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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12035

FusionGeneSummary for ERICH1_PTPRR

check button Fusion gene summary
Fusion gene informationFusion gene name: ERICH1_PTPRR
Fusion gene ID: 12035
HgeneTgene
Gene symbol

ERICH1

PTPRR

Gene ID

157697

5801

Gene nameglutamate rich 1protein tyrosine phosphatase, receptor type R
SynonymsHSPC319EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ
Cytomap

8p23.3

12q15

Type of geneprotein-codingprotein-coding
Descriptionglutamate-rich protein 1receptor-type tyrosine-protein phosphatase RCh-1 PTPaseNC-PTPCOM1R-PTP-Rch-1PTPaseprotein tyrosine phosphatase Cr1PTPaseprotein-tyrosine phosphatase NC-PTPCOM1protein-tyrosine phosphatase PCPTP1
Modification date2018051920180519
UniProtAcc

Q86X53

Q15256

Ensembl transtripts involved in fusion geneENST00000522706, ENST00000262109, 
ENST00000518277, 
ENST00000283228, 
ENST00000440835, ENST00000537619, 
ENST00000378778, ENST00000342084, 
ENST00000549308, 
Fusion gene scores* DoF score5 X 4 X 4=8033 X 13 X 10=4290
# samples 631
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(31/4290*10)=-3.79063752711267
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERICH1 [Title/Abstract] AND PTPRR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A2NE-06AERICH1chr8

642478

-PTPRRchr12

71286757

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000522706ENST00000283228ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000440835ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000537619ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000378778ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000342084ERICH1chr8

642478

-PTPRRchr12

71286757

-
intron-intronENST00000522706ENST00000549308ERICH1chr8

642478

-PTPRRchr12

71286757

-
In-frameENST00000262109ENST00000283228ERICH1chr8

642478

-PTPRRchr12

71286757

-
5CDS-intronENST00000262109ENST00000440835ERICH1chr8

642478

-PTPRRchr12

71286757

-
5CDS-intronENST00000262109ENST00000537619ERICH1chr8

642478

-PTPRRchr12

71286757

-
5CDS-intronENST00000262109ENST00000378778ERICH1chr8

642478

-PTPRRchr12

71286757

-
5CDS-intronENST00000262109ENST00000342084ERICH1chr8

642478

-PTPRRchr12

71286757

-
5CDS-intronENST00000262109ENST00000549308ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-3CDSENST00000518277ENST00000283228ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000440835ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000537619ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000378778ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000342084ERICH1chr8

642478

-PTPRRchr12

71286757

-
5UTR-intronENST00000518277ENST00000549308ERICH1chr8

642478

-PTPRRchr12

71286757

-

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FusionProtFeatures for ERICH1_PTPRR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERICH1

