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Fusion gene ID: 1202 |
FusionGeneSummary for AHDC1_DNAJC8 |
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Fusion gene information | Fusion gene name: AHDC1_DNAJC8 | Fusion gene ID: 1202 | Hgene | Tgene | Gene symbol | AHDC1 | DNAJC8 | Gene ID | 27245 | 22826 |
Gene name | AT-hook DNA binding motif containing 1 | DnaJ heat shock protein family (Hsp40) member C8 | |
Synonyms | MRD25 | HSPC331|SPF31 | |
Cytomap | 1p36.11-p35.3 | 1p35.3 | |
Type of gene | protein-coding | protein-coding | |
Description | AT-hook DNA-binding motif-containing protein 1 | dnaJ homolog subfamily C member 8DnaJ (Hsp40) homolog, subfamily C, member 8splicing protein spf31 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q5TGY3 | O75937 | |
Ensembl transtripts involved in fusion gene | ENST00000247087, ENST00000374011, ENST00000480033, | ENST00000263697, ENST00000489277, | |
Fusion gene scores | * DoF score | 11 X 7 X 8=616 | 1 X 1 X 1=1 |
# samples | 12 | 1 | |
** MAII score | log2(12/616*10)=-2.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: AHDC1 [Title/Abstract] AND DNAJC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-EB-A82B-01A | AHDC1 | chr1 | 27929908 | - | DNAJC8 | chr1 | 28537148 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000247087 | ENST00000263697 | AHDC1 | chr1 | 27929908 | - | DNAJC8 | chr1 | 28537148 | - |
5UTR-5UTR | ENST00000247087 | ENST00000489277 | AHDC1 | chr1 | 27929908 | - | DNAJC8 | chr1 | 28537148 | - |
5UTR-3CDS | ENST00000374011 | ENST00000263697 | AHDC1 | chr1 | 27929908 | - | DNAJC8 | chr1 | 28537148 | - |
5UTR-5UTR | ENST00000374011 | ENST00000489277 | AHDC1 | chr1 | 27929908 | - | DNAJC8 | chr1 | 28537148 | - |
5UTR-3CDS | ENST00000480033 | ENST00000263697 | AHDC1 | chr1 | 27929908 | - | DNAJC8 | chr1 | 28537148 | - |
5UTR-5UTR | ENST00000480033 | ENST00000489277 | AHDC1 | chr1 | 27929908 | - | DNAJC8 | chr1 | 28537148 | - |
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FusionProtFeatures for AHDC1_DNAJC8 |
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Hgene | Tgene |
AHDC1 | DNAJC8 |
Suppresses polyglutamine (polyQ) aggregation of ATXN3 inneuronal cells (PubMed:27133716). {ECO:0000269|PubMed:27133716}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for AHDC1_DNAJC8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for AHDC1_DNAJC8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
AHDC1 | ITSN2, ATXN1, APP, CBX5, CBX6, ZDHHC17, HIST3H3, CBX1, FBL, UBR3, DOK5, MYH9, IKZF5, ZNF324B, TRIM68, TRIM25 | DNAJC8 | SF3A2, IKBKG, SRRM1, SRRM2, APP, RAP1A, PIN4, TPX2, HMGA1, FBXO25, SRPK2, SRPK1, HECW2, ANXA2, LOC100128588, HUWE1, HSPA5, HSPA9, METTL13, PDLIM5, HSPA4L, HYOU1, NEDD8, EWSR1, EGR1, XRCC3, REEP5, EMC2, MMGT1, PIGS, CNTROB, PA2G4, TRAP1, SND1, ANXA5, SNRPB2, UBE2N, G3BP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for AHDC1_DNAJC8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for AHDC1_DNAJC8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |