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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 12183

FusionGeneSummary for ETV6_INO80D

check button Fusion gene summary
Fusion gene informationFusion gene name: ETV6_INO80D
Fusion gene ID: 12183
HgeneTgene
Gene symbol

ETV6

INO80D

Gene ID

2120

54891

Gene nameETS variant 6INO80 complex subunit D
SynonymsTEL|TEL/ABL|THC5-
Cytomap

12p13.2

2q33.3

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor ETV6ETS translocation variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)INO80 complex subunit D
Modification date2018052320180523
UniProtAcc

P41212

Q53TQ3

Ensembl transtripts involved in fusion geneENST00000396373, ENST00000544715, 
ENST00000403263, 
Fusion gene scores* DoF score23 X 26 X 11=65782 X 2 X 1=4
# samples 472
** MAII scorelog2(47/6578*10)=-3.8069163462704
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: ETV6 [Title/Abstract] AND INO80D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1JF736506ETV6chr12

12022904

+INO80Dchr2

206870260

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000396373ENST00000403263ETV6chr12

12022904

+INO80Dchr2

206870260

-
intron-3CDSENST00000544715ENST00000403263ETV6chr12

12022904

+INO80Dchr2

206870260

-

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FusionProtFeatures for ETV6_INO80D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETV6

P41212

INO80D

Q53TQ3

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignanttransformation. {ECO:0000269|PubMed:25581430}. Putative regulatory component of the chromatinremodeling INO80 complex which is involved in transcriptionalregulation, DNA replication and probably DNA repair.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneETV6chr12:12022904chr2:206870260ENST00000396373+5840_124336453DomainPNT

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneETV6chr12:12022904chr2:206870260ENST00000396373+58339_420336453DNA bindingETS
TgeneINO80Dchr12:12022904chr2:206870260ENST00000403263-911360_3636391028Compositional biasNote=Poly-Asp


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FusionGeneSequence for ETV6_INO80D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ETV6_ENST00000396373_chr12_12022904_+_INO80D_ENST00000403263_chr2_206870260_-_725aa
MSETPAQCSIKQERISTTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMN
GKALLLLTKEDFRTRSPHSGDVLTELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLH
RSRSPITTNHRPSPDPEQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMP
SPIMHPLILNPRHSVDFKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIAGKNGDLLPTTEEAEELERALQAVT
SLECLSTIGVLAQSDGVPVQELSDRGIGVFSTGTGASGIQSLSREVNTDLGELLNGRIVHDNFSSLELDENLLRSATLSNPPTPLAGQIQ
GQFSAPANVGLTSATLISQSALGERAFPGQFHGLHDGSHASQRPHPAQLLSKADDLITSRQQYSSDHSHSSPHGSHTDSEHVPSPYSDHI
TSPHTTSYSGDNMAATFSAEMPIMAQHLLPTQLEVPLGGVVNPRTHWGNLPVNLGDPSPFSNLLGADGHLLSTSLSTPPTTSNSETTQPA
FATVTPSSSSVLPGLPQTSFSGMGPSAELMASTSPKQQLPQFSAAFGHQLSSHSGIPKDLQPSHSSIAPPTGFTVTGATATSTNNASSPF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ETV6_ENST00000396373_chr12_12022904_+_INO80D_ENST00000403263_chr2_206870260_-_2175nt
ATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTCCTCG
ACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAATTTAC
TGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAAT
GGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCATATT
CTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCATCAG
AACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTTGCAC
CGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGATCCGC
CGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCCCATG
GAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGATGCCC
AGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAGGGAA
GGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATG
CCCATTGGGAGAATAGCAGGGAAGAATGGAGACCTCCTCCCAACTACCGAAGAGGCTGAGGAGCTTGAACGGGCCTTGCAGGCTGTAACT
TCTCTCGAGTGCCTGAGTACCATTGGGGTCCTTGCCCAGTCAGATGGTGTGCCAGTCCAGGAGTTGTCAGATAGAGGAATAGGGGTGTTC
TCCACAGGTACTGGAGCTTCAGGAATACAATCCTTGAGCCGAGAGGTGAACACAGACCTAGGGGAGCTATTGAATGGGCGTATAGTACAT
GATAATTTTTCTAGTCTAGAGCTGGATGAGAACCTGCTCCGTTCTGCTACCTTGTCAAACCCACCTACACCCCTGGCAGGGCAGATCCAG
GGGCAGTTCTCTGCCCCAGCCAACGTTGGCCTTACTTCTGCCACTCTGATCAGCCAGAGTGCACTTGGGGAGAGAGCCTTCCCAGGACAG
TTTCATGGACTTCATGACGGCAGCCATGCCTCCCAGAGGCCACATCCTGCCCAGCTGCTGAGCAAGGCAGATGACCTAATCACCTCACGA
CAGCAATACAGCAGTGATCACTCACACTCCTCACCCCATGGAAGCCATTATGATAGTGAGCATGTGCCGTCTCCCTACAGTGACCATATC
ACCTCTCCCCACACAACATCGTACTCTGGTGATAATATGGCAGCTACCTTTTCAGCAGAGATGCCCATCATGGCGCAGCACTTGCTCCCA
ACCCAACTTGAGGTGCCACTTGGAGGCGTGGTAAACCCCAGAACTCACTGGGGCAATCTCCCTGTCAACCTTGGAGACCCCTCTCCATTT
AGCAACCTTCTCGGCGCAGATGGACATCTTCTTTCCACTTCCCTATCCACGCCACCCACCACTTCGAACTCAGAGACCACACAGCCTGCC
TTCGCCACCGTGACCCCCAGCAGCTCCAGTGTGCTTCCGGGGTTACCACAGACCAGCTTCAGTGGCATGGGGCCTTCTGCTGAACTAATG
GCCTCCACCTCTCCCAAGCAGCAACTCCCTCAGTTCAGCGCAGCCTTTGGCCACCAGCTGAGTTCTCACAGTGGCATTCCTAAGGACCTG
CAGCCCAGCCACAGCTCTATAGCCCCTCCTACAGGCTTCACAGTAACAGGTGCCACAGCTACAAGTACCAATAATGCATCTTCTCCCTTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ETV6_ENST00000396373_chr12_12022904_+_INO80D_ENST00000403263_chr2_206870260_-_13096nt
GCGTCCCGGGTCCCCGCGCCGCGCCGCGACCTGCAGACCCCGCCGCCGCGCTCGGGCCCGTCTCCCACGCCCCCGCCGCCCCGCGCGCCC
AACTCCGCCGGCCGCCCCGCCCCGCCCCGCGCGCTCCAGACCCCCGGGGCGGCTGCCGGGAGAGATGCTGGAAGAAACTTCTTAAATGAC
CGCGTCTGGCTGGCCGTGGAGCCTTTCTGGGTTGGGGAGAGGAAAGGAAAGTGGAAAAAACCTGAGAACTTCCTGATCTCTCTCGCTGTG
AGACATGTCTGAGACTCCTGCTCAGTGTAGCATTAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTC
CTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAAT
TTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAAT
GAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCA
TATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCA
TCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTT
GCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGAT
CCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCC
CATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGAT
GCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAG
GGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGC
CATGCCCATTGGGAGAATAGCAGGGAAGAATGGAGACCTCCTCCCAACTACCGAAGAGGCTGAGGAGCTTGAACGGGCCTTGCAGGCTGT
AACTTCTCTCGAGTGCCTGAGTACCATTGGGGTCCTTGCCCAGTCAGATGGTGTGCCAGTCCAGGAGTTGTCAGATAGAGGAATAGGGGT
GTTCTCCACAGGTACTGGAGCTTCAGGAATACAATCCTTGAGCCGAGAGGTGAACACAGACCTAGGGGAGCTATTGAATGGGCGTATAGT
ACATGATAATTTTTCTAGTCTAGAGCTGGATGAGAACCTGCTCCGTTCTGCTACCTTGTCAAACCCACCTACACCCCTGGCAGGGCAGAT
CCAGGGGCAGTTCTCTGCCCCAGCCAACGTTGGCCTTACTTCTGCCACTCTGATCAGCCAGAGTGCACTTGGGGAGAGAGCCTTCCCAGG
ACAGTTTCATGGACTTCATGACGGCAGCCATGCCTCCCAGAGGCCACATCCTGCCCAGCTGCTGAGCAAGGCAGATGACCTAATCACCTC
ACGACAGCAATACAGCAGTGATCACTCACACTCCTCACCCCATGGAAGCCATTATGATAGTGAGCATGTGCCGTCTCCCTACAGTGACCA
TATCACCTCTCCCCACACAACATCGTACTCTGGTGATAATATGGCAGCTACCTTTTCAGCAGAGATGCCCATCATGGCGCAGCACTTGCT
CCCAACCCAACTTGAGGTGCCACTTGGAGGCGTGGTAAACCCCAGAACTCACTGGGGCAATCTCCCTGTCAACCTTGGAGACCCCTCTCC
ATTTAGCAACCTTCTCGGCGCAGATGGACATCTTCTTTCCACTTCCCTATCCACGCCACCCACCACTTCGAACTCAGAGACCACACAGCC
TGCCTTCGCCACCGTGACCCCCAGCAGCTCCAGTGTGCTTCCGGGGTTACCACAGACCAGCTTCAGTGGCATGGGGCCTTCTGCTGAACT
AATGGCCTCCACCTCTCCCAAGCAGCAACTCCCTCAGTTCAGCGCAGCCTTTGGCCACCAGCTGAGTTCTCACAGTGGCATTCCTAAGGA
CCTGCAGCCCAGCCACAGCTCTATAGCCCCTCCTACAGGCTTCACAGTAACAGGTGCCACAGCTACAAGTACCAATAATGCATCTTCTCC
CTTTCCCTCCCCTAACTGAGGGTGTCTGTGTGTTTGCAGGCAGGTGGGGAACCCAGTGTTTTCTATCTTTGTTTCCTCTTTAGCACCCCT
CTCCCCTTTTCCTAAAGAAGATATAACAGATGGGGATCAGAGGGGCACCCCCCTTCCCAGTTCAATGAGTGGCCCTGCAGTGGACCTCGC
TACAGTGTTCACATGTGCTCCTTAGCACTGGTGCTCATTCCCTCCTGGCAGGCCCACTCCGCCCCAGTGGTTTCCTTAGTGGTTCAGCAC
AGTGACTGGATAGGATTGATTTTTAGCAGCAAGTCCTAGAAGTGGAAGATACCTCAGAATACCAGTGCCCTTTACTATTTCCTAGTATTC
AGATCAGTGCTTTCCATTCTGTTGCCAGGTTTTTACATAGGTGGTTCTAGATAGAATGATCTTATTAATTGAGTTCCTGTATAAGAGACA
GCAAATGGTGTGTGGCAGGTCAAGATTCTGACCTAGCACCAACTGCTAAACACCACAGTGAGGCCAGGATTCCATTCGTAATTGTGATCA
TGTTTAACTAAAAGAAAAAAATGTGTCTTTTGACTGCCTGTGAGTATGCGTGTGCCCACGCGTGTGTTTTTGTGCAGTGCAGGAAGCAGC
TGTCCCATTAGTTTGATTTTTTTTTGTTCTCCCCTTCCCCCTACTTAATGAGTATAAAACTCTTACTTTTCTCCTGTCCTACATCTCACA
GTCCTAATAAGGTTGGTCCTTCTTTTCCTCAAGTTTCCTGAATAGGGAGGGTGGTGGACTGGTCGTGTGAGTAGCACAACCTTTTTCTGC
TAAAAGTTAGCCCAAGAAGAAACAGAACATAGAAAGCTTGGATTCCCGTCAGTGAGGTAGGGATGTCCTAAAAAGCTTGCCTGGGATGAC
TGCAGGCTGCCGGGGTTCTGGGGCCTGATGGTCACTTTGTCTTTTCAGACATTTGTTTGTTTCTAAATCCCTCTCTCATGGAATACATTT
GCAAGATGTAATTAAAGAAAATATTTTGATGTGAAAAAGCAGGATAGGTCAGATAGATTTGAAAAGATGGGATCTGTCAACTCCTTGATC
CATCTTTTGCTTTTGAATTTTTCATGTTTACAGTAGTGATTCTTTGGTAAGATTTGTAAAATGTTAAGACACTTGTAGAATCAGTGTACC
AGTTGTGAAGTGATGTGTAATATCTGAAGGATACACATTTTAAAGTTTCTTTCAAAGCAGAATATGGAAATTAGATATAAATTTTATTCG
CCCTTTGGTCCTTTTAAAATAATTCAAGTACTTGGGTTTAAGTAAATTTGAAAATAGCTTTGGGAAATGTTTTTAAAATGCCAGGATTTT
AGGGGTTAAAGATCATATGGGGTAGTTTAGGAAGTTTGTGACTATGAGATGAATTTGTGAGGTTTCTTGCCTACCTTTTTTCCCCCCCAG
AGAAGGGTGGAACTAGATTTTAAAGGCATCTCTACTCTGCTTTTGCTGAGTAGTTTCACTGTCCCTTGAGATACCATTGGCTATTTATAC
CTGAGTCTAGTCTAATTCACATATATATATATTTTAAAAGTTGAGAGAACATACCTATTGATGTGGTTCAATAATTCATTTGTCAGGGAA
TATTTGATCTTAATTCCTTTCTAATAGGTAGTGATTGGATGTATTTTCCTACTTCCTGTATGTAATCTCTTTATGCCATGCTAGTTCTAA
CCAGTCCCTTCTTTTGAAAGCTTTTCTTTCTCTGCTTTTTAAAGGAATGATGGTGATCAGCAGGCATTATGCAGATACCACGTGCCTGAG
GTTATGGAGGGGAAATGTCACATGACTGTATGAAATCATTATATGCCCTATTTTGTATTTATTGATGTTTCTTTTTGTGGGCCAAAAATA
TGTTTGTAATATATTTAGTTTTTTTAAAATCATGGTAATTGATTGGAAGATTTATTTTTAATAGCTTTGCCTTTTTTGCAGAGTGCAAAA
TTTCTAAATTATAACTTATGTCATAAAGCAAAATTATATTTGGTATCACCATAAATTTCTATTCTGAATGGTGAGAACAGATAATTTGAA
TATTTCTCACCTGTGAGTCTATATTAGTAAGCTTTTTTATTTTAATGTACTGTAATGAAGTGGTCACGAGTAGTTACCTCGGCTCAAAAA
TGTCATTTAGTTTGTTAAACTATTTTCACAACCATCATAAGCATAACTAGATAACTGTCCATTCCCAGCAGTTCAGTTTAGTCTCCATTG
TGTATTTAAAGGTTGTCGCAGAGCAGCACATTGACTTCCTCATCAGCCCTTTGACAAGGAAGGGAAAGTCGTGGGTAGTCGATTTGAACT
TTTTCTGTCTACTTGTCCCCTCATGTTAGCTGCTTGAAATTCTTCAGTTATGATACAAAGCTGAGTTTGCAGTAAGTTGCACATTTTATT
GTTTGCAATTTTCTGTTTTATGTGCATTTAAAAGCCCTTCTCTGCTTTCTAGTAAGGAGGCATGAAATTATCAGGAATGTTGCTAGTTAC
AGCTTCACACCAAAAACTTTGAGTAAATACATTTTCGTTTGGATGCCCATGATGAAAGCTGAGGAAAGTGGTTGAGGAATTATCAACAAC
AAACTTTTCCTCTTATTTTATCTAGTTCAAAACAGATATCAAAGTTTGCAATTTGCTTTGCTCTTGCTGTTTCTTATGAGTCCCTTTTTG
GAAGAGAGGAGAACATCTATAAGCCCAGAGAGATCTGTGTTTTTCTTTTACTTAATAGAGCCATTCTCGTCTATTAGTAGGAACTTTGCT
ATTAATATGTATAGAAAGGAATGAAGTGGCTTTTACTCCAGAAATATGAAAATTAGTATCTTTTAAAATAGCACTTATGCTATCACAAGG
CAATACTGGAATGAAAAACAAATCTTATATAAGGTCCTAAATAGGTAGAAACTAGCTTTTATTCTAGTGTTGAACCCAGGAGAAATAGTG
GCAAAGAAGTTTCACTCTGTTTCTGCAGTTCTTTGGGACTATTTATAAAGGCCAGTTAGATTGTGTTACTGTGATTTAATTTACAAAGTT
GCTGCAGTTAATGGATACATTCTGTGCTCTGAGAATCTGAATTCCATTCTAATGTGTGATATTCACTGGCTATGATCAGTAGTATCTGAA
GAAAAGATGGGCTTTTTCTCCTTTACTCTCTCTACATAATTATTAATATTATTTTAATTAAAGTACTTAAGACATTGTTTTTTCTTCTGT
AAAAATGGCTTAGCAATTTGCACATCTGGGTAGGTTATGTAGCTAGTAAACAACTCAATAGTAAGTAGCAATTATACTTAACCCACCAAG
TGACAGACTATGCAATGGAAAAATTTTCTAATTATCGTCACATAGCTTAGACAGCAAAGGATTATTTTCTCTGGTGACCTACCATGTGTG
ATATAACTGCTTTATAAATGACTTCCTGAGCAATTTCATGTTGGCAGGCAGTGTGGTGTGTCTAGTGCCCCTCTATGAGAAGACTATAAT
TTAATCAGAAACAAATAGTAGGCATGGGGAGCAAGTTGGAAAGTGAGGTTATTATTTTTTTTCCTTAAAATTGGTGTTACTGTCTTTAGT
GGCTTGAGGCTAAAGAAAGCTGATACTTTATCTTTGCCAAATAATTATTTATAAGATTTATTTTTAAATAAGCCCAATCTCTCACCTGCA
GTTAAGAATCATCATTTTCTGTGACTGACACTAAAGCTCTTCCTTATCAGAGCTTGTTCTCAATCTGTGATCACAGTCCACAGTGGCAAA
GACAACTCTTTGATTAGGAAGGAAACCATGTTTGGGATGCACAGAGGTGCCCTGTCCATACGGTTTTCTTCTTACATGAAAGAATTGACC
TTTCTGTTGACCTATACCATTCTGTTTTTATAAAGTGGGATTAGAATTTGAGCATATCTAGTAAATGCCGTGTGGTCAGTCCGCTGATGC
TTGCCCGCCGTCTTTGCCGTGCCTTGGCATCCTAGGGGTGCTGGTGATGGTCAGTGGGCATCATCGGTCAGCAGTGCACGTGTAAGGCAA
TCTCCTCTCCTCCAGGTTAGTTCAGAAGGTCGCTATGGGTTGGTATTGCAAAAAGATGAGTATATGAACACTAAACTTATTAAGAGGTTT
GAAATTCATTAAAAATTAGTTTTCAGTTTCTTCATCTTTCTTTTCAGACTTCTTTAAAAATACTGTTCTTAATCTGGTATATATAGAAAT
CTAATATTATGGTCTTCTAAATGGTCAACAGAACTCTCCAGTTTAATGAGGCAATTTAGAGGATTCCTTGAAAGAAAATTTCATCATACT
GAACAGTCCTCATTTGTATCTCTTTTGTTACCAGTATTTACATTGTTCCAAGGATTTTTTTCCTGACAAAAAATATATTTCTCGGGAGTG
GAGAGTTTTTTATATATATATATGAAAGAACATAGATGTTTCCCCCCGCCCAATACATTAACTGAATCTTCACTGGCATTCTGTAGAAAA
GTTAAAACAGTTTAATAATGTCTTAACATCTTTATACATTTTCCTATATTCTGGAGGAAACCAGAATCATGTTTAGTAGATTAAAGTAAC
ATTTTAAATACTACCTTTCCAATAATTTGTAATAAAATACCAGTGAAGGACATGTTTGGATATCTGTTAAGCATTTTTCCCTGACTAATG
AATTAGGAAAGAAAACATAAAACATAAATGAATAGTTATGTCTCTTCTAATAAACAGTGTCATTAATGCTGCAGTTGTGGGTCAAACTTA
GGGAGCCTTATTTCTAAATAGCAAAAATTCTGTTTTCACTTCAGCCCTTATTTTTTTTTGTTAGTTTTTCTCTGCACTGTGATACAGAGC
TAATAAGAGGAAATGTGACGTTTCAGAGAGAGAGCAAGCAAATTGGGTATGACTTTTTTACCCTATGTTCCCCAATACTGGGGATGTTTG
GCTACTTTGAACAGCAGTTTTTAGTGATCTAAAGTTTAGATCAATACTCGTATAAGAGAAAAATCTAACTCTCAGTGAGCTCCATAGGGC
AGCACAGCTTTCCATCTTCTCTTTCGCCTTCTTGCGTCTGCCCACCACAGTCCCGAAGAATGCACACGCACATATGATCTGTACCCATCC
CGCCCGAAGAGTCATAGAATCCTCTTCTTTCACTTGTTTCTTTTTTCTTCGTTTGTTTGTTTTTGTTTGTTTGTTTTTTAAGCTGGGGAC
CACTGAAGTAAGCTCTGTATGCACCCAAAGTTCCCCTTGGAAAAATTTTCAACACGCAGTGCAGAAGGCTCCAGTGCAGCTAAATGCCAC
ACCATTGGTTCTACCTGGGGGAATAGACTGATTTGCCCTAAAATGACTCCAACCTGCATCATTAAGGTACAGTTGGCTCCAGTGGATTAG
TGCTGAAATGATGGGAAGTCTGACACTTGTTGACATTGTCTTCATCTGTTTGGAAGGGTTGAATCTGTTCCTCTCAACAGTGATAGTTCT
TTTCACTGTATAGTATTGAGTATGTCTCAGGGATTCCTTGTGGAAATTAGGGCAGTTTTTAAAATAAGAAAATAGTTTTAAAAGAAACTA
AAGGTGACTCATCATTGAAGAGAGCGGAAGAAAGAGGAAACATTTGGTTTTGTAGCCCACAGTGTCTTGCATAGGACTTTTTCCTTTCTC
CTCCAGGCTCTCATCTCAGCTTCAGAATACAGAATCCTTTCCCATCACGCACAGCTTTAAAACTTTTATTTAAAAATTTCCTTCCCCAAT
GAGCTTTCAGAATACTTATTGTAGATTTTAAGAGAAAAGGTATATTAATTTATGCTATTAACATCACCTCATAAATTATAAGTTTTATAC
TAAAGCTGTATCGAGTGTAATGAATTATGTTGCCTATGTGTTTAATAGCTAAATATATATGAGCTTTTTTTTTTTTTTTTTTTTTTGACA
AAACAAACTAGTGAAGCACCTTTTTACACTGGATCTCTGCCGTGTCAAGGTGTATAGCTATCCTTTGCTACCTTGCAGATATATAAAATA
AAAGGATATCCTGGGGCCTCAAAATGTAGAACACCTTTAGACCATTTATAACTGTTCCTAGAACTGTTGAGAATCATGTTCTTTAGTAAA
TGATCTGTGGTTTACACTTAAGATGGCTAGAAGCTTAGTTACAGGGTACATAGAAATACATAGATCAAGTAAAACTCCAACTACTGTAGC
TGGAATTTGTAAACTAAGTTTGTAAGACCTCTTTTATTTCCTATGGAGTTATTCTTTAATTTACAGTTTATTCTGTAAGTTGGGAAGTAA
AATAGAGAAAATAATAAATCTAGATGTTCTCAGTGTCTTATTCAGGAACTTTTTATCCCTCCTCACTAAGGAATTCCCACTGTGACTTTA
AAATAGAACTAAATTACTTGTGTGCATGTATATGTCTGTATTTTTTACACACATGCAAAAATATACATTGGGGGCACGTGTGTGAGAGAT
ATGAATGTGTGCTTATATAAAAATAGATAAAGGTAACCGAATGTATTGTAGAAACATGATTTATTTAGTTGAGGGTATTGGAGTTACTTT
CTCATTGTCTCTGTTGTATAAATACACCAAATTAATCATTATGTTATCTTATGTTAAAAGGCTAGCTCTGATATCATGTGCATTTTATGT
TAACCTTTGGATTAACTTATATTATGCTATGTTCATAAAATGACATGAGAAACAGGAGGTTCTAAGATCAGCCTCTCACTTTCGAGCATA
AAAATAAGAGAGGGAGACAGACAGCCCCAGACATGAGCTGTGTTTATCTATTGTGGTGATGGGACCACAGATCTATTGAATCTTTTTTAT
GTTAATTATAGATTTCTTTATATTCGAGTAAGAAAATATTGTTGATCATCTTTTCTTGGTGAAGTTAAGAAAAAGTATAGGCCTTTCATA
AACAATTTTTGGAAGGGGCTGCTTTGTTTAAGGAGTTGGTGGGATCATTTCACCGTGCATATTTCAAAGCTGGGGTGATTTCATTTATTT
CCAAAATTTTTCAAAAAACTTTTACTCAGTTCTGCTGTTATTTATTAACTTAAGAGTGCTCCCATCCCCATATTTCAGCTATAGGAAAAT
TGTGCTACCCCTGATTCATATGGAATTAAAAAAAAATACATCCCTTTATTTTGAGTTTTAAGTTGTTATTTTGCTATACATTTATTACTG
GAGTATCTGGTGGTCTGAAATAGTCAAAAGTAGAGTTGGTATTAAATGTTCCAATGACATTTATTTTTAATACTTAAAAAATCATGTACT
TTGAAATATGTCAAAGCAACTTCTGATAATATACCTGAATTTGTAGTTGTCTCTTGAGCATCATTTACTTCATCTTAGATATAGTGAAGA
TCTAGGAAAGCTCTATATGCTGTTCTTTTCTACAGTTGTATTTTTGCAGCATCTCCTGGTTTCATTCACTCTTGTTTTGGGATTTTTTTT
TAGATCTGCATATTTCTTGTACATATGCATGCAAATGAAAGAAGGGAGTTTGTACTGGTGCCATTTCTCCCTTCAGTTGCTGGTTAATGG
GATTTGCTAGAAAAAATTCTCCCGGTTGAAGGGTGAAAACAGACCCTTATGTGTATATCTGTACAGAGATGTGTATATGGGATGTGGTGG
CACTTTGCTGAATGTGAACTTGCCTTGTCAATGGAAAGATTGAAAAGTATTATGTTTATTTATACATTTGTATAAATCTATATATACACG
TATGTATATGTGTGTGTATAGATAAAGCTATATACATATATTTCCCTTAAAAATGTGTGTGTATAATAGGTAAACAGCCTTTGTTAAGCA
AGATTAATGTCTATGGAAAGTTCTGGATTATTCTGTAAGCCAGAGGAGGTGACAGTCTAGAGTACATCATCAGAACATACTAAAATGGAA
GTCCTTTGGATTATAGTTTTGTTTATGGATATTACACAATGAATGCTTGTCTGAACAGTTCTTACTTGCCAGTTCCACTATTCTTCATCT
TCACCACCTTCTACTGGTCAGTCTTTCATCACTTAAAAAAAAAAAAAAAATCACACATCATTGTGGTTTTTTTCCCCCTTAATTCTGTCT
CTTCTAGCCAGAAGCATCTGGCTTAAGCATATTTCATCAACTTCTCTGTTATTTCTTTTAAAGATCTTTATCTCTGAAATTTTCCCAGAA
GATACAAGTTTTGGTAATATTATCAATAGGAATTTTGAGACTTGGGCATTCATCTTTGTCTCAAAAACAAACAGAAAGCCAACCTTCAAA
TAAAACAAATTTGAAAGTTTTAGCTCAATAATTTGGGGACATTTTACTTAAATTACAAAAGAACATAATTATGATTTTATGATCGATATT
AGTGTTAGGTTTATTTCCACACTTACTGTCATTAATTTGTCATTTACATATTTTTATTTGCTTTGTAGTTTAATCATAACTTCACCATTT
ACATTTTAATGGAAAGCATACAAGGTCACATGTTAGCCTCTTGAATTCTGTAACTAACTCATTTTTCTCATGATGAAACTGCTTTGATGA
ATTCCTGTGTGATGAATTCTGCTATATTTCCTTTTGACTTTTCTCAGTTTGTGACATTCTGTATTAACTTTGCTGCAGCTCTCTAGAAAA
CTTGCATCCCTATATATTGTGCCTTTAAAGCTCTTATGCACACACAGACAAAAGTGTATATATACATGTCAGAGCATGTGTACATATGCT
TTCGTATGTACTCACACAGTATGTCTCTAGTATATATTGTGGGAGTAGATATATAGATATTCAAAGGCAATGAAATATTGCTCTCCAGAT
ATATATGTATATAAATAGTGTTGATATAACTGTATATACACATGTATATGTATGAGTTTTAAATGGCAATCTTTTACATTTAGCAAAATG
CTGCCCCTACTGGAATATTGTCACTGCAGTGGCAGTTGTATGTAATGATTTAAAATACATTATCAAAAGTTATTTAAAGAACATTTAAAG
TCTCATCTAAAGACATCCACACACTATTTATTTATCTTCCTTTTCCTTTTATTGTTGTGTTTTTCTTAACTGAAAGGGAGACTGTCATTT
TAAAAATGCCATCTGTCCCATGAGAGTAAGAAAGAGCTGGAGATTCACTTGAGGAGCTTTGTGCATTTTTCCTCTCTCTGAAGTGGAGAT
GTTCCACAGACCAGACTGTTTATTTCACTTATAAAGCAATCCTAATATTTCCGTTAGTGTATGTCAGCCACCATCTCCTAGATCAACTTA
ATTCACCAATTTGCCTCCTCCTTTCATTAATAAATAATGATTATTGAGATCATTTTGCCTGGGGGAAGTTAACTACTCCCATGCTGCAGG
GAAATATATCACCTAATTGTTATTTTGCCTTGTTCAAAATTCAAATTTGAAAGAAGGCAGCTCTCTCATGAAGCTGTCTTAAGCACATTT
TAGTTAAGGGCCCTCCCAAACTCTTTTTTCTTTCTTTCTTTCTTTCTTTTTTTTTTTTTTTTGCGAGTTCCAAGTTGCATGTGCTTGAAA
TAGATTTAATTCTTATTCCCCACAGTTTAGGTATTTTTCATTAGTACATCAATTTGACACACTGAATGCAAGACTATTAAGGAAGAACGA
TTAAATATTATTTTATTTTGTGAAGAGTTGGCAGCAGATTACATCTCAAGAACTTGCAGAGAGAGGAAGGTAGATGGACAATCCTAAATT
GTAAGATGTTACAAAAAACAGTGAAGTAAGAGTACTCCTGAAGACTAAAATAGAGAGGCTGGGGTTTGAGCCATTTTACTGAGTAGCTTA
GCTGGAACCTGATATCAGAAGTAGCCTTTAACAAAAAGCCTCTTGGCAATTGTATGGTACTAACAACTAGAGTACTGAAGTGTAAGTTGA
AACCAAGTTGCAGTGGGAAATCAAAGGTGAGGTAGCTTATTTGAAACCAGCAAATGAGACAGGTTGGACAGTTTTAAAATCTCTTCTAAC
AAAGAAACTGCACGGTAGCAAGGACTAGCGGTTCTCAAAGCCCTTCTTTTTCAGTGTTCTCATTCACCTTGGCACCCAAGTATGTTTAAC
AGGCCATGCATTAAAAATAAATACAAAAATATAAAAGCCGCTTAAAGGGAACTTACAAACTGACAATCTCTCCTCTGTATTTGTGTTCAT
AGTGGCTGGGAGTTTAATTATATGCACAAAAGTTAGGAGCCACTTGTTTCTGCACAGACTGTAGGAGCAAGATGAGGAGATGGGCAGGTT
TTGGTAAGAGCCCCCAGTTCTGGTGGACAGGCATACTTGTGGCATTGGGTGCGGCATTGCTGGGAGGACCACGTCTTGGGAGGCGATTGA
CTTTTGGTTTGTAATTTCCCTTTAAACAAGAAGAGATGGCTCACATTTTCCATATATATCTCAATGAATGTACTGTATTACTGTTTTAAA
AATTTGATGAAATAATAATGAATTGGTCTCCTTTTGTTATCTGGTCCTTGTTTAATTTGTTTAAGGGTTTTTGTATACAAAAGTTTACAT
TTTTATGTATATTTTTCTTGTGTAAAAACTGATGTAATATGTGTATGAAACACTGTATGTATTATCTGTATATAGTGTGACAAAATCATT


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FusionGenePPI for ETV6_INO80D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ETV6KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2INO80DINO80, INO80E, YY1, RUVBL1, RUVBL2, ACTR5, ACTR8, TFPT, INO80B, ACTL6A, INO80C, NFRKB, UCHL5, MCRS1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ETV6_INO80D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ETV6_INO80D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
HgeneETV6C0040034Thrombocytopenia2CTD_human;HPO
HgeneETV6C0236969Substance-Related Disorders1CTD_human
HgeneETV6C0376545Hematologic Neoplasms1CTD_human
HgeneETV6C1838656Macrocytosis, Familial1CTD_human
HgeneETV6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneETV6C3495559Juvenile arthritis1CTD_human
HgeneETV6C4015537THROMBOCYTOPENIA 51UNIPROT