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Fusion gene ID: 12035 |
FusionGeneSummary for ERICH1_PTPRR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ERICH1_PTPRR | Fusion gene ID: 12035 | Hgene | Tgene | Gene symbol | ERICH1 | PTPRR | Gene ID | 157697 | 5801 |
| Gene name | glutamate rich 1 | protein tyrosine phosphatase, receptor type R | |
| Synonyms | HSPC319 | EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ | |
| Cytomap | 8p23.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamate-rich protein 1 | receptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q86X53 | Q15256 | |
| Ensembl transtripts involved in fusion gene | ENST00000522706, ENST00000262109, ENST00000518277, | ENST00000283228, ENST00000440835, ENST00000537619, ENST00000378778, ENST00000342084, ENST00000549308, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 33 X 13 X 10=4290 |
| # samples | 6 | 31 | |
| ** MAII score | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(31/4290*10)=-3.79063752711267 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ERICH1 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A2NE-06A | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000522706 | ENST00000283228 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| intron-intron | ENST00000522706 | ENST00000440835 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| intron-intron | ENST00000522706 | ENST00000537619 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| intron-intron | ENST00000522706 | ENST00000378778 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| intron-intron | ENST00000522706 | ENST00000342084 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| intron-intron | ENST00000522706 | ENST00000549308 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| In-frame | ENST00000262109 | ENST00000283228 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5CDS-intron | ENST00000262109 | ENST00000440835 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5CDS-intron | ENST00000262109 | ENST00000537619 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5CDS-intron | ENST00000262109 | ENST00000378778 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5CDS-intron | ENST00000262109 | ENST00000342084 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5CDS-intron | ENST00000262109 | ENST00000549308 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5UTR-3CDS | ENST00000518277 | ENST00000283228 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5UTR-intron | ENST00000518277 | ENST00000440835 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5UTR-intron | ENST00000518277 | ENST00000537619 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5UTR-intron | ENST00000518277 | ENST00000378778 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5UTR-intron | ENST00000518277 | ENST00000342084 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
| 5UTR-intron | ENST00000518277 | ENST00000549308 | ERICH1 | chr8 | 642478 | - | PTPRR | chr12 | 71286757 | - |
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FusionProtFeatures for ERICH1_PTPRR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ERICH1 | PTPRR |
| Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ERICH1_PTPRR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ERICH1_ENST00000262109_chr8_642478_-_PTPRR_ENST00000283228_chr12_71286757_-_740aa MAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCWPEPSSCGS PENASSGDDTEGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLA MDGQDLEVENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDALPSEEVLRS LNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQP ALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAM EYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGK EKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYW YTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ERICH1_ENST00000262109_chr8_642478_-_PTPRR_ENST00000283228_chr12_71286757_-_2220nt ATGGCGGCGCACAGGAAGCACGTGTTTGTGGAGAAGGTGCTGCAGAGACTTTTTCCTCCTGTTCCAAGTGGCCAAGGAAAGAGGGAACCC CAGACGCTGGCCGTCCAAAATCCACCAAAGAAAGTGACCTCTGAGAAAGTGAGCCAGAAACATGCTGAGCCTTTGACAGACACTGGCTCT GAGACCCCGACTGCCCGACGGCTCTACACTGCCAGCGGGCCTCCTGAGGGCTACGTCCCCTGTTGGCCGGAGCCCAGCAGCTGTGGGAGC CCCGAGAACGCCTCCAGCGGGGATGACACAGAAGGGTGCTTTTCAGGAAACAATGATCATTTTTTGGCAATTAATCAGAAGAAGAGTGGG AAGCCGGTATTCATTTATAAGCATTCACAAGACATTGAGAAGAGCCTGGATATAGCCCCACAAAAAATCTACAGACATAGCTACCATTCC TCTTCCGAAGCTCAAGTAAGCAAACGCCACCAGATTGTCAATTCAGCATTTCCTAGACCCGCATATGACCCGTCTCTCAATCTGCTGGCC ATGGATGGTCAAGATCTTGAAGTGGAAAATCTCCCAATCCCAGCAGCAAATGTAATTGTGGTGACACTGCAAATGGATGTAAACAAGCTG AACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATCGCCTCATTGGA AAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTGCCCTCTGAGGAAGTTCTTCGTTCA CTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAGGGCAGCATGAA GCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATTATAGTAACGTGTTTGATGATTCTT TACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCACATTACAGCCA GCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAATGTTGTCGTGGACCCTCAAGGCCGA GGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAGAGAGAAGAGGG TCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCAACACCACGGGAGAAGGTAGCAATG GAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAAGTGAATTCATG GAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCC CTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAG GAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATT GTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTG GTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGG TACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCC CAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTG AAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ERICH1_ENST00000262109_chr8_642478_-_PTPRR_ENST00000283228_chr12_71286757_-_3400nt AGGAGGGCGGAACCCGGAAGGCACGGCGCTCAGCTCAGGACCGCGCGCCGTGGTCTGAGGTCCGCGGCAGGGTCCCGCATGGCGGCGCAC AGGAAGCACGTGTTTGTGGAGAAGGTGCTGCAGAGACTTTTTCCTCCTGTTCCAAGTGGCCAAGGAAAGAGGGAACCCCAGACGCTGGCC GTCCAAAATCCACCAAAGAAAGTGACCTCTGAGAAAGTGAGCCAGAAACATGCTGAGCCTTTGACAGACACTGGCTCTGAGACCCCGACT GCCCGACGGCTCTACACTGCCAGCGGGCCTCCTGAGGGCTACGTCCCCTGTTGGCCGGAGCCCAGCAGCTGTGGGAGCCCCGAGAACGCC TCCAGCGGGGATGACACAGAAGGGTGCTTTTCAGGAAACAATGATCATTTTTTGGCAATTAATCAGAAGAAGAGTGGGAAGCCGGTATTC ATTTATAAGCATTCACAAGACATTGAGAAGAGCCTGGATATAGCCCCACAAAAAATCTACAGACATAGCTACCATTCCTCTTCCGAAGCT CAAGTAAGCAAACGCCACCAGATTGTCAATTCAGCATTTCCTAGACCCGCATATGACCCGTCTCTCAATCTGCTGGCCATGGATGGTCAA GATCTTGAAGTGGAAAATCTCCCAATCCCAGCAGCAAATGTAATTGTGGTGACACTGCAAATGGATGTAAACAAGCTGAACATAACCTTG CTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATCGCCTCATTGGAAAGAAGAACAGT ATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTGCCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAAT GTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAGGGCAGCATGAAGCGGACAAAATC TGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATTATAGTAACGTGTTTGATGATTCTTTACAGATTAAAA GAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCACATTACAGCCAGCACTGTCCGAG GCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAATGTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAG ATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCT CTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCAACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAG TCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAAGTGAATTCATGGAAATACCAATG AACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGTG TGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTC ATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCACA AAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTA AATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATGG CCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGG CCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGA GTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCAT GCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGAGTCATTGAAGACTTGTCAGACCATCAATCTCTTGGGGTGATT AATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCTTCCTGCAATGGAAGGAAGGAGAAGCTCTGAAGCCCATGTATGGCATGGATTGTG GAAGACTGGGCAACATATTTAAGATTTCCAGCTCCTTGTGTATATGAATGCATTTGTAAGCATCCCCCAAATTATTCTGAAGGTTTTTTG ATGATGGAGGTATGATAGGTTTATCACACAGCCTAAGGCAGATTTTGTTTTGTCTGTACTGACTCTATCTGCCACACAGAATGTATGTAT GTAATATTCAGTAATAAATGTCATCAGGTGATGACTGGATGAGCTGCTGAAGACATTCGTATTATGTGTTAGATGCTTTAATGTTTGCAA AATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACTGTTCCTGTTTTGAAGTGCTATTACCTTTCTCAGTTACCAGAATCTTGCTGCTAA AGTTGCAAGTGATTGATAATGGATTTTTAACAGAGAAGTCTTTGTTTTTGAAAAACAAAAATCAAAAACAGTAACTATTTTATATGGAAA TGTGTCTTGATAATATTACCTATTAAATGTGTATTTATAGTCCCTCCTATCAAACAATTACAGAGCACAATGATTGTCATTGGGTATATA TGTATTTACTCTCTATTATTGGGCATAAAGGTGGCTTCTGCTCCAGAACTCTATCCACTGTATTTCCACATCGTGAGTCATTTTACTTTA AAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTATCAAGAGTTTTAACTACTTGTCTCTCTTTTGCTAAGAAGGGATTTTTGAATATGC TATCTACCTGGAATCTCTCTCTCAACAAAAGGTATATGCCTTCAGGAATGATATAATCTGTCCCATTTTCGAGGCTCCTTATAAGGACAT TTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAATCTTCAAGAGACAAAAAAAATTAAAATAACTACCCTCAGCAAACACTAGCTGTT |
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FusionGenePPI for ERICH1_PTPRR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ERICH1 | EWSR1 | PTPRR | MAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ERICH1_PTPRR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ERICH1_PTPRR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | PTPRR | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | PTPRR | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
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