Q86X53

PTPRR

Q15256

Sequesters mitogen-activated protein kinases (MAPKs)such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactiveform. The MAPKs bind to a dephosphorylated kinase interactingmotif, phosphorylation of which by the protein kinase A complexreleases the MAPKs for activation and translocation into thenucleus (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERICH1_PTPRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ERICH1_ENST00000262109_chr8_642478_-_PTPRR_ENST00000283228_chr12_71286757_-_740aa
MAAHRKHVFVEKVLQRLFPPVPSGQGKREPQTLAVQNPPKKVTSEKVSQKHAEPLTDTGSETPTARRLYTASGPPEGYVPCWPEPSSCGS
PENASSGDDTEGCFSGNNDHFLAINQKKSGKPVFITKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPATDPSLNLLA
MDGQDLEVENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDALPSEEVLRS
LNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFTAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQP
ALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAM
ETLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRTKTILPNPLSRVCLRPKNVTDSLSTYINANTIRGYSGK
EKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGITGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYW
YTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQTE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ERICH1_ENST00000262109_chr8_642478_-_PTPRR_ENST00000283228_chr12_71286757_-_2220nt
ATGGCGGCGCACAGGAAGCACGTGTTTGTGGAGAAGGTGCTGCAGAGACTTTTTCCTCCTGTTCCAAGTGGCCAAGGAAAGAGGGAACCC
CAGACGCTGGCCGTCCAAAATCCACCAAAGAAAGTGACCTCTGAGAAAGTGAGCCAGAAACATGCTGAGCCTTTGACAGACACTGGCTCT
GAGACCCCGACTGCCCGACGGCTCTACACTGCCAGCGGGCCTCCTGAGGGCTACGTCCCCTGTTGGCCGGAGCCCAGCAGCTGTGGGAGC
CCCGAGAACGCCTCCAGCGGGGATGACACAGAAGGGTGCTTTTCAGGAAACAATGATCATTTTTTGGCAATTAATCAGAAGAAGAGTGGG
AAGCCGGTATTCATTTATAAGCATTCACAAGACATTGAGAAGAGCCTGGATATAGCCCCACAAAAAATCTACAGACATAGCTACCATTCC
TCTTCCGAAGCTCAAGTAAGCAAACGCCACCAGATTGTCAATTCAGCATTTCCTAGACCCGCATATGACCCGTCTCTCAATCTGCTGGCC
ATGGATGGTCAAGATCTTGAAGTGGAAAATCTCCCAATCCCAGCAGCAAATGTAATTGTGGTGACACTGCAAATGGATGTAAACAAGCTG
AACATAACCTTGCTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATCGCCTCATTGGA
AAGAAGAACAGTATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTGCCCTCTGAGGAAGTTCTTCGTTCA
CTTAATATCAATGTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAGGGCAGCATGAA
GCGGACAAAATCTGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATTATAGTAACGTGTTTGATGATTCTT
TACAGATTAAAAGAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCACATTACAGCCA
GCACTGTCCGAGGCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAATGTTGTCGTGGACCCTCAAGGCCGA
GGTGCTCCTGAGATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAGAGAGAAGAGGG
TCCAACGTATCTCTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCAACACCACGGGAGAAGGTAGCAATG
GAGTATCTGCAGTCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAAGTGAATTCATG
GAAATACCAATGAACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCC
CTCAGCAGAGTGTGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAG
GAGAAAGCCTTCATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATT
GTTATGATCACAAAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTG
GTTATCAGTGTAAATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGG
TACACCTCATGGCCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCC
CAGGGCCGAGGGCCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTG
AAAGAAGAAGGAGTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ERICH1_ENST00000262109_chr8_642478_-_PTPRR_ENST00000283228_chr12_71286757_-_3400nt
AGGAGGGCGGAACCCGGAAGGCACGGCGCTCAGCTCAGGACCGCGCGCCGTGGTCTGAGGTCCGCGGCAGGGTCCCGCATGGCGGCGCAC
AGGAAGCACGTGTTTGTGGAGAAGGTGCTGCAGAGACTTTTTCCTCCTGTTCCAAGTGGCCAAGGAAAGAGGGAACCCCAGACGCTGGCC
GTCCAAAATCCACCAAAGAAAGTGACCTCTGAGAAAGTGAGCCAGAAACATGCTGAGCCTTTGACAGACACTGGCTCTGAGACCCCGACT
GCCCGACGGCTCTACACTGCCAGCGGGCCTCCTGAGGGCTACGTCCCCTGTTGGCCGGAGCCCAGCAGCTGTGGGAGCCCCGAGAACGCC
