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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 12034

FusionGeneSummary for ERICH1_PCM1

check button Fusion gene summary
Fusion gene informationFusion gene name: ERICH1_PCM1
Fusion gene ID: 12034
HgeneTgene
Gene symbol

ERICH1

PCM1

Gene ID

157697

5108

Gene nameglutamate rich 1pericentriolar material 1
SynonymsHSPC319PTC4|RET/PCM-1
Cytomap

8p23.3

8p22

Type of geneprotein-codingprotein-coding
Descriptionglutamate-rich protein 1pericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1
Modification date2018051920180523
UniProtAcc

Q86X53

Q15154

Ensembl transtripts involved in fusion geneENST00000522706, ENST00000262109, 
ENST00000518277, 
ENST00000325083, 
ENST00000519253, ENST00000524226, 
ENST00000518537, ENST00000518936, 
ENST00000327578, 
Fusion gene scores* DoF score5 X 4 X 4=805 X 5 X 3=75
# samples 65
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ERICH1 [Title/Abstract] AND PCM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E2-A14T-01AERICH1chr8

665861

-PCM1chr8

17882870

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000522706ENST00000325083ERICH1chr8

665861

-PCM1chr8

17882870

+
intron-3CDSENST00000522706ENST00000519253ERICH1chr8

665861

-PCM1chr8

17882870

+
intron-3CDSENST00000522706ENST00000524226ERICH1chr8

665861

-PCM1chr8

17882870

+
intron-intronENST00000522706ENST00000518537ERICH1chr8

665861

-PCM1chr8

17882870

+
intron-intronENST00000522706ENST00000518936ERICH1chr8

665861

-PCM1chr8

17882870

+
intron-intronENST00000522706ENST00000327578ERICH1chr8

665861

-PCM1chr8

17882870

+
Frame-shiftENST00000262109ENST00000325083ERICH1chr8

665861

-PCM1chr8

17882870

+
Frame-shiftENST00000262109ENST00000519253ERICH1chr8

665861

-PCM1chr8

17882870

+
Frame-shiftENST00000262109ENST00000524226ERICH1chr8

665861

-PCM1chr8

17882870

+
5CDS-intronENST00000262109ENST00000518537ERICH1chr8

665861

-PCM1chr8

17882870

+
5CDS-intronENST00000262109ENST00000518936ERICH1chr8

665861

-PCM1chr8

17882870

+
5CDS-intronENST00000262109ENST00000327578ERICH1chr8

665861

-PCM1chr8

17882870

+
5UTR-3CDSENST00000518277ENST00000325083ERICH1chr8

665861

-PCM1chr8

17882870

+
5UTR-3CDSENST00000518277ENST00000519253ERICH1chr8

665861

-PCM1chr8

17882870

+
5UTR-3CDSENST00000518277ENST00000524226ERICH1chr8

665861

-PCM1chr8

17882870

+
5UTR-intronENST00000518277ENST00000518537ERICH1chr8

665861

-PCM1chr8

17882870

+
5UTR-intronENST00000518277ENST00000518936ERICH1chr8

665861

-PCM1chr8

17882870

+
5UTR-intronENST00000518277ENST00000327578ERICH1chr8

665861

-PCM1chr8

17882870

+

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FusionProtFeatures for ERICH1_PCM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERICH1

Q86X53

PCM1

Q15154


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ERICH1_PCM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ERICH1_PCM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ERICH1EWSR1PCM1BBS4, KRT15, ING5, KIAA0368, KRT19, CCDC53, ABI2, EXOC8, EPS8, CEP72, PCNT, HAP1, EWSR1, HNRNPUL1, CLTC, MIB1, FUS, CEP131, PPIB, SIRT7, NEURL4, PAN2, CASK, E2F4, YWHAQ, LATS2, SAV1, CEP250, HAUS2, OBSL1, CCDC8, CSPP1, CCDC183, SLC25A41, SSFA2, RASSF8, RASSF7, IFT81, NTRK1, BTRC, MED4, HERC2, AHI1, CEP162, RPGRIP1L, CC2D2A, CEP128, LCA5, OFD1, CCDC138, CEP170, PIBF1, SSX2IP, WRAP73, HAUS1, HAUS4, KIAA0753, CCDC77, CCNB2, CEP350, CEP95, CSNK1A1, DSP, KIF20A, LUZP1, MCM10, MCRS1, MPRIP, NDC80, SMARCD2, TPGS1, SUPT5H, SSBP1, KIF7, SKA1, TSPYL1, SREK1IP1, CSNK1D, IFT172, CEP55, IFT20, CCDC14, HMMR, CFAP97, IPO5, KCTD12, SNRPE, SPICE1, ABCD3, ACOT9, ATP5L, CAMSAP1, CC2D1A, CCDC66, CEP120, CKAP2, FGFR1OP, HAUS3, HAUS5, HAUS6, HAUS7, HAUS8, IDH3B, IFT57, IFT74, NCKAP5L, RAE1, STAU1, TP53BP2, TTK, TXLNA, TXLNG, TBC1D31, WDR83, XRN1, ZNF280C, ACTR2, ANKRD26, BAIAP2, BICD1, BICD2, BTF3, C11orf49, KNSTRN, C2CD3, CAMSAP2, CCDC112, CCDC18, CCDC22, CCDC85C, CCDC92, CCNB1, CCP110, CDC123, CEP164, CEP192, CEP57L1, CEP63, CEP85, CEP89, CEP97, CKAP2L, CNOT10, COMMD2, COMMD4, CSNK1E, DAPK3, DIAPH3, ERC1, EXOC4, FOPNL, GNAO1, GPATCH1, IBTK, IQCB1, KIAA1328, KIF14, LRRC49, LRRCC1, MAGED1, MAP7D3, MED29, MIS18A, MIS18BP1, MOB4, MPHOSPH9, MYO9A, NAV1, NEDD1, NME7, NOL11, NUF2, ODF2L, ODF2, PCBP3, PKN2, PLK1, KIZ, PPP1R9B, IFT22, RRM2, SCLT1, SDCCAG3, SECISBP2, SMG5, SMG7, SPATA24, SPATS2, SPC24, SRGAP2, STRN4, TANC1, TCHP, TEX9, TNIP1, TRAF3IP1, TTC12, TTF2, TTLL4, TTLL5, CEP104, CEP290, CEP152, CEP135, CNTRL, FBF1, NINL, NIN, POC5, SASS6, RPGRIP1, STIL, CENPJ, CENPE, PPP2CA, PRKAR2B, DYNLL1, MAPRE1, SLAIN2, CEP170P1, PPP2R3C, YWHAE, YWHAZ, MTMR7, C6orf118, BIN3, CCDC172, LPXN, FAM81B, COG5, ING2, CCDC65, LCA5L, CCDC40, DKK3, NECAB2, ATG14, TSC1, RNF168


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ERICH1_PCM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ERICH1_PCM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePCM1C0036341Schizophrenia1CTD_human