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Fusion gene ID: 12142 |
FusionGeneSummary for ETHE1_UGT2A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ETHE1_UGT2A3 | Fusion gene ID: 12142 | Hgene | Tgene | Gene symbol | ETHE1 | UGT2A3 | Gene ID | 23474 | 79799 |
| Gene name | ETHE1, persulfide dioxygenase | UDP glucuronosyltransferase family 2 member A3 | |
| Synonyms | HSCO|YF13H12 | - | |
| Cytomap | 19q13.31 | 4q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | persulfide dioxygenase ETHE1, mitochondrialethylmalonic encephalopathy 1hepatoma subtracted clone one proteinprotein ETHE1, mitochondrialsulfur dioxygenase ETHE1 | UDP-glucuronosyltransferase 2A3UDP glucuronosyltransferase 2 family, polypeptide A3UDPGT 2A3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95571 | Q6UWM9 | |
| Ensembl transtripts involved in fusion gene | ENST00000292147, ENST00000600651, | ENST00000251566, ENST00000420231, ENST00000547910, | |
| Fusion gene scores | * DoF score | 8 X 5 X 7=280 | 4 X 1 X 3=12 |
| # samples | 8 | 4 | |
| ** MAII score | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ETHE1 [Title/Abstract] AND UGT2A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ETHE1 | GO:0006749 | glutathione metabolic process | 23144459 |
| Hgene | ETHE1 | GO:0070813 | hydrogen sulfide metabolic process | 23144459 |
| Tgene | UGT2A3 | GO:0052695 | cellular glucuronidation | 19858781 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A1OY-01A | ETHE1 | chr19 | 44030353 | - | UGT2A3 | chr4 | 69798477 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000292147 | ENST00000251566 | ETHE1 | chr19 | 44030353 | - | UGT2A3 | chr4 | 69798477 | - |
| 5CDS-5UTR | ENST00000292147 | ENST00000420231 | ETHE1 | chr19 | 44030353 | - | UGT2A3 | chr4 | 69798477 | - |
| 5CDS-intron | ENST00000292147 | ENST00000547910 | ETHE1 | chr19 | 44030353 | - | UGT2A3 | chr4 | 69798477 | - |
| In-frame | ENST00000600651 | ENST00000251566 | ETHE1 | chr19 | 44030353 | - | UGT2A3 | chr4 | 69798477 | - |
| 5CDS-5UTR | ENST00000600651 | ENST00000420231 | ETHE1 | chr19 | 44030353 | - | UGT2A3 | chr4 | 69798477 | - |
| 5CDS-intron | ENST00000600651 | ENST00000547910 | ETHE1 | chr19 | 44030353 | - | UGT2A3 | chr4 | 69798477 | - |
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FusionProtFeatures for ETHE1_UGT2A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ETHE1 | UGT2A3 |
| Sulfur dioxygenase that plays an essential role inhydrogen sulfide catabolism in the mitochondrial matrix. Hydrogensulfide (H(2)S) is first oxidized by SQRDL, giving rise tocysteine persulfide residues. ETHE1 consumes molecular oxygen tocatalyze the oxidation of the persulfide, once it has beentransferred to a thiophilic acceptor, such as glutathione (R-SSH).Plays an important role in metabolic homeostasis in mitochondriaby metabolizing hydrogen sulfide and preventing the accumulationof supraphysiological H(2)S levels that have toxic effects, due tothe inhibition of cytochrome c oxidase. First described as aprotein that can shuttle between the nucleus and the cytoplasm andsuppress p53-induced apoptosis by sequestering the transcriptionfactor RELA/NFKB3 in the cytoplasm and preventing its accumulationin the nucleus (PubMed:12398897). {ECO:0000269|PubMed:12398897,ECO:0000269|PubMed:14732903, ECO:0000269|PubMed:19136963,ECO:0000269|PubMed:23144459}. | UDP-glucuronosyltransferases catalyze phase IIbiotransformation reactions in which lipophilic substrates areconjugated with glucuronic acid to increase water solubility andenhance excretion. They are of major importance in the conjugationand subsequent elimination of potentially toxic xenobiotics andendogenous compounds (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >UGT2A3 | chr19:44030353 | chr4:69798477 | ENST00000251566 | - | 1 | 6 | 513_527 | 288 | 528 | Topological domain | Cytoplasmic |
| Tgene | >UGT2A3 | chr19:44030353 | chr4:69798477 | ENST00000251566 | - | 1 | 6 | 492_512 | 288 | 528 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | UGT2A3 | chr19:44030353 | chr4:69798477 | ENST00000251566 | - | 1 | 6 | 24_491 | 288 | 528 | Topological domain | Extracellular |
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FusionGeneSequence for ETHE1_UGT2A3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ETHE1_ENST00000292147_chr19_44030353_-_UGT2A3_ENST00000251566_chr4_69798477_-_365aa MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL LRSLLPGCQSVISRLSGAQADLHIEDGDSIRFGRFEMENFVQSSGEDGIVVFSLGSLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPS TLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITD SSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVATAIFLFTKCFLFSCQKFNKTRKI >In-frame_ETHE1_ENST00000600651_chr19_44030353_-_UGT2A3_ENST00000251566_chr4_69798477_-_365aa MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGL LRSLLPGCQSVISRLSGAQADLHIEDGDSIRFGRFEMENFVQSSGEDGIVVFSLGSLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPS TLGANTRLYDWIPQNDLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDLLRALRTVITD SSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYSIDVIGFLLACVATAIFLFTKCFLFSCQKFNKTRKI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ETHE1_ENST00000292147_chr19_44030353_-_UGT2A3_ENST00000251566_chr4_69798477_-_1095nt ATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAG CCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGG GATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGTGAATACCCACTGCCACGCGGACCACATTACAGGCTCGGGGCTG CTCCGTTCCCTCCTCCCTGGCTGCCAGTCTGTCATCTCCCGCCTTAGTGGGGCCCAGGCTGACTTACACATTGAGGATGGAGACTCCATC CGCTTCGGGCGCTTCGAAATGGAAAATTTTGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGGTCACTGTTTCAAAAT GTTACAGAAGAAAAGGCTAATATCATTGCTTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAAGGAAAAAAACCATCC ACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCATGGT GGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGCTCAC ATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTACCGAT TCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGATCGAG TTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGATTGGG TTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAAGATA >In-frame_ETHE1_ENST00000600651_chr19_44030353_-_UGT2A3_ENST00000251566_chr4_69798477_-_1095nt ATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAG CCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGG GATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGTGAATACCCACTGCCACGCGGACCACATTACAGGCTCGGGGCTG CTCCGTTCCCTCCTCCCTGGCTGCCAGTCTGTCATCTCCCGCCTTAGTGGGGCCCAGGCTGACTTACACATTGAGGATGGAGACTCCATC