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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12158

FusionGeneSummary for ETS2_WRB

check button Fusion gene summary
Fusion gene informationFusion gene name: ETS2_WRB
Fusion gene ID: 12158
HgeneTgene
Gene symbol

ETS2

WRB

Gene ID

2114

7485

Gene nameETS proto-oncogene 2, transcription factortryptophan rich basic protein
SynonymsETS2IT1CHD5|GET1
Cytomap

21q22.2

21q22.2

Type of geneprotein-codingprotein-coding
Descriptionprotein C-ets-2oncogene ETS-2v-ets avian erythroblastosis virus E2 oncogene homolog 2v-ets avian erythroblastosis virus E26 oncogene homolog 2v-ets erythroblastosis virus E26 oncogene homolog 2tail-anchored protein insertion receptor WRBcongenital heart disease 5 protein
Modification date2018052320180519
UniProtAcc

P15036

O00258

Ensembl transtripts involved in fusion geneENST00000360214, ENST00000360938, 
ENST00000333781, ENST00000541890, 
ENST00000398753, ENST00000380708, 
ENST00000466787, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 4 X 4=80
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ETS2 [Title/Abstract] AND WRB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETS2

GO:0000122

negative regulation of transcription by RNA polymerase II

12637547

HgeneETS2

GO:0045893

positive regulation of transcription, DNA-templated

11909962


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A6E1-01AETS2chr21

40178044

+WRBchr21

40765092

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000360214ENST00000333781ETS2chr21

40178044

+WRBchr21

40765092

+
5UTR-3CDSENST00000360214ENST00000541890ETS2chr21

40178044

+WRBchr21

40765092

+
5UTR-3CDSENST00000360214ENST00000398753ETS2chr21

40178044

+WRBchr21

40765092

+
5UTR-3CDSENST00000360214ENST00000380708ETS2chr21

40178044

+WRBchr21

40765092

+
5UTR-3UTRENST00000360214ENST00000466787ETS2chr21

40178044

+WRBchr21

40765092

+
5UTR-3CDSENST00000360938ENST00000333781ETS2chr21

40178044

+WRBchr21

40765092

+
5UTR-3CDSENST00000360938ENST00000541890ETS2chr21

40178044

+WRBchr21

40765092

+
5UTR-3CDSENST00000360938ENST00000398753ETS2chr21

40178044

+WRBchr21

40765092

+
5UTR-3CDSENST00000360938ENST00000380708ETS2chr21

40178044

+WRBchr21

40765092

+
5UTR-3UTRENST00000360938ENST00000466787ETS2chr21

40178044

+WRBchr21

40765092

+

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FusionProtFeatures for ETS2_WRB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETS2

P15036

WRB

O00258

Transcription factor activating transcription. Bindsspecifically the DNA GGAA/T core motif (Ets-binding site or EBS)in gene promoters and stimulates transcription.{ECO:0000269|PubMed:11909962}. Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.{ECO:0000269|PubMed:21444755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ETS2_WRB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ETS2_WRB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ETS2CDK10, ZMYND11, EP300, SPI1, NR3C1, FOS, JUN, ERG, ETS1, NCOA3, NCOR1, CREBBP, TP53, XPO1, SRA1, ZFYVE9, POU5F1, TWIST1, TWIST2, RFWD2, NCOA1, EWSR1, VPS51, CTDP1, GTF3C5, IMPACT, MRPL14, ANKS6, DET1WRBCAMLG, MCOLN3, FAS, SERPINA6, LPAR6, TOR3A, DPEP2, ERGIC3, ITGB8, HTR3C, CNDP1, DUSP6, ASNA1, SLC39A12, SLC22A9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ETS2_WRB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ETS2_WRB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETS2C0027746Nerve Degeneration1CTD_human
HgeneETS2C0162820Dermatitis, Allergic Contact1CTD_human
HgeneETS2C0376634Craniofacial Abnormalities1CTD_human
HgeneETS2C1458155Mammary Neoplasms1CTD_human
TgeneWRBC0023893Liver Cirrhosis, Experimental1CTD_human