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Fusion gene ID: 12110 |
FusionGeneSummary for ESRRG_ADCY10 |
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Fusion gene information | Fusion gene name: ESRRG_ADCY10 | Fusion gene ID: 12110 | Hgene | Tgene | Gene symbol | ESRRG | ADCY10 | Gene ID | 2104 | 55811 |
Gene name | estrogen related receptor gamma | adenylate cyclase 10 | |
Synonyms | ERR-gamma|ERR3|ERRg|ERRgamma|NR3B3 | HCA2|HEL-S-7a|SAC|SACI|Sacy|hsAC | |
Cytomap | 1q41 | 1q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | estrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3 | adenylate cyclase type 103',5'-cyclic AMP synthetaseAH-related proteinATP pyrophosphate-lyaseadenylate cyclase 10, solubleepididymis secretory sperm binding protein Li 7agerm cell soluble adenylyl cyclasetesticular soluble adenylyl cyclase (SAC) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P62508 | Q96PN6 | |
Ensembl transtripts involved in fusion gene | ENST00000361525, ENST00000366940, ENST00000361395, ENST00000366938, ENST00000359162, ENST00000493603, ENST00000463665, ENST00000487276, ENST00000493748, ENST00000471371, ENST00000391890, ENST00000366937, ENST00000408911, ENST00000360012, | ENST00000545172, ENST00000367851, ENST00000367848, ENST00000476818, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 1 X 1 X 1=1 |
# samples | 4 | 1 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ESRRG [Title/Abstract] AND ADCY10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ESRRG | GO:0006355 | regulation of transcription, DNA-templated | 23836911 |
Tgene | ADCY10 | GO:0006171 | cAMP biosynthetic process | 12609998|15659711 |
Tgene | ADCY10 | GO:0071241 | cellular response to inorganic substance | 12609998 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-C8-A12L-01A | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000361525 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000361525 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000361525 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-intron | ENST00000361525 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000366940 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000366940 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000366940 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-intron | ENST00000366940 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000361395 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000361395 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000361395 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-intron | ENST00000361395 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000366938 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000366938 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000366938 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-intron | ENST00000366938 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000359162 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000359162 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000359162 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-intron | ENST00000359162 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000493603 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000493603 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000493603 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-intron | ENST00000493603 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000463665 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000463665 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000463665 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-intron | ENST00000463665 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000487276 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000487276 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-3CDS | ENST00000487276 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
5UTR-intron | ENST00000487276 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000493748 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000493748 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000493748 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-intron | ENST00000493748 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000471371 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000471371 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000471371 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-intron | ENST00000471371 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000391890 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000391890 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000391890 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-intron | ENST00000391890 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000366937 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000366937 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000366937 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-intron | ENST00000366937 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000408911 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000408911 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000408911 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-intron | ENST00000408911 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000360012 | ENST00000545172 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000360012 | ENST00000367851 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-3CDS | ENST00000360012 | ENST00000367848 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
intron-intron | ENST00000360012 | ENST00000476818 | ESRRG | chr1 | 217038403 | - | ADCY10 | chr1 | 167794093 | - |
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FusionProtFeatures for ESRRG_ADCY10 |
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Hgene | Tgene |
ESRRG | ADCY10 |
Catalyzes the formation of the signaling molecule cAMP(PubMed:12609998, PubMed:15659711, PubMed:24616449,PubMed:25040695, PubMed:24567411). May function as sensor thatmediates responses to changes in cellular bicarbonate and CO(2)levels (PubMed:15659711, PubMed:17591988). Has a critical role inmammalian spermatogenesis by producing the cAMP which regulatescAMP-responsive nuclear factors indispensable for sperm maturationin the epididymis. Induces capacitation, the maturational processthat sperm undergo prior to fertilization (By similarity).Involved in ciliary beat regulation (PubMed:17591988).{ECO:0000250|UniProtKB:Q8C0T9, ECO:0000269|PubMed:15659711,ECO:0000269|PubMed:17591988, ECO:0000269|PubMed:24567411,ECO:0000269|PubMed:24616449, ECO:0000269|PubMed:25040695}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ESRRG_ADCY10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ESRRG_ADCY10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ESRRG | ESRRG, NCOA1, HGS, ESRRA, NRIP1, SP1, PPARGC1A, NR0B2, PARK2, NR0B1, DUT, PROX1, EBP, PNRC1, PNRC2, ARHGEF15, TLE1, APP, SRA1, SRPK1, KIFC3, MEOX2, NUP160, KIAA1598, CCDC67, SUMO1P1, PSMC5, DNMT3L | ADCY10 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ESRRG_ADCY10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ESRRG | P62508 | DB00675 | Tamoxifen | Estrogen-related receptor gamma | small molecule | approved |
Hgene | ESRRG | P62508 | DB02659 | Cholic Acid | Estrogen-related receptor gamma | small molecule | approved |
Hgene | ESRRG | P62508 | DB00255 | Diethylstilbestrol | Estrogen-related receptor gamma | small molecule | approved|investigational |
Hgene | ESRRG | P62508 | DB00783 | Estradiol | Estrogen-related receptor gamma | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for ESRRG_ADCY10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |