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Fusion gene ID: 12077 |
FusionGeneSummary for ESCO1_MGRN1 |
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Fusion gene information | Fusion gene name: ESCO1_MGRN1 | Fusion gene ID: 12077 | Hgene | Tgene | Gene symbol | ESCO1 | MGRN1 | Gene ID | 114799 | 23295 |
Gene name | establishment of sister chromatid cohesion N-acetyltransferase 1 | mahogunin ring finger 1 | |
Synonyms | A930014I12Rik|CTF|ECO1|EFO1|ESO1 | RNF156 | |
Cytomap | 18q11.2 | 16p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | N-acetyltransferase ESCO1CTF7 homolog 1ECO1 homolog 1EFO1pESO1 homolog 1N-acetyltransferase ESCO1 variant 2establishment factor-like protein 1establishment of cohesion 1 homolog 1hEFO1 | E3 ubiquitin-protein ligase MGRN1RING finger protein 156RING-type E3 ubiquitin transferase MGRN1mahogunin RING finger protein 1mahogunin ring finger 1, E3 ubiquitin protein ligaseprobable E3 ubiquitin-protein ligase MGRN1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q5FWF5 | O60291 | |
Ensembl transtripts involved in fusion gene | ENST00000269214, ENST00000580101, | ENST00000262370, ENST00000415496, ENST00000399577, ENST00000588994, ENST00000586183, ENST00000588015, | |
Fusion gene scores | * DoF score | 10 X 5 X 7=350 | 4 X 6 X 5=120 |
# samples | 13 | 6 | |
** MAII score | log2(13/350*10)=-1.42884329880387 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ESCO1 [Title/Abstract] AND MGRN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ESCO1 | GO:0018394 | peptidyl-lysine acetylation | 27112597 |
Tgene | MGRN1 | GO:0043951 | negative regulation of cAMP-mediated signaling | 19737927 |
Tgene | MGRN1 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway | 19737927 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BU161418 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000269214 | ENST00000262370 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-3CDS | ENST00000269214 | ENST00000415496 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-3CDS | ENST00000269214 | ENST00000399577 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-3CDS | ENST00000269214 | ENST00000588994 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-3CDS | ENST00000269214 | ENST00000586183 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-intron | ENST00000269214 | ENST00000588015 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-3CDS | ENST00000580101 | ENST00000262370 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-3CDS | ENST00000580101 | ENST00000415496 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-3CDS | ENST00000580101 | ENST00000399577 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-3CDS | ENST00000580101 | ENST00000588994 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-3CDS | ENST00000580101 | ENST00000586183 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
5UTR-intron | ENST00000580101 | ENST00000588015 | ESCO1 | chr18 | 19180583 | - | MGRN1 | chr16 | 4700364 | + |
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FusionProtFeatures for ESCO1_MGRN1 |
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Hgene | Tgene |
ESCO1 | MGRN1 |
E3 ubiquitin-protein ligase. Mediates monoubiquitinationat multiple sites of TSG101 in the presence of UBE2D1, but not ofUBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling bycompeting with GNAS-binding to MCRs and inhibiting agonist-inducedcAMP production. Does not inhibit ADRB2-signaling. Does notpromote MC1R ubiquitination. Acts also as a negative regulator ofhedgehog signaling (By similarity). {ECO:0000250|UniProtKB:Q9D074,ECO:0000269|PubMed:17229889, ECO:0000269|PubMed:19703557,ECO:0000269|PubMed:19737927}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ESCO1_MGRN1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ESCO1_MGRN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ESCO1 | KDM1A, HDAC1, HDAC2, HIST1H3A, EHMT2, SUV39H1, SETDB1, HECW2, CDK1, FGFR1OP, CBX8, SMC6, TRIM25 | MGRN1 | UBE2G2, TSG101, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2I, UBE2J2, UBE2W, UBE2T, MC1R, MC4R, MC2R, MRAP, ELAVL1, FBXO6, ITCH, NEDD4, HSPA4, TRIM74, TUBA4A, ATXN3, HTT, APBB1, TAZ, ATP1B4, BTNL8, PTPRK, AMFR, DUSP6, PSG8, ANKRD46, ATRN, C9orf40, PDCD2, INTS7, C19orf52, HSDL1, MEGF8, FAM19A4, MFN1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ESCO1_MGRN1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ESCO1_MGRN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |