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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12090

FusionGeneSummary for ESR1_ASPH

check button Fusion gene summary
Fusion gene informationFusion gene name: ESR1_ASPH
Fusion gene ID: 12090
HgeneTgene
Gene symbol

ESR1

ASPH

Gene ID

2099

444

Gene nameestrogen receptor 1aspartate beta-hydroxylase
SynonymsER|ESR|ESRA|ESTRR|Era|NR3A1AAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctin
Cytomap

6q25.1-q25.2

8q12.3

Type of geneprotein-codingprotein-coding
Descriptionestrogen receptorE2 receptor alphaER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1oestrogen receptor alphaaspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase
Modification date2018052720180519
UniProtAcc

P03372

Q12797

Ensembl transtripts involved in fusion geneENST00000440973, ENST00000338799, 
ENST00000456483, ENST00000443427, 
ENST00000206249, ENST00000406599, 
ENST00000427531, ENST00000482101, 
ENST00000541428, ENST00000379454, 
ENST00000523897, ENST00000522919, 
ENST00000356457, ENST00000518068, 
ENST00000517903, ENST00000445642, 
ENST00000517847, ENST00000522835, 
ENST00000517856, ENST00000389204, 
ENST00000522603, ENST00000379449, 
ENST00000517661, 
Fusion gene scores* DoF score12 X 7 X 4=33612 X 12 X 3=432
# samples 1216
** MAII scorelog2(12/336*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/432*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ESR1 [Title/Abstract] AND ASPH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESR1

GO:0006366

transcription by RNA polymerase II

15831516

HgeneESR1

GO:0010629

negative regulation of gene expression

21695196

HgeneESR1

GO:0030520

intracellular estrogen receptor signaling pathway

9841876

HgeneESR1

GO:0032355

response to estradiol

15304487

HgeneESR1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

7651415|16043358

HgeneESR1

GO:0043433

negative regulation of DNA binding transcription factor activity

10816575

HgeneESR1

GO:0043627

response to estrogen

11581164

HgeneESR1

GO:0045893

positive regulation of transcription, DNA-templated

9841876|20074560

HgeneESR1

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

9841876

HgeneESR1

GO:0045944

positive regulation of transcription by RNA polymerase II

11544182|12047722|15345745|15831516|18563714

HgeneESR1

GO:0051091

positive regulation of DNA binding transcription factor activity

9328340|10681512

HgeneESR1

GO:0071392

cellular response to estradiol stimulus

15831516

TgeneASPH

GO:0045862

positive regulation of proteolysis

18387192

TgeneASPH

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A3KD-01AESR1chr6

152201906

+ASPHchr8

62416068

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000440973ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000440973ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000440973ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000338799ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000338799ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000338799ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000456483ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000456483ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000456483ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000443427ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000443427ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000443427ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000206249ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000206249ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000206249ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-3CDSENST00000406599ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-3CDSENST00000406599ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000406599ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
In-frameENST00000427531ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
Frame-shiftENST00000427531ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
5CDS-intronENST00000427531ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-3CDSENST00000482101ENST00000541428ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-3CDSENST00000482101ENST00000379454ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000523897ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000522919ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000356457ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000518068ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000517903ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000445642ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000517847ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000522835ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000517856ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000389204ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000522603ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000379449ESR1chr6

152201906

+ASPHchr8

62416068

-
intron-intronENST00000482101ENST00000517661ESR1chr6

152201906

+ASPHchr8

62416068

-

Top

FusionProtFeatures for ESR1_ASPH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESR1

