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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 12093

FusionGeneSummary for ESR1_MTHFD1L

check button Fusion gene summary
Fusion gene informationFusion gene name: ESR1_MTHFD1L
Fusion gene ID: 12093
HgeneTgene
Gene symbol

ESR1

MTHFD1L

Gene ID

2099

25902

Gene nameestrogen receptor 1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
SynonymsER|ESR|ESRA|ESTRR|Era|NR3A1FTHFSDC1|MTC1THFS|dJ292B18.2
Cytomap

6q25.1-q25.2

6q25.1

Type of geneprotein-codingprotein-coding
Descriptionestrogen receptorE2 receptor alphaER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1oestrogen receptor alphamonofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1
Modification date2018052720180523
UniProtAcc

P03372

Q6UB35

Ensembl transtripts involved in fusion geneENST00000440973, ENST00000338799, 
ENST00000456483, ENST00000443427, 
ENST00000206249, ENST00000406599, 
ENST00000427531, ENST00000482101, 
ENST00000367321, ENST00000367307, 
ENST00000478643, 
Fusion gene scores* DoF score12 X 7 X 4=3369 X 8 X 4=288
# samples 1214
** MAII scorelog2(12/336*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/288*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESR1 [Title/Abstract] AND MTHFD1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESR1

GO:0006366

transcription by RNA polymerase II

15831516

HgeneESR1

GO:0010629

negative regulation of gene expression

21695196

HgeneESR1

GO:0030520

intracellular estrogen receptor signaling pathway

9841876

HgeneESR1

GO:0032355

response to estradiol

15304487

HgeneESR1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

7651415|16043358

HgeneESR1

GO:0043433

negative regulation of DNA binding transcription factor activity

10816575

HgeneESR1

GO:0043627

response to estrogen

11581164

HgeneESR1

GO:0045893

positive regulation of transcription, DNA-templated

9841876|20074560

HgeneESR1

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

9841876

HgeneESR1

GO:0045944

positive regulation of transcription by RNA polymerase II

11544182|12047722|15345745|15831516|18563714

HgeneESR1

GO:0051091

positive regulation of DNA binding transcription factor activity

9328340|10681512

HgeneESR1

GO:0071392

cellular response to estradiol stimulus

15831516

TgeneMTHFD1L

GO:0006760

folic acid-containing compound metabolic process

12937168

TgeneMTHFD1L

GO:0015942

formate metabolic process

16171773

TgeneMTHFD1L

GO:0046653

tetrahydrofolate metabolic process

12937168


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A5J0-01AESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000440973ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000440973ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000440973ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
In-frameENST00000338799ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000338799ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000338799ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000456483ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-intronENST00000456483ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000456483ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
In-frameENST00000443427ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000443427ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000443427ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
In-frameENST00000206249ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000206249ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000206249ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-3CDSENST00000406599ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-intronENST00000406599ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
intron-3UTRENST00000406599ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
In-frameENST00000427531ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-intronENST00000427531ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
5CDS-3UTRENST00000427531ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
3UTR-3CDSENST00000482101ENST00000367321ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
3UTR-intronENST00000482101ENST00000367307ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+
3UTR-3UTRENST00000482101ENST00000478643ESR1chr6

152265643

+MTHFD1Lchr6

151330955

+

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FusionProtFeatures for ESR1_MTHFD1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESR1

P03372

MTHFD1L

Q6UB35

Nuclear hormone receptor. The steroid hormones and theirreceptors are involved in the regulation of eukaryotic geneexpression and affect cellular proliferation and differentiationin target tissues. Ligand-dependent nuclear transactivationinvolves either direct homodimer binding to a palindromic estrogenresponse element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2,Sp1 and Sp3, to mediate ERE-independent signaling. Ligand bindinginduces a conformational change allowing subsequent orcombinatorial association with multiprotein coactivator complexesthrough LXXLL motifs of their respective components. Mutualtransrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcriptionfrom the IL6 promoter and displace RELA/p65 and associatedcoregulators from the promoter. Recruited to the NF-kappa-Bresponse element of the CCL2 and IL8 promoters and can displaceCREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50on ERE sequences. Can also act synergistically with NF-kappa-B toactivate transcription involving respective recruitment adjacentresponse elements; the function involves CREBBP. Can activate thetranscriptional activity of TFF1. Also mediates membrane-initiatedestrogen signaling involving various kinase cascades. Isoform 3 isinvolved in activation of NOS3 and endothelial nitric oxideproduction. Isoforms lacking one or several functional domains arethought to modulate transcriptional activity by competitive ligandor DNA binding and/or heterodimerization with the full-lengthreceptor. Essential for MTA1-mediated transcriptional regulationof BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform1. {ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575,ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626,ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875,ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358,ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779,ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106,ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539,ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611,ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956,ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}. May provide the missing metabolic reaction required tolink the mitochondria and the cytoplasm in the mammalian model ofone-carbon folate metabolism in embryonic an transformed cellscomplementing thus the enzymatic activities of MTHFD2.{ECO:0000250, ECO:0000269|PubMed:16171773}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48185_250365596DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59185_250365596DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610185_250365596DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59185_250365596DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48251_310365596RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59251_310365596RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610251_310365596RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59251_310365596RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48185_205365596Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48221_245365596Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59185_205365596Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59221_245365596Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610185_205365596Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610221_245365596Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59185_205365596Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59221_245365596Zinc fingerNR C4-type
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367307+0834_42-90276Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367307+08423_430-90276Nucleotide bindingATP
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367307+0831_348-90276RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367307+08349_978-90276RegionNote=Formyltetrahydrofolate synthetase

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18185_250-73484DNA bindingNuclear receptor
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48311_547365596DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59311_547365596DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610311_547365596DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59311_547365596DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18311_547-73484DomainNR LBD
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48264_595365596RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48311_595365596RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59264_595365596RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59311_595365596RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610264_595365596RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610311_595365596RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59264_595365596RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59311_595365596RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18251_310-73484RegionNote=Hinge
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18264_595-73484RegionNote=Self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18311_595-73484RegionNote=Transactivation AF-2
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18185_205-73484Zinc fingerNR C4-type
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18221_245-73484Zinc fingerNR C4-type
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367321+192834_42708932Compositional biasNote=Poly-Gly
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367321+1928423_430708932Nucleotide bindingATP
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367321+192831_348708932RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneMTHFD1Lchr6:152265643chr6:151330955ENST00000367321+1928349_978708932RegionNote=Formyltetrahydrofolate synthetase


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FusionGeneSequence for ESR1_MTHFD1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ESR1_ENST00000440973_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_636aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGV
PVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIE
LSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQ

>In-frame_ESR1_ENST00000338799_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_636aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGV
PVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIE
LSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQ

>In-frame_ESR1_ENST00000443427_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_636aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGV
PVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIE
LSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQ

>In-frame_ESR1_ENST00000206249_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_636aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQ
RDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGV
PVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAVYGAKDIE
LSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTETEQ

>In-frame_ESR1_ENST00000427531_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_463aa
MAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGR
MLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRE
LVHMINWAKRVPVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQ
ITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVPIVDKIRTIAQAV
YGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDID


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ESR1_ENST00000440973_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_1908nt
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAG
CTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGC
TCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTAC
AGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAG
AGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAG
AGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGC
TCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAG
TATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGG
GCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTG
GTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAG
AAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTT
CCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTT
GATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGC
CGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAA
CTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCT
CTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATT
TACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAA

>In-frame_ESR1_ENST00000338799_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_1908nt
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAG
CTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGC
TCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTAC
AGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAG
AGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAG
AGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGC
TCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAG
TATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGG
GCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTG
GTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAG
AAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTT
CCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTT
GATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGC
CGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAA
CTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCT
CTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATT
TACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAA

>In-frame_ESR1_ENST00000443427_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_1908nt
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAG
CTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGC
TCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTAC
AGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAG
AGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAG
AGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGC
TCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAG
TATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGG
GCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTG
GTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAG
AAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTT
CCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTT
GATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGC
CGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAA
CTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCT
CTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATT
TACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAA

>In-frame_ESR1_ENST00000206249_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_1908nt
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAG
CTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGC
TCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTAC
AGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAG
AGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAG
AGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGC
TCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAG
TATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGG
GCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTG
GTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAG
AAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTT
CCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTT
GATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGC
CGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAA
CTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCT
CTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATT
TACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAA

>In-frame_ESR1_ENST00000427531_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_1389nt
ATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAG
GGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGG
AGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGA
ATGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCA
AGCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAG
CCCCCGATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAG
CTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATC
AAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTA
ACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAG
ATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTT
GCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGA
GAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTC
TATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGC
ATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCC
AGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ESR1_ENST00000440973_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_2671nt
ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAAACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGG
CTCGAAAGGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTCTGAGTGATAATCTTCTCTTCAAGAAGAAGAAAA
CTAGGAAGGAGTAAGCACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCACAGCACTTCTTGAAAAAGGATGTAGA
TTTTAATCTGAACTTTGAACCATCACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCG
GCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAA
CCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGG
CGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGC
GGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCT
GTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCC
GGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGA
ATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGC
CTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTG
CCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACA
CAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCAT
GATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACT
CTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACAT
GATCAACTGGGCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGC
TTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGT
TCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCT
CTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGC
TGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAG
TAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAA
AGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGAC
CCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGC
TGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGA
AACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTT
GCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTT
CAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTG
GAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTT

>In-frame_ESR1_ENST00000338799_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_3761nt
CTAGAGCATGGGTGGCCATTGTTGACCTACAGGAGGCACCACTGTCACCAACAAAGGGTAACAGTCTTTCTTTTCAATATTTATTTATAT
CCAGTATTTATTTTCAATACTGACTATGGAGAGAGCTCTCCTGTGCTCAAACACTGCAATACTGGGGGTCTTTCAAAGCACAAAAACATA
TATTTGCATGATGGCATCATTAACATTTTTATGGCTTTCTATTTCTTTTTTGTACTGGTCTCAAGAGCCACTCATAAATCTCTCAGTAAC
TGCATAGTGTCCCAGGGCCAGAGACCGGCCACTCCTGGCATTGTGATTAGAGTCATTTAATATCCAAGGTGGTGACTAATGTCTGGCAAC
AAAGCCTCCATTGGGTGTCATGTGTCCTGGGACCCTGAGCGTGGGCACTCTAGGAGCACCTCAGTATTGCGTGTTAGTACTATGGCCGAG
AGAATAGTTGAGAAAGTGGTCAAGAGGTGGATCCATGTGAACGCCACTGGGAAATGAGAGACCTCGTTCCCAATCACGGTCAGTGCAACT
CGAAAGCCTAAAATCAGTTTAAAACAAAGGTATCTACCTTTATCTTATGTTCATATCCTAGGCTTTTAATAATACGTATTTTTCACATGT
TTACAGAAAGCAGTCAACTGAGCTATTCATGGAAAGGTTTGTGGGTTTGGTTAACGAAGTGGAGGAGTATTACATTTCAGCTGGAAACAC
ATCCCTAGAATGCCAAAACATTTATTCCAAAGTCTGGTTTCCTGGTGCAATCGGAGGCATGGCAATGCCTCTGTTCAGAGACTGGGGGCT
AGGGCCAGTAAGGCATTTGATCCACATGTATCCCAGAAGGCTTTTATTGTTAAATTATATTCTTTCGGAAAAACCACCCATGTCCTATTT
TGTAAACTTGATATCCATACACTTTTGACTGGCATTCTATTTTAGCCGTAAGACTATGATTCACAGCAAGCCTGTTTTTCCTCTTGCTTG
GGGTGGCAGCAGAAAGCATAGGGTACTTTCCAGCCTCCAAGGGTAGGGGCAAAGGGGCTGGGGTTTCTCCTCCCCAGTACAGCTTTCTCT
GGCTGTGCCACACTGCTCCCTGTGAGCAGACAGCAAGTCTCCCCTCACTCCCCACTGCCATTCATCCAGCGCTGTGCAGTAGCCCAGCTG
CGTGTCTGCCGGGAGGGGCTGCCAAGTGCCCTGCCTACTGGCTGCTTCCCGAATCCCTGCCATTCCACGCACAAACACATCCACACACTC
TCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGGCCCTTGACTTCTACAAGC
CCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCAC
CCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGG
AGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACT
ACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGT
CTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGC
CGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGG
CCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTA
TGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGG
GCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGA
GGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAA
TGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAA
GCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGC
CCCCGATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGC
TGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCA
AGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAA
CGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGA
TCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTG
CAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAG
AGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCT
ATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCA
TGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCA
GCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATC
TTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCT
TTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTT
CTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTC
TGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAG

>In-frame_ESR1_ENST00000443427_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_2562nt
GACAAACAGAGATATATCGGAGTCTGGCACGGGGCACATAAGGCAGCACATTAGAGAAAGCCGGCCCCTGGATCCGTCTTTCGCGTTTAT
TTTAAGCCCAGTCTTCCCTGGGCCACCTTTAGCAGATCCTCGTGCGCCCCCGCCCCCTGGCCGTGAAACTCAGCCTCTATCCAGCAGCGA
CGACAAGTAAAGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATG
ACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATC
CCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAAC
GCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGC
CTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCC
CACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAAT
TCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGC
TACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATT
CAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGT
AAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGAT
GGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAG
AACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCT
ACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGG
GTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAAC
GTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATAT
ACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTG
GTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTC
CCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAG
TTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCT
GAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCAC
CAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTG
GTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGC
TTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAA
CTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCAC
AGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTAC
TGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTAC

>In-frame_ESR1_ENST00000206249_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_2663nt
GAGTTGTGCCTGGAGTGATGTTTAAGCCAATGTCAGGGCAAGGCAACAGTCCCTGGCCGTCCTCCAGCACCTTTGTAATGCATATGAGCT
CGGGAGACCAGTACTTAAAGTTGGAGGCCCGGGAGCCCAGGAGCTGGCGGAGGGCGTTCGTCCTGGGACTGCACTTGCTCCCGTCGGGTC
GCCCGGCTTCACCGGACCCGCAGGCTCCCGGGGCAGGGCCGGGGCCAGAGCTCGCGTGTCGGCGGGACATGCGCTGCGTCGCCTCTAACC
TCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGA
CCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGC
AGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCT
ACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCG
GCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT
TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCT
ACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCA
AGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCA
AGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCT
GCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCC
AGAGAGATGATGGGGAGGGCAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAAC
GCTCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCG
AGTATGATCCTACCAGACCCTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACT
GGGCGAAGAGGGTGCCAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCT
TGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTA
AGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGG
TTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCT
TTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAA
GCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTG
AACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTT
CTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCA
TTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAAC
AAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGT
TGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGA
ATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCC
ATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTC

>In-frame_ESR1_ENST00000427531_chr6_152265643_+_MTHFD1L_ENST00000367321_chr6_151330955_+_2014nt
GCTTAAAAATAATCTCCTGCCAGCCCAGTGACAAGCCTGTCCCACCCGGGGAGAATGCCCCGGAGTGGCGTGCGGGTCAGCCAGGGTCTG
CGCCTCGCAGCCACTGTGGAAGGAGCGCGGCCGGTCCAGGACACAGGAGACCACTTTGTGACTTCAATGGCGAAGGCCAAATTCAGATAA
TCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGC
AGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACA
TAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTA
CGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGAGGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGG
CAGGGGTGAAGTGGGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGCTCTAAGAAGAACAGCCT
GGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTGGATGCTGAGCCCCCGATACTCTATTCCGAGTATGATCCTACCAGACC
CTTCAGTGAAGCTTCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGGGCGAAGAGGGTGCCAGT
GACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGT
GTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGCGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGA
GAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAGAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCT
GAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTGGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTA
TCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCTCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTA
TGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATTGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACA
AGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAATTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGA
CAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGTGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAAC
GATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTTTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTA
AGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGAAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTT
GAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAATAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGT
ATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAAACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACA
CTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAGTGTGAACTAAAAGGTAACATTTTCCACTCTCAAGTTTTCTACTTTGTCTT


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FusionGenePPI for ESR1_MTHFD1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ESR1PPARGC1B, SMARCA4, DDX54, DNTTIP2, NCOA6, BRCA1, NCOA4, RBM39, SRC, NELFB, GADD45G, GADD45A, CTNNB1, PTEN, SAFB, ZBTB16, XBP1, PHB2, PTMA, SMARCD1, TDG, SAFB2, AHR, EP300, MTA1, MNAT1, CCNH, SMARCE1, SMARCA2, FKBP5, FKBP4, HSP90AA1, HSPA4, PPID, PTGES3, YWHAQ, CDC25B, MGMT, PELP1, TRIP4, NCOA1, CREBBP, PRDM2, KDM5A, PRMT1, ESR1, NR2C2, POU2F1, POU2F2, STAT5A, RBFOX2, DAP3, NR2F1, MAPK1, TP53, MDM2, CDK7, GTF2H1, NCOA2, MVP, ESR2, NRIP1, CEBPA, CEBPB, CCND1, STAT3, SVIL, NR0B2, IGF1R, PAK6, POU4F1, POU4F2, REXO4, NR2C1, AKAP13, TBP, PPARGC1A, NCOA3, SHC1, TADA3, CAV1, RNF4, PIAS2, TRIM24, NR2F6, ISL1, NCOA7, FOXO1, FOXO4, PIK3R1, BAG1, NCOR1, JUN, ZNF398, PRMT2, SMAD2, MED12, MED1, MED14, MED23, MED24, MED16, MED6, MED20, MED10, MED17, MED7, MED21, MED13, CCNC, CDK8, RLIM, PDLIM1, LDB1, TRAM1, TRIM25, KAT5, MUC1, UBE3A, STUB1, HSPA8, HDAC7, HDAC4, HDAC5, HDAC9, FLII, SP1, SIN3A, KLF5, SMYD3, MYOD1, TOP2B, PRKDC, PARP1, XRCC5, XRCC6, MEN1, SP3, MTA2, RELA, MYC, RBBP7, RBBP4, AHRR, ING1, HDAC1, LMO4, LCOR, TAF1A, TAF1B, SETD7, SP2, MSH2, PGC, CDKN1A, IRS1, IRS2, CITED1, GRIP1, ATAD2, RPS6KA1, GTF2B, NCOR2, LRIF1, HDAC3, PHB, KAT6A, FOS, HDAC2, KDM1A, GSN, ACTB, NPM1, ACTC1, RPL18, DDX5, RPLP0, RPL7A, MYL6, RPL7, RPS4X, MYO1C, DDX3X, RPS9, RPS8, ACTR3, ACTR2, POLR2A, MBD2, RBBP6, SMAD3, SMURF1, SGK3, BARD1, ACTN4, OTUB1, DUT, NPPA, MTCH2, PNRC2, KIF1A, KMT2D, RBBP5, ASH2L, WDR5, AKT1, TUBB1, TUBA1A, MED25, PSMC5, RPS6KA3, AKT2, DDX17, TRRAP, MPG, BCAR1, PIK3R2, ERBB2, SOS2, FHL2, UBE2I, PIAS1, CUEDC2, SKIL, SKI, KDM4B, ARHGDIA, SIRT1, PRKCZ, TFF1, CALM1, BLOC1S1, EHMT2, TAF2, PGR, XPO1, RAN, E2F1, RABGEF1, TAB2, UIMC1, CBLL1, PPP1CC, CDK11B, SPOP, CUL3, COPS5, ANIB1, ARID5A, TRAF6, RBCK1, TBL1XR1, SIN3B, RBM23, ANP32A, CHUK, BCL3, CRIPAK, TSC2, EGFR, MYLK2, ARG1, DSG1, HIF1A, CLTCL1, HPCAL1, APOD, SERPINH1, BUD13, AKAP8, ATAD3A, BCLAF1, ELMSAN1, CAPRIN1, CLTC, DDX18, DDX21, DDX27, DHX15, DHX9, DKC1, EWSR1, FLNA, FTSJ3, FUS, GNL3, GTPBP4, HNRNPA3, HNRNPF, HNRNPK, HNRNPM, HNRNPR, HNRNPA1, HNRNPA1L2, ILF2, JUP, MKI67, MYBBP1A, MYH9, MYO1B, NAT10, NCL, NOP56, NUMA1, PABPC1, PGAM5, PTPLAD1, RBM14, RBMX, RPL10, RPL13, RPL13A, RPL14, RPL17, RPL18A, RPL19, RPL22, RPL24, RPL27A, RPL3, RPL36AL, RPL36A, RPL37A, RPL4, RPL6, RPL8, RPN1, RPN2, RPS14, RPS16, RPS2, RPS23, RPS26, RPS3A, RPS6, RRP12, RSL1D1, SRSF1, SRSF2, SRSF7, SLC25A5, SRRM1, TF, TFRC, THRAP3, TOP1, TOP2A, TRIP12, UBTF, U2AF2, ACTN1, AHNAK, AIFM1, ALKBH7, AP2M1, ARFGAP2, ARSB, ATP5B, ATP9A, BRI3BP, CAPZB, CHD4, LUC7L3, YBX3, DBN1, DDX50, DECR1, DEK, DHX30, DNAH2, DNAJB11, EFTUD2, EIF4A1, EIF4G1, EIF4G3, EP400, EPB41L5, FLNB, FMR1, G3BP1, G3BP2, GNB1, GNB2, GNB4, GNL2, GOLGA2, HNRNPA0, HNRNPA2B1, HNRNPAB, LYAR, MRPS9, MTDH, MYH14, MYO6, NOP2, NOP58, GLYR1, NUP153, POP1, PPP1CA, PRPF4B, PSIP1, RBM28, RPL10A, RPL11, RPL23A, RPL36, RPL5, RPL9, RPS12, RPS13, RPS15A, RPS20, RPS24, RPS3, RPSA, RUVBL1, RUVBL2, SCYL2, SRSF6, SHOC2, SNRPD1, SPTAN1, SPTBN1, SRPK1, SRPK2, SRRM2, STAU1, SUPT16H, TBL2, TCOF1, UBAP2L, UNC45A, UPF1, UTP3, WDR36, YBX1, YTHDF2, ANXA2, DDX3Y, THEM6, EMD, EPPK1, EXOSC10, H2AFX, HSPA1L, SYNCRIP, GAPDH, TECR, KHDRBS1, LGALS7, MAPKAPK2, MYL6B, NCCRP1, POF1B, PLEC, RPL29, RRP1B, RPL12, RPL28, RPL21, RPS18, RDX, SRSF5, S100A7, SERPINB4, SFN, SEC61B, SF3B1, SRSF3, S100A8, U2SURP, WDR18, VPS13D, ZNF512B, SRA1, NR1H4, BTF3, FHL1, VAV3, PPP5C, HEXIM1, CCNT1, PAK1, RAC3, SLC25A20, EZH2, TSC1, PAGR1, MMS19, CHD9, BCAS2, PIK3CA, ESRRA, FKBPL, ZDHHC21, ZDHHC7, KRT1, CEP290, HSPB1, PRDX2, NME2, PPIA, PFN1, CBR1, GSTM3, RNF31, RANBP9, WIPI1, NSD1, ZNF131, PSMB9, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2L, POLR2J, POLR2K, TTC5, ASCC1, SKP2, SKP1, CUL1, RBX1, CDK2, SMYD2, SUV39H1, WHSC1, SUV420H1, ANP32B, SND1, SFPQ, PQBP1, ALYREF, GNB2L1, CCT2, TCERG1, NUDT21, TOPBP1, CIRBP, DARS, DDX1, EEF2, EIF5A, TUBB, EPRS, FARSA, SEPT8, SERBP1, PRPF19, PDIA3, HIST1H2BD, H3F3A, H3F3B, HDLBP, HNRNPC, HNRNPD, ILF3, KARS, KRT8, KRT10, KRT18, KRT19, MARS, MTHFD1, NAP1L4, SEPT2, NONO, NSF, P4HB, PA2G4, RTCB, LARS, PPIB, SARS2, PPP2R1A, PSPC1, PRKCSH, PSMD1, SNX6, SET, SHMT2, HSP90B1, VCP, SMC1A, HIST2H2AC, HIST1H2BG, HIST1H2BF, HIST1H2BE, HIST1H2BI, HIST1H2BC, GRWD1, SARNP, TUBA1C, FBXO18, YARS, FUBP1, EIF2S2, SMC3, MED27, EIF4A3, BCAS3, DYX1C1, GNAI1, GNAI2, GNAI3, SMARCD3, ARID1A, SUPT6H, RNF40, FOXK2, ANGPTL4, BAP1, CXCL1, EPSTI1, GLCE, KLK5, KLK9, PSMC3IP, SERPINB5, WHSC1L1, CFL1, CSRP1, HBP1, UBE4B, RAD51, TUBG1, HECTD1, PPP2R3A, SASH1, UBE3C, USP16, SUZ12, NDC80, ZNF182, TAB3, HSPD1, TXNRD1, PATZ1, PPP2CA, PPP2CB, TRAF3, TBK1, IKBKE, FBXO45, TTK, CHD6, MPRIP, SNRPN, TMOD3, AGFG1, EIF6, GCN1L1, CORO1C, RAD50, APITD1-CORT, PRPF8, CAT, AP2A2, STOM, MED9, PRR12, BCOR, YTHDF1, HOXD9, HOXC10, NFYA, E2F6, HNRNPH2, FIP1L1, TIA1, SMC2, NCAPG, NCAPH2, SMC4, NCAPD2, NCAPH, NCAPD3, NCAPG2, DNMT3L, ARNT, VPRBP, LATS1, DCAF13, PPP1R14C, GBP1, PGK2, SIGLEC10, PNMT, CNDP1, ERBB4, RPTOR, MTOR, WBP2, FOXA1, HSPA1A, HSPA2, HSPA5, HSPA6, HSPA9, HSP90AB1, HSPH1, HSPA4L, DNAJA2, DNAJA3, DNAJB1, DNAJB4, DNAJB6, DNAJC7, DNAJC9, DNAJC10, HSPB8, HSPE1, PBX1, CARM1MTHFD1LCASP4, MAGED1, WRAP73, HGS, USP50, SIRT7, CUL3, COPS5, ADRB2, HECW2, ASB12, BPHL, CNN1, CNN3, ISOC1, TAGLN2, PAPOLA, PAPOLB, XPNPEP1, NTRK1, CEP152, NPM1, LRPPRC, NFATC1, MTMR7, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+4835_174365596DDX5%3B self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+5935_174365596DDX5%3B self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+61035_174365596DDX5%3B self-association
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+5935_174365596DDX5%3B self-association


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneESR1chr6:152265643chr6:151330955ENST00000206249+48262_595365596AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000338799+59262_595365596AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000440973+610262_595365596AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000443427+59262_595365596AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+18262_595-73484AKAP13
HgeneESR1chr6:152265643chr6:151330955ENST00000456483+1835_174-73484DDX5%3B self-association


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ESR1_MTHFD1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneESR1P03372DB00286Conjugated estrogensEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00304DesogestrelEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00648MitotaneEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00655EstroneEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00675TamoxifenEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00841DobutamineEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00977Ethinyl EstradiolEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB01406DanazolEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB01431AllylestrenolEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB06710MethyltestosteroneEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB09369Polyestradiol phosphateEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB09371NorethynodrelEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB11071Phenyl salicylateEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB11619GestrinoneEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB01185FluoxymesteroneEstrogen receptorsmall moleculeapproved|illicit
HgeneESR1P03372DB00255DiethylstilbestrolEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00294EtonogestrelEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00367LevonorgestrelEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00481RaloxifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00539ToremifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00603Medroxyprogesterone acetateEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00624TestosteroneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00882ClomifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00890DienestrolEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00947FulvestrantEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00957NorgestimateEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB01196EstramustineEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB01593ZincEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB04930PermethrinEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB04938OspemifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB06202LasofoxifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB06401BazedoxifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB09070TiboloneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB01708PrasteroneEstrogen receptorsmall moleculeapproved|investigational|nutraceutical
HgeneESR1P03372DB00783EstradiolEstrogen receptorsmall moleculeapproved|investigational|vet_approved
HgeneESR1P03372DB04573EstriolEstrogen receptorsmall moleculeapproved|investigational|vet_approved
HgeneESR1P03372DB01108TrilostaneEstrogen receptorsmall moleculeapproved|investigational|vet_approved|withdrawn
HgeneESR1P03372DB01065MelatoninEstrogen receptorsmall moleculeapproved|nutraceutical|vet_approved
HgeneESR1P03372DB00396ProgesteroneEstrogen receptorsmall moleculeapproved|vet_approved
HgeneESR1P03372DB01183NaloxoneEstrogen receptorsmall moleculeapproved|vet_approved
HgeneESR1P03372DB00431LindaneEstrogen receptorsmall moleculeapproved|withdrawn
HgeneESR1P03372DB00756HexachloropheneEstrogen receptorsmall moleculeapproved|withdrawn
HgeneESR1P03372DB04824PhenolphthaleinEstrogen receptorsmall moleculeapproved|withdrawn

