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Fusion gene ID: 12183 |
FusionGeneSummary for ETV6_INO80D |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ETV6_INO80D | Fusion gene ID: 12183 | Hgene | Tgene | Gene symbol | ETV6 | INO80D | Gene ID | 2120 | 54891 |
| Gene name | ETS variant 6 | INO80 complex subunit D | |
| Synonyms | TEL|TEL/ABL|THC5 | - | |
| Cytomap | 12p13.2 | 2q33.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor ETV6ETS translocation variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene) | INO80 complex subunit D | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P41212 | Q53TQ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000396373, ENST00000544715, | ENST00000403263, | |
| Fusion gene scores | * DoF score | 23 X 26 X 11=6578 | 2 X 2 X 1=4 |
| # samples | 47 | 2 | |
| ** MAII score | log2(47/6578*10)=-3.8069163462704 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ETV6 [Title/Abstract] AND INO80D [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ETV6 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 10514502 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | JF736506 | ETV6 | chr12 | 12022904 | + | INO80D | chr2 | 206870260 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000396373 | ENST00000403263 | ETV6 | chr12 | 12022904 | + | INO80D | chr2 | 206870260 | - |
| intron-3CDS | ENST00000544715 | ENST00000403263 | ETV6 | chr12 | 12022904 | + | INO80D | chr2 | 206870260 | - |
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FusionProtFeatures for ETV6_INO80D |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ETV6 | INO80D |
| Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignanttransformation. {ECO:0000269|PubMed:25581430}. | Putative regulatory component of the chromatinremodeling INO80 complex which is involved in transcriptionalregulation, DNA replication and probably DNA repair. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ETV6 | chr12:12022904 | chr2:206870260 | ENST00000396373 | + | 5 | 8 | 40_124 | 336 | 453 | Domain | PNT |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ETV6 | chr12:12022904 | chr2:206870260 | ENST00000396373 | + | 5 | 8 | 339_420 | 336 | 453 | DNA binding | ETS |