P03372

ASPH

Q12797

Nuclear hormone receptor. The steroid hormones and theirreceptors are involved in the regulation of eukaryotic geneexpression and affect cellular proliferation and differentiationin target tissues. Ligand-dependent nuclear transactivationinvolves either direct homodimer binding to a palindromic estrogenresponse element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2,Sp1 and Sp3, to mediate ERE-independent signaling. Ligand bindinginduces a conformational change allowing subsequent orcombinatorial association with multiprotein coactivator complexesthrough LXXLL motifs of their respective components. Mutualtransrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcriptionfrom the IL6 promoter and displace RELA/p65 and associatedcoregulators from the promoter. Recruited to the NF-kappa-Bresponse element of the CCL2 and IL8 promoters and can displaceCREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50on ERE sequences. Can also act synergistically with NF-kappa-B toactivate transcription involving respective recruitment adjacentresponse elements; the function involves CREBBP. Can activate thetranscriptional activity of TFF1. Also mediates membrane-initiatedestrogen signaling involving various kinase cascades. Isoform 3 isinvolved in activation of NOS3 and endothelial nitric oxideproduction. Isoforms lacking one or several functional domains arethought to modulate transcriptional activity by competitive ligandor DNA binding and/or heterodimerization with the full-lengthreceptor. Essential for MTA1-mediated transcriptional regulationof BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform1. {ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575,ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626,ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875,ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358,ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779,ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106,ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539,ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611,ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956,ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38185_250253596DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49185_250253596DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510185_250253596DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49185_250253596DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48185_250253484DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38185_205253596Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38221_245253596Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49185_205253596Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49221_245253596Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510185_205253596Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510221_245253596Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49185_205253596Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49221_245253596Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48185_205253484Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48221_245253484Zinc fingerNR C4-type
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-01490_102-75314Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-0590_102-59204Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-0690_102-29226Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-01690_102-27651Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-01590_102-27300Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-01590_102-31299Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-01390_102-66271Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-0590_102-33211Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-01490_102-42257Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-014111_312-75314Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-014323_332-75314Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-0149_29-75314Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-05111_312-59204Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-05323_332-59204Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-059_29-59204Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-06111_312-29226Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-06323_332-29226Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-069_29-29226Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-016111_312-27651Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-016323_332-27651Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-0169_29-27651Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-015111_312-27300Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-015323_332-27300Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-0159_29-27300Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-015111_312-31299Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-015323_332-31299Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-0159_29-31299Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-013111_312-66271Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-013323_332-66271Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-0139_29-66271Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-05111_312-33211Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-05323_332-33211Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-059_29-33211Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-014111_312-42257Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-014323_332-42257Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-0149_29-42257Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-014688_690-75314Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-05688_690-59204Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-06688_690-29226Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-016688_690-27651Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-015688_690-27300Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-015688_690-31299Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-013688_690-66271Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-05688_690-33211Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-014688_690-42257Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-2325688_690679730Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-014341_374-75314RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-014454_487-75314RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-014489_521-75314RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-014525_557-75314RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-05341_374-59204RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-05454_487-59204RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-05489_521-59204RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-05525_557-59204RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-06341_374-29226RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-06454_487-29226RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-06489_521-29226RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-06525_557-29226RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-016341_374-27651RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-016454_487-27651RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-016489_521-27651RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-016525_557-27651RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-015341_374-27300RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-015454_487-27300RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-015489_521-27300RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-015525_557-27300RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-015341_374-31299RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-015454_487-31299RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-015489_521-31299RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-015525_557-31299RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-013341_374-66271RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-013454_487-66271RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-013489_521-66271RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-013525_557-66271RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-05341_374-33211RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-05454_487-33211RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-05489_521-33211RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-05525_557-33211RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-014341_374-42257RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-014454_487-42257RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-014489_521-42257RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-014525_557-42257RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-0141_53-75314Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-01475_758-75314Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-051_53-59204Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-0575_758-59204Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-061_53-29226Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-0675_758-29226Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-0161_53-27651Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-01675_758-27651Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-0151_53-27300Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-01575_758-27300Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-0151_53-31299Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-01575_758-31299Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-0131_53-66271Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-01375_758-66271Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-051_53-33211Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-0575_758-33211Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-0141_53-42257Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-01475_758-42257Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000356457-01454_74-75314TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000379449-0554_74-59204TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000389204-0654_74-29226TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000445642-01654_74-27651TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000517847-01554_74-27300TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000517903-01554_74-31299TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000518068-01354_74-66271TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000522603-0554_74-33211TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000522835-01454_74-42257TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38311_547253596DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49311_547253596DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510311_547253596DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49311_547253596DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48311_547253484DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38251_310253596RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38264_595253596RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38311_595253596RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49251_310253596RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49264_595253596RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49311_595253596RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510251_310253596RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510264_595253596RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510311_595253596RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49251_310253596RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49264_595253596RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49311_595253596RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48251_310253484RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48264_595253484RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48311_595253484RegionNote=Transactivation AF-2
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-232590_102708759Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-232590_102679730Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-2325111_312708759Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-2325323_332708759Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-23259_29708759Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-2325111_312679730Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-2325323_332679730Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-23259_29679730Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-2325688_690708759Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-2325341_374708759RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-2325454_487708759RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-2325489_521708759RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-2325525_557708759RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-2325341_374679730RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-2325454_487679730RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-2325489_521679730RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-2325525_557679730RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-23251_53708759Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-232575_758708759Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-23251_53679730Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-232575_758679730Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000379454-232554_74708759TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000541428-232554_74679730TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for ESR1_ASPH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ESR1_ENST00000440973_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_303aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

>In-frame_ESR1_ENST00000338799_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_303aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

>In-frame_ESR1_ENST00000456483_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_303aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

>In-frame_ESR1_ENST00000443427_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_303aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

>In-frame_ESR1_ENST00000206249_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_303aa
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

>In-frame_ESR1_ENST00000427531_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_130aa
MAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ESR1_ENST00000440973_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_911nt
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAG
CTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGC
TCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTAC
AGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAG
AGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACG
AGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTC

>In-frame_ESR1_ENST00000338799_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_911nt
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAG
CTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGC
TCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTAC
AGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAG
AGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACG
AGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTC

>In-frame_ESR1_ENST00000456483_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_911nt
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAG
CTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGC
TCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTAC
AGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAG
AGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACG
AGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTC

>In-frame_ESR1_ENST00000443427_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_911nt
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAG
CTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGC
TCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTAC
AGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAG
AGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACG
AGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTC

>In-frame_ESR1_ENST00000206249_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_911nt
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAG
CTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGC
TCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTAC
AGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAG
AGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACG
AGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTC

>In-frame_ESR1_ENST00000427531_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_392nt
ATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAG
GGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGG
AGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCT
TTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ESR1_ENST00000440973_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_4083nt
ATGGTCATAACAGCCTCCTGTCTACCGACTCAGAACGGATTTTACCAAAACTGAAAATGCAGGCTCCATGCTCAGAAGCTCTTTAACAGG
CTCGAAAGGTCCATGCTCCTTTCTCCTGCCCATTCTATAGCATAAGAAGACAGTCTCTGAGTGATAATCTTCTCTTCAAGAAGAAGAAAA
CTAGGAAGGAGTAAGCACAAAGATCTCTTCACATTCTCCGGGACTGCGGTACCAAATATCAGCACAGCACTTCTTGAAAAAGGATGTAGA
TTTTAATCTGAACTTTGAACCATCACTGAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCG
GCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAA
CCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGG
CGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGC
GGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCT
GTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCC
GGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGA
ATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGC
CTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTG
CCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCC
TTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGA
CGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTG
AGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAG
GGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTG
AACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAA
ACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTAC
ATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTT
TTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAA
CTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAA
AATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTT
TTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCT
GCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATG
TCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAAT
GCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGA
GAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATA
GGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAAT
CAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATG
GCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTC
ATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACT
TTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTA
AAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGC
AATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTAT
AAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATA
TGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAA
TAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTC
TTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTG
TGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTT
ATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAG
AGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAG
CTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGA
GCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAA
CATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGG

>In-frame_ESR1_ENST00000338799_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_5173nt
CTAGAGCATGGGTGGCCATTGTTGACCTACAGGAGGCACCACTGTCACCAACAAAGGGTAACAGTCTTTCTTTTCAATATTTATTTATAT
CCAGTATTTATTTTCAATACTGACTATGGAGAGAGCTCTCCTGTGCTCAAACACTGCAATACTGGGGGTCTTTCAAAGCACAAAAACATA
TATTTGCATGATGGCATCATTAACATTTTTATGGCTTTCTATTTCTTTTTTGTACTGGTCTCAAGAGCCACTCATAAATCTCTCAGTAAC
TGCATAGTGTCCCAGGGCCAGAGACCGGCCACTCCTGGCATTGTGATTAGAGTCATTTAATATCCAAGGTGGTGACTAATGTCTGGCAAC
AAAGCCTCCATTGGGTGTCATGTGTCCTGGGACCCTGAGCGTGGGCACTCTAGGAGCACCTCAGTATTGCGTGTTAGTACTATGGCCGAG
AGAATAGTTGAGAAAGTGGTCAAGAGGTGGATCCATGTGAACGCCACTGGGAAATGAGAGACCTCGTTCCCAATCACGGTCAGTGCAACT
CGAAAGCCTAAAATCAGTTTAAAACAAAGGTATCTACCTTTATCTTATGTTCATATCCTAGGCTTTTAATAATACGTATTTTTCACATGT
TTACAGAAAGCAGTCAACTGAGCTATTCATGGAAAGGTTTGTGGGTTTGGTTAACGAAGTGGAGGAGTATTACATTTCAGCTGGAAACAC
ATCCCTAGAATGCCAAAACATTTATTCCAAAGTCTGGTTTCCTGGTGCAATCGGAGGCATGGCAATGCCTCTGTTCAGAGACTGGGGGCT
AGGGCCAGTAAGGCATTTGATCCACATGTATCCCAGAAGGCTTTTATTGTTAAATTATATTCTTTCGGAAAAACCACCCATGTCCTATTT
TGTAAACTTGATATCCATACACTTTTGACTGGCATTCTATTTTAGCCGTAAGACTATGATTCACAGCAAGCCTGTTTTTCCTCTTGCTTG
GGGTGGCAGCAGAAAGCATAGGGTACTTTCCAGCCTCCAAGGGTAGGGGCAAAGGGGCTGGGGTTTCTCCTCCCCAGTACAGCTTTCTCT
GGCTGTGCCACACTGCTCCCTGTGAGCAGACAGCAAGTCTCCCCTCACTCCCCACTGCCATTCATCCAGCGCTGTGCAGTAGCCCAGCTG
CGTGTCTGCCGGGAGGGGCTGCCAAGTGCCCTGCCTACTGGCTGCTTCCCGAATCCCTGCCATTCCACGCACAAACACATCCACACACTC
TCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGGCCCTTGACTTCTACAAGC
CCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCAC
CCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGG
AGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACT
ACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGT
CTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGC
CGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGG
CCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTA
TGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGG
GCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGA
GGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTT
TGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACC
ACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTC
CTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAA
GACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGT
ATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAAC
ATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCAT
GTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGA
CTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAG
TGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAG
ATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAG
ATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGG
ATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATC
CATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGT
TACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTC
TCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACAT
AGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTA
TATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGC
TGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTT
TCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTT
GCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAA
TTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAAC
TGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAA
TTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGT
AAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAA
GTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTC
ACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTT
ATTATTTTTGTGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTG
TTTCAACTTTATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCC
ATTGAGAAAGAGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTG
AATTATTTAGCTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGT
TTGACTTTGAGCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGG
TCTTGGAAAACATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCC

>In-frame_ESR1_ENST00000456483_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_3931nt
AAACACATCCACACACTCTCTCTGCCTAGTTCACACACTGAGCCACTCGCACATGCGAGCACATTCCTTCCTTCCTTCTCACTCTCTCGG
CCCTTGACTTCTACAAGCCCATGGAACATTTCTGGAAAGACGTTCTTGATCCAGCAGGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTG
CGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGA
TCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCA
AGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCC
TCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGC
TGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCG
GCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTA
CCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATG
GAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCA
CCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGA
AGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTG
GCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTG
CCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGC
CTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAG
CACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAAT
TCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCT
AGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGC
ATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGA
AAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTC
ACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATA
TTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGT
TCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGT
CTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAG
GATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTT
GGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTT
TAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATT
CATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGC
CAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCT
AAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAG
CTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATG
GGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTA
TTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGT
ATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAA
ACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAA
TGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATA
AAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGG
TAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGA
GAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAA
AATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTG
AATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTAT
TAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATG
TCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAA

>In-frame_ESR1_ENST00000443427_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_3974nt
GACAAACAGAGATATATCGGAGTCTGGCACGGGGCACATAAGGCAGCACATTAGAGAAAGCCGGCCCCTGGATCCGTCTTTCGCGTTTAT
TTTAAGCCCAGTCTTCCCTGGGCCACCTTTAGCAGATCCTCGTGCGCCCCCGCCCCCTGGCCGTGAAACTCAGCCTCTATCCAGCAGCGA
CGACAAGTAAAGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGACCATGACCATG
ACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATC
CCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTACGAGTTCAAC
GCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGC
CTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTCCTGCAGCCC
CACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAAT
TCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGC
TACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATT
CAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGT
AAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGC
AGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTT
AGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACAC
CAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGC
AATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTAC
CTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTT
AGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATG
ACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAA
GATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCT
CAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAG
AGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAG
AGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCT
GGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCA
GTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGG
GCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAA
ACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCT
ACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGT
TAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAA
GTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTT
GAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTT
GCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCA
AACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCAT
GTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCC
ATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTC
ACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCAT
TGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATC
TATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACAC
AAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAAT
ATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAAT
TAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCC
AAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTA
ATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATA
TCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGGTAAATAAAATG

>In-frame_ESR1_ENST00000206249_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_4075nt
GAGTTGTGCCTGGAGTGATGTTTAAGCCAATGTCAGGGCAAGGCAACAGTCCCTGGCCGTCCTCCAGCACCTTTGTAATGCATATGAGCT
CGGGAGACCAGTACTTAAAGTTGGAGGCCCGGGAGCCCAGGAGCTGGCGGAGGGCGTTCGTCCTGGGACTGCACTTGCTCCCGTCGGGTC
GCCCGGCTTCACCGGACCCGCAGGCTCCCGGGGCAGGGCCGGGGCCAGAGCTCGCGTGTCGGCGGGACATGCGCTGCGTCGCCTCTAACC
TCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTCTGAGCCTTCTGCCCTGCGGGGACACGGTCTGCACCCTGCCCGCGGCCACGGA
CCATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGGAACGAGCTGGAGCCCCTGAACCGTCCGC
AGCTCAAGATCCCCCTGGAGCGGCCCCTGGGCGAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCT
ACGAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTACGGCCCCGGGTCTGAGGCTGCGGCGTTCG
GCTCCAACGGCCTGGGGGGTTTCCCCCCACTCAACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTT
TCCTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACGGTGCGCGAGGCCGGCCCGCCGGCATTCT
ACAGGCCAAATTCAGATAATCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCA
AGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCA
AGAGAAGTATTCAAGGACATAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCT
GCCGGCTCCGTAAATGCTACGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCA
CGAGGTATGGCAGGATGCCTCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCT
TCCAGCAATTTAGCATGAATTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGA
ATTTCGAACACCAAGAGTCAATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATT
TGCCTCGCTGCAATTCATTTAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTG
ATAGCTTCTACCTTACCAGCCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAA
TGGATTGCTTTAGTTTGTAATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGT
TTATTTTAATGACAAGCTGTATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCT
TCTTAGTAAAAGATACTCATGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCC
ATCCCAACTCTCAAATCGTTTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTAT
TTCTTTCAAAGAGGAACTTTTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATG
CCAATTATTAGAGCTTCTGGGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGT
GTCTGGCTCCTGGCGGCTTTGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAG
CCAGCTCTTCAGTCTTGGAGATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGAT
GTTTTTCTTGGGCGTAGGAGGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTC
TGCCATTTTAAACATCACTGTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAA
TCGTCTTGCCTACTCATTCCAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTA
ACTAGGAATGTTAGATATAAGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATAT
AGGTCACCAAAGTTCATTCACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAG
AACAGCTCTTTGAAATTGAAATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGT
TCTTTTGTTTTGCTGGTATTGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAG
AAGAGAAGGCAAACTCTTGAAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAAT
TCAATGTTCATGTAGTAACATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTC
ATTTTTGAGCCATCATCTTACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTT
AAAATCAGGTCACTACAGTAAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGAC
TCCAATAGCATTGTAAATACTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTC
TCTTACCTATCTATGTCTTGGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCG
TATGTCTACACAAAAATGAATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCC
AAGTGTATAATATAAAAATTACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATG
TAATAAATAATTAAGATTAGTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAA
TTAACTCTCCCAAATATTTAAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAAC
TGGTAATACTAATAAATACCCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCAC
AAGTAAGGATATCATATATGATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGG

>In-frame_ESR1_ENST00000427531_chr6_152201906_+_ASPH_ENST00000541428_chr8_62416068_-_3426nt
GCTTAAAAATAATCTCCTGCCAGCCCAGTGACAAGCCTGTCCCACCCGGGGAGAATGCCCCGGAGTGGCGTGCGGGTCAGCCAGGGTCTG
CGCCTCGCAGCCACTGTGGAAGGAGCGCGGCCGGTCCAGGACACAGGAGACCACTTTGTGACTTCAATGGCGAAGGCCAAATTCAGATAA
TCGACGCCAGGGTGGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAGGAGACTCGCTACTGTGC
AGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGGTCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACA
TAACGACTATATGTGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGCCGGCTCCGTAAATGCTA
CGAAGTGGGAATGATGAAAGGTGGACCTGGGAGGAAGGCAAGGTGCTCATCTTTGATGACTCCTTTGAGCACGAGGTATGGCAGGATGCC
TCATCTTTCCGGCTGATATTCATCGTGGATGTGTGGCATCCGGAACTGACACCACAGCAGAGACGCAGCCTTCCAGCAATTTAGCATGAA
TTCATGCAAGCTTGGGAAACTCTGGAGAGAGGCTGCCTTTCTGGTTCCATCTCCTTGGGTGTGAGGATAGAATTTCGAACACCAAGAGTC
AATTCCCTTGACTTGCAGCCCGAGTAATTCAAAGCCTCCTCCTAGGGTCAGAAGACACTAAAGGGAATATTTGCCTCGCTGCAATTCATT
TAGGAAACACCCTGCTGTGTGTCATCTCATGACAGCACTGGTCTTCTGCCAGTATTTAAGGTGAACATTTGATAGCTTCTACCTTACCAG
CCAAAGATATTTTTTCCACATAGAATAGGTCTAATTCAATGTATAATGAGAACATATGTAGAAACTGTGAATGGATTGCTTTAGTTTGTA
ATTTTTCTATGCAGTTATATTTTTCTAGTGTAGCTAGACTATTTTGTCATCATGTACCACTACATTTTTGTTTATTTTAATGACAAGCTG
TATAAATGCTTTACTTCTAGCTATTTAATGGTAGCATTACTGGGGAACTCAGACTTCCCTCTTTTAATTCTTCTTAGTAAAAGATACTCA
TGAAAAAAGCAGTTTTATTTTCCTAACAAAAAAGAAAGAGCTCATTATGTCAGTGTCTATGAACTGTACCCATCCCAACTCTCAAATCGT
TTGGTTTTTTTTATCTTGATTGAGATCCTCTTCTCACTATGCTAGTGGTGGAGATATTGACAAAATCCTATTTCTTTCAAAGAGGAACTT
TTCACACCGAAAAAAGAGCATGGAATTATTTTATATTGTTATAAAAATCCCAGATGCAAATTTTTTTAATGCCAATTATTAGAGCTTCTG
GGGAAAAAGTATAGTTCACGGAAATAAAACTATGTTCTTTCAGGGTTGGGTGGATAGGTGGCTGCTAGGGTGTCTGGCTCCTGGCGGCTT
TGCCATCCATGAGGCAAGGGCTGGGAACACAGTGTCTTTGCCTATGGTAGATCCATGTGAATGTCAGGAAGCCAGCTCTTCAGTCTTGGA
GATGATTTCTGCTACAATTCTGTAGAAAGATTAAGGATGGCAGAGTAAAAGGTTACCAAGAATGCCAGGATGTTTTTCTTGGGCGTAGGA
GGTCCAGATTACTTTCCTTTTTGATGAAAGAGTTTGGAAGACTGTCCCATCTCTCTGGCTTGAGAAATCTCTGCCATTTTAAACATCACT
GTGAAATAGCAATTATTATCATCTGTATTTAGTTTTAACATTACCCACAACATAGAAATAATAGGTAAAAATCGTCTTGCCTACTCATTC
CAAAGATGATCAAGTCATTAATCTAGCAAAGTATTCATGTATCAGATTTTGTATATTTTGAATCAAAGCTAACTAGGAATGTTAGATATA
AGAATGTAATGATATTCATGCACTGAATTCTAAGCCAATATGAACAAAAATGCTGCATGAATGGCACATATAGGTCACCAAAGTTCATTC
ACAGGTAGAAAAAACTTGTGCTTTCTTTTCCATCTAAAAACAAAAGGAGACTTTCTTTATCTCATTTAAAGAACAGCTCTTTGAAATTGA
AATTGACCCTTTTTGCTTGACCTTAAGGAGATTAGCTTCCAGTAGATGAGTTTGCAAAATACTTTTCCTGTTCTTTTGTTTTGCTGGTAT
TGAAAACATCCCACTAAATCAGATGAAGAGGCATGGGAGGAAAAATATCCAAATTAATTACTAAAATCGAGAAGAGAAGGCAAACTCTTG
AAAAGTAAAAAGGTGTTTGTGACCTTCAGTATTTATTGAACAGAGGAAATAACTGACAAGGGCAATACAATTCAATGTTCATGTAGTAAC
ATTCATGTCACTTGTTGAATTTGGTTCTCATATGTATATTGCATACACATAAATTCAAACTATAAGTCGTCATTTTTGAGCCATCATCTT
ACATTCATGTAATGAAATTATGGAAGAGAGTAAAAACTAGCTCTTAACTTAGTAAATATAATATGGTATTTAAAATCAGGTCACTACAGT
AAGGTTCTAAGTATTGCCAATTGAAAAGCTAGAAATGGTATTACTGTTGCAAAGTGTTGTCAATAATTGACTCCAATAGCATTGTAAATA
CTTGTATCCCACAACTATTTTAAACCCAAGCAATAAAATGGATTTTCTAATTCACTTCAATTCTTTATTTCTCTTACCTATCTATGTCTT
GGTACATAAGAAAAGTGTTTCCATCACTGCATTGGTAGAATTATTTCAGTGTTATTATTTTTGTGATTTCGTATGTCTACACAAAAATGA
ATTAGTTTAATTTATATTGTGATACAGTTGTTTGAGAAATATTTTTAATTCTGTTTCAACTTTATTTCTCCAAGTGTATAATATAAAAAT
TACTTCTGTTATTGTTCTCTACCAATAGGGGAAAAAATTAAAACATTAGATCCATTGAGAAAGAGATGATGTAATAAATAATTAAGATTA
GTAATAATATTATCAGGGGTGATTATGACCAGTTGAATAATCTCTTTCCCTTGAATTATTTAGCTAACAAATTAACTCTCCCAAATATTT
AAAATAATGTAAAATCATATTTTACTGCCCATTATTAACTAAAATATTTTTGTTTGACTTTGAGCACCAACTGGTAATACTAATAAATAC
CCATGTCATGCAGATGGCTGGGCGAATAAGAGATGTCTAAAAATATGCACTGGTCTTGGAAAACATGGCACAAGTAAGGATATCATATAT
GATGTCTGTTTATTTTATGTCTGATTTCTTTTGAATGAGTAGTTGGGGACTCCATTTCTAAGGAGACTAGGTAAATAAAATGACCTTTGA