CGCTTCGGGCGCTTCGAAATGGAAAATTTTGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGGTCACTGTTTCAAAAT GTTACAGAAGAAAAGGCTAATATCATTGCTTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAAGGAAAAAAACCATCC ACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCATGGT GGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGCTCAC ATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTACCGAT TCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGATCGAG TTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGATTGGG TTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAAGATA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ETHE1_ENST00000292147_chr19_44030353_-_UGT2A3_ENST00000251566_chr4_69798477_-_2512nt AGTGCCGTAGCGCCCGGCTCCTGCAGGCGCTCGGCCTCCGCTCATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGT CGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCCATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTA CCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGACCCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCT GGGGCTGCGGCTGCTCTATGCTGTGAATACCCACTGCCACGCGGACCACATTACAGGCTCGGGGCTGCTCCGTTCCCTCCTCCCTGGCTG CCAGTCTGTCATCTCCCGCCTTAGTGGGGCCCAGGCTGACTTACACATTGAGGATGGAGACTCCATCCGCTTCGGGCGCTTCGAAATGGA AAATTTTGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTTTCTCTGGGGTCACTGTTTCAAAATGTTACAGAAGAAAAGGCTAATAT CATTGCTTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGGAGGTACAAAGGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCT GTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAAACCAAAGCTTTTATCACTCATGGTGGAATGAATGGGATCTATGAAGC TATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGTGATCAGCTTGATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGT AGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGGGCTTTGAGAACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTAT GAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTAGATCGAGCAGTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGC CAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAGCACTACTCTATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAAC TGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAAAAATTTAATAAAACTAGAAAGATAGAAAAGAGGGAATAGATCTTTCC AAATTCAAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGCCACATAGAATTTGGTGAAAACCTTGCTATTTTCATATTATCTATTCT GTTATTTTATCTTAGCTATATAGCCTAGAATTCCACGATCATGAGGTTGTGAGTATATCTCATTCTTTCGTTGTATTTTCCTAGGTGTCT TTACTCTCTTCTCTCACTTTGTGACACAAGGACATGAATACATCTAAATTTTCCTATTTCTGATATGACTGTTTTGATGATGTCATTACT TCTATAACCTTAAGTGATAGGGTGACATGCAATATGATTATTCCTGGTGTGCGCCCAAACACATGGATATAAAGAGGTAAAAAACTTAAA ATTCACAAAATTCAGTAAACCACACAAATCAGGTAAGTGTTCTATGAGATTAGCTGGCTATGAGAAACATAATGATGTTTCTTTTTCAAT TTAAATAAGCCCTTCTACATAGCCAGCATCAGTGATCTCAGAAAATAAATTGCTAATAATGATGACATGGCATTATGCTTAGAAAAGTTT GCTGTATTTCCATAGACCTCATCTAGATGTCATGGCCTACATTTCTGCCATCACTCAACCAATACTTTTTTCTGTTTTCTTGATGATAAA AAGACCTTTCTCATGATTGCCATCAAATAACAAAAGAAACTATTTTTTTTCTCACATAGAGAACATGTCAGTAAGATATTCAAGGTGAAC AGATTATTTTTGGGATTAGTAACTATTTGAAATATGTGGTGATAATTACTGAGTTTATAAAATTTATTTGATAGTACACTTAAAGAAGAT TTATATGTTTATTCTTTAAAAATGATGAATACTCATAATTCTTATCTCTATAATCAAAAGTATAATTTACTGTAGAAAAATAAAGAGATG CTTGTTCTGAAAGTAAGATCAGTGAACTGCTTTTCAGTCTCAATCTTTGAGAATTGTAAATTCATCAAATAATTGCTTACATAGTAAAAA TTTAAGGTATTAGAAAACCTGCATAACAAATAGTATTATATATTAAATATTTTGATATGTAAAGCTCTACACAAAGCTAAATATAGTGTA ATAATGTTTACACTAATAAGCAAATATGTTAATCTTCTCATTTTTTTACTGTCATATAATCTTAGTGATATGCCTATTAATAGTTTTAAA TAAATAAATTGGCTCATCTGGCTTTTTGAAAATTTTGAAATTCTTACAGATGTTGATTAGGTATATCTACAAATTAATTTCAATTTTAAA >In-frame_ETHE1_ENST00000600651_chr19_44030353_-_UGT2A3_ENST00000251566_chr4_69798477_-_2469nt ATTCCTGACCCCGCAGTGGGCGCGATGGCGGAGGCTGTACTGAGGGTCGCCCGGCGGCAGCTGAGCCAGCGCGGCGGGTCTGGAGCCCCC ATCCTCCTGCGGCAGATGTTCGAGCCTGTGAGCTGCACCTTCACGTACCTGCTGGGTGACAGAGAGTCCCGGGAGGCCGTTCTGATCGAC CCAGTCCTGGAAACAGCGCCTCGGGATGCCCAGCTGATCAAGGAGCTGGGGCTGCGGCTGCTCTATGCTGTGAATACCCACTGCCACGCG GACCACATTACAGGCTCGGGGCTGCTCCGTTCCCTCCTCCCTGGCTGCCAGTCTGTCATCTCCCGCCTTAGTGGGGCCCAGGCTGACTTA CACATTGAGGATGGAGACTCCATCCGCTTCGGGCGCTTCGAAATGGAAAATTTTGTCCAGAGTTCAGGGGAAGATGGTATTGTGGTGTTT TCTCTGGGGTCACTGTTTCAAAATGTTACAGAAGAAAAGGCTAATATCATTGCTTCAGCCCTTGCCCAGATCCCACAGAAGGTGTTATGG AGGTACAAAGGAAAAAAACCATCCACATTAGGAGCCAATACTCGGCTGTATGATTGGATACCCCAGAATGATCTTCTTGGTCATCCCAAA ACCAAAGCTTTTATCACTCATGGTGGAATGAATGGGATCTATGAAGCTATTTACCATGGGGTCCCTATGGTGGGAGTTCCCATATTTGGT GATCAGCTTGATAACATAGCTCACATGAAGGCCAAAGGAGCAGCTGTAGAAATAAACTTCAAAACTATGACAAGCGAAGATTTACTGAGG GCTTTGAGAACAGTCATTACCGATTCCTCTTATAAAGAGAATGCTATGAGATTATCAAGAATTCACCATGATCAACCTGTAAAGCCCCTA GATCGAGCAGTCTTCTGGATCGAGTTTGTCATGCGCCACAAAGGAGCCAAGCACCTGCGATCAGCTGCCCATGACCTCACCTGGTTCCAG CACTACTCTATAGATGTGATTGGGTTCCTGCTGGCCTGTGTGGCAACTGCTATATTCTTGTTCACAAAATGTTTTTTATTTTCCTGTCAA AAATTTAATAAAACTAGAAAGATAGAAAAGAGGGAATAGATCTTTCCAAATTCAAGAAAGACCTGATGGGGTAATCCTGTTAATTCCAGC CACATAGAATTTGGTGAAAACCTTGCTATTTTCATATTATCTATTCTGTTATTTTATCTTAGCTATATAGCCTAGAATTCCACGATCATG AGGTTGTGAGTATATCTCATTCTTTCGTTGTATTTTCCTAGGTGTCTTTACTCTCTTCTCTCACTTTGTGACACAAGGACATGAATACAT CTAAATTTTCCTATTTCTGATATGACTGTTTTGATGATGTCATTACTTCTATAACCTTAAGTGATAGGGTGACATGCAATATGATTATTC CTGGTGTGCGCCCAAACACATGGATATAAAGAGGTAAAAAACTTAAAATTCACAAAATTCAGTAAACCACACAAATCAGGTAAGTGTTCT ATGAGATTAGCTGGCTATGAGAAACATAATGATGTTTCTTTTTCAATTTAAATAAGCCCTTCTACATAGCCAGCATCAGTGATCTCAGAA AATAAATTGCTAATAATGATGACATGGCATTATGCTTAGAAAAGTTTGCTGTATTTCCATAGACCTCATCTAGATGTCATGGCCTACATT TCTGCCATCACTCAACCAATACTTTTTTCTGTTTTCTTGATGATAAAAAGACCTTTCTCATGATTGCCATCAAATAACAAAAGAAACTAT TTTTTTTCTCACATAGAGAACATGTCAGTAAGATATTCAAGGTGAACAGATTATTTTTGGGATTAGTAACTATTTGAAATATGTGGTGAT AATTACTGAGTTTATAAAATTTATTTGATAGTACACTTAAAGAAGATTTATATGTTTATTCTTTAAAAATGATGAATACTCATAATTCTT ATCTCTATAATCAAAAGTATAATTTACTGTAGAAAAATAAAGAGATGCTTGTTCTGAAAGTAAGATCAGTGAACTGCTTTTCAGTCTCAA TCTTTGAGAATTGTAAATTCATCAAATAATTGCTTACATAGTAAAAATTTAAGGTATTAGAAAACCTGCATAACAAATAGTATTATATAT TAAATATTTTGATATGTAAAGCTCTACACAAAGCTAAATATAGTGTAATAATGTTTACACTAATAAGCAAATATGTTAATCTTCTCATTT TTTTACTGTCATATAATCTTAGTGATATGCCTATTAATAGTTTTAAATAAATAAATTGGCTCATCTGGCTTTTTGAAAATTTTGAAATTC TTACAGATGTTGATTAGGTATATCTACAAATTAATTTCAATTTTAAAATGATGATATAAAAATAAATATAAGTATTTTTCTTGTGTATGT |
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FusionGenePPI for ETHE1_UGT2A3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ETHE1 | IGSF21, LRIF1, RELA, TP53, HDAC1, APP, FGL1, IDH1, NDUFS7 | UGT2A3 | UGT2A2, UGT2B15, HBA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ETHE1_UGT2A3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ETHE1_UGT2A3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ETHE1 | C1865349 | Ethylmalonic encephalopathy | 2 | CTD_human;ORPHANET;UNIPROT |
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