| Tgene | INO80D | chr12:12022904 | chr2:206870260 | ENST00000403263 | - | 9 | 11 | 360_363 | 639 | 1028 | Compositional bias | Note=Poly-Asp |
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FusionGeneSequence for ETV6_INO80D |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ETV6_ENST00000396373_chr12_12022904_+_INO80D_ENST00000403263_chr2_206870260_-_725aa MSETPAQCSIKQERISYTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN GKALLLLTKEDFRYRSPHSGDVLYELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAGKNGDLLPTTEEAEELERALQAVT SLECLSTIGVLAQSDGVPVQELSDRGIGVFSTGTGASGIQSLSREVNTDLGELLNGRIVHDNFSSLELDENLLRSATLSNPPTPLAGQIQ GQFSAPANVGLTSATLISQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHYDSEHVPSPYSDHI TSPHTTSYSGDNMAATFSAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLGADGHLLSTSLSTPPTTSNSETTQPA FATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ETV6_ENST00000396373_chr12_12022904_+_INO80D_ENST00000403263_chr2_206870260_-_2175nt ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTCCTCG ACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAATTTAC TGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAAT GGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCATATT CTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCATCAG AACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTTGCAC CGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGATCCGC CGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCCCATG GAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGATGCCC AGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAGGGAA GGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATG CCCATTGGGAGAATAGCAGGGAAGAATGGAGACCTCCTCCCAACTACCGAAGAGGCTGAGGAGCTTGAACGGGCCTTGCAGGCTGTAACT TCTCTCGAGTGCCTGAGTACCATTGGGGTCCTTGCCCAGTCAGATGGTGTGCCAGTCCAGGAGTTGTCAGATAGAGGAATAGGGGTGTTC TCCACAGGTACTGGAGCTTCAGGAATACAATCCTTGAGCCGAGAGGTGAACACAGACCTAGGGGAGCTATTGAATGGGCGTATAGTACAT GATAATTTTTCTAGTCTAGAGCTGGATGAGAACCTGCTCCGTTCTGCTACCTTGTCAAACCCACCTACACCCCTGGCAGGGCAGATCCAG GGGCAGTTCTCTGCCCCAGCCAACGTTGGCCTTACTTCTGCCACTCTGATCAGCCAGAGTGCACTTGGGGAGAGAGCCTTCCCAGGACAG TTTCATGGACTTCATGACGGCAGCCATGCCTCCCAGAGGCCACATCCTGCCCAGCTGCTGAGCAAGGCAGATGACCTAATCACCTCACGA CAGCAATACAGCAGTGATCACTCACACTCCTCACCCCATGGAAGCCATTATGATAGTGAGCATGTGCCGTCTCCCTACAGTGACCATATC ACCTCTCCCCACACAACATCGTACTCTGGTGATAATATGGCAGCTACCTTTTCAGCAGAGATGCCCATCATGGCGCAGCACTTGCTCCCA ACCCAACTTGAGGTGCCACTTGGAGGCGTGGTAAACCCCAGAACTCACTGGGGCAATCTCCCTGTCAACCTTGGAGACCCCTCTCCATTT AGCAACCTTCTCGGCGCAGATGGACATCTTCTTTCCACTTCCCTATCCACGCCACCCACCACTTCGAACTCAGAGACCACACAGCCTGCC TTCGCCACCGTGACCCCCAGCAGCTCCAGTGTGCTTCCGGGGTTACCACAGACCAGCTTCAGTGGCATGGGGCCTTCTGCTGAACTAATG GCCTCCACCTCTCCCAAGCAGCAACTCCCTCAGTTCAGCGCAGCCTTTGGCCACCAGCTGAGTTCTCACAGTGGCATTCCTAAGGACCTG CAGCCCAGCCACAGCTCTATAGCCCCTCCTACAGGCTTCACAGTAACAGGTGCCACAGCTACAAGTACCAATAATGCATCTTCTCCCTTT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ETV6_ENST00000396373_chr12_12022904_+_INO80D_ENST00000403263_chr2_206870260_-_13096nt GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC CATGCCCATTGGGAGAATAGCAGGGAAGAATGGAGACCTCCTCCCAACTACCGAAGAGGCTGAGGAGCTTGAACGGGCCTTGCAGGCTGT AACTTCTCTCGAGTGCCTGAGTACCATTGGGGTCCTTGCCCAGTCAGATGGTGTGCCAGTCCAGGAGTTGTCAGATAGAGGAATAGGGGT GTTCTCCACAGGTACTGGAGCTTCAGGAATACAATCCTTGAGCCGAGAGGTGAACACAGACCTAGGGGAGCTATTGAATGGGCGTATAGT ACATGATAATTTTTCTAGTCTAGAGCTGGATGAGAACCTGCTCCGTTCTGCTACCTTGTCAAACCCACCTACACCCCTGGCAGGGCAGAT CCAGGGGCAGTTCTCTGCCCCAGCCAACGTTGGCCTTACTTCTGCCACTCTGATCAGCCAGAGTGCACTTGGGGAGAGAGCCTTCCCAGG ACAGTTTCATGGACTTCATGACGGCAGCCATGCCTCCCAGAGGCCACATCCTGCCCAGCTGCTGAGCAAGGCAGATGACCTAATCACCTC ACGACAGCAATACAGCAGTGATCACTCACACTCCTCACCCCATGGAAGCCATTATGATAGTGAGCATGTGCCGTCTCCCTACAGTGACCA TATCACCTCTCCCCACACAACATCGTACTCTGGTGATAATATGGCAGCTACCTTTTCAGCAGAGATGCCCATCATGGCGCAGCACTTGCT CCCAACCCAACTTGAGGTGCCACTTGGAGGCGTGGTAAACCCCAGAACTCACTGGGGCAATCTCCCTGTCAACCTTGGAGACCCCTCTCC ATTTAGCAACCTTCTCGGCGCAGATGGACATCTTCTTTCCACTTCCCTATCCACGCCACCCACCACTTCGAACTCAGAGACCACACAGCC TGCCTTCGCCACCGTGACCCCCAGCAGCTCCAGTGTGCTTCCGGGGTTACCACAGACCAGCTTCAGTGGCATGGGGCCTTCTGCTGAACT AATGGCCTCCACCTCTCCCAAGCAGCAACTCCCTCAGTTCAGCGCAGCCTTTGGCCACCAGCTGAGTTCTCACAGTGGCATTCCTAAGGA CCTGCAGCCCAGCCACAGCTCTATAGCCCCTCCTACAGGCTTCACAGTAACAGGTGCCACAGCTACAAGTACCAATAATGCATCTTCTCC CTTTCCCTCCCCTAACTGAGGGTGTCTGTGTGTTTGCAGGCAGGTGGGGAACCCAGTGTTTTCTATCTTTGTTTCCTCTTTAGCACCCCT CTCCCCTTTTCCTAAAGAAGATATAACAGATGGGGATCAGAGGGGCACCCCCCTTCCCAGTTCAATGAGTGGCCCTGCAGTGGACCTCGC TACAGTGTTCACATGTGCTCCTTAGCACTGGTGCTCATTCCCTCCTGGCAGGCCCACTCCGCCCCAGTGGTTTCCTTAGTGGTTCAGCAC AGTGACTGGATAGGATTGATTTTTAGCAGCAAGTCCTAGAAGTGGAAGATACCTCAGAATACCAGTGCCCTTTACTATTTCCTAGTATTC AGATCAGTGCTTTCCATTCTGTTGCCAGGTTTTTACATAGGTGGTTCTAGATAGAATGATCTTATTAATTGAGTTCCTGTATAAGAGACA GCAAATGGTGTGTGGCAGGTCAAGATTCTGACCTAGCACCAACTGCTAAACACCACAGTGAGGCCAGGATTCCATTCGTAATTGTGATCA TGTTTAACTAAAAGAAAAAAATGTGTCTTTTGACTGCCTGTGAGTATGCGTGTGCCCACGCGTGTGTTTTTGTGCAGTGCAGGAAGCAGC TGTCCCATTAGTTTGATTTTTTTTTGTTCTCCCCTTCCCCCTACTTAATGAGTATAAAACTCTTACTTTTCTCCTGTCCTACATCTCACA GTCCTAATAAGGTTGGTCCTTCTTTTCCTCAAGTTTCCTGAATAGGGAGGGTGGTGGACTGGTCGTGTGAGTAGCACAACCTTTTTCTGC TAAAAGTTAGCCCAAGAAGAAACAGAACATAGAAAGCTTGGATTCCCGTCAGTGAGGTAGGGATGTCCTAAAAAGCTTGCCTGGGATGAC TGCAGGCTGCCGGGGTTCTGGGGCCTGATGGTCACTTTGTCTTTTCAGACATTTGTTTGTTTCTAAATCCCTCTCTCATGGAATACATTT GCAAGATGTAATTAAAGAAAATATTTTGATGTGAAAAAGCAGGATAGGTCAGATAGATTTGAAAAGATGGGATCTGTCAACTCCTTGATC CATCTTTTGCTTTTGAATTTTTCATGTTTACAGTAGTGATTCTTTGGTAAGATTTGTAAAATGTTAAGACACTTGTAGAATCAGTGTACC AGTTGTGAAGTGATGTGTAATATCTGAAGGATACACATTTTAAAGTTTCTTTCAAAGCAGAATATGGAAATTAGATATAAATTTTATTCG CCCTTTGGTCCTTTTAAAATAATTCAAGTACTTGGGTTTAAGTAAATTTGAAAATAGCTTTGGGAAATGTTTTTAAAATGCCAGGATTTT AGGGGTTAAAGATCATATGGGGTAGTTTAGGAAGTTTGTGACTATGAGATGAATTTGTGAGGTTTCTTGCCTACCTTTTTTCCCCCCCAG AGAAGGGTGGAACTAGATTTTAAAGGCATCTCTACTCTGCTTTTGCTGAGTAGTTTCACTGTCCCTTGAGATACCATTGGCTATTTATAC CTGAGTCTAGTCTAATTCACATATATATATATTTTAAAAGTTGAGAGAACATACCTATTGATGTGGTTCAATAATTCATTTGTCAGGGAA TATTTGATCTTAATTCCTTTCTAATAGGTAGTGATTGGATGTATTTTCCTACTTCCTGTATGTAATCTCTTTATGCCATGCTAGTTCTAA CCAGTCCCTTCTTTTGAAAGCTTTTCTTTCTCTGCTTTTTAAAGGAATGATGGTGATCAGCAGGCATTATGCAGATACCACGTGCCTGAG GTTATGGAGGGGAAATGTCACATGACTGTATGAAATCATTATATGCCCTATTTTGTATTTATTGATGTTTCTTTTTGTGGGCCAAAAATA TGTTTGTAATATATTTAGTTTTTTTAAAATCATGGTAATTGATTGGAAGATTTATTTTTAATAGCTTTGCCTTTTTTGCAGAGTGCAAAA TTTCTAAATTATAACTTATGTCATAAAGCAAAATTATATTTGGTATCACCATAAATTTCTATTCTGAATGGTGAGAACAGATAATTTGAA TATTTCTCACCTGTGAGTCTATATTAGTAAGCTTTTTTATTTTAATGTACTGTAATGAAGTGGTCACGAGTAGTTACCTCGGCTCAAAAA TGTCATTTAGTTTGTTAAACTATTTTCACAACCATCATAAGCATAACTAGATAACTGTCCATTCCCAGCAGTTCAGTTTAGTCTCCATTG TGTATTTAAAGGTTGTCGCAGAGCAGCACATTGACTTCCTCATCAGCCCTTTGACAAGGAAGGGAAAGTCGTGGGTAGTCGATTTGAACT TTTTCTGTCTACTTGTCCCCTCATGTTAGCTGCTTGAAATTCTTCAGTTATGATACAAAGCTGAGTTTGCAGTAAGTTGCACATTTTATT GTTTGCAATTTTCTGTTTTATGTGCATTTAAAAGCCCTTCTCTGCTTTCTAGTAAGGAGGCATGAAATTATCAGGAATGTTGCTAGTTAC AGCTTCACACCAAAAACTTTGAGTAAATACATTTTCGTTTGGATGCCCATGATGAAAGCTGAGGAAAGTGGTTGAGGAATTATCAACAAC AAACTTTTCCTCTTATTTTATCTAGTTCAAAACAGATATCAAAGTTTGCAATTTGCTTTGCTCTTGCTGTTTCTTATGAGTCCCTTTTTG