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FusionGenePPI for ESR1_ASPH


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ESR1PPARGC1B, SMARCA4, DDX54, DNTTIP2, NCOA6, BRCA1, NCOA4, RBM39, SRC, NELFB, GADD45G, GADD45A, CTNNB1, PTEN, SAFB, ZBTB16, XBP1, PHB2, PTMA, SMARCD1, TDG, SAFB2, AHR, EP300, MTA1, MNAT1, CCNH, SMARCE1, SMARCA2, FKBP5, FKBP4, HSP90AA1, HSPA4, PPID, PTGES3, YWHAQ, CDC25B, MGMT, PELP1, TRIP4, NCOA1, CREBBP, PRDM2, KDM5A, PRMT1, ESR1, NR2C2, POU2F1, POU2F2, STAT5A, RBFOX2, DAP3, NR2F1, MAPK1, TP53, MDM2, CDK7, GTF2H1, NCOA2, MVP, ESR2, NRIP1, CEBPA, CEBPB, CCND1, STAT3, SVIL, NR0B2, IGF1R, PAK6, POU4F1, POU4F2, REXO4, NR2C1, AKAP13, TBP, PPARGC1A, NCOA3, SHC1, TADA3, CAV1, RNF4, PIAS2, TRIM24, NR2F6, ISL1, NCOA7, FOXO1, FOXO4, PIK3R1, BAG1, NCOR1, JUN, ZNF398, PRMT2, SMAD2, MED12, MED1, MED14, MED23, MED24, MED16, MED6, MED20, MED10, MED17, MED7, MED21, MED13, CCNC, CDK8, RLIM, PDLIM1, LDB1, TRAM1, TRIM25, KAT5, MUC1, UBE3A, STUB1, HSPA8, HDAC7, HDAC4, HDAC5, HDAC9, FLII, SP1, SIN3A, KLF5, SMYD3, MYOD1, TOP2B, PRKDC, PARP1, XRCC5, XRCC6, MEN1, SP3, MTA2, RELA, MYC, RBBP7, RBBP4, AHRR, ING1, HDAC1, LMO4, LCOR, TAF1A, TAF1B, SETD7, SP2, MSH2, PGC, CDKN1A, IRS1, IRS2, CITED1, GRIP1, ATAD2, RPS6KA1, GTF2B, NCOR2, LRIF1, HDAC3, PHB, KAT6A, FOS, HDAC2, KDM1A, GSN, ACTB, NPM1, ACTC1, RPL18, DDX5, RPLP0, RPL7A, MYL6, RPL7, RPS4X, MYO1C, DDX3X, RPS9, RPS8, ACTR3, ACTR2, POLR2A, MBD2, RBBP6, SMAD3, SMURF1, SGK3, BARD1, ACTN4, OTUB1, DUT, NPPA, MTCH2, PNRC2, KIF1A, KMT2D, RBBP5, ASH2L, WDR5, AKT1, TUBB1, TUBA1A, MED25, PSMC5, RPS6KA3, AKT2, DDX17, TRRAP, MPG, BCAR1, PIK3R2, ERBB2, SOS2, FHL2, UBE2I, PIAS1, CUEDC2, SKIL, SKI, KDM4B, ARHGDIA, SIRT1, PRKCZ, TFF1, CALM1, BLOC1S1, EHMT2, TAF2, PGR, XPO1, RAN, E2F1, RABGEF1, TAB2, UIMC1, CBLL1, PPP1CC, CDK11B, SPOP, CUL3, COPS5, ANIB1, ARID5A, TRAF6, RBCK1, TBL1XR1, SIN3B, RBM23, ANP32A, CHUK, BCL3, CRIPAK, TSC2, EGFR, MYLK2, ARG1, DSG1, HIF1A, CLTCL1, HPCAL1, APOD, SERPINH1, BUD13, AKAP8, ATAD3A, BCLAF1, ELMSAN1, CAPRIN1, CLTC, DDX18, DDX21, DDX27, DHX15, DHX9, DKC1, EWSR1, FLNA, FTSJ3, FUS, GNL3, GTPBP4, HNRNPA3, HNRNPF, HNRNPK, HNRNPM, HNRNPR, HNRNPA1, HNRNPA1L2, ILF2, JUP, MKI67, MYBBP1A, MYH9, MYO1B, NAT10, NCL, NOP56, NUMA1, PABPC1, PGAM5, PTPLAD1, RBM14, RBMX, RPL10, RPL13, RPL13A, RPL14, RPL17, RPL18A, RPL19, RPL22, RPL24, RPL27A, RPL3, RPL36AL, RPL36A, RPL37A, RPL4, RPL6, RPL8, RPN1, RPN2, RPS14, RPS16, RPS2, RPS23, RPS26, RPS3A, RPS6, RRP12, RSL1D1, SRSF1, SRSF2, SRSF7, SLC25A5, SRRM1, TF, TFRC, THRAP3, TOP1, TOP2A, TRIP12, UBTF, U2AF2, ACTN1, AHNAK, AIFM1, ALKBH7, AP2M1, ARFGAP2, ARSB, ATP5B, ATP9A, BRI3BP, CAPZB, CHD4, LUC7L3, YBX3, DBN1, DDX50, DECR1, DEK, DHX30, DNAH2, DNAJB11, EFTUD2, EIF4A1, EIF4G1, EIF4G3, EP400, EPB41L5, FLNB, FMR1, G3BP1, G3BP2, GNB1, GNB2, GNB4, GNL2, GOLGA2, HNRNPA0, HNRNPA2B1, HNRNPAB, LYAR, MRPS9, MTDH, MYH14, MYO6, NOP2, NOP58, GLYR1, NUP153, POP1, PPP1CA, PRPF4B, PSIP1, RBM28, RPL10A, RPL11, RPL23A, RPL36, RPL5, RPL9, RPS12, RPS13, RPS15A, RPS20, RPS24, RPS3, RPSA, RUVBL1, RUVBL2, SCYL2, SRSF6, SHOC2, SNRPD1, SPTAN1, SPTBN1, SRPK1, SRPK2, SRRM2, STAU1, SUPT16H, TBL2, TCOF1, UBAP2L, UNC45A, UPF1, UTP3, WDR36, YBX1, YTHDF2, ANXA2, DDX3Y, THEM6, EMD, EPPK1, EXOSC10, H2AFX, HSPA1L, SYNCRIP, GAPDH, TECR, KHDRBS1, LGALS7, MAPKAPK2, MYL6B, NCCRP1, POF1B, PLEC, RPL29, RRP1B, RPL12, RPL28, RPL21, RPS18, RDX, SRSF5, S100A7, SERPINB4, SFN, SEC61B, SF3B1, SRSF3, S100A8, U2SURP, WDR18, VPS13D, ZNF512B, SRA1, NR1H4, BTF3, FHL1, VAV3, PPP5C, HEXIM1, CCNT1, PAK1, RAC3, SLC25A20, EZH2, TSC1, PAGR1, MMS19, CHD9, BCAS2, PIK3CA, ESRRA, FKBPL, ZDHHC21, ZDHHC7, KRT1, CEP290, HSPB1, PRDX2, NME2, PPIA, PFN1, CBR1, GSTM3, RNF31, RANBP9, WIPI1, NSD1, ZNF131, PSMB9, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2L, POLR2J, POLR2K, TTC5, ASCC1, SKP2, SKP1, CUL1, RBX1, CDK2, SMYD2, SUV39H1, WHSC1, SUV420H1, ANP32B, SND1, SFPQ, PQBP1, ALYREF, GNB2L1, CCT2, TCERG1, NUDT21, TOPBP1, CIRBP, DARS, DDX1, EEF2, EIF5A, TUBB, EPRS, FARSA, SEPT8, SERBP1, PRPF19, PDIA3, HIST1H2BD, H3F3A, H3F3B, HDLBP, HNRNPC, HNRNPD, ILF3, KARS, KRT8, KRT10, KRT18, KRT19, MARS, MTHFD1, NAP1L4, SEPT2, NONO, NSF, P4HB, PA2G4, RTCB, LARS, PPIB, SARS2, PPP2R1A, PSPC1, PRKCSH, PSMD1, SNX6, SET, SHMT2, HSP90B1, VCP, SMC1A, HIST2H2AC, HIST1H2BG, HIST1H2BF, HIST1H2BE, HIST1H2BI, HIST1H2BC, GRWD1, SARNP, TUBA1C, FBXO18, YARS, FUBP1, EIF2S2, SMC3, MED27, EIF4A3, BCAS3, DYX1C1, GNAI1, GNAI2, GNAI3, SMARCD3, ARID1A, SUPT6H, RNF40, FOXK2, ANGPTL4, BAP1, CXCL1, EPSTI1, GLCE, KLK5, KLK9, PSMC3IP, SERPINB5, WHSC1L1, CFL1, CSRP1, HBP1, UBE4B, RAD51, TUBG1, HECTD1, PPP2R3A, SASH1, UBE3C, USP16, SUZ12, NDC80, ZNF182, TAB3, HSPD1, TXNRD1, PATZ1, PPP2CA, PPP2CB, TRAF3, TBK1, IKBKE, FBXO45, TTK, CHD6, MPRIP, SNRPN, TMOD3, AGFG1, EIF6, GCN1L1, CORO1C, RAD50, APITD1-CORT, PRPF8, CAT, AP2A2, STOM, MED9, PRR12, BCOR, YTHDF1, HOXD9, HOXC10, NFYA, E2F6, HNRNPH2, FIP1L1, TIA1, SMC2, NCAPG, NCAPH2, SMC4, NCAPD2, NCAPH, NCAPD3, NCAPG2, DNMT3L, ARNT, VPRBP, LATS1, DCAF13, PPP1R14C, GBP1, PGK2, SIGLEC10, PNMT, CNDP1, ERBB4, RPTOR, MTOR, WBP2, FOXA1, HSPA1A, HSPA2, HSPA5, HSPA6, HSPA9, HSP90AB1, HSPH1, HSPA4L, DNAJA2, DNAJA3, DNAJB1, DNAJB4, DNAJB6, DNAJC7, DNAJC9, DNAJC10, HSPB8, HSPE1, PBX1, CARM1ASPHSQSTM1, CUL3, APP, IQCB1, NOS2, TARDBP, ASNA1, PVRL3, HLA-E, FBLN7, PTCH1, OLFM1, ATL3, TCTN1, CCDC109B, MCU, STEAP3, FAM162A, TMEM160, STX4, SMDT1, NDUFAF1, WDYHV1, LEMD2, LYZL2, TMEM192, NELL2, ECSIT, CD93, STXBP3, BCHE, LRRC59, STX8, VTI1B, SERPINA12, EXD2, BNIP1, ACAD9, HTR2C, SLC7A6OS, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+3835_174253596DDX5%3B self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+4935_174253596DDX5%3B self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+51035_174253596DDX5%3B self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+4935_174253596DDX5%3B self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+4835_174253484DDX5%3B self-association


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38262_595253596AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49262_595253596AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510262_595253596AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49262_595253596AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48262_595253484AKAP13


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ESR1_ASPH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneESR1P03372DB00286Conjugated estrogensEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00304DesogestrelEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00648MitotaneEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00655EstroneEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00675TamoxifenEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00841DobutamineEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB00977Ethinyl EstradiolEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB01406DanazolEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB01431AllylestrenolEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB06710MethyltestosteroneEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB09369Polyestradiol phosphateEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB09371NorethynodrelEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB11071Phenyl salicylateEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB11619GestrinoneEstrogen receptorsmall moleculeapproved
HgeneESR1P03372DB01185FluoxymesteroneEstrogen receptorsmall moleculeapproved|illicit
HgeneESR1P03372DB00255DiethylstilbestrolEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00294EtonogestrelEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00367LevonorgestrelEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00481RaloxifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00539ToremifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00603Medroxyprogesterone acetateEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00624TestosteroneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00882ClomifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00890DienestrolEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00947FulvestrantEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB00957NorgestimateEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB01196EstramustineEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB01593ZincEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB04930PermethrinEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB04938OspemifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB06202LasofoxifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB06401BazedoxifeneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB09070TiboloneEstrogen receptorsmall moleculeapproved|investigational
HgeneESR1P03372DB01708PrasteroneEstrogen receptorsmall moleculeapproved|investigational|nutraceutical
HgeneESR1P03372DB00783EstradiolEstrogen receptorsmall moleculeapproved|investigational|vet_approved
HgeneESR1P03372DB04573EstriolEstrogen receptorsmall moleculeapproved|investigational|vet_approved
HgeneESR1P03372DB01108TrilostaneEstrogen receptorsmall moleculeapproved|investigational|vet_approved|withdrawn
HgeneESR1P03372DB01065MelatoninEstrogen receptorsmall moleculeapproved|nutraceutical|vet_approved
HgeneESR1P03372DB00396ProgesteroneEstrogen receptorsmall moleculeapproved|vet_approved
HgeneESR1P03372DB01183NaloxoneEstrogen receptorsmall moleculeapproved|vet_approved
HgeneESR1P03372DB00431LindaneEstrogen receptorsmall moleculeapproved|withdrawn
HgeneESR1P03372DB00756HexachloropheneEstrogen receptorsmall moleculeapproved|withdrawn
HgeneESR1P03372DB04824PhenolphthaleinEstrogen receptorsmall moleculeapproved|withdrawn

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RelatedDiseases for ESR1_ASPH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneESR1C1458155Mammary Neoplasms11CTD_human
HgeneESR1C0005586Bipolar Disorder5PSYGENET
HgeneESR1C0011570Mental Depression5PSYGENET
HgeneESR1C0011581Depressive disorder5PSYGENET
HgeneESR1C0036341Schizophrenia5PSYGENET
HgeneESR1C0525045Mood Disorders4PSYGENET
HgeneESR1C0001418Adenocarcinoma2CTD_human
HgeneESR1C0021364Male infertility2CTD_human
HgeneESR1C0024121Lung Neoplasms2CTD_human
HgeneESR1C0024667Animal Mammary Neoplasms2CTD_human
HgeneESR1C0025500Mesothelioma2CTD_human
HgeneESR1C0033578Prostatic Neoplasms2CTD_human
HgeneESR1C1956346Coronary Artery Disease2CTD_human
HgeneESR1C3809250ESTROGEN RESISTANCE2ORPHANET;UNIPROT
HgeneESR1C0002395Alzheimer's Disease1CTD_human
HgeneESR1C0004114Astrocytoma1CTD_human
HgeneESR1C0004153Atherosclerosis1CTD_human
HgeneESR1C0005695Bladder Neoplasm1CTD_human
HgeneESR1C0005944Metabolic Bone Disorder1CTD_human
HgeneESR1C0007621Neoplastic Cell Transformation1CTD_human
HgeneESR1C0014170Endometrial Neoplasms1CTD_human
HgeneESR1C0015799Feminization1CTD_human
HgeneESR1C0017658Glomerulonephritis1CTD_human
HgeneESR1C0021361Female infertility1CTD_human
HgeneESR1C0023267Fibroid Tumor1CTD_human
HgeneESR1C0023418leukemia1CTD_human
HgeneESR1C0023903Liver neoplasms1CTD_human
HgeneESR1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneESR1C0024809Marijuana Abuse1PSYGENET
HgeneESR1C0026858Musculoskeletal Pain1CTD_human
HgeneESR1C0027051Myocardial Infarction1CTD_human
HgeneESR1C0027627Neoplasm Metastasis1CTD_human
HgeneESR1C0027643Neoplasm Recurrence, Local1CTD_human
HgeneESR1C0028754Obesity1CTD_human
HgeneESR1C0028960Oligospermia1CTD_human
HgeneESR1C0033941Psychoses, Substance-Induced1CTD_human
HgeneESR1C0036939Shared Paranoid Disorder1PSYGENET
HgeneESR1C0149931Migraine Disorders1CTD_human
HgeneESR1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
HgeneESR1C1720887Female Urogenital Diseases1CTD_human
HgeneESR1C2239176Liver carcinoma1CTD_human
TgeneASPHC1832167Ectopia Lentis, Spontaneous Filtering Blebs, and Craniofacial Dysmorphism1ORPHANET;UNIPROT