![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 12068 |
FusionGeneSummary for ERVV-2_SDC1 |
![]() |
Fusion gene information | Fusion gene name: ERVV-2_SDC1 | Fusion gene ID: 12068 | Hgene | Tgene | Gene symbol | ERVV-2 | SDC1 | Gene ID | 100271846 | 6382 |
Gene name | endogenous retrovirus group V member 2, envelope | syndecan 1 | |
Synonyms | ENVV2|HERV-V2 | CD138|SDC|SYND1|syndecan | |
Cytomap | 19q13.41 | 2p24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | endogenous retrovirus group V member 2 Env polyproteinHERV-V_19q13.41 provirus ancestral Env polyprotein 2endogenous retrovirus HSV2endogenous retrovirus group V, member 2envelope glycoprotein ENVV2envelope protein ENVV2 | syndecan-1CD138 antigenheparan sulfate proteoglycan fibroblast growth factor receptorsyndecan proteoglycan 1 | |
Modification date | 20180329 | 20180527 | |
UniProtAcc | B6SEH9 | P18827 | |
Ensembl transtripts involved in fusion gene | ENST00000601417, | ENST00000254351, ENST00000381150, ENST00000403076, ENST00000482879, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 3 X 2=24 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ERVV-2 [Title/Abstract] AND SDC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG002190 | ERVV-2 | chr19 | 53552907 | + | SDC1 | chr2 | 20417299 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000601417 | ENST00000254351 | ERVV-2 | chr19 | 53552907 | + | SDC1 | chr2 | 20417299 | - |
5CDS-intron | ENST00000601417 | ENST00000381150 | ERVV-2 | chr19 | 53552907 | + | SDC1 | chr2 | 20417299 | - |
5CDS-intron | ENST00000601417 | ENST00000403076 | ERVV-2 | chr19 | 53552907 | + | SDC1 | chr2 | 20417299 | - |
5CDS-intron | ENST00000601417 | ENST00000482879 | ERVV-2 | chr19 | 53552907 | + | SDC1 | chr2 | 20417299 | - |
Top |
FusionProtFeatures for ERVV-2_SDC1 |
![]() |
Hgene | Tgene |
ERVV-2 | SDC1 |
Cell surface proteoglycan that bears both heparansulfate and chondroitin sulfate and that links the cytoskeleton tothe interstitial matrix. Regulates exosome biogenesis in concertwith SDCBP and PDCD6IP (PubMed:22660413).{ECO:0000269|PubMed:22660413}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ERVV-2_SDC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ERVV-2_SDC1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ERVV-2_SDC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ERVV-2_SDC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SDC1 | C0345967 | Malignant mesothelioma | 1 | CTD_human |