TCCAGCGGGGATGACACAGAAGGGTGCTTTTCAGGAAACAATGATCATTTTTTGGCAATTAATCAGAAGAAGAGTGGGAAGCCGGTATTC
ATTTATAAGCATTCACAAGACATTGAGAAGAGCCTGGATATAGCCCCACAAAAAATCTACAGACATAGCTACCATTCCTCTTCCGAAGCT
CAAGTAAGCAAACGCCACCAGATTGTCAATTCAGCATTTCCTAGACCCGCATATGACCCGTCTCTCAATCTGCTGGCCATGGATGGTCAA
GATCTTGAAGTGGAAAATCTCCCAATCCCAGCAGCAAATGTAATTGTGGTGACACTGCAAATGGATGTAAACAAGCTGAACATAACCTTG
CTTCGGATCTTCCGCCAAGGAGTGGCTGCAGCTTTAGGACTCTTACCCCAGCAAGTGCACATCAATCGCCTCATTGGAAAGAAGAACAGT
ATTGAACTGTTTGTGTCTCCCATAAACCGAAAAACAGGAATTTCTGATGCTCTGCCCTCTGAGGAAGTTCTTCGTTCACTTAATATCAAT
GTTTTGCATCAAAGTTTATCCCAGTTTGGAATTACAGAAGTCTCTCCTGAGAAAAATGTTTTACAAGGGCAGCATGAAGCGGACAAAATC
TGGAGCAAAGAAGGATTTTATGCTGTTGTCATTTTTCTCAGCATCTTTGTTATTATAGTAACGTGTTTGATGATTCTTTACAGATTAAAA
GAAAGATTTCAGCTTTCCTTAAGACAAGACAAAGAGAAAAACCAGGAGATCCACCTATCGCCCATCACATTACAGCCAGCACTGTCCGAG
GCAAAGACAGTCCACAGCATGGTCCAACCTGAGCAGGCCCCAAAGGTACTGAATGTTGTCGTGGACCCTCAAGGCCGAGGTGCTCCTGAG
ATCAAAGCTACCACCGCTACCTCTGTTTGCCCTTCTCCTTTCAAAATGAAGCCCATAGGACTTCAAGAGAGAAGAGGGTCCAACGTATCT
CTTACATTGGACATGAGTAGCTTGGGGAACATTGAACCCTTTGTGTCTATACCAACACCACGGGAGAAGGTAGCAATGGAGTATCTGCAG
TCAGCCAGCCGAATTCTCACAAGGTCTCAGCTGAGGGACGTCGTGGCAAGTTCACATTTACTCCAAAGTGAATTCATGGAAATACCAATG
AACTTTGTGGATCCCAAAGAAATTGATATTCCGCGTCATGGAACTAAAAATCGCTATAAGACCATTTTACCAAATCCCCTCAGCAGAGTG
TGTTTAAGACCAAAAAATGTAACCGATTCATTGAGCACCTACATTAATGCTAATTATATTAGGGGCTACAGTGGCAAGGAGAAAGCCTTC
ATTGCCACGCAGGGCCCCATGATCAACACCGTGGATGATTTCTGGCAGATGGTTTGGCAGGAAGACAGCCCTGTGATTGTTATGATCACA
AAACTCAAAGAAAAAAATGAGAAATGTGTGCTATACTGGCCGGAAAAGAGAGGGATATATGGAAAAGTTGAGGTTCTGGTTATCAGTGTA
AATGAATGTGATAACTACACCATTCGAAACCTTGTCTTAAAGCAAGGAAGCCACACCCAACATGTGAAGCATTACTGGTACACCTCATGG
CCTGATCACAAGACTCCAGACAGTGCCCAGCCCCTCCTACAGCTCATGCTGGATGTAGAAGAAGACAGACTTGCTTCCCAGGGCCGAGGG
CCTGTGGTTGTCCACTGCAGTGCAGGAATAGGTAGAACAGGGTGTTTTATTGCTACATCCATTGGCTGTCAACAGCTGAAAGAAGAAGGA
GTTGTGGATGCACTAAGCATTGTCTGCCAGCTTCGTATGGATAGAGGTGGAATGGTGCAAACCAGTGAGCAGTATGAATTTGTGCACCAT
GCTCTGTGCCTGTATGAGAGCAGACTTTCAGCAGAGACTGTCCAGTGAGTCATTGAAGACTTGTCAGACCATCAATCTCTTGGGGTGATT
AATCAAATTACCCACCCAAGGCTTCTAGAAGGAGCTTCCTGCAATGGAAGGAAGGAGAAGCTCTGAAGCCCATGTATGGCATGGATTGTG
GAAGACTGGGCAACATATTTAAGATTTCCAGCTCCTTGTGTATATGAATGCATTTGTAAGCATCCCCCAAATTATTCTGAAGGTTTTTTG
ATGATGGAGGTATGATAGGTTTATCACACAGCCTAAGGCAGATTTTGTTTTGTCTGTACTGACTCTATCTGCCACACAGAATGTATGTAT
GTAATATTCAGTAATAAATGTCATCAGGTGATGACTGGATGAGCTGCTGAAGACATTCGTATTATGTGTTAGATGCTTTAATGTTTGCAA
AATCTGTCTTGTGAATGGACTGTCAGCTGTTAAACTGTTCCTGTTTTGAAGTGCTATTACCTTTCTCAGTTACCAGAATCTTGCTGCTAA
AGTTGCAAGTGATTGATAATGGATTTTTAACAGAGAAGTCTTTGTTTTTGAAAAACAAAAATCAAAAACAGTAACTATTTTATATGGAAA
TGTGTCTTGATAATATTACCTATTAAATGTGTATTTATAGTCCCTCCTATCAAACAATTACAGAGCACAATGATTGTCATTGGGTATATA
TGTATTTACTCTCTATTATTGGGCATAAAGGTGGCTTCTGCTCCAGAACTCTATCCACTGTATTTCCACATCGTGAGTCATTTTACTTTA
AAAGGGAAAAACAAATTTGTAGCAACTCTGAAGTATCAAGAGTTTTAACTACTTGTCTCTCTTTTGCTAAGAAGGGATTTTTGAATATGC
TATCTACCTGGAATCTCTCTCTCAACAAAAGGTATATGCCTTCAGGAATGATATAATCTGTCCCATTTTCGAGGCTCCTTATAAGGACAT
TTCCATGTATGTCCTTACATTTCTGAAAGCTTTCAATCTTCAAGAGACAAAAAAAATTAAAATAACTACCCTCAGCAAACACTAGCTGTT


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FusionGenePPI for ERICH1_PTPRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERICH1EWSR1PTPRRMAPK1, MAPK3, MAPK7, MAPK14, NTRK1, CEP290, EGFR, ERBB2, IGF1R, RET, MST1R, ERBB4, FGFR2, FGFR4, KDR, TEK, INSR, ALDH18A1, DHPS, PNMA2, TRIM11, KIAA0196, TBC1D5, DNAJC13, SNX6, PTPRR, MAPK1IP1L, MAPKAPK3, MAD2L1BP, CBS, MAPK11, CCT8L1P, HSPA4L, LMTK2, AATK, ERBB3, RYK, ROR1, ROR2, PTK7, EPHA2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERICH1_PTPRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERICH1_PTPRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRRC0041696Unipolar Depression1PSYGENET
TgenePTPRRC1269683Major Depressive Disorder1PSYGENET