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Fusion gene ID: 12125 |
FusionGeneSummary for ESYT2_ZNF595 |
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Fusion gene information | Fusion gene name: ESYT2_ZNF595 | Fusion gene ID: 12125 | Hgene | Tgene | Gene symbol | ESYT2 | ZNF595 | Gene ID | 57488 | 152687 |
Gene name | extended synaptotagmin 2 | zinc finger protein 595 | |
Synonyms | CHR2SYT|E-Syt2|FAM62B | - | |
Cytomap | 7q36.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | extended synaptotagmin-2chr2 synaptotagminextended synaptotagmin like protein 2extended synaptotagmin protein 2family with sequence similarity 62 (C2 domain containing), member B | zinc finger protein 595 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | A0FGR8 | ||
Ensembl transtripts involved in fusion gene | ENST00000251527, ENST00000497111, ENST00000435514, | ENST00000339368, ENST00000509152, ENST00000526473, | |
Fusion gene scores | * DoF score | 10 X 8 X 7=560 | 7 X 1 X 7=49 |
# samples | 10 | 7 | |
** MAII score | log2(10/560*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/49*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ESYT2 [Title/Abstract] AND ZNF595 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | HNSC | TCGA-QK-A8ZA-01A | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000251527 | ENST00000339368 | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000251527 | ENST00000509152 | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
5CDS-3UTR | ENST00000251527 | ENST00000526473 | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
5UTR-3UTR | ENST00000497111 | ENST00000339368 | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
5UTR-3UTR | ENST00000497111 | ENST00000509152 | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
5UTR-3UTR | ENST00000497111 | ENST00000526473 | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
intron-3UTR | ENST00000435514 | ENST00000339368 | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
intron-3UTR | ENST00000435514 | ENST00000509152 | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
intron-3UTR | ENST00000435514 | ENST00000526473 | ESYT2 | chr7 | 158590633 | - | ZNF595 | chr4 | 59323 | + |
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FusionProtFeatures for ESYT2_ZNF595 |
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Hgene | Tgene |
ESYT2 | ZNF595 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ESYT2_ZNF595 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ESYT2_ZNF595 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ESYT2 | CAMKK2, CLN3, SLC2A4, SLC25A17, ECT2, FN1, MAPK15, DERL1, ESYT1, NTRK1, TMEM17, FGD1, PAEP, ATP6AP2, NOP56, ELL2, NCSTN, MPHOSPH8, TUBA1C, IRF3, FAF2, CDH1, CTDSPL, TRIM25, UBQLN1 | ZNF595 | JUNB, TRIM28 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ESYT2_ZNF595 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ESYT2_ZNF595 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |