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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12125

FusionGeneSummary for ESYT2_ZNF595

check button Fusion gene summary
Fusion gene informationFusion gene name: ESYT2_ZNF595
Fusion gene ID: 12125
HgeneTgene
Gene symbol

ESYT2

ZNF595

Gene ID

57488

152687

Gene nameextended synaptotagmin 2zinc finger protein 595
SynonymsCHR2SYT|E-Syt2|FAM62B-
Cytomap

7q36.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionextended synaptotagmin-2chr2 synaptotagminextended synaptotagmin like protein 2extended synaptotagmin protein 2family with sequence similarity 62 (C2 domain containing), member Bzinc finger protein 595
Modification date2018052320180522
UniProtAcc

A0FGR8

Ensembl transtripts involved in fusion geneENST00000251527, ENST00000497111, 
ENST00000435514, 
ENST00000339368, 
ENST00000509152, ENST00000526473, 
Fusion gene scores* DoF score10 X 8 X 7=5607 X 1 X 7=49
# samples 107
** MAII scorelog2(10/560*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/49*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ESYT2 [Title/Abstract] AND ZNF595 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-QK-A8ZA-01AESYT2chr7

158590633

-ZNF595chr4

59323

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000251527ENST00000339368ESYT2chr7

158590633

-ZNF595chr4

59323

+
5CDS-3UTRENST00000251527ENST00000509152ESYT2chr7

158590633

-ZNF595chr4

59323

+
5CDS-3UTRENST00000251527ENST00000526473ESYT2chr7

158590633

-ZNF595chr4

59323

+
5UTR-3UTRENST00000497111ENST00000339368ESYT2chr7

158590633

-ZNF595chr4

59323

+
5UTR-3UTRENST00000497111ENST00000509152ESYT2chr7

158590633

-ZNF595chr4

59323

+
5UTR-3UTRENST00000497111ENST00000526473ESYT2chr7

158590633

-ZNF595chr4

59323

+
intron-3UTRENST00000435514ENST00000339368ESYT2chr7

158590633

-ZNF595chr4

59323

+
intron-3UTRENST00000435514ENST00000509152ESYT2chr7

158590633

-ZNF595chr4

59323

+
intron-3UTRENST00000435514ENST00000526473ESYT2chr7

158590633

-ZNF595chr4

59323

+

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FusionProtFeatures for ESYT2_ZNF595


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESYT2

A0FGR8

ZNF595

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ESYT2_ZNF595


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ESYT2_ZNF595


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ESYT2CAMKK2, CLN3, SLC2A4, SLC25A17, ECT2, FN1, MAPK15, DERL1, ESYT1, NTRK1, TMEM17, FGD1, PAEP, ATP6AP2, NOP56, ELL2, NCSTN, MPHOSPH8, TUBA1C, IRF3, FAF2, CDH1, CTDSPL, TRIM25, UBQLN1ZNF595JUNB, TRIM28


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ESYT2_ZNF595


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ESYT2_ZNF595


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource