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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12156

FusionGeneSummary for ETS1_UBE2V2

check button Fusion gene summary
Fusion gene informationFusion gene name: ETS1_UBE2V2
Fusion gene ID: 12156
HgeneTgene
Gene symbol

ETS1

UBE2V2

Gene ID

2113

7336

Gene nameETS proto-oncogene 1, transcription factorubiquitin conjugating enzyme E2 V2
SynonymsETS-1|EWSR2|c-ets-1|p54DDVIT1|DDVit-1|EDAF-1|EDPF-1|EDPF1|MMS2|UEV-2|UEV2
Cytomap

11q24.3

8q11.21

Type of geneprotein-codingprotein-coding
Descriptionprotein C-ets-1Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1v-ets avian erythroblastosis virus E2 oncogene homolog 1v-ets avian erythroblastosis virus E26 oncogene homolog 1ubiquitin-conjugating enzyme E2 variant 21 alpha,25-dihydroxyvitamin D3-inducibleDDVit 1MMS2 homologenterocyte differentiation promoting factorenterocyte differentiation-associated factor 1enterocyte differentiation-associated factor EDAF-1enterocy
Modification date2018052320180523
UniProtAcc

P14921

Q15819

Ensembl transtripts involved in fusion geneENST00000392668, ENST00000525404, 
ENST00000345075, ENST00000535549, 
ENST00000526145, ENST00000531611, 
ENST00000319397, 		ENST00000523111, 
ENST00000521346, ENST00000517630, 
ENST00000520809, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 2 X 8=80
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/80*10)=0
Context

PubMed: ETS1 [Title/Abstract] AND UBE2V2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneETS1

GO:0030578

PML body organization

11909962|15247905

HgeneETS1

GO:0045648

positive regulation of erythrocyte differentiation

8620536

HgeneETS1

GO:0045893

positive regulation of transcription, DNA-templated

11909962

HgeneETS1

GO:0045944

positive regulation of transcription by RNA polymerase II

15001984|15247905

HgeneETS1

GO:0050729

positive regulation of inflammatory response

21310411

HgeneETS1

GO:0061614

pri-miRNA transcription by RNA polymerase II

21711453


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-FX-A2QS-01AETS1chr11

128391808

-UBE2V2chr8

48955593

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000392668ENST00000523111ETS1chr11

128391808

-UBE2V2chr8

48955593

+
intron-5UTRENST00000392668ENST00000521346ETS1chr11

128391808

-UBE2V2chr8

48955593

+
intron-5UTRENST00000392668ENST00000517630ETS1chr11

128391808

-UBE2V2chr8

48955593

+
intron-5UTRENST00000392668ENST00000520809ETS1chr11

128391808

-UBE2V2chr8

48955593

+
intron-3CDSENST00000525404ENST00000523111ETS1chr11

128391808

-UBE2V2chr8

48955593

+
intron-5UTRENST00000525404ENST00000521346ETS1chr11

128391808

-UBE2V2chr8

48955593

+
intron-5UTRENST00000525404ENST00000517630ETS1chr11

128391808

-UBE2V2chr8

48955593

+
intron-5UTRENST00000525404ENST00000520809ETS1chr11

128391808

-UBE2V2chr8

48955593

+
Frame-shiftENST00000345075ENST00000523111ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000345075ENST00000521346ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000345075ENST00000517630ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000345075ENST00000520809ETS1chr11

128391808

-UBE2V2chr8

48955593

+
Frame-shiftENST00000535549ENST00000523111ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000535549ENST00000521346ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000535549ENST00000517630ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000535549ENST00000520809ETS1chr11

128391808

-UBE2V2chr8

48955593

+
Frame-shiftENST00000526145ENST00000523111ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000526145ENST00000521346ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000526145ENST00000517630ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000526145ENST00000520809ETS1chr11

128391808

-UBE2V2chr8

48955593

+
Frame-shiftENST00000531611ENST00000523111ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000531611ENST00000521346ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000531611ENST00000517630ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000531611ENST00000520809ETS1chr11

128391808

-UBE2V2chr8

48955593

+
Frame-shiftENST00000319397ENST00000523111ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000319397ENST00000521346ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000319397ENST00000517630ETS1chr11

128391808

-UBE2V2chr8

48955593

+
5CDS-5UTRENST00000319397ENST00000520809ETS1chr11

128391808

-UBE2V2chr8

48955593

+

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FusionProtFeatures for ETS1_UBE2V2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ETS1

P14921

UBE2V2

Q15819

Transcription factor. Directly controls the expressionof cytokine and chemokine genes in a wide variety of differentcellular contexts. May control the differentiation, survival andproliferation of lymphoid cells. May also regulate angiogenesisthrough regulation of expression of genes controlling endothelialcell migration and invasion. {ECO:0000269|PubMed:10698492,ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905,ECO:0000269|PubMed:15592518}. Has no ubiquitin ligase activity on its own. TheUBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonicalpoly-ubiquitin chains that are linked through 'Lys-63'. This typeof poly-ubiquitination does not lead to protein degradation by theproteasome. Mediates transcriptional activation of target genes.Plays a role in the control of progress through the cell cycle anddifferentiation. Plays a role in the error-free DNA repair pathwayand contributes to the survival of cells after DNA damage.{ECO:0000269|PubMed:10089880, ECO:0000269|PubMed:14562038,ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:9705497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ETS1_UBE2V2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ETS1_UBE2V2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ETS1DAXX, BRCA1, TDP2, EP300, SPI1, ETS2, MAF, JUN, RUNX2, UBE2I, RBBP6, PIAS4, NCOA3, NCOR1, CREBBP, MED23, PLEC, MAPK7, TP53, ELAVL1, RUNX1T1, ATF2, SP100, APP, EPAS1, SRA1, MEIS1, SRSF11, C17orf62, ARID4B, EIF5B, APLP2, RPL13A, ARL6IP4, NCL, RFWD2, KAT2B, NCOA1, PTEN, ZBTB7A, MAPK1, AR, NFKB1, SMAD3, PKM, CHI3L2, THUMPD1, ATP2B1, SP1, TBP, DNMT3L, ZMIZ1UBE2V2MOB4, LRIF1, IGSF21, HLTF, EGFR, XIAP, ZNRF1, SIAH1, DZIP3, MKRN3, RNF144A, RNF2, TRIM5, UBE2N, RNF8, SHPRH, TRIM32, OTUB1, UBC, TRAF2, UBE2B, RAD23B, UBE2V1, ZYX, UBXN1, ATP6V1B2, USP9X, USP34, UBXN7, SSSCA1, TTLL12, VPS26A, STUB1, UBE2L3, SEC23A, CPLX1, ZFYVE19, ZPR1, ZRANB2, UFM1, CD2BP2, RPS21, TTC9C, RNF11, BCL10, MALT1, UBE2M, RHOA, POLK, TIGD6, RC3H2, RC3H1, TP53, MUL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ETS1_UBE2V2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ETS1_UBE2V2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneETS1C0007570Celiac Disease1CTD_human
HgeneETS1C0024141Lupus Erythematosus, Systemic1CTD_human
HgeneETS1C0035126Reperfusion Injury1CTD_human