGATGGAAGTGTCAGCTGA
GACCCTGTTTGGAAATGTCCCCAGCCTGATTCGAACCCACCGGAGCTTTTGGGATGAGGTGCTGGGGCCCACCCTGGAGGAGACTCGGGC
CTCGGGCCAGCCTCTGGACCCCATTGGTCTGCAAAGTGGCTTCCTGACGTTTGGCCAGCGGTTCCACCCCTATGTCCAGTACTGCCTCCG
AGTGAAGCAGACCATGGCTTACGCCCGAGAACAGCAAGAAACTAACCCTCTCTTCCATGCCTTCGTGCAGTGGTGTGAGAAGCACAAGCG
CTCTGGGAGGCAGATGCTCTGTGACTTGCTTATCAAGCCCCACCAGCGCATCACCAAGTACCCACTGCTGCTCCATGCTGTGCTCAAGAG
GAGCCCCGAGGCACGAGCCCAAGAGGCCCTGAATGCCATGATTGAAGCCGTGGAGTCATTCCTGCGACACATCAATGGGCAGGTCCGCCA
GGGCGAAGAGCAAGAGAGCTTGGCGGCTGCAGCACAACGCATCGGGCCCTACGAGGTGCTGGAGCCACCCAGTGATGAGGTGGAGAAGAA
CCTGCGCCCATTCTCCACCCTGGACCTGACGTCCCCCATGCTGGGGGTTGCATCTGAGCACACCAGACAGCTGCTGCTGGAGGGGCCTGT
GCGAGTGAAGGAGGGACGAGAAGGGAAGCTGGACGTGTACCTGTTCCTCTTCTCTGATGTGCTCCTTGTGACCAAGCCCCAGCGCAAGGC
GGACAAAGCCAAGGTCATCCGACCCCCTCTCATGCTGGAGAAGCTCGTGTGCCAACCCCTGCGAGACCCCAACAGCTTCCTGCTGATCCA
CCTCACTGAATTCCAGTGTGTCTCCAGCGCCCTCCTTGTGCACTGTCCCAGTCCTACAGACCGTGCCCAGTGGCTGGAGAAGACCCAGCA
GGCCCAGGCCGCCCTACAGAAGCTGAAGGCAGAGGAGTATGTTCAACAGAAGAGGGAGCTCCTGACCCTCTATCGGGACCAGGACAGGGA
GTCCCCCAGCACCAGGCCCTCCACGCCTTCCCTGGAGGGCTCTCAGAGCAGCGCAGAGGGGAGGACTCCTGAGTTCTCGACCATTATCCC
CCACCTGGTGGTGACAGAAGACACAGATGAAGATGCTCCCCTTGTGCCAGATGATACCTCAGACTCTGGCTACGGCACTTTGATCCCAGG
CACCCCCACGGGGTCCCGCTCCCCACTGAGCCGTCTACGCCAAAGAGCCCTTCGGCGGGACCCTCGCCTCACCTTCTCCACCCTGGAACT
CCGGGACATCCCTCTGCGTCCCCACCCTCCCGACCCCCAAGCTCCTCAACGCCGAAGCGCCCCCGAACTGCCGGAAGGAATCCTAAAAGG
AGGCAGTCTTCCCCAGGAAGACCCACCAACCTGGTCTGAGGAAGAAGATGGGGCCTCCGAGCGAGGGAATGTGGTGGTGGAAACACTCCA
CAGGGCCCGGCTTCGGGGCCAGCTTCCCTCCTCCCCAACCCATGCTGACTCTGCCGGGGAAAGCCCCTGGGAGTCCTCAGGGGAGGAGGA
AGAAGAGGGGCCTCTGTTCCTGAAAGCTGGCCACACATCCCTGCGCCCAATGCGGGCTGAGGACATGCTCAGAGAGATCCGGGAGGAGCT
GGCCAGCCAAAGGATTGAGGGGGCCGAGGAGCCCCGGGACAGCAGGCCACGGAAGCTGACTCGGGCCCAGCTGCAGAGGATGCGGGGGCC
CCACATCATTCAGCTGGACACCCCTCTGTCCGCATCAGAGGTATGAGGAATGCAGAGGACCTTTGGCATGCATCTCTCCCAGAGGAGATC
TCTCCCCAGTAGTGCTGGTCACCCTCCGGCATCTGTGACTCTACCTCAAGGACCACATTTCCCAAAGGAAGCCTGGCCCAGGCACCCTGC
CTCCTGCTCTGTTTGGGGATCAAGAACTGTAAATTTATGTATCATAGGTGCACCTGAGCCCCACAGAAAGTTGTGCATAAAAATGACTGC
CCTGGCTGGGCATGGCTGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGTGGGAGGATCCCTTGAGCCCAGGAGTTCCAGACCAGCCTGG


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FusionGenePPI for ETV6_PLEKHG6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ETV6KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2PLEKHG6CEP55, PCDHGA5, BPIFA2, CST1, C9orf41, CST5, PIGR, IGJ, ZG16B, GSN, ACTB, AMY1C, ACTA2, LIMA1, TMOD2, IKBIP, IGHA1, TMOD1, CST4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ETV6_PLEKHG6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ETV6_PLEKHG6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
HgeneETV6C0040034Thrombocytopenia2CTD_human;HPO
HgeneETV6C0236969Substance-Related Disorders1CTD_human
HgeneETV6C0376545Hematologic Neoplasms1CTD_human
HgeneETV6C1838656Macrocytosis, Familial1CTD_human
HgeneETV6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneETV6C3495559Juvenile arthritis1CTD_human
HgeneETV6C4015537THROMBOCYTOPENIA 51UNIPROT