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RelatedDiseases for ESR1_MTHFD1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneESR1C1458155Mammary Neoplasms11CTD_human
HgeneESR1C0005586Bipolar Disorder5PSYGENET
HgeneESR1C0011570Mental Depression5PSYGENET
HgeneESR1C0011581Depressive disorder5PSYGENET
HgeneESR1C0036341Schizophrenia5PSYGENET
HgeneESR1C0525045Mood Disorders4PSYGENET
HgeneESR1C0001418Adenocarcinoma2CTD_human
HgeneESR1C0021364Male infertility2CTD_human
HgeneESR1C0024121Lung Neoplasms2CTD_human
HgeneESR1C0024667Animal Mammary Neoplasms2CTD_human
HgeneESR1C0025500Mesothelioma2CTD_human
HgeneESR1C0033578Prostatic Neoplasms2CTD_human
HgeneESR1C1956346Coronary Artery Disease2CTD_human
HgeneESR1C3809250ESTROGEN RESISTANCE2ORPHANET;UNIPROT
HgeneESR1C0002395Alzheimer's Disease1CTD_human
HgeneESR1C0004114Astrocytoma1CTD_human
HgeneESR1C0004153Atherosclerosis1CTD_human
HgeneESR1C0005695Bladder Neoplasm1CTD_human
HgeneESR1C0005944Metabolic Bone Disorder1CTD_human
HgeneESR1C0007621Neoplastic Cell Transformation1CTD_human
HgeneESR1C0014170Endometrial Neoplasms1CTD_human
HgeneESR1C0015799Feminization1CTD_human
HgeneESR1C0017658Glomerulonephritis1CTD_human
HgeneESR1C0021361Female infertility1CTD_human
HgeneESR1C0023267Fibroid Tumor1CTD_human
HgeneESR1C0023418leukemia1CTD_human
HgeneESR1C0023903Liver neoplasms1CTD_human
HgeneESR1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneESR1C0024809Marijuana Abuse1PSYGENET
HgeneESR1C0026858Musculoskeletal Pain1CTD_human
HgeneESR1C0027051Myocardial Infarction1CTD_human
HgeneESR1C0027627Neoplasm Metastasis1CTD_human
HgeneESR1C0027643Neoplasm Recurrence, Local1CTD_human
HgeneESR1C0028754Obesity1CTD_human
HgeneESR1C0028960Oligospermia1CTD_human
HgeneESR1C0033941Psychoses, Substance-Induced1CTD_human
HgeneESR1C0036939Shared Paranoid Disorder1PSYGENET
HgeneESR1C0149931Migraine Disorders1CTD_human
HgeneESR1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
HgeneESR1C1720887Female Urogenital Diseases1CTD_human
HgeneESR1C2239176Liver carcinoma1CTD_human