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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1203

FusionGeneSummary for AHDC1_IFI6

check button Fusion gene summary
Fusion gene informationFusion gene name: AHDC1_IFI6
Fusion gene ID: 1203
HgeneTgene
Gene symbol

AHDC1

IFI6

Gene ID

27245

2537

Gene nameAT-hook DNA binding motif containing 1interferon alpha inducible protein 6
SynonymsMRD256-16|FAM14C|G1P3|IFI-6-16|IFI616
Cytomap

1p36.11-p35.3

1p35.3

Type of geneprotein-codingprotein-coding
DescriptionAT-hook DNA-binding motif-containing protein 1interferon alpha-inducible protein 6interferon, alpha-inducible protein clone IFI-6-16interferon-induced protein 6-16
Modification date2018051920180523
UniProtAcc

Q5TGY3

P09912

Ensembl transtripts involved in fusion geneENST00000247087, ENST00000374011, 
ENST00000480033, 
ENST00000361157, 
ENST00000339145, ENST00000362020, 
Fusion gene scores* DoF score11 X 7 X 8=6162 X 2 X 2=8
# samples 122
** MAII scorelog2(12/616*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: AHDC1 [Title/Abstract] AND IFI6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-1738-01AAHDC1chr1

27873772

-IFI6chr1

27992986

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000247087ENST00000361157AHDC1chr1

27873772

-IFI6chr1

27992986

-
3UTR-3CDSENST00000247087ENST00000339145AHDC1chr1

27873772

-IFI6chr1

27992986

-
3UTR-3CDSENST00000247087ENST00000362020AHDC1chr1

27873772

-IFI6chr1

27992986

-
3UTR-3CDSENST00000374011ENST00000361157AHDC1chr1

27873772

-IFI6chr1

27992986

-
3UTR-3CDSENST00000374011ENST00000339145AHDC1chr1

27873772

-IFI6chr1

27992986

-
3UTR-3CDSENST00000374011ENST00000362020AHDC1chr1

27873772

-IFI6chr1

27992986

-
intron-3CDSENST00000480033ENST00000361157AHDC1chr1

27873772

-IFI6chr1

27992986

-
intron-3CDSENST00000480033ENST00000339145AHDC1chr1

27873772

-IFI6chr1

27992986

-
intron-3CDSENST00000480033ENST00000362020AHDC1chr1

27873772

-IFI6chr1

27992986

-

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FusionProtFeatures for AHDC1_IFI6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AHDC1

Q5TGY3

IFI6

P09912


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AHDC1_IFI6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AHDC1_IFI6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
AHDC1ITSN2, ATXN1, APP, CBX5, CBX6, ZDHHC17, HIST3H3, CBX1, FBL, UBR3, DOK5, MYH9, IKZF5, ZNF324B, TRIM68, TRIM25IFI6ELAVL1, APP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AHDC1_IFI6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AHDC1_IFI6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIFI6C0000786Spontaneous abortion1CTD_human
TgeneIFI6C0021400Influenza1CTD_human