GAAGAGAGGAGAACATCTATAAGCCCAGAGAGATCTGTGTTTTTCTTTTACTTAATAGAGCCATTCTCGTCTATTAGTAGGAACTTTGCT ATTAATATGTATAGAAAGGAATGAAGTGGCTTTTACTCCAGAAATATGAAAATTAGTATCTTTTAAAATAGCACTTATGCTATCACAAGG CAATACTGGAATGAAAAACAAATCTTATATAAGGTCCTAAATAGGTAGAAACTAGCTTTTATTCTAGTGTTGAACCCAGGAGAAATAGTG GCAAAGAAGTTTCACTCTGTTTCTGCAGTTCTTTGGGACTATTTATAAAGGCCAGTTAGATTGTGTTACTGTGATTTAATTTACAAAGTT GCTGCAGTTAATGGATACATTCTGTGCTCTGAGAATCTGAATTCCATTCTAATGTGTGATATTCACTGGCTATGATCAGTAGTATCTGAA GAAAAGATGGGCTTTTTCTCCTTTACTCTCTCTACATAATTATTAATATTATTTTAATTAAAGTACTTAAGACATTGTTTTTTCTTCTGT AAAAATGGCTTAGCAATTTGCACATCTGGGTAGGTTATGTAGCTAGTAAACAACTCAATAGTAAGTAGCAATTATACTTAACCCACCAAG TGACAGACTATGCAATGGAAAAATTTTCTAATTATCGTCACATAGCTTAGACAGCAAAGGATTATTTTCTCTGGTGACCTACCATGTGTG ATATAACTGCTTTATAAATGACTTCCTGAGCAATTTCATGTTGGCAGGCAGTGTGGTGTGTCTAGTGCCCCTCTATGAGAAGACTATAAT TTAATCAGAAACAAATAGTAGGCATGGGGAGCAAGTTGGAAAGTGAGGTTATTATTTTTTTTCCTTAAAATTGGTGTTACTGTCTTTAGT GGCTTGAGGCTAAAGAAAGCTGATACTTTATCTTTGCCAAATAATTATTTATAAGATTTATTTTTAAATAAGCCCAATCTCTCACCTGCA GTTAAGAATCATCATTTTCTGTGACTGACACTAAAGCTCTTCCTTATCAGAGCTTGTTCTCAATCTGTGATCACAGTCCACAGTGGCAAA GACAACTCTTTGATTAGGAAGGAAACCATGTTTGGGATGCACAGAGGTGCCCTGTCCATACGGTTTTCTTCTTACATGAAAGAATTGACC TTTCTGTTGACCTATACCATTCTGTTTTTATAAAGTGGGATTAGAATTTGAGCATATCTAGTAAATGCCGTGTGGTCAGTCCGCTGATGC TTGCCCGCCGTCTTTGCCGTGCCTTGGCATCCTAGGGGTGCTGGTGATGGTCAGTGGGCATCATCGGTCAGCAGTGCACGTGTAAGGCAA TCTCCTCTCCTCCAGGTTAGTTCAGAAGGTCGCTATGGGTTGGTATTGCAAAAAGATGAGTATATGAACACTAAACTTATTAAGAGGTTT GAAATTCATTAAAAATTAGTTTTCAGTTTCTTCATCTTTCTTTTCAGACTTCTTTAAAAATACTGTTCTTAATCTGGTATATATAGAAAT CTAATATTATGGTCTTCTAAATGGTCAACAGAACTCTCCAGTTTAATGAGGCAATTTAGAGGATTCCTTGAAAGAAAATTTCATCATACT GAACAGTCCTCATTTGTATCTCTTTTGTTACCAGTATTTACATTGTTCCAAGGATTTTTTTCCTGACAAAAAATATATTTCTCGGGAGTG GAGAGTTTTTTATATATATATATGAAAGAACATAGATGTTTCCCCCCGCCCAATACATTAACTGAATCTTCACTGGCATTCTGTAGAAAA GTTAAAACAGTTTAATAATGTCTTAACATCTTTATACATTTTCCTATATTCTGGAGGAAACCAGAATCATGTTTAGTAGATTAAAGTAAC ATTTTAAATACTACCTTTCCAATAATTTGTAATAAAATACCAGTGAAGGACATGTTTGGATATCTGTTAAGCATTTTTCCCTGACTAATG AATTAGGAAAGAAAACATAAAACATAAATGAATAGTTATGTCTCTTCTAATAAACAGTGTCATTAATGCTGCAGTTGTGGGTCAAACTTA GGGAGCCTTATTTCTAAATAGCAAAAATTCTGTTTTCACTTCAGCCCTTATTTTTTTTTGTTAGTTTTTCTCTGCACTGTGATACAGAGC TAATAAGAGGAAATGTGACGTTTCAGAGAGAGAGCAAGCAAATTGGGTATGACTTTTTTACCCTATGTTCCCCAATACTGGGGATGTTTG GCTACTTTGAACAGCAGTTTTTAGTGATCTAAAGTTTAGATCAATACTCGTATAAGAGAAAAATCTAACTCTCAGTGAGCTCCATAGGGC AGCACAGCTTTCCATCTTCTCTTTCGCCTTCTTGCGTCTGCCCACCACAGTCCCGAAGAATGCACACGCACATATGATCTGTACCCATCC CGCCCGAAGAGTCATAGAATCCTCTTCTTTCACTTGTTTCTTTTTTCTTCGTTTGTTTGTTTTTGTTTGTTTGTTTTTTAAGCTGGGGAC CACTGAAGTAAGCTCTGTATGCACCCAAAGTTCCCCTTGGAAAAATTTTCAACACGCAGTGCAGAAGGCTCCAGTGCAGCTAAATGCCAC ACCATTGGTTCTACCTGGGGGAATAGACTGATTTGCCCTAAAATGACTCCAACCTGCATCATTAAGGTACAGTTGGCTCCAGTGGATTAG TGCTGAAATGATGGGAAGTCTGACACTTGTTGACATTGTCTTCATCTGTTTGGAAGGGTTGAATCTGTTCCTCTCAACAGTGATAGTTCT TTTCACTGTATAGTATTGAGTATGTCTCAGGGATTCCTTGTGGAAATTAGGGCAGTTTTTAAAATAAGAAAATAGTTTTAAAAGAAACTA AAGGTGACTCATCATTGAAGAGAGCGGAAGAAAGAGGAAACATTTGGTTTTGTAGCCCACAGTGTCTTGCATAGGACTTTTTCCTTTCTC CTCCAGGCTCTCATCTCAGCTTCAGAATACAGAATCCTTTCCCATCACGCACAGCTTTAAAACTTTTATTTAAAAATTTCCTTCCCCAAT GAGCTTTCAGAATACTTATTGTAGATTTTAAGAGAAAAGGTATATTAATTTATGCTATTAACATCACCTCATAAATTATAAGTTTTATAC TAAAGCTGTATCGAGTGTAATGAATTATGTTGCCTATGTGTTTAATAGCTAAATATATATGAGCTTTTTTTTTTTTTTTTTTTTTTGACA AAACAAACTAGTGAAGCACCTTTTTACACTGGATCTCTGCCGTGTCAAGGTGTATAGCTATCCTTTGCTACCTTGCAGATATATAAAATA AAAGGATATCCTGGGGCCTCAAAATGTAGAACACCTTTAGACCATTTATAACTGTTCCTAGAACTGTTGAGAATCATGTTCTTTAGTAAA TGATCTGTGGTTTACACTTAAGATGGCTAGAAGCTTAGTTACAGGGTACATAGAAATACATAGATCAAGTAAAACTCCAACTACTGTAGC TGGAATTTGTAAACTAAGTTTGTAAGACCTCTTTTATTTCCTATGGAGTTATTCTTTAATTTACAGTTTATTCTGTAAGTTGGGAAGTAA AATAGAGAAAATAATAAATCTAGATGTTCTCAGTGTCTTATTCAGGAACTTTTTATCCCTCCTCACTAAGGAATTCCCACTGTGACTTTA AAATAGAACTAAATTACTTGTGTGCATGTATATGTCTGTATTTTTTACACACATGCAAAAATATACATTGGGGGCACGTGTGTGAGAGAT ATGAATGTGTGCTTATATAAAAATAGATAAAGGTAACCGAATGTATTGTAGAAACATGATTTATTTAGTTGAGGGTATTGGAGTTACTTT CTCATTGTCTCTGTTGTATAAATACACCAAATTAATCATTATGTTATCTTATGTTAAAAGGCTAGCTCTGATATCATGTGCATTTTATGT TAACCTTTGGATTAACTTATATTATGCTATGTTCATAAAATGACATGAGAAACAGGAGGTTCTAAGATCAGCCTCTCACTTTCGAGCATA AAAATAAGAGAGGGAGACAGACAGCCCCAGACATGAGCTGTGTTTATCTATTGTGGTGATGGGACCACAGATCTATTGAATCTTTTTTAT GTTAATTATAGATTTCTTTATATTCGAGTAAGAAAATATTGTTGATCATCTTTTCTTGGTGAAGTTAAGAAAAAGTATAGGCCTTTCATA AACAATTTTTGGAAGGGGCTGCTTTGTTTAAGGAGTTGGTGGGATCATTTCACCGTGCATATTTCAAAGCTGGGGTGATTTCATTTATTT CCAAAATTTTTCAAAAAACTTTTACTCAGTTCTGCTGTTATTTATTAACTTAAGAGTGCTCCCATCCCCATATTTCAGCTATAGGAAAAT TGTGCTACCCCTGATTCATATGGAATTAAAAAAAAATACATCCCTTTATTTTGAGTTTTAAGTTGTTATTTTGCTATACATTTATTACTG GAGTATCTGGTGGTCTGAAATAGTCAAAAGTAGAGTTGGTATTAAATGTTCCAATGACATTTATTTTTAATACTTAAAAAATCATGTACT TTGAAATATGTCAAAGCAACTTCTGATAATATACCTGAATTTGTAGTTGTCTCTTGAGCATCATTTACTTCATCTTAGATATAGTGAAGA TCTAGGAAAGCTCTATATGCTGTTCTTTTCTACAGTTGTATTTTTGCAGCATCTCCTGGTTTCATTCACTCTTGTTTTGGGATTTTTTTT TAGATCTGCATATTTCTTGTACATATGCATGCAAATGAAAGAAGGGAGTTTGTACTGGTGCCATTTCTCCCTTCAGTTGCTGGTTAATGG GATTTGCTAGAAAAAATTCTCCCGGTTGAAGGGTGAAAACAGACCCTTATGTGTATATCTGTACAGAGATGTGTATATGGGATGTGGTGG CACTTTGCTGAATGTGAACTTGCCTTGTCAATGGAAAGATTGAAAAGTATTATGTTTATTTATACATTTGTATAAATCTATATATACACG TATGTATATGTGTGTGTATAGATAAAGCTATATACATATATTTCCCTTAAAAATGTGTGTGTATAATAGGTAAACAGCCTTTGTTAAGCA AGATTAATGTCTATGGAAAGTTCTGGATTATTCTGTAAGCCAGAGGAGGTGACAGTCTAGAGTACATCATCAGAACATACTAAAATGGAA GTCCTTTGGATTATAGTTTTGTTTATGGATATTACACAATGAATGCTTGTCTGAACAGTTCTTACTTGCCAGTTCCACTATTCTTCATCT TCACCACCTTCTACTGGTCAGTCTTTCATCACTTAAAAAAAAAAAAAAAATCACACATCATTGTGGTTTTTTTCCCCCTTAATTCTGTCT CTTCTAGCCAGAAGCATCTGGCTTAAGCATATTTCATCAACTTCTCTGTTATTTCTTTTAAAGATCTTTATCTCTGAAATTTTCCCAGAA GATACAAGTTTTGGTAATATTATCAATAGGAATTTTGAGACTTGGGCATTCATCTTTGTCTCAAAAACAAACAGAAAGCCAACCTTCAAA TAAAACAAATTTGAAAGTTTTAGCTCAATAATTTGGGGACATTTTACTTAAATTACAAAAGAACATAATTATGATTTTATGATCGATATT AGTGTTAGGTTTATTTCCACACTTACTGTCATTAATTTGTCATTTACATATTTTTATTTGCTTTGTAGTTTAATCATAACTTCACCATTT ACATTTTAATGGAAAGCATACAAGGTCACATGTTAGCCTCTTGAATTCTGTAACTAACTCATTTTTCTCATGATGAAACTGCTTTGATGA ATTCCTGTGTGATGAATTCTGCTATATTTCCTTTTGACTTTTCTCAGTTTGTGACATTCTGTATTAACTTTGCTGCAGCTCTCTAGAAAA CTTGCATCCCTATATATTGTGCCTTTAAAGCTCTTATGCACACACAGACAAAAGTGTATATATACATGTCAGAGCATGTGTACATATGCT TTCGTATGTACTCACACAGTATGTCTCTAGTATATATTGTGGGAGTAGATATATAGATATTCAAAGGCAATGAAATATTGCTCTCCAGAT ATATATGTATATAAATAGTGTTGATATAACTGTATATACACATGTATATGTATGAGTTTTAAATGGCAATCTTTTACATTTAGCAAAATG CTGCCCCTACTGGAATATTGTCACTGCAGTGGCAGTTGTATGTAATGATTTAAAATACATTATCAAAAGTTATTTAAAGAACATTTAAAG TCTCATCTAAAGACATCCACACACTATTTATTTATCTTCCTTTTCCTTTTATTGTTGTGTTTTTCTTAACTGAAAGGGAGACTGTCATTT TAAAAATGCCATCTGTCCCATGAGAGTAAGAAAGAGCTGGAGATTCACTTGAGGAGCTTTGTGCATTTTTCCTCTCTCTGAAGTGGAGAT GTTCCACAGACCAGACTGTTTATTTCACTTATAAAGCAATCCTAATATTTCCGTTAGTGTATGTCAGCCACCATCTCCTAGATCAACTTA ATTCACCAATTTGCCTCCTCCTTTCATTAATAAATAATGATTATTGAGATCATTTTGCCTGGGGGAAGTTAACTACTCCCATGCTGCAGG GAAATATATCACCTAATTGTTATTTTGCCTTGTTCAAAATTCAAATTTGAAAGAAGGCAGCTCTCTCATGAAGCTGTCTTAAGCACATTT TAGTTAAGGGCCCTCCCAAACTCTTTTTTCTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTTTGCGAGTTCCAAGTTGCATGTGCTTGAAA TAGATTTAATTCTTATTCCCCACAGTTTAGGTATTTTTCATTAGTACATCAATTTGACACACTGAATGCAAGACTATTAAGGAAGAACGA TTAAATATTATTTTATTTTGTGAAGAGTTGGCAGCAGATTACATCTCAAGAACTTGCAGAGAGAGGAAGGTAGATGGACAATCCTAAATT GTAAGATGTTACAAAAAACAGTGAAGTAAGAGTACTCCTGAAGACTAAAATAGAGAGGCTGGGGTTTGAGCCATTTTACTGAGTAGCTTA GCTGGAACCTGATATCAGAAGTAGCCTTTAACAAAAAGCCTCTTGGCAATTGTATGGTACTAACAACTAGAGTACTGAAGTGTAAGTTGA AACCAAGTTGCAGTGGGAAATCAAAGGTGAGGTAGCTTATTTGAAACCAGCAAATGAGACAGGTTGGACAGTTTTAAAATCTCTTCTAAC AAAGAAACTGCACGGTAGCAAGGACTAGCGGTTCTCAAAGCCCTTCTTTTTCAGTGTTCTCATTCACCTTGGCACCCAAGTATGTTTAAC AGGCCATGCATTAAAAATAAATACAAAAATATAAAAGCCGCTTAAAGGGAACTTACAAACTGACAATCTCTCCTCTGTATTTGTGTTCAT AGTGGCTGGGAGTTTAATTATATGCACAAAAGTTAGGAGCCACTTGTTTCTGCACAGACTGTAGGAGCAAGATGAGGAGATGGGCAGGTT TTGGTAAGAGCCCCCAGTTCTGGTGGACAGGCATACTTGTGGCATTGGGTGCGGCATTGCTGGGAGGACCACGTCTTGGGAGGCGATTGA CTTTTGGTTTGTAATTTCCCTTTAAACAAGAAGAGATGGCTCACATTTTCCATATATATCTCAATGAATGTACTGTATTACTGTTTTAAA AATTTGATGAAATAATAATGAATTGGTCTCCTTTTGTTATCTGGTCCTTGTTTAATTTGTTTAAGGGTTTTTGTATACAAAAGTTTACAT TTTTATGTATATTTTTCTTGTGTAAAAACTGATGTAATATGTGTATGAAACACTGTATGTATTATCTGTATATAGTGTGACAAAATCATT |
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FusionGenePPI for ETV6_INO80D |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ETV6 | KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2 | INO80D | INO80, INO80E, YY1, RUVBL1, RUVBL2, ACTR5, ACTR8, TFPT, INO80B, ACTL6A, INO80C, NFRKB, UCHL5, MCRS1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ETV6_INO80D |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ETV6_INO80D |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ETV6 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 3 | CTD_human |
| Hgene | ETV6 | C0040034 | Thrombocytopenia | 2 | CTD_human;HPO |
| Hgene | ETV6 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
| Hgene | ETV6 | C0376545 | Hematologic Neoplasms | 1 | CTD_human |
| Hgene | ETV6 | C1838656 | Macrocytosis, Familial | 1 | CTD_human |
| Hgene | ETV6 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
| Hgene | ETV6 | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Hgene | ETV6 | C4015537 | THROMBOCYTOPENIA 5 | 1 | UNIPROT |
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