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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12110

FusionGeneSummary for ESRRG_ADCY10

check button Fusion gene summary
Fusion gene informationFusion gene name: ESRRG_ADCY10
Fusion gene ID: 12110
HgeneTgene
Gene symbol

ESRRG

ADCY10

Gene ID

2104

55811

Gene nameestrogen related receptor gammaadenylate cyclase 10
SynonymsERR-gamma|ERR3|ERRg|ERRgamma|NR3B3HCA2|HEL-S-7a|SAC|SACI|Sacy|hsAC
Cytomap

1q41

1q24.2

Type of geneprotein-codingprotein-coding
Descriptionestrogen-related receptor gammaERR gamma-2estrogen receptor-related protein 3nuclear receptor subfamily 3 group B member 3adenylate cyclase type 103',5'-cyclic AMP synthetaseAH-related proteinATP pyrophosphate-lyaseadenylate cyclase 10, solubleepididymis secretory sperm binding protein Li 7agerm cell soluble adenylyl cyclasetesticular soluble adenylyl cyclase (SAC)
Modification date2018051920180523
UniProtAcc

P62508

Q96PN6

Ensembl transtripts involved in fusion geneENST00000361525, ENST00000366940, 
ENST00000361395, ENST00000366938, 
ENST00000359162, ENST00000493603, 
ENST00000463665, ENST00000487276, 
ENST00000493748, ENST00000471371, 
ENST00000391890, ENST00000366937, 
ENST00000408911, ENST00000360012, 
ENST00000545172, ENST00000367851, 
ENST00000367848, ENST00000476818, 
Fusion gene scores* DoF score4 X 4 X 2=321 X 1 X 1=1
# samples 41
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: ESRRG [Title/Abstract] AND ADCY10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESRRG

GO:0006355

regulation of transcription, DNA-templated

23836911

TgeneADCY10

GO:0006171

cAMP biosynthetic process

12609998|15659711

TgeneADCY10

GO:0071241

cellular response to inorganic substance

12609998


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A12L-01AESRRGchr1

217038403

-ADCY10chr1

167794093

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000361525ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000361525ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000361525ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-intronENST00000361525ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000366940ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000366940ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000366940ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-intronENST00000366940ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000361395ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000361395ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000361395ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-intronENST00000361395ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000366938ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000366938ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000366938ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-intronENST00000366938ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000359162ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000359162ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000359162ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-intronENST00000359162ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000493603ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000493603ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000493603ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-intronENST00000493603ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000463665ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000463665ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000463665ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-intronENST00000463665ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000487276ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000487276ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-3CDSENST00000487276ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
5UTR-intronENST00000487276ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000493748ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000493748ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000493748ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-intronENST00000493748ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000471371ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000471371ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000471371ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-intronENST00000471371ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000391890ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000391890ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000391890ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-intronENST00000391890ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000366937ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000366937ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000366937ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-intronENST00000366937ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000408911ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000408911ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000408911ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-intronENST00000408911ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000360012ENST00000545172ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000360012ENST00000367851ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-3CDSENST00000360012ENST00000367848ESRRGchr1

217038403

-ADCY10chr1

167794093

-
intron-intronENST00000360012ENST00000476818ESRRGchr1

217038403

-ADCY10chr1

167794093

-

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FusionProtFeatures for ESRRG_ADCY10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESRRG

P62508

ADCY10

Q96PN6

Catalyzes the formation of the signaling molecule cAMP(PubMed:12609998, PubMed:15659711, PubMed:24616449,PubMed:25040695, PubMed:24567411). May function as sensor thatmediates responses to changes in cellular bicarbonate and CO(2)levels (PubMed:15659711, PubMed:17591988). Has a critical role inmammalian spermatogenesis by producing the cAMP which regulatescAMP-responsive nuclear factors indispensable for sperm maturationin the epididymis. Induces capacitation, the maturational processthat sperm undergo prior to fertilization (By similarity).Involved in ciliary beat regulation (PubMed:17591988).{ECO:0000250|UniProtKB:Q8C0T9, ECO:0000269|PubMed:15659711,ECO:0000269|PubMed:17591988, ECO:0000269|PubMed:24567411,ECO:0000269|PubMed:24616449, ECO:0000269|PubMed:25040695}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ESRRG_ADCY10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ESRRG_ADCY10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ESRRGESRRG, NCOA1, HGS, ESRRA, NRIP1, SP1, PPARGC1A, NR0B2, PARK2, NR0B1, DUT, PROX1, EBP, PNRC1, PNRC2, ARHGEF15, TLE1, APP, SRA1, SRPK1, KIFC3, MEOX2, NUP160, KIAA1598, CCDC67, SUMO1P1, PSMC5, DNMT3LADCY10


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ESRRG_ADCY10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneESRRGP62508DB00675TamoxifenEstrogen-related receptor gammasmall moleculeapproved
HgeneESRRGP62508DB02659Cholic AcidEstrogen-related receptor gammasmall moleculeapproved
HgeneESRRGP62508DB00255DiethylstilbestrolEstrogen-related receptor gammasmall moleculeapproved|investigational
HgeneESRRGP62508DB00783EstradiolEstrogen-related receptor gammasmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for ESRRG_ADCY10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource