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Fusion gene ID: 12158 |
FusionGeneSummary for ETS2_WRB |
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Fusion gene information | Fusion gene name: ETS2_WRB | Fusion gene ID: 12158 | Hgene | Tgene | Gene symbol | ETS2 | WRB | Gene ID | 2114 | 7485 |
Gene name | ETS proto-oncogene 2, transcription factor | tryptophan rich basic protein | |
Synonyms | ETS2IT1 | CHD5|GET1 | |
Cytomap | 21q22.2 | 21q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein C-ets-2oncogene ETS-2v-ets avian erythroblastosis virus E2 oncogene homolog 2v-ets avian erythroblastosis virus E26 oncogene homolog 2v-ets erythroblastosis virus E26 oncogene homolog 2 | tail-anchored protein insertion receptor WRBcongenital heart disease 5 protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P15036 | O00258 | |
Ensembl transtripts involved in fusion gene | ENST00000360214, ENST00000360938, | ENST00000333781, ENST00000541890, ENST00000398753, ENST00000380708, ENST00000466787, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 4 X 4=80 |
# samples | 2 | 5 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ETS2 [Title/Abstract] AND WRB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ETS2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12637547 |
Hgene | ETS2 | GO:0045893 | positive regulation of transcription, DNA-templated | 11909962 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-KK-A6E1-01A | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000360214 | ENST00000333781 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
5UTR-3CDS | ENST00000360214 | ENST00000541890 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
5UTR-3CDS | ENST00000360214 | ENST00000398753 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
5UTR-3CDS | ENST00000360214 | ENST00000380708 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
5UTR-3UTR | ENST00000360214 | ENST00000466787 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
5UTR-3CDS | ENST00000360938 | ENST00000333781 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
5UTR-3CDS | ENST00000360938 | ENST00000541890 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
5UTR-3CDS | ENST00000360938 | ENST00000398753 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
5UTR-3CDS | ENST00000360938 | ENST00000380708 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
5UTR-3UTR | ENST00000360938 | ENST00000466787 | ETS2 | chr21 | 40178044 | + | WRB | chr21 | 40765092 | + |
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FusionProtFeatures for ETS2_WRB |
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Hgene | Tgene |
ETS2 | WRB |
Transcription factor activating transcription. Bindsspecifically the DNA GGAA/T core motif (Ets-binding site or EBS)in gene promoters and stimulates transcription.{ECO:0000269|PubMed:11909962}. | Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.{ECO:0000269|PubMed:21444755}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ETS2_WRB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ETS2_WRB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ETS2 | CDK10, ZMYND11, EP300, SPI1, NR3C1, FOS, JUN, ERG, ETS1, NCOA3, NCOR1, CREBBP, TP53, XPO1, SRA1, ZFYVE9, POU5F1, TWIST1, TWIST2, RFWD2, NCOA1, EWSR1, VPS51, CTDP1, GTF3C5, IMPACT, MRPL14, ANKS6, DET1 | WRB | CAMLG, MCOLN3, FAS, SERPINA6, LPAR6, TOR3A, DPEP2, ERGIC3, ITGB8, HTR3C, CNDP1, DUSP6, ASNA1, SLC39A12, SLC22A9 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ETS2_WRB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ETS2_WRB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ETS2 | C0027746 | Nerve Degeneration | 1 | CTD_human |
Hgene | ETS2 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
Hgene | ETS2 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | ETS2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | WRB | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |